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1-29 of 29
Keywords: cell signalling
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Articles
Bulk autophagy induction and life extension is achieved when iron is the only limited nutrient in Saccharomyces cerevisiae
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2021) 478 (4): 811–837.
Published: 24 February 2021
... by Portland Press Limited on behalf of the Biochemical Society 2021 autophagy cell signalling iron metabolism Snf1/AMPK Tor2/Ypk1 TORC1 Iron is an essential metal for the majority of cellular types. It is required for many metabolic processes such as respiration, proteins, lipids...
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (6): 877–883.
Published: 07 March 2017
... BY) . cell signalling oxidative stress photoinhibition photosynthesis reactive oxygen species ROS play numerous important roles in plant development and environmental responses. ROS functions in plants are tightly intertwined with signalling pathways through phytohormones. It has long been...
Articles
Notch ligand delta-like1: X-ray crystal structure and binding affinity
Available to PurchaseNadia J. Kershaw, Nicole L. Church, Michael D.W. Griffin, Cindy S. Luo, Timothy E. Adams, Antony W. Burgess
Journal:
Biochemical Journal
Biochem J (2015) 468 (1): 159–166.
Published: 05 May 2015
... fragment of any Notch ligand structure to date. Comparison with the Jagged1 structures reveals similarities and differences between the ligand families and potential receptor binding sites. cell signalling cell surface protein C2 domain epidermal growth factor (EGF)-like repeat Notch X-ray...
Includes: Supplementary data
Articles
Leo K. Iwai, Leo S. Payne, Maciej T. Luczynski, Francis Chang, Huifang Xu, Ryan W. Clinton, Angela Paul, Edward A. Esposito, Scott Gridley, Birgit Leitinger, Kristen M. Naegle, Paul H. Huang
Journal:
Biochemical Journal
Biochem J (2013) 454 (3): 501–513.
Published: 29 August 2013
... approaches, DDR2-specific signalling components such as SHP-2 were identified. We further demonstrate that SHP-2 is phosphorylated by a subset of DDR2 lung cancer mutants. cell signalling collagen discoidin domain receptor lung cancer mass spectrometry phosphoproteomics Collagen...
Includes: Supplementary data
Articles
Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2013) 450 (3): 619–628.
Published: 28 February 2013
...-ribose) polymerase] and vinculin were from Cell Signaling Technology; anti-LC3-2G6 antibody was from Nanotools and anti-α-tubulin antibody was from Sigma. The ODC (ornithine decarboxylase) inhibitors ODC-I and DFMO (α-difluoromethylornithine) were from Merck and from Tocris respectively. PI-103...
Includes: Supplementary data
Articles
Regulation and function of the RSK family of protein kinases
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2012) 441 (2): 553–569.
Published: 21 December 2011
... [email protected] ). 14 2 2011 11 8 2011 11 8 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 cell signalling mitogen-activated protein kinase (MAPK) phosphorylation proliferation protein kinase 90 kDa ribosomal S6 kinase (RSK) The Ras...
Articles
NAADP regulates human platelet function
Available to PurchaseCarmen H. Coxon, Alexander M. Lewis, Amanda J. Sadler, Sridhar R. Vasudevan, Andrew Thomas, Kirsten A. Dundas, Lewis Taylor, R. Duncan Campbell, Jonathan M. Gibbins, Grant C. Churchill, Katherine L. Tucker
Journal:
Biochemical Journal
Biochem J (2012) 441 (1): 435–442.
Published: 14 December 2011
... to this work. 2 To whom correspondence should be addressed (email [email protected] ). 1 7 2011 30 9 2011 3 10 2011 3 10 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 calcium cell signalling Ned-19 nicotinamide acid–adenine...
Articles
Lipid binding to cytoglobin leads to a change in haem co-ordination: a role for cytoglobin in lipid signalling of oxidative stress
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2011) 434 (3): 483–492.
Published: 24 February 2011
... occurs under an oxidative environment and may thus be related to redox-linked cell signalling mechanisms. Oleate binds to the protein in a 1:1 stoichiometry and with high affinity ( K d =0.7 μM); however, stopped-flow kinetic measurements yield a K d value of 110 μM. The discrepancy between these K d...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 430 (1): 161–169.
Published: 28 July 2010
...) signalling. These data indicate that the highly selective targeting of some protein thiols by HOSCN can result in perturbation of cellular phosphorylation and altered cell signalling. These changes occur with (patho)physiological concentrations of SCN − ions, and implicate HOSCN as an important mediator...
Articles
Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2010) 425 (3): 501–512.
