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Keywords: co-activator
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Articles
Biochem J (2015) 466 (3): 587–599.
Published: 06 March 2015
...Purin Charoensuksai; Peter Kuhn; Lu Wang; Nathan Sherer; Wei Xu O-GlcNAcylation (O-linked-β-N-acetylglucosaminidation) sites of CARM1 (co-activator-associated arginine methyltransferase 1) have been mapped to four possible sites. O-GlcNAc (O-linked-β-N-acetylglucosamine)-depleted CARM1 generated...
Includes: Supplementary data
Articles
Biochem J (2014) 461 (1): 15–32.
Published: 13 June 2014
... for the different isoforms. © The Authors Journal compilation © 2014 Biochemical Society 2014 co-activator co-repressor promoter transcription Wilms’ tumour 1 (WT1) zinc finger The WT1 (Wilms’ tumour 1) protein was among the first tumour suppressor genes to be cloned. Research over...
Articles
Biochem J (2013) 453 (1): 49–60.
Published: 13 June 2013
... (steroid receptor co-activator 1), but not by PCAF (p300/CBP-associated factor) and PGC-1α (PPAR co-activator 1α). The physical interaction between lipin1 and PPARγ occurs at the lipin1 C-terminal region from residues 825 to 926, and the VXXLL motif at residue 885 is critical for binding...
Includes: Supplementary data
Articles
Biochem J (2012) 447 (3): 437–447.
Published: 05 October 2012
...Geun Hyang Kim; Kyung Jin Lee; Gyun-Sik Oh; Jin Yoon; Hae Won Kim; Seung-Whan Kim ASC-2 (activating signal co-integrator-2, also known as AIB3 and NCoA6) is a transcriptional co-activator and regulates insulin secretion and β-cell survival. The present study was performed to elucidate the role...
Includes: Supplementary data
Articles
Biochem J (2011) 437 (3): 531–540.
Published: 13 July 2011
... (interleukin enhancer-binding factor 3). ILF3 formed a complex with LRH-1 and the other two nuclear receptor co-activators PRMT1 (protein arginine methyltransferase 1) and PGC-1α (peroxisome proliferator-activated receptor γ co-activator-1α). We demonstrated that ILF3, PRMT1 and PGC-1α were recruited...
Articles
Biochem J (2009) 421 (2): 253–261.
Published: 26 June 2009
... that both enzymes selectively methylate histone H4 suggest that PRMT2, like PRMT1, may act as a transcription co-activator through this modification. 1 To whom correspondence should be addressed (email afrankel@interchange.ubc.ca ). 12 2 2009 6 4 2009 30 4 2009 30 4 2009 ©...
Includes: Supplementary data
Articles
Biochem J (2007) 404 (2): 197–206.
Published: 14 May 2007
... Biochemical Society 2007 chromosome translocation co-activator extraskeletal myxoid chondrosarcoma hTAF II 68-TEC glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein–protein interaction transactivation Human EMCs (extraskeletal myxoid chondrosarcomas) are soft tissue tumours...
Articles
Biochem J (2005) 386 (1): E1.
Published: 08 February 2005
... the p300 transcriptional co-activator and is required for Smad3-dependent transcriptional activation. This study raises interesting questions about the nature and regulation of Smad-regulated gene activation and elevates the status of the linker domain to rival that of the much-lauded MH1 and MH2 domains...
Articles
Biochem J (2004) 382 (1): 323–329.
Published: 10 August 2004
...Min LI; Padmavathy NAIDU; Yihong YU; Nathan A. BERGER; Perry KANNAN Poly(ADP-ribose) polymerase-1 (PARP-1) is a co-activator for AP-2α (activator protein 2α)-mediated transcriptional activation. In the present study, we find that the role of PARP-1 in AP-2α transcription is distinctly dualistic...
Articles
Biochem J (2004) 382 (1): 111–119.
Published: 10 August 2004
...Shih-Ming HUANG; Yi-Shan CHENG The p160 co-activators, SRC1 (steroid receptor co-activator 1), GRIP1 (glucocorticoid-receptor-interacting protein 1) and ACTR (activator for thyroid hormone and retinoid receptors), have two ADs (activation domains), AD1 and AD2. AD1 is a binding site for the related...
Articles
Biochem J (2004) 381 (2): 357–363.
Published: 06 July 2004
... in liver and most other human tissues. SREBP-1c is transcriptionally less active than SREBP-1a, but is a main mediator of hepatic insulin action and is selectively up-regulated by LXR (liver X receptor) agonists. LXR-mediated transactivation is co-activated by PGC-1α (peroxisome-proliferator-activated...
Articles
Biochem J (2004) 381 (1): 267–273.
Published: 22 June 2004
... or lack of involucrin expression. Recently, a dominant-negative construct of the transcriptional co-activator P/CAF [p300/CBP-associated factor, where CBP stands for CREB (cAMP-response-element-binding protein)-binding protein] was shown to inhibit involucrin expression in immortalized keratinocytes...
Articles
Biochem J (2003) 376 (2): 465–472.
Published: 01 December 2003
... and chlorpromazine. Also, the induction of CYP2B10 mRNA by oestrogens was less pronounced in mouse primary hepatocytes. Yeast two-hybrid assays indicated that, unlike androstenol and the established activators, oestrogens attracted both nuclear receptor co-repressors and co-activators to the mCAR ligand-binding...
Articles
Biochem J (2003) 375 (2): 373–383.
Published: 15 October 2003
...@interchange.ubc.ca ). 9 5 2003 10 7 2003 15 7 2003 15 7 2003 The Biochemical Society, London ©2003 2003 androgen receptor co-activator prostate cancer Abbreviations used: AR, androgen receptor; RTA, repressed transactivator; DDC, l -dopa decarboxylase; GR, glucocorticoid...
Articles
Biochem J (2001) 353 (2): 253–258.
Published: 08 January 2001
... known co-activating proteins interact in a ligand-dependent manner with the C-terminal ligand-regulated activation function (AF)-2 domain of nuclear receptors. Since PPARα exhibits a strong constitutive transactivating function contained within an N-terminal AF-1 region, it can be speculated...