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1-31 of 31
Keywords: cell migration
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Articles
Ravichandran Vignesh, Anita Sjölander, Ganesh Venkatraman, Suresh Kumar Rayala, Gopala Krishna Aradhyam
Journal:
Biochemical Journal
Biochem J (2021) 478 (12): 2265–2283.
Published: 18 June 2021
...) was purchased from Cell Signaling Technology (Danvers, MA, USA). Mouse monoclonal anti-calnuc (sc-100793) was used at 1 : 100 dilution (in 5% BSA in TBST) for mouse experiments. The dilution for other antibodies was performed as per the manufacturer's instructions. calnuc cell migration exosomes...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (1): 247–260.
Published: 15 January 2021
...Shan Cao; Lan Xiao; Junyao Wang; Guodong Chen; Yulan Liu The integrity of the intestinal mucosal barrier protects hosts against pathological conditions. Early mucosal restitution after wounding refers to epithelial cell migration into a defect. The RNA-binding protein HuR plays an important role...
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (12): 2281–2293.
Published: 24 June 2020
...′-UTR sequence of OCT4 gene . Unlike in HCT116 cells, overexpression of miR-3658 in SW480 cells brought about growth inhibition, cell cycle arrest and reduced cell migration, detected by flow cytometry, and scratch test assay. Overall, these findings demonstrated that miR-3658 as a tumor suppressor...
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (6): 1159–1178.
Published: 27 March 2020
... myosin (NM) isoforms (IIA > IIC > IIB) leading to the redistribution of actomyosin filaments to enhance cell migration. Using COS-7 cells which do not naturally express NMIIA, S100P is now shown to interact directly with α,β-tubulin in vitro and in vivo with an equilibrium K d of 2–3 × 10 −7 M...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (20): 2953–2963.
Published: 18 October 2019
... incubated for 72–96 h for efficient gene silencing of FHOD1. © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 active FHOD1 cell migration cell spreading centripetal flow stress fiber transverse arcs Actin filaments assemble...
Includes: Supplementary data
Articles
In Collection
Awards
Journal:
Biochemical Journal
Biochem J (2019) 476 (4): 705–718.
Published: 28 February 2019
... that subsequently initiate signalling pathways to control a broad range of functional endpoints including cell migration, proliferation and survival. The α4 and α9 integrins form a small sub-family of receptors that share some specific ligands and binding partners. Although relatively poorly studied compared...
Articles
Alice C. Copsey, Simon Cooper, Robert Parker, Ella Lineham, Cuzack Lapworth, Deema Jallad, Steve Sweet, Simon J. Morley
Journal:
Biochemical Journal
Biochem J (2017) 474 (18): 3109–3120.
Published: 31 August 2017
... factors at the leading edge of migrating cells to promote cell migration and spreading. * These authors contributed equally to this work. 12 5 2017 14 7 2017 19 7 2017 21 7 2017 © 2017 The Author(s) 2017 This is an open access article published by Portland Press...
Includes: Supplementary data
Articles
Lucía Rodríguez-Fernández, Iván Ferrer-Vicens, Concha García, Sara S. Oltra, Rosa Zaragozá, Juan R. Viña, Elena R. García-Trevijano
Journal:
Biochemical Journal
Biochem J (2016) 473 (18): 2893–2909.
Published: 12 September 2016
... for cell migration in pathological states such as breast cancer. The intracellular Ca 2+ -dependent proteases, calpains (CAPNs), are known to cleave adhesion proteins. The isoform-specific function of CAPN1 and CAPN2 was explored and compared in two models of cell adhesion disruption: mice mammary gland...
Includes: Supplementary data
Articles
Giorgio Cozza, Sofia Zanin, Stefania Sarno, Elena Costa, Cristina Girardi, Giovanni Ribaudo, Mauro Salvi, Giuseppe Zagotto, Maria Ruzzene, Lorenzo A. Pinna
Journal:
Biochemical Journal
Biochem J (2015) 471 (3): 415–430.
Published: 16 October 2015
... by kinetic and mutational analyses. bisubstrate inhibitor cell migration CK2 ecto-kinase protein kinase inhibitor protein phosphorylation signal transduction Protein kinases are implicated in a wide variety of human diseases, with special reference to neoplasia. Consequently, compounds...
Articles
Missing-in-Metastasis regulates cell motility and invasion via PTPδ-mediated changes in SRC activity
Journal:
Biochemical Journal
Biochem J (2015) 465 (1): 89–101.
Published: 12 December 2014
... migration and invasion. This defined a signature of signalling events that may be exploited for selective targeting of MIM-deficient metastatic tumours. breast cancer cell invasion cell migration metastasis metastasis suppressor 1 (MTSS1) Missing in Metastasis (MIM) protein tyrosine phosphatase...
Articles
Angela Oppelt, Ellen M. Haugsten, Tobias Zech, Håvard E. Danielsen, Anita Sveen, Viola H. Lobert, Rolf I. Skotheim, Jørgen Wesche
Journal:
Biochemical Journal
Biochem J (2014) 461 (3): 383–390.
