... of both actin and myosin II were maintained normally. Importantly, the loss of FHOD1 led to slower actin centripetal flow, resulting in abnormal cell spreading and migration defects. Taken together, these results reveal a critical role of FHOD1 in temporal- and spatial- control of the morphology...

...Yoshinobu Kariya; Mayumi Kanno; Kana Matsumoto-Morita; Midori Konno; Yoshiki Yamaguchi; Yasuhiro Hashimoto OPN (osteopontin) is a multiphosphorylated extracellular glycoprotein, which has important roles in bone remodelling, inflammation and cancer metastasis. OPN regulates cell spreading...

... Biochemical Society 2009 cell attachment cell migration cell spreading β1 integrin ligand-independent receptor tyrosine kinase High expression of the EphB4 receptor has been documented in a large variety of human cancers, including breast, ovarian and prostate cancer, early colorectal...

... stretch which precedes the PTB domain. These same molecular features are required for Dab2 to enhance the spreading of COS7 cells on fibronectin. The ability of the p82 isoform of Dab2 to enhance cell spreading was confirmed in both HeLa cells and HBL cells (human breast epithelial cells). COS7 cells...

... receptors α and β. Fibulin-5 also modulated fibronectin-mediated cell spreading and morphology. We have thus identified the β1 integrins on primary SMCs that fibulin-5 interacts with, and have shown that failure of fibulin-5 to activate these receptors limits cell spreading, migration and proliferation...

...Yoshikazu TSUMURA; Jiro TOSHIMA; Onno C. LEEKSMA; Kazumasa OHASHI; Kensaku MIZUNO TESK1 (testicular protein kinase 1) is a serine/threonine kinase that phosphorylates cofilin and plays a critical role in integrin-mediated actin cytoskeletal reorganization and cell spreading. We previously showed...