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Amy R. Cameron, Katherine Wallace, Lisa Logie, Alan R. Prescott, Terry G. Unterman, Jean Harthill, Graham Rena
Biochem J (2012) 443 (1): 57–64.
Published: 14 March 2012
... underlying these diseases, with the scope to identify common cellular targets for therapy. In the present study we have examined the insulin-like signalling properties of an experimental AD 8-hydroxyquinoline drug known as CQ (clioquinol). The IIS [insulin/IGF-1 (insulin-like growth factor-1) signalling...
Biochem J (2011) 436 (2): 481–491.
Published: 13 May 2011
...Michael A. Cater; Ygal Haupt Clioquinol (5-chloro-7-iodo-8-quinolinol) is a copper ionophore that was used primarily during the 1950–1970s as an oral antimicrobial agent. It has been established that clioquinol displays toxicity towards malignant cells, inducing caspase-dependent apoptosis. In the...
Includes: Supplementary data
Biochem J (2009) 417 (1): 133–139.
Published: 12 December 2008
...Haijun Yu; Yunfeng Zhou; Stuart E. Lind; Wei-Qun Ding We have previously demonstrated that clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) acts as a zinc ionophore and induces apoptosis of human cancer cells; however, the mechanisms of clioquinol/zinc-induced apoptotic cell death remain to be...