... mechanism of Hh/GLI signaling pathway regulation in cancer cells. 21 8 2022 20 7 2023 21 7 2023 © 2023 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2023 BCL2 cell survival GLI1 pancreatic cancer SUFU Correspondence...

... of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . Open access for this article was enabled by the participation of Yale University in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society. cell survival DNA damage...

...-based phosphoproteomics in WRL68 cells showed that the oxidative damage induced by H 2 O 2 increased the phosphorylation of YAP1, a transcriptional co-activator involved in cell survival, and modified the phosphorylation of other proteins involved in transcription. Genetic or pharmacological inhibition...

...-cells increase following BCR engagement and are characterized by a metabolic switch to aerobic glycolysis; however, the signalling pathways involved in this metabolic reprogramming are poorly defined. The PKC (protein kinase C) family plays an integral role in B-cell survival and antigenic responses...

..., whose mechanisms are not completely defined. In the present study we show that the uPA (urokinase-type plasminogen activator)/uPAR (uPA receptor) system can initiate both cell survival and pro-apoptotic signals in human MCs in response to different apoptotic stimuli. uPA abrogated MC apoptosis induced...

... signalling. 1 To whom correspondence should be addressed (email [email protected] ). 27 11 2007 19 12 2007 8 1 2008 8 1 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 cell survival lipid phosphate phosphatase (LPP) phosphatidic acid...

... in parallel, counted and subtracted from the c.p.m. of the assays. cell motility cell survival extracellular-signal-regulated kinase 5 (ERK5) focal adhesion kinase (FAK) protein phosphatase 1 (PP1) phorbol ester FAK (focal adhesion kinase) is a non-receptor tyrosine kinase that localizes...

... MAPK activation and induces mesangial cell death. 1 To whom correspondence should be addressed (email [email protected] ). 6 12 2006 25 4 2007 10 5 2007 10 5 2007 © The Authors Journal compilation © 2007 Biochemical Society 2007 cell survival...

... a critical role in insulin signalling, cation transport and cell survival. SGK - 1 mRNA expression is transiently induced following cellular stress, and SGK-1 protein levels are tightly regulated by rapid proteasomal degradation. In the present study we report that SGK-1 forms a complex with the stress...

... To whom correspondence should be addressed (email [email protected] ). 12 10 2004 4 2 2005 7 2 2005 7 2 2005 The Biochemical Society, London 2005 cell-cycle arrest cell growth cell survival myristoylation sphingolipid sphingosine Sphingosine kinases...

... in the cytosol was almost soluble, in contrast with the αA-crystallin protein. Differences in the amino acid sequence between the proteins in a phenylalanine-rich region next to the N-terminal consensus α-crystallin domain was considered to be responsible for chaperone activity and cell survival. Biochem. J...

... to participate in transformation and tumorigenesis. 1 e-mail [email protected] 20 9 2002 21 10 2002 23 10 2002 23 10 2002 The Biochemical Society, London ©2003 2003 apoptosis cell cycle cell survival dual-specificity kinase phosphorylation Abbreviations used...

...: actin-binding protein, cell motility, cell survival, cytoskeleton, destrin. which harbour characteristic functional defects, and compared them with a previously reported mutant, which possesses enor- mously reduced filament-severing activity (A120-cofilin). Based on extensive biochemical analyses, we...

...Alison O'TOOLE; S. Kelly MOULE; Peter J. LOCKYER; Andrew P. HALESTRAP Tumour necrosis factor-α (TNF-α) may activate both cell survival and cell death pathways. In the murine fibrosarcoma cell line WEHI-164, physiological concentrations (1ng/ml) of TNF-α induced wortmannin-sensitive cell ruffling...

... by G i protein(s). We therefore focused on the role of G i -protein-mediated signalling events in the promotion of cell survival by LPA. In addition to activation of mitogen-activated protein kinase (MAPK), LPA stimulates a modest PTX-sensitive phosphorylation/activation of the serine/threonine kinase...