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Keywords: chemical biology
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Articles
In Collection
Cell signaling in the 21st century
Journal:
Biochemical Journal
Biochem J (2023) 480 (18): 1445–1457.
Published: 21 September 2023
...Megan H. Wright Multicellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology...
Articles
In Collection
Coronavirus
Journal:
Biochemical Journal
Biochem J (2021) 478 (1): 157–177.
Published: 13 January 2021
..., chemical biology has a great deal to contribute. This review will describe the importance of science at the chemistry/biology interface to both understand and combat the SARS-CoV-2 pandemic. The ongoing global pandemic of coronavirus disease 2019 (COVID-19) is caused by a recently emerged zoonotic...
Articles
Maria Zachari, Julie M. Rainard, George C. Pandarakalam, Lindsay Robinson, Jonathan Gillespie, Muralikrishnan Rajamanickam, Veronique Hamon, Angus Morrison, Ian G. Ganley, Stuart P. McElroy
Journal:
Biochemical Journal
Biochem J (2020) 477 (4): 801–814.
Published: 27 February 2020
... the Creative Commons Attribution License 4.0 (CC BY) . autophagy chemical biology high-throughput screening kinases Macroautophagy (referred to as autophagy here for simplicity) is a lysosome-dependent degradative pathway that recycles intracellular components such as proteins and/or whole...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2017) 474 (7): 1127–1147.
Published: 15 March 2017
... of molecules that promote protein degradation as chemical tools, the preclinical and clinical examples disclosed to date, and the future prospects for this exciting area of chemical biology. CC-122 and CC-885 are the most recently developed IMiDs ( Figure 2B ). CC-122 is a pleiotropic pathway modifier...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (17): 2573–2589.
Published: 30 August 2016
... The Author(s) 2016 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . biochemical techniques and resources cellular targeting chemical biology protein dynamics...
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (10): 1297–1314.
Published: 11 May 2016
... a powerful means of selective protein functionalization, intein technology has become the mainstay of many semisynthetic methodologies [ 48 , 49 ]. atypical chemical biology chemoenzymatic isopeptide ligation post-translational modification semisynthesis ubiquitin ubiquitination ubiquitylation...
Articles
The Tribbles 2 (TRB2) pseudokinase binds to ATP and autophosphorylates in a metal-independent manner
Fiona P. Bailey, Dominic P. Byrne, Krishnadev Oruganty, Claire E. Eyers, Christopher J. Novotny, Kevan M. Shokat, Natarajan Kannan, Patrick A. Eyers
Journal:
Biochemical Journal
Biochem J (2015) 467 (1): 47–62.
Published: 20 March 2015
... pseudokinases, with the translation of this information likely to furnish new leads for drug discovery. adenosine 5′-triphosphate (ATP) chemical biology kinase pseudokinase Tribbles Tribbles 2 (TRB2/TRIB2) thermo-stability assay (TSA) Protein pseudokinases are key components of all...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 465 (2): 271–279.
Published: 06 January 2015
... by inhibiting the serine/threonine kinases known as the salt-inducible kinases. bosutinib chemical biology dasatinib inflammation interleukin-10 salt-inducible kinase Drug development for the treatment of chronic inflammatory diseases has mainly focused on interfering with the pro...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 464 (1): 1.
Published: 23 October 2014
... Asian Chemical Biology Initiative chemical biology metabolism Science in Asia has been developing rapidly in recent years in both quality and quality. The Biochemical Journal spotted this trend more than 10 years ago and we have been building strong links with top-level Asian researchers...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 463 (1): 53–63.
Published: 08 September 2014
... with ROS elimination by ROS-scavenging molecules, such as superoxide dismutases and glutathione peroxidase [ 1 , 2 ]. cancer therapy chemical biology glutathione GST KRAS reactive oxygen species (ROS) Compound-immobilized affinity beads were prepared by a photo-cross-linking method...
Includes: Supplementary data
Articles
Xiaoying Koh-Stenta, Joma Joy, Anders Poulsen, Rong Li, Yvonne Tan, Yoonjung Shim, Jung-Hyun Min, Liling Wu, Anna Ngo, Jianhe Peng, Wei Guang Seetoh, Jing Cao, John Liang Kuan Wee, Perlyn Zekui Kwek, Alvin Hung, Umayal Lakshmanan, Horst Flotow, Ernesto Guccione, Jeffrey Hill
Journal:
Biochemical Journal
Biochem J (2014) 461 (2): 323–334.
Published: 26 June 2014
... emerged as important regulators of disease and developmental processes. To gain insight into the mechanistic actions of the PRDM family, we have performed comprehensive characterization of a prototype member protein, the histone methyltransferase PRDM9, using biochemical, biophysical and chemical biology...
Includes: Supplementary data
Articles
Rupesh Paudyal, Adam Jamaluddin, James P. Warren, Siamsa M. Doyle, Stéphanie Robert, Stuart L. Warriner, Alison Baker
Journal:
Biochemical Journal
Biochem J (2014) 460 (2): 177–185.
Published: 13 May 2014
... TE1 (Supplementary Figure S1A). Germination was unaffected by TE1, but at concentrations above 10 μM necrotic seedlings were observed after 7 days (Supplementary Figures S1B and S8A, top row). An advantage of chemical biology methods is the possibility to test the reversibility of the chemical...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 425 (1): 53–54.
Published: 14 December 2009
... © The Authors Journal compilation © 2010 Biochemical Society 2010 cell regulation chemical biology chemical inhibitor protein kinase signal transduction Over the past 15 years I have been involved in exploiting cell-permeable chemical inhibitors of protein kinases to understand...