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A guide to ERK dynamics, part 2: downstream decoding

In Collection

Cell signaling in the 21st century

Abhineet Ram, Devan Murphy, Nicholaus DeCuzzi, Madhura Patankar, Jason Hu, Michael Pargett, John G. Albeck

Biochem J (2023) 480 (23): 1909–1928.

https://doi.org/10.1042/BCJ20230277

Published: 01 December 2023

... and improve disease outcomes. cell proliferation eukaryotic gene expression extracellular signal-regulated kinases gene regulatory networks receptor tyrosine kinases The extracellular signal-regulated kinases (ERK) are a subset of the mitogen-activated protein kinases (MAPKs) that regulate many...

View articletitled, A guide to ERK dynamics, part 2: downstream decoding

Articles

Expression and function of SLC38A5, an amino acid-coupled Na + /H + exchanger, in triple-negative breast cancer and its relevance to macropinocytosis

Sabarish Ramachandran, Souad R. Sennoune, Monica Sharma, Muthusamy Thangaraju, Varshini V. Suresh, Tyler Sneigowski, Yangzom D. Bhutia, Kevin Pruitt, Vadivel Ganapathy

Biochem J (2021) 478 (21): 3957–3976.

https://doi.org/10.1042/BCJ20210585

Published: 12 November 2021

.... Surprisingly, the transport function of SLC38A5 is inhibited by amilorides, the well-known inhibitors of Na + /H + exchanger. Down-regulation of SLC38A5 in TNBC cells attenuates serine-induced macropinocytosis and reduces cell proliferation significantly as assessed by multiple methods, but does not induce...

View articletitled, Expression and function of SLC38A5, an amino acid-coupled Na + /H + exchanger, in triple-negative breast cancer and its relevance to macropinocytosis

Includes: Supplementary data

Articles

Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity

Vasily Rybakin, Melissa Stas, Estefania Ugarte-Berzal, Sam Noppen, Jennifer Vandooren, Ilse Van Aelst, Sandra Liekens, Paul Proost, Ghislain Opdenakker

Biochem J (2019) 476 (15): 2191–2208.

https://doi.org/10.1042/BCJ20180382

Published: 09 August 2019

... 2019 1 7 2019 1 7 2019 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 cell proliferation IL-2 receptor interleukin 2 metalloproteases neutrophils Graphs show mean values of biological replicates within...

View articletitled, Gelatinase B/matrix metalloproteinase-9 and other neutrophil proteases switch off interleukin-2 activity

Includes: Supplementary data

Articles

HDAC1 overexpression enhances β-cell proliferation by down-regulating Cdkn1b/p27

Carrie Draney, Matthew C. Austin, Aaron H. Leifer, Courtney J. Smith, Kyle B. Kener, Talon J. Aitken, Kavan H. Hess, Amanda C. Haines, Elle Lett, Angelina Hernandez-Carretero, Patrick T. Fueger, Michelle Arlotto, Jeffery S. Tessem

Biochem J (2018) 475 (24): 3997–4010.

https://doi.org/10.1042/BCJ20180465

Published: 19 December 2018

... functional β-cell mass, where functional β-cell mass refers to the combination of β-cell proliferation, glucose-stimulated insulin secretion (GSIS) and β-cell survival. Here, we demonstrate that the histone deacetylase 1 (HDAC1), which is an early target of Nkx6.1, is sufficient to increase functional β-cell...

View articletitled, HDAC1 overexpression enhances β-cell proliferation by down-regulating Cdkn1b/p27

Articles

IFN-γ-response mediator GBP-1 represses human cell proliferation by inhibiting the Hippo signaling transcription factor TEAD

Bea Unterer, Veit Wiesmann, Mekala Gunasekaran, Heinrich Sticht, Clara Tenkerian, Jürgen Behrens, Marina Leone, Felix B. Engel, Nathalie Britzen-Laurent, Elisabeth Naschberger, Thomas Wittenberg, Michael Stürzl

Biochem J (2018) 475 (18): 2955–2967.

https://doi.org/10.1042/BCJ20180123

Published: 25 September 2018

... BY) . cell proliferation colorectal cancer guanylate-binding proteins interferons IFN-γ regulates many cellular processes including innate and acquired immune responses, host defense reactions, and exerts direct anti-tumorigenic effects [ 1 , 2 ]. The large GTPase human guanylate-binding protein 1...

