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1-38 of 38
Keywords: cell death
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Articles
Journal:
Biochemical Journal
Biochem J (2024) 481 (22): 1679–1705.
Published: 14 November 2024
...Shamaita Chatterjee; Tarang Gupta; Gurvinder Kaur; Kausik Chattopadhyay Gasdermin D (GSDMD) is the chief executioner of inflammatory cell death or pyroptosis. During pyroptosis, proteolytic processing of GSDMD releases its N-terminal domain (NTD), which then forms large oligomeric pores...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2022) 479 (19): 2049–2062.
Published: 14 October 2022
...Bart Tummers; Douglas R. Green Apoptosis and necroptosis regulate many aspects of organismal biology and are involved in various human diseases. TNF is well known to induce both of these forms of cell death and the underlying mechanisms have been elaborately described. However, cells can also...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (15): 1621–1651.
Published: 05 August 2022
...Holly Anderton; Suhaib Alqudah Cell death is an essential process that plays a vital role in restoring and maintaining skin homeostasis. It supports recovery from acute injury and infection and regulates barrier function and immunity. Cell death can also provoke inflammatory responses. Loss of cell...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (9): 995–1006.
Published: 12 May 2022
...Christine J. Watson The mammary gland provides a spectacular example of physiological cell death whereby the cells that produce milk during lactation are removed swiftly, efficiently, and without inducing inflammation upon the cessation of lactation. The milk-producing cells arise primarily during...
Articles
In Collection
Cell death and survival
Ayelén Mariana Distéfano, Gabriel Alejandro López, Victoria Bauer, Eduardo Zabaleta, Gabriela Carolina Pagnussat
Journal:
Biochemical Journal
Biochem J (2022) 479 (7): 857–866.
Published: 19 April 2022
...Ayelén Mariana Distéfano; Gabriel Alejandro López; Victoria Bauer; Eduardo Zabaleta; Gabriela Carolina Pagnussat Regulated cell death (RCD) is an essential process that plays key roles along the plant life cycle. Unlike accidental cell death, which is an uncontrolled biological process, RCD...
Articles
In Collection
Cell death and survival
Journal:
Biochemical Journal
Biochem J (2022) 479 (3): 357–384.
Published: 11 February 2022
...Laura Lossi Regulated cell death is a vital and dynamic process in multicellular organisms that maintains tissue homeostasis and eliminates potentially dangerous cells. Apoptosis, one of the better-known forms of regulated cell death, is activated when cell-surface death receptors like Fas...
Articles
In Collection
Cell death and survival
Benedikt Kolbrink, Theresa Riebeling, Nikolas K. Teiwes, Claudia Steinem, Hubert Kalbacher, Ulrich Kunzendorf, Stefan Krautwald
Journal:
Biochemical Journal
Biochem J (2022) 479 (3): 259–272.
Published: 04 February 2022
...-containing adaptor-inducing interferon-β. Remarkably, all four aforementioned mammalian proteins harbouring such a RHIM domain are key components of inflammatory signalling and regulated cell death (RCD) processes. Immunogenic cell death by regulated necrosis causes extensive tissue damage in a wide range...
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (4): 749–764.
Published: 24 February 2021
... including energy metabolism, cell death and dynamics and its consequences, such as the generation of ROS and potentiation of OS. Finally, we examine the metabolic effects arising as a result of prenatal cocaine exposure. Impaired energy metabolism in the brain is a characteristic feature of exposure...
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (7): 1253–1265.
Published: 05 April 2018
... ischemia (oxygen and glucose deprivation, OGD) to assess the mechanistic involvement of SR-B1, PI3K (phosphatidylinositol-3-kinase), and AKT in HDL-mediated protection of cardiomyocytes from cell death. Neonatal mouse cardiomyocytes and immortalized human ventricular cardiomyocytes, subjected to OGD for 4...
Articles
Damián Estrada, Gabriela Specker, Alejandra Martínez, Patricia Pereira Dias, Barbara Hissa, Luciana O. Andrade, Rafael Radi, Lucía Piacenza
Journal:
Biochemical Journal
Biochem J (2018) 475 (7): 1235–1251.
Published: 05 April 2018
... mediators may control parasite proliferation through the induction of intracellular amastigote programmed cell death (PCD). In this work, we show that T. cruzi (CL-Brener strain) infection in primary cardiomyocytes produced an early (24 h post infection) mitochondrial dysfunction with H 2 O 2 generation...
