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Keywords: cell polarity
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Biochem J (2021) 478 (7): 1321–1332.
Published: 06 April 2021
...Jing Yuan How; Rebecca K. Stephens; Krystle Y.B. Lim; Patrick O. Humbert; Marc Kvansakul Scribble is a critical cell polarity regulator that has been shown to work as either an oncogene or tumor suppressor in a context dependent manner, and also impacts cell migration, tissue architecture and...
Includes: Supplementary data
Biochem J (2013) 451 (2): 329–342.
Published: 28 March 2013
... (protein kinase C)] isoforms ι and ζ play crucial roles in the formation and maintenance of cell polarity and represent attractive anti-oncogenic drug targets in Ras-dependent tumours. To date, few isoform-specific chemical biology tools are available to inhibit aPKC catalytic activity. In the present...
Includes: Multimedia, Supplementary data
Biochem J (2011) 439 (2): 195–205.
Published: 28 September 2011
..., contribute to the development of human malignancies. These regulate processes as diverse as cytoskeletal organization, cell polarity, cell proliferation and many signal transduction pathways. In the present review, we discuss how PBM–PDZ recognition and imbalances therein can perturb cellular homoeostasis...
Biochem J (2007) 401 (2): 377–390.
Published: 21 December 2006
... chemotaxis results from co-ordinated chemoattractant gradient sensing, cell polarization and cellular motility, and accumulating data suggest that small GTPase signalling plays a central role in each of these processes as well as in signal relay. The present review summarizes these recent findings, which...
Biochem J (2006) 397 (3): 389–398.
Published: 13 July 2006
... cytoplasmic distribution of Rhotekin in polarized MDCK cells. These results suggest that there is (1) Rho-dependent regulation of Rhotekin-PIST interaction, (2) involvement of PIST in the recruitment of Rhotekin to AJs and (3) a possible role(s) for these two proteins in cell-polarity development and/or...
Biochem J (2006) 394 (3): e7.
Published: 24 February 2006
... are involved in regulating cell polarity, whereas others appear to control cellular differentiation. Of the 12 human AMPK-related protein kinase family members, 11 can be activated following phosphorylation of their T-loop threonine residue by the LKB1 complex. Nine of these AMPK-related kinases...
Biochem J (2005) 388 (1): 177–184.
Published: 10 May 2005
...Edward WHEATLEY; Katrin RITTINGER The multi-domain protein Scd2 acts as a scaffold upon which the small GTPase Cdc42 (cell division cycle 42), its nucleotide-exchange factor Scd1 and the p21-activated kinase Shk1 assemble to regulate cell polarity and the mating response in fission yeast. In the...