View articletitled, IFN-γ-response mediator GBP-1 represses human cell proliferation by inhibiting the Hippo signaling transcription factor TEAD

Includes: Supplementary data

Articles

Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/β-catenin pathway

Fatima Lahdaoui, Mathieu Messager, Audrey Vincent, Flora Hec, Anne Gandon, Maxime Warlaumont, Florence Renaud, Emmanuelle Leteurtre, Guillaume Piessen, Nicolas Jonckheere, Christophe Mariette, Isabelle Van Seuningen

Biochem J (2017) 474 (22): 3733–3746.

https://doi.org/10.1042/BCJ20170348

Published: 01 November 2017

... of tumour cell proliferation and survival properties [ 11 – 15 ], alteration of metastatic properties of breast cancer cells [ 16 ] and cancer cell resistance to chemotherapeutic drugs [ 17 ]. Cells were seeded in triplicate at 20 000 cells/well in 96-well plates and cultured until confluence. Plates...

View articletitled, Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/β-catenin pathway

Includes: Supplementary data

Articles

Dual histone reader ZMYND8 inhibits cancer cell invasion by positively regulating epithelial genes

Moitri Basu, Isha Sengupta, Md Wasim Khan, Dushyant Kumar Srivastava, Partha Chakrabarti, Siddhartha Roy, Chandrima Das

Biochem J (2017) 474 (11): 1919–1934.

https://doi.org/10.1042/BCJ20170223

Published: 19 May 2017

... of H3.1K36Me2/H4K16Ac marks. Through differential gene expression analysis upon silencing this chromatin reader, we identified a subset of genes involved in cell proliferation and invasion/migration regulated by ZMYND8. Detailed analysis uncovered its antiproliferative activity through BrdU incorporation...

View articletitled, Dual histone reader ZMYND8 inhibits cancer cell invasion by positively regulating epithelial genes

Includes: Supplementary data

Articles

DDB2 is involved in ubiquitination and degradation of PAQR3 and regulates tumorigenesis of gastric cancer cells

Shanshan Qiao, Weiwei Guo, Lujian Liao, Lin Wang, Zheng Wang, Rui Zhang, Daqian Xu, Yuxue Zhang, Yi Pan, Zhenzhen Wang, Yan Chen

Biochem J (2015) 469 (3): 469–480.

https://doi.org/10.1042/BJ20150253

Published: 23 July 2015

...)- and insulin-induced signalling by PAQR3 is also altered by DDB2. At the molecular level, Lys 61 of PAQR3 is targeted by DDB2 for ubiquitination. The cell proliferation rate and migration of gastric cancer cells are inhibited by DDB2 knockdown and such effects are abrogated by PAQR3 knockdown, indicating...

View articletitled, DDB2 is involved in ubiquitination and degradation of PAQR3 and regulates tumorigenesis of gastric cancer cells

Articles

The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway

Alexandra Coomans de Brachène, Emeline Bollaert, Astrid Eijkelenboom, Audrey de Rocca Serra, Kristan E. van der Vos, Boudewijn M. T. Burgering, Paul J. Coffer, Ahmed Essaghir, Jean-Baptiste Demoulin

Biochem J (2014) 460 (1): 25–36.

https://doi.org/10.1042/BJ20131467

Published: 25 April 2014

... that HBP1 limits cell growth. Finally, by analysing a transcriptomics dataset from The Cancer Genome Atlas, we observed that HBP1 expression was lower in breast tumours that had lost FOXO expression. In conclusion, HBP1 is a novel target of the PI3K/FOXO pathway and controls cell proliferation in response...