Includes: Supplementary data
Articles
Maria C. Tanzer, Anne Tripaydonis, Andrew I. Webb, Samuel N. Young, Leila N. Varghese, Cathrine Hall, Warren S. Alexander, Joanne M. Hildebrand, John Silke, James M. Murphy
Journal:
Biochemical Journal
Biochem J (2015) 471 (2): 255–265.
Published: 02 October 2015
... of a phosphomimetic S345D MLKL activation loop mutant-induced stimulus-independent cell death in all knockout cells, demonstrating that RIPK3 phosphorylation of the activation loop of MLKL is sufficient to induce cell death. Cell death was also induced by S228A, S228E and S158A MLKL mutants in the absence of death...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 469 (2): e5–e7.
Published: 06 July 2015
...-terminus domain. alopecia cell death gasdermin Gsdma3 mutant mouse pro-autophagic activity The skin is an immune organ and acts as an epidermal barrier. A collapse of these functions causes immune-related diseases, such as atopic dermatitis and cancers derived from epithelial cell...
Articles
Ariane Neumann, Evelien T. M. Berends, Andreas Nerlich, E. Margo Molhoek, Richard L. Gallo, Timo Meerloo, Victor Nizet, Hassan Y. Naim, Maren von Köckritz-Blickwede
Journal:
Biochemical Journal
Biochem J (2014) 464 (1): 3–11.
Published: 23 October 2014
... membrane of neutrophils. cathelicidin cell death hydrophobicity nuclear membrane NETosis neutrophil extracellular trap The cell death mechanism ‘NETosis’ is a novel fundamental innate immune defence based on the specialized cell death of activated neutrophils, which release extracellular...
Articles
Journal:
Biochemical Journal
Biochem J (2014) 463 (3): e3–e5.
Published: 10 October 2014
...Eric Fontaine Metformin is the most widely prescribed drug used to treat patients affected by Type 2 diabetes. Metformin has also been shown to prevent some forms of cell death; however, evidence suggests that it may have anti-neoplastic properties. All of these effects have been attributed...
Articles
Teresa Arnandis, Ivan Ferrer-Vicens, Luis Torres, Concha García, Elena R. Garcia-Trevijano, Rosa Zaragoza, Juan R. Viña
Journal:
Biochemical Journal
Biochem J (2014) 459 (2): 355–368.
Published: 28 March 2014
... for calpain-1 in the weaned gland after the pregnancy/lactation cycle, controlling programmed cell death and participating in the epigenetic programme during adipocyte differentiation. Total protein was extracted from snap-frozen mammary glands (0.1 g) by homogenization in a buffer containing detergents...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 447 (2): 281–289.
Published: 26 September 2012
... in any medium, provided the original work is properly cited. cell death energy metabolism mitochondrion Src tyrosine kinase reactive oxygen species (ROS) Mitochondrial oxygen consumption was determined using a Clark-type oxygen electrode (Strathkelvin Instruments) as described...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 119–125.
Published: 15 December 2010
...Allison M. McGee; Christopher P. Baines Opening of the MPT (mitochondrial permeability transition) pore is a critical event in mitochondrial-mediated cell death. However, with the exception of CypD (cyclophilin D), the exact molecular composition of the MPT pore remains uncertain. C1qbp (complement...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 245–252.
Published: 15 December 2010
... target gene expression under ER (endoplasmic reticulum) stress in MEFs (mouse embryonic fibroblasts). Consistent with XBP1s favouring cell survival under ER stress, Sirt1 −/− MEFs display a greater resistance to ER-stress-induced apoptotic cell death compared with Sirt1 +/+ MEFs. Taken together...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 419 (1): 185–194.
Published: 13 March 2009
... by immunoblotting. HEK-293 cells, transfected or not with the indicated plasmids, AR230 cells or MDA-MB-231 cells were incubated with the indicated doses of FLAG–rhTRAIL plus 1 μg/ml of M2 for different time periods. HEK-293 cell death was measured by morphological observation of Trypan Blue-stained cells. Each...
Includes: Supplementary data
Articles
Natalia Tkachuk, Julia Kiyan, Sergey Tkachuk, Roman Kiyan, Nelli Shushakova, Hermann Haller, Inna Dumler
Journal:
Biochemical Journal
Biochem J (2008) 415 (2): 265–273.
Published: 25 September 2008
...Natalia Tkachuk; Julia Kiyan; Sergey Tkachuk; Roman Kiyan; Nelli Shushakova; Hermann Haller; Inna Dumler Deregulated apoptosis of MCs (mesangial cells) is associated with a number of kidney diseases including end-stage diabetic nephropathy. Cell death by apoptosis is a tightly orchestrated event...