Published: 10 July 2014
... protein 3), together with their lipid product PtdIns5 P , are important for migration of normal human fibroblasts. As these proteins are a kinase and a phosphatase respectively, and thereby considered druggable, we wanted to test their involvement in cancer cell migration and invasion. First, we showed...
Includes: Supplementary data
Articles
Soo Youn Lee, Jung Mi Kim, Soo Young Cho, Hyun Suk Kim, Hee Sun Shin, Jeong Yong Jeon, Rukhsana Kausar, Seon Yong Jeong, Young Seek Lee, Myung Ae Lee
Journal:
Biochemical Journal
Biochem J (2014) 459 (3): 565–576.
Published: 11 April 2014
... to the lower chamber, followed by incubation for an additional 12 h to allow cell migration. The cells adhering to the upper surface were wiped off with a filter wiper. After the filter wipe, the remaining cells were fixed with 4% paraformaldehyde solution and stained with haematoxylin (Sigma). The cells...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 457 (1): 19–26.
Published: 10 December 2013
.... Neural crest cells exhibit collective cell migration, moving in streams of high directionality. The migratory neural crest streams are kept in shape by the presence of negative signals in their vicinity. The directionality of the migrating neural crest is achieved by contact-dependent cell polarization...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 453 (2): 201–208.
Published: 28 June 2013
... requirement protein A4), which encodes a serine protease crucial for cell migration and invasion. As a result, migration and invasion activities are down-regulated in RACK1 -knockdown BeWo cells. The present study reveals a novel function for RACK1 to regulate GCM1 activity and placental cell migration...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 453 (1): 17–25.
Published: 13 June 2013
...Fumihiko Nakamura Cell migration, phagocytosis and cytokinesis are mechanically intensive cellular processes that are mediated by the dynamic assembly and contractility of the actin cytoskeleton. GAPs (GTPase-activating proteins) control activities of the Rho family proteins including Cdc42, Rac1...
Articles
Svend Kjær, Mark Linch, Andrew Purkiss, Brenda Kostelecky, Phillip P. Knowles, Carine Rosse, Philippe Riou, Christelle Soudy, Sarah Kaye, Bhavisha Patel, Erika Soriano, Judith Murray-Rust, Caroline Barton, Christian Dillon, Jon Roffey, Peter J. Parker, Neil Q. McDonald
Journal:
Biochemical Journal
Biochem J (2013) 451 (2): 329–342.
Published: 28 March 2013
... 18 2 2013 18 2 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 ATP pocket atypical protein kinase C cell-based assay cell migration cell polarity chemical inhibitor crystallography Madin–Darby canine kidney (MDCK) cell protein kinase A/protein kinase...
Includes: Multimedia, Supplementary data
Articles
Olivia C. Probst, Evren Karayel, Nicole Schida, Elisabeth Nimmerfall, Elisabeth Hehenberger, Verena Puxbaum, Lukas Mach
Journal:
Biochemical Journal
Biochem J (2013) 451 (1): 91–99.
Published: 14 March 2013
... may promote the invasiveness of malignant tumour cells [ 24 ]. Various studies have shown that M6P/IGF2R indeed has the capacity to impede tumour cell migration [ 25 , 26 ]. Interestingly, we have recently found that M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind M6P...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 443 (3): 587–601.
Published: 16 April 2012
... 2012 1 To whom correspondence should be addressed (email [email protected] ). cell migration glucose transport insulin secretion phosphoinositide phosphoinositide 3-kinase (PI3K) Phosphoinositides are phospholipids comprising two fatty acid chains linked by a glycerol...
Articles
Jing Zhao, Donghong He, Evgeny Berdyshev, Mintao Zhong, Ravi Salgia, Andrew J. Morris, Susan S. Smyth, Viswanathan Natarajan, Yutong Zhao
Journal:
Biochemical Journal
Biochem J (2011) 439 (1): 45–55.
Published: 14 September 2011
...Jing Zhao; Donghong He; Evgeny Berdyshev; Mintao Zhong; Ravi Salgia; Andrew J. Morris; Susan S. Smyth; Viswanathan Natarajan; Yutong Zhao Lung cell migration is a crucial step for re-epithelialization that in turn is essential for remodelling and repair after lung injury. In the present paper we...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 145–153.
Published: 15 December 2010
...) and rabbit polyclonal anti-c-Fos (1:3000 dilution) antibodies (Santa Cruz Biotechnology). activator protein 1 (AP-1) breast cancer cell migration JunB protein kinase C (PKC) TBX3 transcription factor Probes WT (5′-GCTGGATGACTGAGGCATTTCAG-3′), AP-371 Mut (5′-GCTGGACGATCGTGGCATTTCAG-3...
Articles
Chia-Hui Wang, Fabian Davamani, Shih-Che Sue, Shao-Chen Lee, Po-long Wu, Fan-Mei Tang, Chiaho Shih, Tai-huang Huang, Wen-guey Wu
Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 127–138.
