...Purin Charoensuksai; Peter Kuhn; Lu Wang; Nathan Sherer; Wei Xu O-GlcNAcylation (O-linked-β-N-acetylglucosaminidation) sites of CARM1 (co-activator-associated arginine methyltransferase 1) have been mapped to four possible sites. O-GlcNAc (O-linked-β-N-acetylglucosamine)-depleted CARM1 generated...

.... 1 To whom correspondence should be addressed (email [email protected] ). 3 12 2013 10 4 2014 24 4 2014 © The Authors Journal compilation © 2014 Biochemical Society 2014 co-activator co-repressor promoter transcription Wilms’ tumour 1 (WT1) zinc finger...

... (steroid receptor co-activator 1), but not by PCAF (p300/CBP-associated factor) and PGC-1α (PPAR co-activator 1α). The physical interaction between lipin1 and PPARγ occurs at the lipin1 C-terminal region from residues 825 to 926, and the VXXLL motif at residue 885 is critical for binding...

...Geun Hyang Kim; Kyung Jin Lee; Gyun-Sik Oh; Jin Yoon; Hae Won Kim; Seung-Whan Kim ASC-2 (activating signal co-integrator-2, also known as AIB3 and NCoA6) is a transcriptional co-activator and regulates insulin secretion and β-cell survival. The present study was performed to elucidate the role...

... (interleukin enhancer-binding factor 3). ILF3 formed a complex with LRH-1 and the other two nuclear receptor co-activators PRMT1 (protein arginine methyltransferase 1) and PGC-1α (peroxisome proliferator-activated receptor γ co-activator-1α). We demonstrated that ILF3, PRMT1 and PGC-1α were recruited...

... that both enzymes selectively methylate histone H4 suggest that PRMT2, like PRMT1, may act as a transcription co-activator through this modification. 1 To whom correspondence should be addressed (email [email protected] ). 12 2 2009 6 4 2009 30 4 2009 30 4 2009...

... chromosome translocation co-activator extraskeletal myxoid chondrosarcoma hTAF II 68-TEC glyceraldehyde-3-phosphate dehydrogenase (GAPDH) protein–protein interaction transactivation Human EMCs (extraskeletal myxoid chondrosarcomas) are soft tissue tumours of uncertain histogenetic origin...

... the p300 transcriptional co-activator and is required for Smad3-dependent transcriptional activation. This study raises interesting questions about the nature and regulation of Smad-regulated gene activation and elevates the status of the linker domain to rival that of the much-lauded MH1 and MH2 domains...

...Min LI; Padmavathy NAIDU; Yihong YU; Nathan A. BERGER; Perry KANNAN Poly(ADP-ribose) polymerase-1 (PARP-1) is a co-activator for AP-2α (activator protein 2α)-mediated transcriptional activation. In the present study, we find that the role of PARP-1 in AP-2α transcription is distinctly dualistic...

...Shih-Ming HUANG; Yi-Shan CHENG The p160 co-activators, SRC1 (steroid receptor co-activator 1), GRIP1 (glucocorticoid-receptor-interacting protein 1) and ACTR (activator for thyroid hormone and retinoid receptors), have two ADs (activation domains), AD1 and AD2. AD1 is a binding site for the related...

... in liver and most other human tissues. SREBP-1c is transcriptionally less active than SREBP-1a, but is a main mediator of hepatic insulin action and is selectively up-regulated by LXR (liver X receptor) agonists. LXR-mediated transactivation is co-activated by PGC-1α (peroxisome-proliferator-activated...

... or lack of involucrin expression. Recently, a dominant-negative construct of the transcriptional co-activator P/CAF [p300/CBP-associated factor, where CBP stands for CREB (cAMP-response-element-binding protein)-binding protein] was shown to inhibit involucrin expression in immortalized keratinocytes...

... and chlorpromazine. Also, the induction of CYP2B10 mRNA by oestrogens was less pronounced in mouse primary hepatocytes. Yeast two-hybrid assays indicated that, unlike androstenol and the established activators, oestrogens attracted both nuclear receptor co-repressors and co-activators to the mCAR ligand-binding...

[email protected] ). 9 5 2003 10 7 2003 15 7 2003 15 7 2003 The Biochemical Society, London ©2003 2003 androgen receptor co-activator prostate cancer Abbreviations used: AR, androgen receptor; RTA, repressed transactivator; DDC, l -dopa decarboxylase; GR, glucocorticoid...

... known co-activating proteins interact in a ligand-dependent manner with the C-terminal ligand-regulated activation function (AF)-2 domain of nuclear receptors. Since PPARα exhibits a strong constitutive transactivating function contained within an N-terminal AF-1 region, it can be speculated...