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1-9 of 9
Keywords: cell polarity
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Cell signaling in the 21st century
Journal:
Biochemical Journal
Biochem J (2023) 480 (24): 2037–2044.
Published: 15 December 2023
... PtdSer does [ 17 , 18 ]. The overall observation that the aPKC PSS can interact with PIs agrees with the long-standing evidence that PSS peptides can mediate interactions with anionic phospholipids [ 19 ]. apkc atypical pkc cell polarity phospholipids protein kinase c Correspondence...
Articles
Journal:
Biochemical Journal
Biochem J (2022) 479 (12): 1303–1315.
Published: 22 June 2022
...Airah Javorsky; Patrick O. Humbert; Marc Kvansakul The Scribble (Scrib) protein is a conserved cell polarity regulator with anti-tumorigenic properties. Viruses like the Tick-born encephalitis virus (TBEV) target Scribble to establish a cellular environment supporting viral replication, which...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2021) 478 (7): 1321–1332.
Published: 06 April 2021
...Jing Yuan How; Rebecca K. Stephens; Krystle Y.B. Lim; Patrick O. Humbert; Marc Kvansakul Scribble is a critical cell polarity regulator that has been shown to work as either an oncogene or tumor suppressor in a context dependent manner, and also impacts cell migration, tissue architecture...
Includes: Supplementary data
Articles
Adenosine-binding motif mimicry and cellular effects of a thieno[2,3- d ]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes
Available to PurchaseSvend Kjær, Mark Linch, Andrew Purkiss, Brenda Kostelecky, Phillip P. Knowles, Carine Rosse, Philippe Riou, Christelle Soudy, Sarah Kaye, Bhavisha Patel, Erika Soriano, Judith Murray-Rust, Caroline Barton, Christian Dillon, Jon Roffey, Peter J. Parker, Neil Q. McDonald
Journal:
Biochemical Journal
Biochem J (2013) 451 (2): 329–342.
Published: 28 March 2013
... (protein kinase C)] isoforms ι and ζ play crucial roles in the formation and maintenance of cell polarity and represent attractive anti-oncogenic drug targets in Ras-dependent tumours. To date, few isoform-specific chemical biology tools are available to inhibit aPKC catalytic activity. In the present...
Includes: Multimedia, Supplementary data
Articles
PDZ domains: the building blocks regulating tumorigenesis
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2011) 439 (2): 195–205.
Published: 28 September 2011
..., contribute to the development of human malignancies. These regulate processes as diverse as cytoskeletal organization, cell polarity, cell proliferation and many signal transduction pathways. In the present review, we discuss how PBM–PDZ recognition and imbalances therein can perturb cellular homoeostasis...
Articles
Big roles for small GTPases in the control of directed cell movement
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2007) 401 (2): 377–390.
Published: 21 December 2006
... chemotaxis results from co-ordinated chemoattractant gradient sensing, cell polarization and cellular motility, and accumulating data suggest that small GTPase signalling plays a central role in each of these processes as well as in signal relay. The present review summarizes these recent findings, which...
Articles
Identification of a PDZ protein, PIST, as a binding partner for Rho effector Rhotekin: biochemical and cell-biological characterization of Rhotekin–PIST interaction
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2006) 397 (3): 389–398.
Published: 13 July 2006
... cytoplasmic distribution of Rhotekin in polarized MDCK cells. These results suggest that there is (1) Rho-dependent regulation of Rhotekin-PIST interaction, (2) involvement of PIST in the recruitment of Rhotekin to AJs and (3) a possible role(s) for these two proteins in cell-polarity development...
Articles
The ubiquitin-associated domain of AMPK-related protein kinases allows LKB1-induced phosphorylation and activation
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2006) 394 (3): e7.
Published: 24 February 2006
... are involved in regulating cell polarity, whereas others appear to control cellular differentiation. Of the 12 human AMPK-related protein kinase family members, 11 can be activated following phosphorylation of their T-loop threonine residue by the LKB1 complex. Nine of these AMPK-related kinases activated...
Articles
Interactions between Cdc42 and the scaffold protein Scd2: requirement of SH3 domains for GTPase binding
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2005) 388 (1): 177–184.
Published: 10 May 2005
...Edward WHEATLEY; Katrin RITTINGER The multi-domain protein Scd2 acts as a scaffold upon which the small GTPase Cdc42 (cell division cycle 42), its nucleotide-exchange factor Scd1 and the p21-activated kinase Shk1 assemble to regulate cell polarity and the mating response in fission yeast...