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Keywords: cholesterol
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Biochem J (2020) 477 (21): 4243–4261.
Published: 13 November 2020
..., mechanisms of the host immune responses against pathogenic bacterial SGs have partially been resolved. This review is focused on the biological functions of SGs in mammals taking into consideration their therapeutic applications in the future. cholesterol glycolipid immune modulation lipid metabolism...
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Biochem J (2019) 476 (18): 2545–2560.
Published: 20 September 2019
...Ngee Kiat Chua; Nicola A. Scott; Andrew J. Brown Squalene monooxygenase (SM) is an essential rate-limiting enzyme in cholesterol synthesis. SM degradation is accelerated by excess cholesterol, and this requires the first 100 amino acids of SM (SM N100). This process is part of a protein quality...
Includes: Supplementary data
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Biochem J (2019) 476 (6): 951–963.
Published: 22 March 2019
...Sarah C. Proudfoot; Daisy Sahoo High-density lipoproteins (HDLs) facilitate reverse cholesterol transport, a process in which HDL removes cholesterol from circulation and carries it to the liver for biliary excretion. Reverse cholesterol transport is also facilitated by HDL's high-affinity receptor...
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Biochem J (2018) 475 (24): 3917–3919.
Published: 14 December 2018
...Normand Cyr In a recent issue of Biochemical Journal , Kathuria et al . [ Biochem. J. (2018) 475 , 3039–3055] report that membrane binding of the pore-forming toxin Vibrio cholerae cytolysin (VCC) is facilitated by the presence of cholesterol, and the presence of this sterol within the lipid...
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Biochem J (2015) 471 (2): 243–253.
Published: 02 October 2015
... by cholesterol accumulation in late endosomes (LE) and lysosomes (Ly). Nascent or mutated NPC1 is degraded through the ubiquitin–proteasome pathway, but how NPC1 degradation is regulated remains currently unknown. In the present study, we demonstrated a link between NPC1 degradation and the Akt (protein kinase B...
Includes: Supplementary data
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Biochem J (2015) 467 (3): 495–505.
Published: 17 April 2015
... of specific lipids on each of the well-characterized steps in Bax-mediated membrane permeabilization. We show that high levels of cholesterol in the membrane inhibit permeabilization by categorically identifying the recruitment of Bax by the activators and Bax insertion in the membrane as the steps being...
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Biochem J (2014) 459 (2): e1–e3.
Published: 28 March 2014
...Nicolas Venteclef; Pascal Ferré Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Accumulation of cholesterol and its intermediates, such as oxysterols, lead to activation of the nuclear receptors LXRs (liver X receptors). LXR is an important...
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Biochem J (2014) 459 (2): 301–312.
Published: 28 March 2014
...Paresh P. Chothe; Peter W. Swaan The sodium/bile acid co-transporter ASBT [apical sodium-dependent bile acid transporter; SLC10A2 (solute carrier family 10 member 2)] plays a key role in the enterohepatic recycling of the bile acids and indirectly contributes to cholesterol homoeostasis. ASBT...
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Biochem J (2014) 458 (3): 481–489.
Published: 28 February 2014
...Romina F. Vazquez; Sabina M. Maté; Laura S. Bakás; Marisa M. Fernández; Emilio L. Malchiodi; Vanesa S. Herlax Several toxins that act on animal cells present different, but specific, interactions with cholesterol or sphingomyelin. In the present study we demonstrate that HlyA (α-haemolysin...
Includes: Supplementary data
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Biochem J (2014) 457 (3): 463–472.
Published: 10 January 2014
... approach, we show that membrane lipids modulate the structure, subcellular localization and activity of FAAH. We report that the FAAH dimer is stabilized by the lipid bilayer and shows a higher membrane-binding affinity and enzymatic activity within membranes containing both cholesterol and the natural...
Includes: Multimedia, Supplementary data
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Biochem J (2014) 457 (1): 99–105.
Published: 10 December 2013
... reticulum). Binding of the LDLR to PCSK9 in the ER promotes autocatalytic cleavage of PCSK9. The cleaved PCSK9 promotes the exit of the LDLR out of the ER. chaperone cholesterol endoplasmic reticulum low-density lipoprotein receptor proprotein convertase subtilisin/kexin type 9 (PCSK9) proteasome...
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Biochem J (2012) 446 (2): 191–201.
Published: 14 August 2012
...James R. Krycer; Lisa Phan; Andrew J. Brown There is growing evidence showing that prostate cancer cells have perturbed cholesterol homoeostasis, accumulating cholesterol to promote cell growth. Consequently, cholesterol-lowering drugs such as statins are being evaluated in prostate cancer...
Includes: Supplementary data
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Biochem J (2011) 437 (3): 541–553.
Published: 13 July 2011
...Sabine Muth; Anja Fries; Gerald Gimpl Recent studies suggest that cholesterol binding is widespread among GPCRs (G-protein-coupled receptors). In the present study, we analysed putative cholesterol-induced changes in the OTR [OT (oxytocin) receptor], a prototype of cholesterol-interacting GPCRs...
Includes: Supplementary data
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Biochem J (2011) 437 (1): 13–24.
Published: 14 June 2011
... to the midbody, and depletion of Exocyst components results in an enhanced accumulation of lum-GFP-containing vesicles in the midbody [ 9 ]. Such data would apparently argue against a role for the Exocyst in tethering these vesicles, but rather implicates the Exocyst in their subsequent fusion. cholesterol...