View articletitled, The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway

Includes: Supplementary data

Articles

Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3

Juan P. Bolaños

Biochem J (2013) 452 (3): e7–e9.

https://doi.org/10.1042/BJ20130560

Published: 31 May 2013

... of PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3), a key glycolysis-promoting enzyme. These results reveal a novel pathway through which MK2 co-ordinates metabolic adaptation to cell proliferation in cancer and highlight PFKFB3 as a potential therapeutic target in this devastating disease...

View articletitled, Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3

Articles

CaMKII-γ mediates phosphorylation of BAD at Ser 170 to regulate cytokine-dependent survival and proliferation

Payman Hojabrpour, Ivan Waissbluth, Mazyar Ghaffari, Michael E. Cox, Vincent Duronio

Biochem J (2012) 442 (1): 139–149.

https://doi.org/10.1042/BJ20111256

Published: 27 January 2012

... effect on the pro-apoptosis function of BAD. Furthermore, mutated BAD with an alanine substitution inhibited cell proliferation, slowing progression specifically through S-phase. We identify the kinase responsible for phosphorylation at this site as CaMKII-γ (γ isoform of Ca 2+ /calmodulin-dependent...

View articletitled, CaMKII-γ mediates phosphorylation of BAD at Ser 170 to regulate cytokine-dependent survival and proliferation

Includes: Supplementary data

Articles

The Hippo pathway and apico–basal cell polarity

Alice Genevet, Nicolas Tapon

Biochem J (2011) 436 (2): 213–224.

https://doi.org/10.1042/BJ20110217

Published: 13 May 2011

... The Authors Journal compilation © 2011 Biochemical Society 2011 cell proliferation epithelial cell polarity Hippo signalling junction scaffold tumour suppressor Epithelia, cellular sheets that act as barriers between two environments, fulfil a variety of functions in animals...

View articletitled, The Hippo pathway and apico–basal cell polarity

Articles

Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor κB (NF-κB) signalling pathway

Zhen-Bo Song, Yong-Li Bao, Yu Zhang, Xu-Guang Mi, Ping Wu, Yin Wu, Chun-Lei Yu, Ying Sun, Li-Hua Zheng, Yan-Xin Huang, Biao Liu, Yu-Xin Li

Biochem J (2011) 436 (2): 457–467.

https://doi.org/10.1042/BJ20101780

Published: 13 May 2011

... it an attractive molecular marker and a potential target for diagnosis and therapy; however, the biological function of TSP50 is still unclear. In the present study, we show that overexpression of TSP50 in CHO (Chinese-hamster ovary) cells markedly increased cell proliferation and colony formation. Mechanistic...

View articletitled, Testes-specific protease 50 (TSP50) promotes cell proliferation through the activation of the nuclear factor κB (NF-κB) signalling pathway

Articles

Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells

Kenji Ishimoto, Keisuke Tachibana, Ikuko Hanano, Daisuke Yamasaki, Hiroki Nakamura, Megumi Kawai, Yasuomi Urano, Toshiya Tanaka, Takao Hamakubo, Juro Sakai, Tatsuhiko Kodama, Takefumi Doi

Biochem J (2010) 429 (2): 347–357.

https://doi.org/10.1042/BJ20091511

Published: 28 June 2010

...-regulatory-element-binding protein 2) and NF-Y. We also investigated whether sterol-mediated FDPS expression is involved in the cell proliferation induced by zoledronic acid, an FDPS inhibitor. We show that the SREBP-2- and NF-Y-mediated regulation of FDPS gene transcription modulates cell proliferation...

