... targets. Figure 5: Comparison between click reactions and solid-phase organic synthesis. (A) Examples of some of the click chemistry reactions that have been used in PROTAC synthesis. (B) Schematic of the steps involved in solid phase organic synthesis. (C) Comparison of the two approaches...

... are described along with evidence that growth is specifically inhibited by blocking N-myristoylation in the parasite. Chagas’ disease click chemistry drug target N-myristoylation Trypanosoma cruzi validation The protozoan parasite Trypanosoma cruzi is the causative agent of Chagas...