...Philipp Ebel; Silke Imgrund; Katharina vom Dorp; Kristina Hofmann; Helena Maier; Helena Drake; Joachim Degen; Peter Dörmann; Matthias Eckhardt; Thomas Franz; Klaus Willecke Five ceramide synthases (CerS2–CerS6) are expressed in mouse skin. Although CerS3 has been shown to fulfill an essential...

... (ceramide synthase 4) levels. Fumonisin-B1, a ceramide synthase inhibitor, partially blocked apoptosis induced by glucolipotoxicity. In contrast, apoptosis was potentiated in the presence of D , L - threo -1-phenyl-2-palmitoylamino-3-morpholinopropan-1-ol, an inhibitor of glucosylceramide synthase. Moreover...

...Stefka D. Spassieva; Thomas D. Mullen; Danyelle M. Townsend; Lina M. Obeid Ceramide metabolism has come under recent scrutiny because of its role in cellular stress responses. CerS2 (ceramide synthase 2) is one of the six mammalian isoforms of ceramide synthase and is responsible for the synthesis...

... for ceramide synthesis by the Lag1p (longevity-assurance gene 1)/Lac1p (longevity-assurance gene cognate 1)/Lip1p (Lag1p/Lac1p interacting protein) ceramide synthase. LAG1 and LAC1 are redundant but LIP1 is essential. Here we show that 4Δ ( lag1 Δ lac1 Δ ypc1 Δ ydc1 Δ) cells devoid of all known endogenous...

...Natsuko Kageyama-Yahara; Howard Riezman Ceramide plays a crucial role as a basic building block of sphingolipids, but also as a signalling molecule mediating cell-fate decisions. Three genes, LAG1 , LAC1 and LIP1 , have been shown to be required for ceramide synthase activity in Saccharomyces...

... reaction. However, at present it is not clear whether Lag1p and Lac1p are part of the catalytically active enzyme or are essential regulators of the ceramide synthase. Recent studies have suggested that in mammalian cells there are four different Lag1p/Lac1p homologues: UOG1 (upstream of growth...