Published: 15 January 2010
...Sinisa Urban Rhomboid proteases are a fascinating class of enzymes that combine a serine protease active site within the core of an integral membrane protein. Despite having key roles in animal cell signalling and microbial pathogenesis, the membrane-immersed nature of these enzymes had long...
Articles
Connexin43 phosphorylation: structural changes and biological effects
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2009) 419 (2): 261–272.
Published: 27 March 2009
... ]. cell signalling connexin gap junction kinase phosphorylation post-translational modification It is evident that these apparent 2–4 kDa or more shifts in connexin migration in SDS/PAGE are not simply due to the addition of the mass of phosphate (80 Da). Instead, there are specific...
Includes: Multimedia, Supplementary data
Articles
Urokinase induces survival or pro-apoptotic signals in human mesangial cells depending on the apoptotic stimulus
Available to PurchaseNatalia Tkachuk, Julia Kiyan, Sergey Tkachuk, Roman Kiyan, Nelli Shushakova, Hermann Haller, Inna Dumler
Journal:
Biochemical Journal
Biochem J (2008) 415 (2): 265–273.
Published: 25 September 2008
... should be addressed (email [email protected] ). 10 12 2007 3 6 2008 19 6 2008 19 6 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 B cl-2/Bcl-X L - a ntagonist causing cell d eath (BAD) protein cell death cell signalling...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 413 (2): 315–322.
Published: 26 June 2008
... the depletion of PKCα. 1 To whom correspondence should be addressed (email [email protected] ). 16 11 2007 3 4 2008 4 4 2008 4 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 cell signalling kinase cross-talk post-transcriptional...
Articles
Distinct requirements for the Sprouty domain for functional activity of Spred proteins
Available to PurchaseJames A. J. KING, Andrew F. L. STRAFFON, Giovanna M. D'ABACO, Carole L. C. POON, Stacey T. T. I, Craig M. SMITH, Michael BUCHERT, Niall M. CORCORAN, Nathan E. HALL, Bernard A. CALLUS, Boris SARCEVIC, Daniel MARTIN, Peter LOCK, Christopher M. HOVENS
Journal:
Biochemical Journal
Biochem J (2005) 388 (2): 445–454.
Published: 24 May 2005
... that Spred proteins may use different mechanisms to induce inhibition of the MAPK pathway. cell signalling mitogen-activated protein kinase (MAPK) Ras Spred Sprouty 1 Present address: Université Montpellier I, Faculté de Pharmacie 15 Avenue Charles Flahault, B.P. 14 491, 34093 Montpellier...
Includes: Supplementary data
Articles
Grb10 and Grb14: enigmatic regulators of insulin action – and more?
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2005) 388 (2): 393–406.
Published: 24 May 2005
.... No interactions have been reported thus far for the N-terminal region of Grb7. adapter protein cell growth cell signalling Type II diabetes tyrosine kinase The Grb (growth factor receptor-bound) proteins Grb7/10/14 are cellular adapter proteins lacking intrinsic enzymatic activity, which share...
Articles
The SARS coronavirus nucleocapsid protein induces actin reorganization and apoptosis in COS-1 cells in the absence of growth factors
Available to PurchaseIn Collection
Coronavirus
Journal:
Biochemical Journal
Biochem J (2004) 383 (1): 13–18.
Published: 24 September 2004
... 5 8 2004 The Biochemical Society, London 2004 actin reorganization caspase cell signalling growth factor programmed cell death SARS coronavirus nucleocapsid The causative viral agent of SARS (severe acute respiratory syndrome) caused severe outbreaks of atypical pneumonia...
Articles
Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 381 (2): 329–342.
Published: 06 July 2004
...-3 proteins may integrate the specificity and strength of signalling through to different cellular responses. 1 e-mail [email protected] 28 5 2004 2 9 2003 14 4 2004 28 5 2004 The Biochemical Society, London 2004 14-3-3 protein cancer cell signalling...
Articles
GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2004) 377 (1): 171–181.
Published: 01 January 2004
..., AY122324; and Drosophila melanogaster KEPI cDNA, AY050669. 15 1 2003 10 9 2003 16 9 2003 16 9 2003 The Biochemical Society, London ©2004 2004 cell signalling inhibitor PKA (protein kinase A) PKC (protein kinase C) PP1 (protein phosphatase 1) Abbreviations...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 372 (1): 193–201.
Published: 15 May 2003
... Fernández Almagro, 3, 28029 Madrid, Spain. 2 To whom correspondence should be addressed (e-mail [email protected] ). 16 12 2002 12 2 2003 13 2 2003 13 2 2003 The Biochemical Society, London ©2003 2003 cell signalling mitogen-activated protein kinase docking...
