... of tryptophan residues, whereas OCN − induced carbamylation of lysine residues to yield homocitrulline. Tryptophan residues were more readily oxidized on apoA-I contained in rHDLs. Exposure of lipid-free apoA-I to HOSCN and OCN − significantly reduced the extent of cholesterol efflux from cholesterol-loaded...

..., NPC1L1-driven free cholesterol transport was unidirectional, since cellular cholesterol efflux to apolipoprotein A-I, high-density lipoprotein or serum was unaffected by NPC1L1 expression or localization. Additionally, NPC1L1 facilitates mass non-esterified-cholesterol uptake only when it is located...

.... The compounds prevent cholesterol gallstone formation and diet-induced fatty liver, and increase reverse cholesterol transport in rodents. The aim of the present study was to investigate the effect of FABACs on cholesterol efflux in human cells. Aramchol (3β-arachidylamido-7α,12α,5β-cholan-24-oic acid...

... the effects of inducible ORP2 overexpression on cellular cholesterol metabolism in HeLa cells and compare the results with those obtained for CHO cells (Chinese-hamster ovary cells) that express ORP2 constitutively. In both cell systems, the prominent phenotype is enhancement of [ 14 C]cholesterol efflux...

... and ABCA12 have been determined to be the causative genes in Tangier disease [ 10 – 12 ], fatal surfactant deficiency [ 13 ], Stargardt's macular dystrophy [ 14 ] and lamellar ichthyosis type 2 [ 15 ] respectively. ABCA1 functions to promote cellular phospholipid and cholesterol efflux to apoA-I...

... cholesterol, free cholesterol and triacylglycerol content of HDL were not significantly altered after EL modification. The ability of EL-HDL to mediate 3 H-cholesterol efflux from SR-BI (scavenger receptor B type I) overexpressing Chinese-hamster ovary cells was impaired and markedly lower compared with LacZ...