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1-15 of 15
Keywords: cell survival
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Articles
Brooke D. Paradise, Vladimir G. Gainullin, Luciana L. Almada, Ashley N. Sigafoos, Sandhya Sen, Renzo E. Vera, Glancis Luzeena Raja Arul, Murat Toruner, David R. Pease, Alina L. Gonzalez, Fatima M. Mentucci, Daniel H. Grasso, Martin E. Fernandez-Zapico
Journal:
Biochemical Journal
Biochem J (2023) 480 (15): 1199–1216.
Published: 02 August 2023
... overexpression ( Figure 1C , upper panel) significantly increased GLI activity in PDAC cell lines, while reducing its activity in 10T1/2 cells ( Figure 1C , lower panel). © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 BCL2 cell survival GLI1...
Articles
Journal:
Biochemical Journal
Biochem J (2022) 479 (22): 2345–2349.
Published: 23 November 2022
... targeting one pathway leads to up-regulation of other pathways that promote cancer cell survival. Therefore, it is essential to fully investigate the mechanisms that drive inhibitor resistance and how other parallel pathways respond in cancer cells to improve the efficiency of cancer treatments targeting...
Articles
Sandra M. Martín-Guerrero, Pedro Casado, Maruan Hijazi, Vinothini Rajeeve, Julio Plaza-Díaz, Francisco Abadía-Molina, Julio Navascués, Miguel A. Cuadros, Pedro R. Cutillas, David Martín-Oliva
Journal:
Biochemical Journal
Biochem J (2020) 477 (23): 4491–4513.
Published: 03 December 2020
...-based phosphoproteomics in WRL68 cells showed that the oxidative damage induced by H 2 O 2 increased the phosphorylation of YAP1, a transcriptional co-activator involved in cell survival, and modified the phosphorylation of other proteins involved in transcription. Genetic or pharmacological inhibition...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 448 (1): 165–169.
Published: 18 October 2012
...-cells increase following BCR engagement and are characterized by a metabolic switch to aerobic glycolysis; however, the signalling pathways involved in this metabolic reprogramming are poorly defined. The PKC (protein kinase C) family plays an integral role in B-cell survival and antigenic responses...
Includes: Supplementary data
Articles
Natalia Tkachuk, Julia Kiyan, Sergey Tkachuk, Roman Kiyan, Nelli Shushakova, Hermann Haller, Inna Dumler
Journal:
Biochemical Journal
Biochem J (2008) 415 (2): 265–273.
Published: 25 September 2008
..., whose mechanisms are not completely defined. In the present study we show that the uPA (urokinase-type plasminogen activator)/uPAR (uPA receptor) system can initiate both cell survival and pro-apoptotic signals in human MCs in response to different apoptotic stimuli. uPA abrogated MC apoptosis induced...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 411 (2): 371–377.
Published: 27 March 2008
... signalling. 1 To whom correspondence should be addressed (email [email protected] ). 27 11 2007 19 12 2007 8 1 2008 8 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 cell survival lipid phosphate phosphatase (LPP) phosphatidic acid...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 408 (1): 7–18.
Published: 29 October 2007
... by autoradiography. Subsequently, the Mef2 protein bands were excised from the gel and counted in a β-scintillation counter. Control assays, prepared with buffer instead of cell extract, were run in parallel, counted and subtracted from the c.p.m. of the assays. cell motility cell survival extracellular...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 406 (1): 131–138.
Published: 26 July 2007
... MAPK activation and induces mesangial cell death. 1 To whom correspondence should be addressed (email [email protected] ). 6 12 2006 25 4 2007 10 5 2007 10 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cell survival...
Articles
Larissa Belova, Sanjay Sharma, Deanna R. Brickley, Jeremy R. Nicolarsen, Cam Patterson, Suzanne D. Conzen
Journal:
Biochemical Journal
Biochem J (2006) 400 (2): 235–244.
Published: 14 November 2006
... a critical role in insulin signalling, cation transport and cell survival. SGK - 1 mRNA expression is transiently induced following cellular stress, and SGK-1 protein levels are tightly regulated by rapid proteasomal degradation. In the present study we report that SGK-1 forms a complex with the stress...
Articles
Farida SAFADI-CHAMBERLAIN, Li-Ping WANG, Shawn G. PAYNE, Chang-Uk LIM, Suzanne STRATFORD, Jose Antonio CHAVEZ, Michael H. FOX, Sarah SPIEGEL, Scott A. SUMMERS
Journal:
Biochemical Journal
Biochem J (2005) 388 (3): 827–834.
Published: 07 June 2005
... The Biochemical Society, London 2005 cell-cycle arrest cell growth cell survival myristoylation sphingolipid sphingosine Sphingosine kinases (SKs) catalyse the production of S1P (sphingosine 1-phosphate), a bioactive sphingolipid implicated in the regulation of cell proliferation, apoptosis...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 375 (2): 471–475.
Published: 15 October 2003
... in the cytosol was almost soluble, in contrast with the αA-crystallin protein. Differences in the amino acid sequence between the proteins in a phenylalanine-rich region next to the N-terminal consensus α-crystallin domain was considered to be responsible for chaperone activity and cell survival. 1 Both...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 369 (1): 1–15.
Published: 01 January 2003
... to participate in transformation and tumorigenesis. apoptosis cell cycle cell survival dual-specificity kinase phosphorylation Abbreviations used: ARC, apoptosis repressor with caspase recruitment domain; CK2, protein kinase CK2 ('casein kinase II'); CKIP-1, CK2-interacting protein-1; FAF, Fas...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 365 (1): 147–155.
Published: 01 July 2002
...: actin-binding protein, cell motility, cell survival, cytoskeleton, destrin. which harbour characteristic functional defects, and compared them with a previously reported mutant, which possesses enor- mously reduced filament-severing activity (A120-cofilin). Based on extensive biochemical analyses, we...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 359 (1): 119–127.
Published: 24 September 2001
...Alison O'TOOLE; S. Kelly MOULE; Peter J. LOCKYER; Andrew P. HALESTRAP Tumour necrosis factor-α (TNF-α) may activate both cell survival and cell death pathways. In the murine fibrosarcoma cell line WEHI-164, physiological concentrations (1ng/ml) of TNF-α induced wortmannin-sensitive cell ruffling...
Includes: Supplementary data
Articles
Xianjun FANG, Shuangxing YU, Ruth LAPUSHIN, Yiling LU, Tatsuro FURUI, Linda Z. PENN, David STOKOE, James R. ERICKSON, Robert C. BAST, JR, Gordon B. MILLS
Journal:
Biochemical Journal
Biochem J (2000) 352 (1): 135–143.
Published: 07 November 2000
... by G i protein(s). We therefore focused on the role of G i -protein-mediated signalling events in the promotion of cell survival by LPA. In addition to activation of mitogen-activated protein kinase (MAPK), LPA stimulates a modest PTX-sensitive phosphorylation/activation of the serine/threonine kinase...