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Keywords: ceramide channel
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Biochem J (2012) 445 (1): 81–91.
Published: 15 June 2012
... polar portion of the ceramide channel facing the bulk phase. In contrast, Bcl-xL binding to ceramide channels is tolerant of stereochemical changes in the headgroup. The present study also revealed that Bcl-xL has an optimal interaction with long-chain ceramides that are elevated early in apoptosis...
Includes: Supplementary data