...Krishna Mohan Sepuru; Krishna Rajarathnam Chemokines Cxcl1/KC and Cxcl2/MIP2 play a crucial role in coordinating neutrophil migration to the insult site. Chemokines’ recruitment activity is regulated by monomer–dimer equilibrium and binding to glycosaminoglycans (GAGs). GAG chains exist...

...Prem Raj B. Joseph; Philip D. Mosier; Umesh R. Desai; Krishna Rajarathnam Chemokine CXCL8/interleukin-8 (IL-8) plays a crucial role in directing neutrophils and oligodendrocytes to combat infection/injury and tumour cells in metastasis development. CXCL8 exists as monomers and dimers...

...Prem Raj B. Joseph; Kirti V. Sawant; Angela Isley; Mesias Pedroza; Roberto P. Garofalo; Ricardo M. Richardson; Krishna Rajarathnam Chemokines mediate diverse functions from organogenesis to mobilizing leucocytes, and are unusual agonists for class-A GPCRs (G-protein-coupled receptors) because...

...Paramita Ray; Sarah A. Lewin; Laura Anne Mihalko; Sasha-Cai Lesher-Perez; Shuichi Takayama; Kathryn E. Luker; Gary D. Luker Chemokine CXCL12 (CXC chemokine ligand 12) signalling through CXCR (CXC chemokine receptor) 4 and CXCR7 has essential functions in development and underlies diseases including...

... be addressed to either of these authors (email [email protected] or [email protected] ). 1 4 2011 1 11 2011 8 11 2011 8 11 2011 © The Authors Journal compilation © 2012 Biochemical Society 2012 chemokine glutaminyl cyclase (QC) lipopolysaccharide (LPS...

...James E. Pease The directed migration of cells in response to chemical cues is known as chemoattraction, and plays a key role in the temporal and spatial positioning of cells in lower- and higher-order life forms. Key molecules in this process are the chemotactic cytokines, or chemokines, which...

...Stephen G. Ward; Federica M. Marelli-Berg T-lymphocyte trafficking is targeted to specific organs by selective molecular interactions depending on their differentiation and functional properties. Specific chemokine receptors have been associated with organ-specific trafficking of memory...

...Geraldine Parenty; Shirley Appelbe; Graeme Milligan Opioid agonists have a broad range of effects on cells of the immune system, including modulation of the inflammatory response, and opioid and chemokine receptors are co-expressed by many white cells. Hetero-oligomerization of the human DOP opioid...

...Morgan O'Hayre; Catherina L. Salanga; Tracy M. Handel; Samantha J. Allen Inappropriate chemokine/receptor expression or regulation is linked to many diseases, especially those characterized by an excessive cellular infiltrate, such as rheumatoid arthritis and other inflammatory disorders...

...Paul E. BLACKBURN; Clare V. SIMPSON; Robert J. B. NIBBS; Maureen O'HARA; Rhona BOOTH; Jemma POULOS; Neil W. ISAACS; Gerard J. GRAHAM There is much interest in chemokine receptors as therapeutic targets in diseases such as AIDS, autoimmune and inflammatory disorders, and cancer. Hampering...

.... The dissociation constant of Syn2 ect (+HS) with respect to interleukin-8 binding was determined by isothermal fluorescence titrations to be 23 nM. Despite its lack of HS chains, Syn2 ect (−HS) exhibited significant binding to the chemokine, with a K d of >1 µM. Thus, in addition to glycosaminoglycan binding...

... to express CXCL9 and CXCL10 mRNAs in response to IFNγ, whereas other carcinoma lines including HSC-2 did express these mRNAs. Production of these chemokine proteins was also impaired in Ca9-22 cells. The impaired expression was not due to any deficiency in the IFNγ/signal transducer and activator...

...Asima BHATTACHARYYA; Shresh PATHAK; Simanti DATTA; Santanu CHATTOPADHYAY; Joyoti BASU; Manikuntala KUNDU Gastric infection, as well as inflammation, caused by Helicobacter pylori , activates the production of cytokines and chemokines by mononuclear cells; interleukin-8 (IL-8) is one of the major...

.... In contrast, mutation of the other two putative NF-jB binding sites did not affect RANTES INTRODUCTION RANTES (regulated upon activation, normal T-cell expressed and secreted) is a member of the chemokine family of proteins, which plays an essential role in inflammation by recruiting T cells, macrophages...

...Helen YOUNG; Vikram ROONGTA; Thomas J. DALY; Kevin H. MAYO Neutrophil-activating peptide 2 (NAP-2), which demonstrates a range of proinflammatory activities, is a 72-residue protein belonging to the α-chemokine family. Although NAP-2, like other α-chemokines, is known to self-associate into dimers...