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Keywords: co-repressor
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Articles
Biochem J (2014) 461 (1): 15–32.
Published: 13 June 2014
... © 2014 Biochemical Society 2014 co-activator co-repressor promoter transcription Wilms’ tumour 1 (WT1) zinc finger Determining the role(s) of the different WT1 gene products, gene regulation, and their effects in development and disease is likely to remain a major challenge for some...
Articles
Biochem J (2013) 453 (1): 49–60.
Published: 13 June 2013
... the present study show that lipin1 activates PPARγ by releasing co-repressors, NCoR1 (nuclear receptor co-repressor 1) and SMRT (silencing mediator of retinoid and thyroid hormone receptor), from PPARγ in the absence of the ligand rosiglitazone. We also identified a novel lipin1 TAD (transcriptional...
Includes: Supplementary data
Articles
Biochem J (2010) 427 (3): 499–511.
Published: 14 April 2010
...Yiming Zhang; Shen Gao; Zhengxin Wang We previously demonstrated that the Groucho protein AES (amino-terminal enhancer of split) functions as a co-repressor of the AR (androgen receptor). It physically interacts with the N-terminal domain of AR and inhibits AR-driven transcription, but the...
Articles
Biochem J (2009) 417 (1): 121–132.
Published: 12 December 2008
... many other processes in the adult including haematopoiesis. The Groucho/TLE (transducin-like enhancer) family of co-repressor proteins also regulate development and modulate the activity of many DNA-binding transcription factors during a range of diverse cellular processes including haematopoiesis. We...
Articles
Biochem J (2008) 411 (1): 19–26.
Published: 13 March 2008
...Kyung-Chul Choi; So-Young Oh; Hee-Bum Kang; Yoo-Hyun Lee; Seungjoo Haam; Ha-Il Kim; Kunhong Kim; Young-Ho Ahn; Kyung-Sup Kim; Ho-Geun Yoon A central issue in mediating repression by nuclear hormone receptors is the distinct or redundant function between co-repressors N-CoR (nuclear receptor co...
Articles
Biochem J (2006) 399 (2): 297–304.
Published: 27 September 2006
... transcription, while enforced expression of Brg1 in murine erythroleukaemia cells reduced P4.2 gene expression. Overexpression of Brg1 was associated with increased occupancy of the P4.2 promoter by the nuclear co-repressor mSin3A and HDAC2 (histone deacetylase 2) and with reduced histone H3 and H4 acetylation...
Includes: Supplementary data
Articles
Biochem J (2005) 392 (1): 1–11.
Published: 08 November 2005
... repression domains located within the N-terminal regions of these proteins are responsible for these differences by facilitating interactions with various co-activators and co-repressors. The present review primarily focuses on discussing the structural, biochemical and biological functions of the repressor...
Articles
Biochem J (2003) 376 (2): 465–472.
Published: 01 December 2003
... chlorpromazine. Also, the induction of CYP2B10 mRNA by oestrogens was less pronounced in mouse primary hepatocytes. Yeast two-hybrid assays indicated that, unlike androstenol and the established activators, oestrogens attracted both nuclear receptor co-repressors and co-activators to the mCAR ligand-binding...
Articles
Biochem J (2003) 370 (3): 737–749.
Published: 15 March 2003
...-mail a.b.vankuilenburg@amc.uva.nl ). 21 8 2002 30 10 2002 12 11 2002 15 3 2003 The Biochemical Society, London ©2003 2003 characterization inhibitor co-repressor gene expression histone deacetylase tissue distribution Abbreviations used: CaMK, Ca 2...