Published: 15 December 2010
... is important for HDGF internalization. We further demonstrate that both HATH and HATH (K96A) could be internalized through macropinocytosis after binding to the cell surface HS. Interestingly, HS-mediated HATH (K96A) internalization is found to exhibit an inhibitory effect on cell migration and proliferation...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2009) 422 (3): 433–442.
Published: 27 August 2009
... Biochemical Society 2009 cell attachment cell migration cell spreading β1 integrin ligand-independent receptor tyrosine kinase High expression of the EphB4 receptor has been documented in a large variety of human cancers, including breast, ovarian and prostate cancer, early colorectal...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2008) 414 (2): 261–270.
Published: 12 August 2008
...-repeat protein 1), is a highly conserved WD-repeat protein in eukaryotes and promotes cofilin-mediated actin filament disassembly in vitro ; however, little is known about the mechanisms by which Aip1 functions in cytokinesis and cell migration in mammalian cells. In the present study, we investigated...
Includes: Multimedia, Supplementary data
Articles
Amanda C. Lomas, Kieran T. Mellody, Lyle J. Freeman, Daniel V. Bax, C. Adrian Shuttleworth, Cay M. Kielty
Journal:
Biochemical Journal
Biochem J (2007) 405 (3): 417–428.
Published: 13 July 2007
... supported primary human aortic SMC (smooth-muscle cell) attachment through α5β1 and α4β1 integrins. Cells on fibulin-5 spread poorly and displayed prominent membrane ruffles but no stress fibres or focal adhesions, unlike cells on fibronectin that also binds these integrins. Cell migration and proliferation...
Articles
Cong Cao, Yun Sun, Sarah Healey, Zhigang Bi, Gang Hu, Shu Wan, Nicola Kouttab, Wenming Chu, Yinsheng Wan
Journal:
Biochemical Journal
Biochem J (2006) 400 (2): 225–234.
Published: 14 November 2006
... known as AQP3 water transport inhibitors, as well as two other bivalent heavy metals Mn 2+ and Co 2+ , inhibited EGF-induced cell migration in human skin fibroblasts. AQP3 knockdown by small interfering RNA inhibited EGF-induced AQP3 expression and cell migration. Furthermore, an EGFR (EGF receptor...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 394 (2): 495–500.
Published: 10 February 2006
...-derived growth factor)- and lysophosphatidic acid-induced migration of embryonic fibroblasts. We demonstrate that the overexpression of LPP1 inhibits cell migration by reducing the PDGF-induced activation of p42/p44 MAPK (mitogen-activated protein kinase). This appears to occur via a mechanism...
Articles
Mariko Omatsu-Kanbe, Kazuko Inoue, Yusuke Fujii, Takefumi Yamamoto, Takahiro Isono, Norihisa Fujita, Hiroshi Matsuura
Journal:
Biochemical Journal
Biochem J (2006) 393 (1): 171–180.
Published: 12 December 2005
... reorganization and membrane ruffling mediated through P2Y receptors. Enhancement of preadipocyte migration into fat cell clusters is one of the essential processes of adipose tissue development in vivo and cell migration assays revealed that stimulation of P2Y receptors enhanced chemokinesis (migration...
Articles
Mariarita Bianchi, Stefania De Lucchini, Oriano Marin, David L. Turner, Steven K. Hanks, Emma Villa-Moruzzi
Journal:
Biochemical Journal
Biochem J (2005) 391 (2): 359–370.
Published: 10 October 2005
... 20 6 2005 24 6 2005 24 6 2005 The Biochemical Society, London 2005 cell adhesion cell migration focal adhesion kinase (FAK) glycogen synthase kinase 3 (GSK3) protein phosphatase protein phosphorylation FAK (focal adhesion kinase) is a non-receptor tyrosine kinase...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 384 (1): E1.
Published: 09 November 2004
... of investigation from other groups to show that the ability of mDab1 to regulate actin dynamics during cell motility was under the negative control of tyrosine phosphorylation, leading to ubiquitin-mediated degradation of mDab1. actin polymerization cell migration filopodium neuronal Wiskott–Aldrich syndrome...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 359 (2): 325–333.
Published: 08 October 2001
... independent of the CaM substrate interaction. We also propose that TIMP-2 acts as a negative regulator of MT1-MMP-dependent activities promoted by the action of CaM inhibitors in U-87 glioblastoma cells. Key words: actin cytoskeleton, cell migration, glioma, MT1- MMP, TIMP-2. membrane domain does not seem...
Articles
Borhane ANNABI, Marie-Paule LACHAMBRE, Nathalie BOUSQUET-GAGNON, Martine PAGÉ, Denis GINGRAS, Richard BÉLIVEAU
Journal:
Biochemical Journal
Biochem J (2001) 353 (3): 547–553.
Published: 25 January 2001
...-dependent cell migration by caveolin 1 also suggests that the localization of MT1-MMP to caveolin-enriched domains might have an important function in the control of its enzymic activity. angiogenesis cancer caveolin cell migration glioblastoma Biochem. J. (2001) 353, 547 553 (Printed in Great...