View articletitled, Sterol-regulatory-element-binding protein 2 and nuclear factor Y control human farnesyl diphosphate synthase expression and affect cell proliferation in hepatoblastoma cells

Includes: Supplementary data

Articles

The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation

Marie Jarry, Mickaël Diallo, Céline Lecointre, Laurence Desrues, Tursonjan Tokay, David Chatenet, Jérôme Leprince, Oriana Rossi, Hubert Vaudry, Marie-Christine Tonon, Laurent Prézeau, Hélène Castel, Pierrick Gandolfo

Biochem J (2010) 428 (1): 113–124.

https://doi.org/10.1042/BJ20090867

Published: 28 April 2010

... energy transfer calcium cell proliferation G-protein urotensin II receptor URP (A CFWKYC V), rat UII (UII, p QHGTAPE CFWKYC I) ( p Q, pyroglutamic acid; underlining indicates the conserved hexapeptide core) and rat ODN DBI 33–50 were synthesized using the solid-phase methodology on a Pioneer...

View articletitled, The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation

Articles

Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger

Jaya P. Gnana-Prakasam, Muthusamy Thangaraju, Kebin Liu, Yonju Ha, Pamela M. Martin, Sylvia B. Smith, Vadivel Ganapathy

Biochem J (2009) 424 (2): 243–252.

https://doi.org/10.1042/BJ20090424

Published: 11 November 2009

... of the final reaction mixture was measured at 450 nm. A calibration curve was used as instructed in the kit to determine the ferritin levels in these samples. activator protein 1 (AP1) cell proliferation cystine/glutamate exchanger glutathione haemochromatosis retinal pigment epithelium...

View articletitled, Absence of iron-regulatory protein Hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger

Includes: Supplementary data

Articles

Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Δ 24 -reductase-deficient cell line

Sara Rodríguez-Acebes, Paloma de la Cueva, Carlos Fernández-Hernando, Antonio J. Ferruelo, Miguel A. Lasunción, Robert B. Rawson, Javier Martínez-Botas, Diego Gómez-Coronado

Biochem J (2009) 420 (2): 305–318.

https://doi.org/10.1042/BJ20081909

Published: 13 May 2009

... addressed the capacity of desmosterol to replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway. J774 cells were able to grow indefinitely after the virtually total replacement of cholesterol by desmosterol (J774-D cells). Inhibition of sterol biosynthesis with lovastatin...

View articletitled, Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Δ 24 -reductase-deficient cell line

Includes: Supplementary data

Articles

How essential is cholesterol?

Julian Stevenson, Andrew J. Brown

Biochem J (2009) 420 (2): e1–e4.

https://doi.org/10.1042/BJ20090445

Published: 13 May 2009

...Julian Stevenson; Andrew J. Brown Cholesterol is an apparently indispensable lipid for numerous processes required for cell proliferation. Levels of this molecule are primarily regulated at the transcriptional level by the SREBPs (sterol-regulatory-element-binding proteins) and LXR (liver X...

View articletitled, How essential is cholesterol?

Articles

Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD 4 motif: evidence that nuclear paxillin promotes cell proliferation

Jing-Ming Dong, Lei-Shong Lau, Yuen-Wai Ng, Louis Lim, Ed Manser

Biochem J (2009) 418 (1): 173–184.

https://doi.org/10.1042/BJ20080170

Published: 28 January 2009

... of nuclear-localized paxillin LIM domains stimulate DNA synthesis and cell proliferation. By real-time PCR analysis we have established that overexpression of either full-length paxillin or a truncated nuclear form suppresses expression of the parental imprinted gene H19, and modulation of this locus...

View articletitled, Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD 4 motif: evidence that nuclear paxillin promotes cell proliferation

Includes: Supplementary data

Articles

MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation

Jing Zhao, Tomonori Izumi, Kazuto Nunomura, Shinya Satoh, Sumiko Watanabe

Biochem J (2007) 408 (1): 51–59.

https://doi.org/10.1042/BJ20070826

Published: 29 October 2007

.... Bands were visualized with ethidium bromide. cell proliferation membrane protein myristoylated alanine-rich C-kinase substrate (MARCKS) neural retina protein kinase C (PKC) proteomics The mature neural retina is organized into a three-layered structure consisting of six types...

