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Keywords: chemical biology
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Biochem J (2023) 480 (18): 1445–1457.
Published: 21 September 2023
...Megan H. Wright Multicellular organisms require carefully orchestrated communication between and within cell types and tissues, and many unicellular organisms also sense their context and environment, sometimes coordinating their responses. This review highlights contributions from chemical biology...
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Biochem J (2021) 478 (1): 157–177.
Published: 13 January 2021
..., chemical biology has a great deal to contribute. This review will describe the importance of science at the chemistry/biology interface to both understand and combat the SARS-CoV-2 pandemic. chemical biology coronavirus drug discovery and design SARS-CoV-2 The ongoing global pandemic...
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Biochem J (2020) 477 (4): 801–814.
Published: 27 February 2020
... Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . autophagy chemical biology high-throughput screening kinases Macroautophagy (referred to as autophagy here for simplicity) is a lysosome-dependent degradative pathway...
Includes: Supplementary data
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Biochem J (2017) 474 (7): 1127–1147.
Published: 15 March 2017
... of molecules that promote protein degradation as chemical tools, the preclinical and clinical examples disclosed to date, and the future prospects for this exciting area of chemical biology. The process by which proteins are systematically degraded in a timely manner represents a fundamental mechanism...
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Biochem J (2016) 473 (17): 2573–2589.
Published: 30 August 2016
... The Author(s) 2016 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution Licence 4.0 (CC BY) . biochemical techniques and resources cellular targeting chemical biology protein dynamics...
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Biochem J (2016) 473 (10): 1297–1314.
Published: 11 May 2016
.... atypical chemical biology chemoenzymatic isopeptide ligation post-translational modification semisynthesis ubiquitin ubiquitination ubiquitylation Modification of substrate proteins with ubiquitin (Ub) and polyubiquitin (polyUb) chains of diverse topology is now firmly established...
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Biochem J (2015) 467 (1): 47–62.
Published: 20 March 2015
... will be useful for further evaluating the TRB pseudokinases, with the translation of this information likely to furnish new leads for drug discovery. adenosine 5′-triphosphate (ATP) chemical biology kinase pseudokinase Tribbles Tribbles 2 (TRB2/TRIB2) thermo-stability assay (TSA) Protein...
Includes: Supplementary data
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Biochem J (2015) 465 (2): 271–279.
Published: 06 January 2015
...-dependent gene transcription in macrophages. bosutinib chemical biology dasatinib inflammation interleukin-10 salt-inducible kinase Drug development for the treatment of chronic inflammatory diseases has mainly focused on interfering with the pro-inflammatory pathways driving the acute...
Includes: Supplementary data
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Biochem J (2014) 464 (1): 1.
Published: 23 October 2014
...Peter R. Shepherd © The Authors Journal compilation © 2014 Biochemical Society 2014 Asia Asian Chemical Biology Initiative chemical biology metabolism Science in Asia has been developing rapidly in recent years in both quality and quality. The Biochemical Journal spotted...
Includes: Supplementary data
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Biochem J (2014) 463 (1): 53–63.
Published: 08 September 2014
...) for 20 min, followed by a WST-8 assay (means±S.D.; n =3); * P <0.05, ** P <0.01, *** P <0.001. CPT was used as a positive control. cancer therapy chemical biology glutathione GST KRAS reactive oxygen species (ROS) Reactive oxygen species (ROS) are natural by-products...
Includes: Supplementary data
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