Articles
Potchanapond Graidist, Michio Yazawa, Moltira Tonganunt, Akiko Nakatomi, Curtis Chun-Jen Lin, Jui-Yoa Chang, Amornrat Phongdara, Ken Fujise
Journal:
Biochemical Journal
Biochem J (2007) 408 (2): 181–191.
Published: 14 November 2007
... a potent anti-apoptotic function: its overexpression protects HeLa [ 3 ] and U2OS [ 7 ] cells against apoptosis. In addition, the depletion of fortilin from cells induces spontaneous cell death in MCF-7 [ 3 ] and U937 cells [ 6 ]. Although fortilin is likely to make cells cancerous and cancerous cells more...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 407 (1): 121–128.
Published: 12 September 2007
...Virginie de Hemptinne; Dieter Rondas; Joël Vandekerckhove; Katia Vancompernolle We have previously shown that TNF (tumour necrosis factor) induces phosphorylation of GLO1 (glyoxalase I), which is required for cell death in L929 cells. In the present paper, we show that the TNF-induced...
Articles
Bruno GUIGAS, Dominique DETAILLE, Christiane CHAUVIN, Cécile BATANDIER, Frédéric De OLIVEIRA, Eric FONTAINE, Xavier LEVERVE
Journal:
Biochemical Journal
Biochem J (2004) 382 (3): 877–884.
Published: 07 September 2004
.... In the present study, the effects of metformin on respiration, complex 1 activity, mitochondrial permeability transition, cytochrome c release and cell death were investigated in cultured cells from a human carcinoma-derived cell line (KB cells). Metformin significantly decreased respiration both in intact cells...
Articles
Kazuhiro AOKI, Ryosuke UCHIYAMA, Saki ITONORI, Mutsumi SUGITA, Fang-Sik CHE, Akira ISOGAI, Noriyasu HADA, Junko HADA, Tadahiro TAKEDA, Hidehiko KUMAGAI, Kenji YAMAMOTO
Journal:
Biochemical Journal
Biochem J (2004) 378 (2): 461–472.
Published: 01 March 2004
... (phytosphingosine) as the sole sphingoid base and 2-hydroxytetracosanoic acid (>90%) as the major fatty acid. ZGLs were found to cause cell death in suspensions of cultured rice cells. The cell death-inducing activity of ZGLs is probably due to the characteristic glycan moiety of Man(α1-6)GlcN, and PC-containing...
Articles
Gerd HEIMLICH, Alastair D. McKINNON, Katussevani BERNARDO, Dieter BRDICZKA, John C. REED, Renate KAIN, Martin KRÖNKE, Juliane M. JÜRGENSMEIER
Journal:
Biochemical Journal
Biochem J (2004) 378 (1): 247–255.
Published: 15 February 2004
..., cell death, cytochrome c, mitochondria. INTRODUCTION Apoptosis plays an important role in many physiological processes, including the removal of autoreactive lymphocytes and of redundant cells during development. Apoptosis is also an essential counterbalance to cell division for tissue homoeostasis [1...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 373 (3): 739–746.
Published: 01 August 2003
... Neuro2A cells. In accordance with this role of EGR-1 in cell death, antisense oligonucleotides increase cell viability in cells cultured in the absence of serum. This apoptotic activity of the EGR-1 appears to be mediated by p73, a member of the p53 family of proteins, since an increase in the amount...
Articles
Hwain SHIN, Kazuya OKADA, John C. WILKINSON, Katherine M. SOLOMON, Colin S. DUCKETT, John C. REED, Guy S. SALVESEN
Journal:
Biochemical Journal
Biochem J (2003) 373 (3): 965–971.
Published: 01 August 2003
.... WILKINSON , Katherine M. SOLOMON , Colin S. DUCKETT , John C. REED* and Guy S. SALVESEN*1 *The Program in Apoptosis and Cell Death Research, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, U.S.A., and Departments of Pathology and Internal Medicine, University of Michigan, Ann Arbor...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 370 (1): 195–203.
Published: 15 February 2003
... a novel family of cell-death-inducing DFF45-like effectors (CIDEs) has been identified. Among CIDEs, two from human (CIDE-A and CIDE-B) and three from mouse (CIDE-A, CIDE-B and FSP27) have been reported. In this study human CIDE-3, a novel member of CIDEs, was identified upon sequence analysis...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 367 (2): 541–548.
Published: 15 October 2002
... To whom correspondence should be addressed (e-mail [email protected] ). 14 11 2001 23 7 2002 30 7 2002 30 7 2002 The Biochemical Society, London ©2002 2002 apoptosis cell death cyclophilin D diamide oxidative stress phenylarsine oxide Abbreviations...