View articletitled, MARCKS-like protein, a membrane protein identified for its expression in developing neural retina, plays a role in regulating retinal cell proliferation

Articles

Novel role for insulin as an autocrine growth factor for malignant brain tumour cells

Alexandre Arcaro, Kathrin T. Doepfner, Danielle Boller, Ana S. Guerreiro, Tarek Shalaby, Shaun P. Jackson, Simone M. Schoenwaelder, Olivier Delattre, Michael A. Grotzer, Barbara Fischer

Biochem J (2007) 406 (1): 57–66.

https://doi.org/10.1042/BJ20070309

Published: 26 July 2007

... and insulin-stimulated AT/RT cell proliferation. Experiments using RNAi and isoform-specific pharmacological inhibitors established a key role for the class I A PI3K p110α isoform in AT/RT cell growth and insulin signalling. Taken together, our results reveal a novel role for autocrine signalling by insulin...

View articletitled, Novel role for insulin as an autocrine growth factor for malignant brain tumour cells

Includes: Supplementary data

Articles

Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region

Lan Liu, Xin Guo, Jaladanki N. Rao, Tongtong Zou, Bernard S. Marasa, Jie Chen, Jose Greenspon, Robert A. Casero, Jr, Jian-Ying Wang

Biochem J (2006) 398 (2): 257–267.

https://doi.org/10.1042/BJ20060217

Published: 15 August 2006

...Lan Liu; Xin Guo; Jaladanki N. Rao; Tongtong Zou; Bernard S. Marasa; Jie Chen; Jose Greenspon; Robert A. Casero, Jr; Jian-Ying Wang Maintenance of intestinal mucosal epithelial integrity requires cellular polyamines that regulate expression of various genes involved in cell proliferation, growth...

View articletitled, Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region

Articles

Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants

Giada A. Locatelli, Monica Savio, Luca Forti, Igor Shevelev, Kristijan Ramadan, Lucia A. Stivala, Vanio Vannini, Ulrich Hübscher, Silvio Spadari, Giovanni Maga

Biochem J (2005) 389 (2): 259–268.

https://doi.org/10.1042/BJ20050094

Published: 05 July 2005

... cell proliferation DNA polymerase DNA replication enzyme kinetics eukaryote resveratrol Resveratrol (3,4,5-trihydroxystilbene) is synthesized by several plants in response to adverse conditions such as environmental stress or pathogenic attack and it is classified as a phytoalexin [ 1 – 3...

View articletitled, Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants

Articles

Independent roles of eIF5A and polyamines in cell proliferation

Kazuhiro NISHIMURA, Kaori MUROZUMI, Akira SHIRAHATA, Myung Hee PARK, Keiko KASHIWAGI, Kazuei IGARASHI

Biochem J (2005) 385 (3): 779–785.

https://doi.org/10.1042/BJ20041477

Published: 24 January 2005

...Kazuhiro NISHIMURA; Kaori MUROZUMI; Akira SHIRAHATA; Myung Hee PARK; Keiko KASHIWAGI; Kazuei IGARASHI To examine the roles of active hypusinated eIF5A (eukaryotic translation initiation factor 5A) and polyamines in cell proliferation, mouse mammary carcinoma FM3A cells were treated...

View articletitled, Independent roles of eIF5A and polyamines in cell proliferation

Articles

14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

Mercedes POZUELO RUBIO, Kathryn M. GERAGHTY, Barry H. C. WONG, Nicola T. WOOD, David G. CAMPBELL, Nick MORRICE, Carol MACKINTOSH

Biochem J (2004) 379 (2): 395–408.

https://doi.org/10.1042/bj20031797

Published: 15 April 2004

... include many enzymes involved in generating precursors such as purines (AMP, GMP and ATP), FAD, NADPH, cysteine and S -adenosylmethionine, which are needed for cell growth, regulators of cell proliferation, including enzymes of DNA replication, proteins of anti-oxidative metabolism, regulators of actin...