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Biochem J (2010) 429 (2): 235–242.
Published: 28 June 2010
... and hypercholesterolaemic as compared with mammals. Upon feeding on a high-cholesterol diet, the plasma total cholesterol in zebrafish was reported to reach an average of approx. 20.7 mmol/l (800 mg/dl), a level observed in cholesterol-fed LDL (low-density lipoprotein)-receptor-knockout mice [ 4 ]. The degree of fatty acid...
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Biochem J (2010) 429 (1): 13–24.
Published: 14 June 2010
...Mike H. Ngo; Terry R. Colbourne; Neale D. Ridgway Cholesterol and its numerous oxygenated derivatives (oxysterols) profoundly affect the biophysical properties of membranes, and positively and negatively regulate sterol homoeostasis through interaction with effector proteins. As the bulk...
Includes: Multimedia, Supplementary data
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Biochem J (2010) 428 (1): 95–101.
Published: 28 April 2010
... efficiently than mock-treated PrP Sc . Whereas the addition of PrP Sc increased cellular cholesterol levels and was predominantly found within lipid raft micro-domains, PrP Sc -G-lyso-PI did not alter cholesterol levels and most of it was found outside lipid rafts. We conclude that the nature of the GPI...
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Biochem J (2009) 424 (2): e5–e6.
Published: 11 November 2009
...’. Model membrane studies revealed that these lipid rafts are related to the more ordered liquid phase that forms in a ternary mixture of cholesterol with a phospholipid containing saturated acyl chains and one with unsaturated acyl chains. Giant plasma membrane vesicles that pinch off from cells undergo...
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Biochem J (2009) 423 (1): 1–14.
Published: 14 September 2009
... literature on protein and lipid roles in exocytosis, with emphasis on the multiple roles of cholesterol in exocytosis and membrane fusion, in an effort to promote a more molecular systems-level view of the as yet poorly understood process of Ca 2+ -triggered membrane mergers. Individual lipid species can...
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Biochem J (2009) 420 (3): 373–381.
Published: 27 May 2009
... remodelling of the PM, including a rapid rearrangement of the glycosphingolipid GM1 and cholesterol into newly formed structures, only partial solubilization of fluid domains and the formation of condensed domains that cover 51% of the remaining membrane. TX does not appear to induce the coalescence of pre...
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Biochem J (2009) 420 (2): 179–191.
Published: 13 May 2009
... delivery vectors. In the present study, qualitative and quantitative analysis of the influence of temperature, peptide concentration and plasma membrane cholesterol on the uptake and subcellular distribution of the model cell-penetrating peptide octa-arginine was performed in a number of suspension...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 419 (3): 577–584.
Published: 14 April 2009
... in cellular LDLc (LDL-cholesterol) and a concomitant increase in serum LDLc. Central to the function of PCSK9 is a direct protein–protein interaction formed with the LDLR. In the present study, we investigated a strategy to modulate LDL uptake by blocking this interaction using specific antibodies directed...
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Biochem J (2009) 418 (2): 369–378.
Published: 11 February 2009
...) are essential for survival inside of host macrophages. These genes act as an operon and have been suggested to be involved in cholesterol metabolism. However, the role of NAT in this catabolic pathway has not been determined. In an effort to better understand the function of these proteins, we have expressed...
Includes: Supplementary data
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Biochem J (2008) 415 (1): 87–96.
Published: 12 September 2008
... Toxoplasma cells and their purified rhoptries. This comparative lipidomic analysis revealed an enrichment of cholesterol, sphingomyelin and, most of all, saturated fatty acids in the rhoptries. These lipids are known, when present in membranes, to contribute to their rigidity and, interestingly, fluorescence...
Includes: Supplementary data
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Biochem J (2008) 412 (3): 553–562.
Published: 28 May 2008
...Alireza Roostaee; Élie Barbar; Jean-Guy LeHoux; Pierre Lavigne Steroidogenesis depends on the delivery of cholesterol from the outer to the inner mitochondrial membrane by StAR (steroidogenic acute regulatory protein). However, the mechanism by which StAR binds to cholesterol and its importance...
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Biochem J (2007) 401 (2): 597–605.
Published: 21 December 2006
... the lipid bilayer and that cholesterol in the bilayer also interacts with MDR1. However, the effects of cholesterol on drug–MDR1 interactions are still unclear. To examine these effects, human MDR1 was expressed in insect cells and purified. The purified MDR1 protein was reconstituted in proteoliposomes...
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Biochem J (2006) 398 (3): 423–430.
Published: 29 August 2006
... normally and did not show significant difference in the levels of cholesterol, BAs or any other bile constituents. However, they did not form cholesterol gallstones when fed a cholic acid-containing high-fat diet, and liver-specific gene expression indicated that Gpbar1-deficient mice have altered feedback...
Includes: Supplementary data
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Biochem J (2006) 397 (3): 407–416.
Published: 13 July 2006
...Eduard B. Babiychuk; Annette Draeger Lateral segregation of cholesterol- and sphingomyelin-rich rafts and glycerophospholipid-containing non-raft microdomains has been proposed to play a role in a variety of biological processes. The most compelling evidence for membrane segregation is based...