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Keywords: cell polarity
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Articles
Biochem J (2023) 480 (24): 2037–2044.
Published: 15 December 2023
... PtdSer does [ 17 , 18 ]. The overall observation that the aPKC PSS can interact with PIs agrees with the long-standing evidence that PSS peptides can mediate interactions with anionic phospholipids [ 19 ]. apkc atypical pkc cell polarity phospholipids protein kinase c Correspondence...
Articles
Biochem J (2022) 479 (12): 1303–1315.
Published: 22 June 2022
...Airah Javorsky; Patrick O. Humbert; Marc Kvansakul The Scribble (Scrib) protein is a conserved cell polarity regulator with anti-tumorigenic properties. Viruses like the Tick-born encephalitis virus (TBEV) target Scribble to establish a cellular environment supporting viral replication, which...
Includes: Supplementary data
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Biochem J (2021) 478 (7): 1321–1332.
Published: 06 April 2021
...Jing Yuan How; Rebecca K. Stephens; Krystle Y.B. Lim; Patrick O. Humbert; Marc Kvansakul Scribble is a critical cell polarity regulator that has been shown to work as either an oncogene or tumor suppressor in a context dependent manner, and also impacts cell migration, tissue architecture...
Includes: Supplementary data
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Articles
Biochem J (2011) 439 (2): 195–205.
Published: 28 September 2011
..., contribute to the development of human malignancies. These regulate processes as diverse as cytoskeletal organization, cell polarity, cell proliferation and many signal transduction pathways. In the present review, we discuss how PBM–PDZ recognition and imbalances therein can perturb cellular homoeostasis...
Articles
Biochem J (2007) 401 (2): 377–390.
Published: 21 December 2006
... chemotaxis results from co-ordinated chemoattractant gradient sensing, cell polarization and cellular motility, and accumulating data suggest that small GTPase signalling plays a central role in each of these processes as well as in signal relay. The present review summarizes these recent findings, which...
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Articles
Biochem J (2006) 394 (3): e7.
Published: 24 February 2006
... are involved in regulating cell polarity, whereas others appear to control cellular differentiation. Of the 12 human AMPK-related protein kinase family members, 11 can be activated following phosphorylation of their T-loop threonine residue by the LKB1 complex. Nine of these AMPK-related kinases activated...
Articles
Biochem J (2005) 388 (1): 177–184.
Published: 10 May 2005
...Edward WHEATLEY; Katrin RITTINGER The multi-domain protein Scd2 acts as a scaffold upon which the small GTPase Cdc42 (cell division cycle 42), its nucleotide-exchange factor Scd1 and the p21-activated kinase Shk1 assemble to regulate cell polarity and the mating response in fission yeast...