View articletitled, 14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking

Articles

Expression patterns and different subcellular localization of the growth factors HDGF (hepatoma-derived growth factor) and HRP-3 (HDGF-related protein-3) suggest functions in addition to their mitogenic activity

Mekky M. ABOUZIED, Stephan L. BAADER, Frank DIETZ, Joachim KAPPLER, Volkmar GIESELMANN, Sebastian FRANKEN

Biochem J (2004) 378 (1): 169–176.

https://doi.org/10.1042/bj20030916

Published: 15 February 2004

... subcellular localization in cultured neurons suggest different functions of HDGF and HRP-3 within single cells. Key words: brain development, cell proliferation, HDGF-related protein-3 (HRP-3), hepatoma-derived growth factor (HDGF), nuclear localization, survival factor. INTRODUCTION HDGF (hepatoma-derived...

View articletitled, Expression patterns and different subcellular localization of the growth factors HDGF (hepatoma-derived growth factor) and HRP-3 (HDGF-related protein-3) suggest functions in addition to their mitogenic activity

Articles

Differential modulation of glucocorticoid action by FK506 in A549 cells

Jamie D. CROXTALL, Mark PAUL-CLARK, Peter Th. W. van HAL

Biochem J (2003) 376 (1): 285–290.

https://doi.org/10.1042/bj20030821

Published: 15 November 2003

... To whom correspondence should be addressed (e-mail [email protected] ). 3 6 2003 28 8 2003 1 9 2003 1 9 2003 The Biochemical Society, London ©2003 2003 arachidonic acid cell proliferation FK506-binding protein 51 (FKB51) glucocorticoid receptor glucocorticoid...

View articletitled, Differential modulation of glucocorticoid action by FK506 in A549 cells

Articles

Attenuation of glucocorticoid functions in an Anx-A1-/- cell line

Jamie D. CROXTALL, Derek W. GILROY, Egle SOLITO, Qamrul CHOUDHURY, Barbara J. WARD, Julia C. BUCKINGHAM, Rod J. FLOWER

Biochem J (2003) 371 (3): 927–935.

https://doi.org/10.1042/bj20021856

Published: 01 May 2003

... to cell proliferation and may help to explain how glucocorticoids regulate these processes. Biochem. J. (2003) 371, 927 935 (Printed in Great Britain) 927 Attenuation of glucocorticoid functions in an Anx-A1 cell line Jamie D. CROXTALL*1, Derek W. GILROY , Egle SOLITO , Qamrul CHOUDHURY*, Barbara J. WARD...

View articletitled, Attenuation of glucocorticoid functions in an Anx-A1-/- cell line

Articles

A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction

John F. REILLY, Shawndra D. MARTINEZ, Gregory MICKEY, Pamela A. MAHER

Biochem J (2002) 366 (2): 501–510.

https://doi.org/10.1042/bj20020560

Published: 01 September 2002

... Sequence Databases under accession number AF309598. 8 4 2002 16 5 2002 21 5 2002 21 5 2002 The Biochemical Society, London ©2002 2002 cell proliferation cyclin ERK farnesylation Ras Abbreviations used: CD-R1, cytoplasmic domain of FGFR1; CKI, cyclin...

View articletitled, A novel role for farnesyl pyrophosphate synthase in fibroblast growth factor-mediated signal transduction

Articles

Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells

Vincenzo Di MARZO, Dominique MELCK, Pierangelo ORLANDO, Tiziana BISOGNO, Orna ZAGOORY, Maurizio BIFULCO, Zvi VOGEL, Luciano de PETROCELLIS

Biochem J (2001) 358 (1): 249–255.

https://doi.org/10.1042/bj3580249

Published: 08 August 2001

... Society, London ©2001 2001 2-arachidonoylglycerol arvanil cell proliferation endocannabinoids receptors Abbreviations used: AC, adenylate cyclase; AEA, arachidonoylethanolamide (anandamide); 2-AG, 2-arachidonoylglycerol; CB 1 /CB 2 receptor, cannabinoid receptor type 1/2; FAAH, fatty...

