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Keywords: cell survival
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Biochem J (2023) 480 (15): 1199–1216.
Published: 02 August 2023
... overexpression ( Figure 1C , upper panel) significantly increased GLI activity in PDAC cell lines, while reducing its activity in 10T1/2 cells ( Figure 1C , lower panel). © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 BCL2 cell survival GLI1...
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Biochem J (2022) 479 (22): 2345–2349.
Published: 23 November 2022
... targeting one pathway leads to up-regulation of other pathways that promote cancer cell survival. Therefore, it is essential to fully investigate the mechanisms that drive inhibitor resistance and how other parallel pathways respond in cancer cells to improve the efficiency of cancer treatments targeting...
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Biochem J (2012) 448 (1): 165–169.
Published: 18 October 2012
...-cells increase following BCR engagement and are characterized by a metabolic switch to aerobic glycolysis; however, the signalling pathways involved in this metabolic reprogramming are poorly defined. The PKC (protein kinase C) family plays an integral role in B-cell survival and antigenic responses...
Includes: Supplementary data
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Biochem J (2008) 415 (2): 265–273.
Published: 25 September 2008
..., whose mechanisms are not completely defined. In the present study we show that the uPA (urokinase-type plasminogen activator)/uPAR (uPA receptor) system can initiate both cell survival and pro-apoptotic signals in human MCs in response to different apoptotic stimuli. uPA abrogated MC apoptosis induced...
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Biochem J (2007) 408 (1): 7–18.
Published: 29 October 2007
... by autoradiography. Subsequently, the Mef2 protein bands were excised from the gel and counted in a β-scintillation counter. Control assays, prepared with buffer instead of cell extract, were run in parallel, counted and subtracted from the c.p.m. of the assays. cell motility cell survival extracellular...
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Biochem J (2005) 388 (3): 827–834.
Published: 07 June 2005
... The Biochemical Society, London 2005 cell-cycle arrest cell growth cell survival myristoylation sphingolipid sphingosine Sphingosine kinases (SKs) catalyse the production of S1P (sphingosine 1-phosphate), a bioactive sphingolipid implicated in the regulation of cell proliferation, apoptosis...
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Biochem J (2003) 369 (1): 1–15.
Published: 01 January 2003
... to participate in transformation and tumorigenesis. apoptosis cell cycle cell survival dual-specificity kinase phosphorylation Abbreviations used: ARC, apoptosis repressor with caspase recruitment domain; CK2, protein kinase CK2 ('casein kinase II'); CKIP-1, CK2-interacting protein-1; FAF, Fas...
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Biochem J (2002) 365 (1): 147–155.
Published: 01 July 2002
...: actin-binding protein, cell motility, cell survival, cytoskeleton, destrin. which harbour characteristic functional defects, and compared them with a previously reported mutant, which possesses enor- mously reduced filament-severing activity (A120-cofilin). Based on extensive biochemical analyses, we...
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Biochem J (2001) 359 (1): 119–127.
Published: 24 September 2001
...Alison O'TOOLE; S. Kelly MOULE; Peter J. LOCKYER; Andrew P. HALESTRAP Tumour necrosis factor-α (TNF-α) may activate both cell survival and cell death pathways. In the murine fibrosarcoma cell line WEHI-164, physiological concentrations (1ng/ml) of TNF-α induced wortmannin-sensitive cell ruffling...
Includes: Supplementary data
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