Articles
A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2002) 367 (1): 179–186.
Published: 01 October 2002
... to ablate expression of specific gene products using interfering dsRNAs. Key words: cell signalling, glucose deprivation, hypoxia, in- terfering RNA, oligomycin. cently, Birnbaum and co-workers [21] were successful in ablating AMPK activity in muscle of transgenic mice by overexpressing a kinase-inactive...
Articles
c-Jun N-terminal kinase-interacting protein 1 inhibits gene expression in response to hypertrophic agonists in neonatal rat ventricular myocytes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 358 (2): 489–495.
Published: 24 August 2001
... correspondence should be addressed (e-mail [email protected] ). 9 1 2001 29 5 2001 25 6 2001 The Biochemical Society, London ©2001 2001 cell signalling hypertrophy mitogen-activated protein kinase Abbreviations used: ANF, atrial natriuretic factor; AP-1, activator...
Articles
Inhibition of peroxisome-proliferator-activated receptor (PPAR)α by MK886
Available to PurchaseJames P. KEHRER, Shyam S. BISWAL, Eunhye LA, Philippe THUILLIER, Kaushik DATTA, Susan M. FISCHER, John P. VANDEN HEUVEL
Journal:
Biochemical Journal
Biochem J (2001) 356 (3): 899–906.
Published: 08 June 2001
... 2001 The Biochemical Society, London ©2001 2001 activating protein apoptosis cell signalling 5-lipoxygenase Abbreviations used: CARLA, coactivator-dependent receptor ligand assay; CMV, cytomegalovirus; DTT, dithiothreitol; EMEM, Eagle's minimal essential medium; FLAP, 5...
Articles
Identification of an extracellular segment of the oxytocin receptor providing agonist-specific binding epitopes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 354 (2): 465–472.
Published: 22 February 2001
...-mail [email protected] ). 9 11 2000 7 12 2000 19 12 2000 The Biochemical Society, London © 2001 2001 cell signalling non-peptide peptide vasopressin Biochem. J. (2001) 354, 465 472 (Printed in Great Britain) 465 Identification of an extracellular segment of the oxytocin...
Articles
NIMA-related kinase 2 (Nek2), a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 349 (2): 509–518.
Published: 10 July 2000
... involving Nek2 and PP1 are discussed in terms of the coordination of centrosome separation with cell cycle progression. Key words: centrosome, cell signalling, NIMA related kinase, protein serine}threonine phosphatase. Interaction of regulatory subunits with PP1c is usually mutu- ally exclusive...
Articles
Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 346 (3): 659–669.
Published: 07 March 2000
... The Biochemical Society, London © 2000 2000 allosteric activation cell signalling metabolic regulation Biochem. J. (2000) 346, 659 669 (Printed in Great Britain) 659 Characterization of AMP-activated protein kinase c-subunit isoforms and their role in AMP binding Peter C. F. CHEUNG*1, Ian P. SALT...
Articles
The regulation of AMP-activated protein kinase by phosphorylation
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 345 (3): 437–443.
Published: 25 January 2000
... 1999 11 11 1999 The Biochemical Society, London © 2000 2000 cell signalling protein kinase cascade site-directed mutagenesis two-dimensional gel electrophoresis Biochem. J. (2000) 345, 437 443 (Printed in Great Britain) 437 The regulation of AMP-activated protein kinase...
Articles
Phage display identifies thioredoxin and superoxide dismutase as novel protein kinase C-interacting proteins: thioredoxin inhibits protein kinase C-mediated phosphorylation of histone
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 343 (2): 301–305.
Published: 08 October 1999
... correspondence should be addressed ( [email protected] ). 8 7 1999 11 8 1999 18 8 1999 The Biochemical Society, London © 1999 1999 binding protein cell signalling overlay assay oxidative stress phagemid Biochem. J. (1999) 343, 301 305 (Printed in Great Britain...
Articles
Expression of I2PP2A, an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 341 (2): 293–298.
Published: 08 July 1999
... in intact cells, and suggest that PP2A might exhibit site selectivity with respect to c-Jun phosphorylation. 1 To whom correspondence should be addressed ( [email protected] ). 23 11 1998 12 3 1999 23 4 1999 The Biochemical Society, London © 1999 1999 cell signalling HEK...
Articles
AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 338 (3): 717–722.
Published: 08 March 1999
...). 1 To whom correspondence should be addressed (e-mail [email protected] ). 30 9 1998 10 12 1998 11 1 1999 The Biochemical Society, London © 1999 1999 5-aminoimidazole-4-carboxamide riboside cell signalling metabolic control zero-order ultrasensitivity...
