... on the evidence of circadian rhythms in tissue physiology, their entrainment mechanisms and disease links, and the tissue-specific clock target genes/pathways. Research in this area holds strong potential to advance our understanding of how circadian rhythms control the health and disease of the musculoskeletal...

... mRNA levels in wild-type MEFs ( P <0.05). Asterisks indicate peaks of rhythmically expressed PPARα mRNA. Representative Northern blots are shown in Supplementary Figure 1(B) at http://www.BiochemJ.org/bj/386/bj3860575add.htm . circadian rhythm CLOCK E-box liver peroxisome...

... circadian rhythms and contributes significantly to the pathogenesis of many diseases including cancer. 1 To whom correspondence should be addressed (email [email protected] ). 12 4 2004 3 6 2004 11 6 2004 11 6 2004 The Biochemical Society, London 2004 Co-transfection...

...) Nature (London) 419 , 841–844]. It is known that mammalian circadian rhythms are controlled by molecular clockwork systems based on negative-feedback loop(s), but the molecular mechanisms for the circadian regulation of Dec2 gene expression have not been clarified. We show here that transcription...

... AB088477 ( hPer1 ), AB002345 ( hPer2 ), AB047686 ( hPer3 ), AB014558 ( hCry2 ) and AB002332 ( hClock ). 27 8 2003 5 1 2004 29 1 2004 29 1 2004 The Biochemical Society, London ©2004 2004 casein kinase Iε circadian rhythm Period phosphorylation proteasomal degradation...