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Keywords: coagulation
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Biochem J (2019) 476 (19): 2909–2926.
Published: 11 October 2019
...Tina M. Misenheimer; Kraig T. Kumfer; Barbara E. Bates; Emily R. Nettesheim; Bradford S. Schwartz The mechanism of generation of factor VIIa, considered the initiating protease in the tissue factor-initiated extrinsic limb of blood coagulation, is obscure. Decreased levels of plasma VIIa in...
Includes: Supplementary data
Biochem J (2016) 473 (24): 4629–4650.
Published: 09 December 2016
... Society 2016 antiphospholipid syndrome β2-glycoprotein I coagulation molecular interactions thrombin β2-Glycoprotein I (β2GpI) is a heavily glycosylated plasma protein (45 kDa), which is synthesized in the liver [ 1 ] and represents the major autoantigen in the antiphospholipid syndrome...
Includes: Supplementary data
Biochem J (2015) 467 (1): 37–46.
Published: 20 March 2015
... membranes can regulate blood coagulation. Large unilamellar vesicles (LUVs; ∼110–130 nm in diameter) of the same composition were prepared in buffer A by the extrusion method as described by Mayer et al. [ 26 ]. Factor V was isolated from either bovine blood or from human fresh frozen plasma as...
Includes: Supplementary data
Biochem J (2011) 437 (3): 455–460.
Published: 13 July 2011
...Hai Po Helena Liang; Teresa M. Brophy; Philip J. Hogg TF (tissue factor) is a transmembrane cofactor that initiates blood coagulation in mammals by binding Factor VIIa to activate Factors X and IX. The cofactor can reside in a cryptic configuration on primary cells and de-encryption may involve a...
Biochem J (2009) 422 (2): 257–264.
Published: 13 August 2009
...Jina Song; Kimberley Talbot; Jeffrey Hewitt; Ross T. A. MacGillivray; Edward L. G. Pryzdial Blood coagulation FV (Factor V) is activated by thrombin-mediated excision of the B domain, resulting in a non-covalent heterodimer, FVa (activated FV). Previous studies implicated Glu 96 , Asp 102 and Asp...
Biochem J (2008) 412 (3): 545–551.
Published: 28 May 2008
...) after excitation at 270 nm (tryptophan absorption). Both the excitation and emission slit widths were fixed at 2.5 nm. coagulation fibrinolysis haemostatic peptide ideal amphipathic peptide (IAP) prothrombinase tenase The generation of Factor Xa by Factor IXa and with various...
Biochem J (2007) 405 (3): 429–438.
Published: 13 July 2007
...Katrine S. Larsen; Henrik Østergaard; Jais R. Bjelke; Ole H. Olsen; Hanne B. Rasmussen; Leif Christensen; Birthe B. Kragelund; Henning R. Stennicke The remarkably high specificity of the coagulation proteases towards macromolecular substrates is provided by numerous interactions involving the...
Biochem J (2006) 393 (2): 529–535.
Published: 23 December 2005
...Joel R. Livingston; Michael R. Sutherland; Harvey M. Friedman; Edward L. G. Pryzdial The HSV1 (herpes simplex virus type 1) surface has been shown recently to initiate blood coagulation by FVIIa (activated Factor VII)-dependent proteolytic activation of FX (Factor X). At least two types of direct...
Biochem J (2005) 390 (2): 485–492.
Published: 23 August 2005
... The Biochemical Society, London 2005 allostery coagulation hirudin limited proteolysis Na + thrombin Thrombin plays a key role at the interface between coagulation, inflammation and cell growth [ 1 ], and exerts either procoagulant or anticoagulant functions in haemostasis [ 2...
Includes: Supplementary data
Biochem J (2003) 369 (1): 129–139.
Published: 01 January 2003
... coagulation haemostasis metalloproteinases thrombosis Abbreviations used: berythractivase, B. erythr omelas prothrombin activase ; CONICET, Consejo Nacional de Investigaciones Científicas y Técnicas; E-64, trans -epoxysuccinyl- l -leucylamido-(4-guanidino)butane; FBS, fetal bovine serum...
Biochem J (2001) 360 (2): 499–506.
Published: 26 November 2001
... reproducing TSR (TSR-peptide) was also synthesized in an attempt to obtain direct evidence of the domain involvement in PS anticoagulant activity. In a coagulation assay, both rTSR-less and factor Xa-cleaved PS were devoid of activated protein C cofactor activity. The TSR-peptide did not inhibit rHPS activity...