View articletitled, Palmitoylethanolamide inhibits the expression of fatty acid amide hydrolase and enhances the anti-proliferative effect of anandamide in human breast cancer cells

Articles

Lysophosphatidic acid prevents apoptosis in fibroblasts via Gi-protein-mediated activation of mitogen-activated protein kinase

Xianjun FANG, Shuangxing YU, Ruth LAPUSHIN, Yiling LU, Tatsuro FURUI, Linda Z. PENN, David STOKOE, James R. ERICKSON, Robert C. BAST, JR, Gordon B. MILLS

Biochem J (2000) 352 (1): 135–143.

https://doi.org/10.1042/bj3520135

Published: 07 November 2000

...]. The most prominent effects of LPA include stimulation of cell proliferation [4], platelet aggregation [5], smooth-muscle cell contraction [6] and tumour cell invasion [7]. As a normal constituent of serum, LPA contributes to its mitogenic activity and has been identified as the factor responsible for serum...

View articletitled, Lysophosphatidic acid prevents apoptosis in fibroblasts via Gi-protein-mediated activation of mitogen-activated protein kinase

Articles

Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells

Carolina LOBO, Miguel A. RUIZ-BELLIDO, Juan C. ALEDO, Javier MÁRQUEZ, Ignacio NÚÑEZ DE CASTRO, Francisco J. ALONSO

Biochem J (2000) 348 (2): 257–261.

https://doi.org/10.1042/bj3480257

Published: 23 May 2000

... provide new ways for the study of gene therapy. 1 To whom correspondence should be addressed (e-mail fcarrion@;uma.es). 4 1 2000 14 2 2000 7 3 2000 The Biochemical Society, London © 2000 2000 cancer cell proliferation gene expression blockage glutamine therapy...

View articletitled, Inhibition of glutaminase expression by antisense mRNA decreases growth and tumourigenicity of tumour cells

Articles

Cellular adaptation to down-regulated iron transport into lymphoid leukaemic cells: effects on the expression of the gene for ribonucleotide reductase

Christopher R. CHITAMBAR, Janine P. WERELEY, Thomas HEIMAN, William E. ANTHOLINE, William J. O'BRIEN

Biochem J (2000) 345 (3): 681–685.

https://doi.org/10.1042/bj3450681

Published: 25 January 2000

... cells can be down-regulated by more than 50% in response to down-regulated iron transport without an adverse effect on cell proliferation. Furthermore, our studies suggest a regulatory link between ribonucleotide reductase activity and iron transport into these cells. 1 To whom correspondence...

View articletitled, Cellular adaptation to down-regulated iron transport into lymphoid leukaemic cells: effects on the expression of the gene for ribonucleotide reductase

Articles

The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses

Cungui MAO, Julie D. SABA, Lina M. OBEID

Biochem J (1999) 342 (3): 667–675.

https://doi.org/10.1042/bj3420667

Published: 05 September 1999

... Society, London © 1999 1999 sphingolipid metabolism cell proliferation sphingosine phosphate phosphatases Biochem. J. (1999) 342, 667 675 (Printed in Great Britain) 667 The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation...

View articletitled, The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses

Articles

Autocrine regulation of growth stimulation in human epithelial ovarian carcinoma by serine-proteinase-catalysed release of the urinary-type-plasminogen-activator N-terminal fragment

David A. FISHMAN, Alicia KEARNS, Susan LARSH, Jan J. ENGHILD, M. Sharon STACK

Biochem J (1999) 341 (3): 765–769.

https://doi.org/10.1042/bj3410765

Published: 26 July 1999

... by modulating both cell invasion and proliferation. Key words: amino-terminal fragment, cell proliferation, urokinase, ovarian cancer. fragment (NTF; amino acids 1 143; Figure 1) which contains a growth-factor and a kringle domain [6,7]. In the present study we report that human ovarian epithelial carcinoma...

View articletitled, Autocrine regulation of growth stimulation in human epithelial ovarian carcinoma by serine-proteinase-catalysed release of the urinary-type-plasminogen-activator N-terminal fragment

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