Articles
Zheng DONG, Junichiro NISHIYAMA, Xiaolan YI, Manjeri A. VENKATACHALAM, Michael DENTON, Sumin GU, Senlin LI, Mei QIANG
Journal:
Biochemical Journal
Biochem J (2002) 364 (2): 413–421.
Published: 01 June 2002
...Zheng DONG; Junichiro NISHIYAMA; Xiaolan YI; Manjeri A. VENKATACHALAM; Michael DENTON; Sumin GU; Senlin LI; Mei QIANG Inhibitors of apoptosis (IAPs) antagonize cell death and regulate the cell cycle. One mechanism controlling IAP expression is translation initiation through the internal ribosome...
Articles
M. Valeria CATANI, Antonio COSTANZO, Isabella SAVINI, Massimo LEVRERO, Vincenzo DE LAURENZI, Jean Y.J. WANG, Gerry MELINO, Luciana AVIGLIANO
Journal:
Biochemical Journal
Biochem J (2002) 364 (2): 441–447.
Published: 01 June 2002
[email protected] ). 22 11 2001 30 1 2002 22 3 2002 The Biochemical Society, London ©2002 2002 c-Abl cell death cisplatin vitamin C Abbreviations used: AA-2P, magnesium l -ascorbate 2-phosphate; CTD, C-terminal repeat domain of RNA polymerase II; GAPDH, glyceraldehyde-3...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 364 (1): 41–47.
Published: 08 May 2002
... to caspase cleavage. casein kinase 2 cell death protein phosphorylation proteolysis Abbreviations used: HS1, haematopoietic lineage cell-specific protein 1; MTT, 3-(4,5-dimethylthiazol-2-yl)-3,5-diphenyltetrazolium bromide; PARP, poly(ADP-ribose) polymerase; TBB, 4,5,6,7...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 362 (3): 573–578.
Published: 08 March 2002
...Sebastian FEHLBERG; Stefan TRAUTWEIN; Alexandra GÖKE; Rüdiger GÖKE Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors which are involved in many biological processes, such as regulation of cell differentiation, lipid metabolism, inflammation and cell death. PPARs...
Articles
Thierry COPPOLA, Véronique PERRET-MENOUD, Sonia GATTESCO, Sarah MAGNIN, Isabel POMBO, Ulrich BLANK, Romano REGAZZI
Journal:
Biochemical Journal
Biochem J (2002) 362 (2): 273–279.
Published: 22 February 2002
... 13 12 2001 The Biochemical Society, London ©2002 2002 cell death exocytosis insulin Abbreviations used: ΔC1, Rab3-GEP mutant lacking 127 amino acids at the C-terminus; ΔC2, Rab3-GEP mutant lacking 229 amino acids at the C-terminus; ΔDD, Rab3-GEP mutant lacking the death...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 356 (2): 509–513.
Published: 24 May 2001
... of the mitochondrial electron transport chain [4], promotes lipid peroxidation [5] and DNA damage [6] and finally leads to mitochondrial permeability transition and cell death [7]. Thus many defence mechanisms have evolved to limit the levels and}or deleterious effects of ONOO in biological systems [8 11...
Articles
Patrice Xavier PETIT, Marie-Claude GENDRON, Nicolas SCHRANTZ, Didier MÉTIVIER, Guido KROEMER, Zofia MACIOROWSKA, Franck SUREAU, Steven KOESTER
Journal:
Biochemical Journal
Biochem J (2001) 353 (2): 357–367.
Published: 08 January 2001
..., London © 2001 2001 Bcl-2 cell death mitochondrial transmembrane potential permeability transition redox status Biochem. J. (2001) 353, 357 367 (Printed in Great Britain) 357 Oxidation of pyridine nucleotides during Fas- and ceramide-induced apoptosis in Jurkat cells : correlation...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 345 (2): 271–278.
Published: 10 January 2000
... 10 1999 29 10 1999 The Biochemical Society, London © 2000 2000 apoptosis Bcl-2 protein cell death Biochem. J. (2000) 345, 271 278 (Printed in Great Britain) 271 Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 337 (1): 83–87.
Published: 17 December 1998
... of the acetyltransferase and overall loss of intracellular polyamines may be involved in the final, possibly necrotic, stages of cell death. cancer cell death polyamine efflux polyamine oxidase spermidine/spermine N1-acetyltransferase Biochem. J. (1999) 337, 83 87 (Printed in Great Britain) 83 Changes...
