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1-11 of 11
Keywords: colorectal cancer
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Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (12): 2281–2293.
Published: 24 June 2020
... is decreased in colorectal cancer (CRC) tumor tissues, compared with normal pairs. Furthermore, RT-qPCR and western blot analysis showed that the OCT4 gene has been down-regulated following the miR-3658 overexpression. Consistently, dual-luciferase assay supported the direct interaction of miR-3658 with the 3...
Articles
Journal:
Biochemical Journal
Biochem J (2019) 476 (5): 779–781.
Published: 06 March 2019
...Phillip T. Newton Colorectal cancer is one of the most common forms of cancer in the world, with more than half a million new cases annually. Amongst the most promising new therapies, niclosamide—an FDA-approved drug for treating tapeworm infections—is being assessed in a stage II clinical trial...
Articles
In Collection
Editors' pick of research highlights published in the Biochemical Journal in 2018 & 2019
Jiangbo Wang, Xiu-rong Ren, Hailan Piao, Shengli Zhao, Takuya Osada, Richard T. Premont, Robert A. Mook, Jr, Michael A. Morse, Herbert Kim Lyerly, Wei Chen
Journal:
Biochemical Journal
Biochem J (2019) 476 (3): 535–546.
Published: 08 February 2019
... types of cancer. Previously, we identified that the anthelmintic drug niclosamide inhibited Wnt signaling by promoting internalization of Wnt receptor Frizzled 1 and degradation of Wnt signaling pathway proteins, Dishevelled 2 and β-catenin, contributing to suppression of colorectal cancer growth...
Includes: Supplementary data
Articles
Bea Unterer, Veit Wiesmann, Mekala Gunasekaran, Heinrich Sticht, Clara Tenkerian, Jürgen Behrens, Marina Leone, Felix B. Engel, Nathalie Britzen-Laurent, Elisabeth Naschberger, Thomas Wittenberg, Michael Stürzl
Journal:
Biochemical Journal
Biochem J (2018) 475 (18): 2955–2967.
Published: 25 September 2018
... 2018 The Author(s) 2018 This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . cell proliferation colorectal cancer guanylate-binding proteins interferons...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2018) 475 (17): 2749–2767.
Published: 05 September 2018
... of IMP1 is shown in two animal cancer models. Mice genetically engineered to carry targeted expression of IMP1 in mammary glands developed mammary adenocarcinoma [ 10 ]. The role of IMP1 in the development of colorectal cancer was suggested by the following findings: (i) in colorectal cancer cell...
Articles
Anan H. Said, Shien Hu, Ameer Abutaleb, Tonya Watkins, Kunrong Cheng, Ahmed Chahdi, Panjamurthy Kuppusamy, Neeraj Saxena, Guofeng Xie, Jean-Pierre Raufman
Journal:
Biochemical Journal
Biochem J (2017) 474 (5): 647–665.
Published: 20 February 2017
... ) * These authors contributed equally to this work. 26 7 2016 16 12 2016 21 12 2016 22 12 2016 © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2017 cell invasion colorectal cancer matrix metalloproteinases muscarinic receptors...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (20): 3597–3610.
Published: 11 October 2016
... the possibility of miR-27a being a new regulator of p53. Using luciferase reporter assay and various mutational and functional analysis, we identified two putative binding sites of miR-27a on the 3′-UTR of p53. The overexpression of miR-27a in the human colorectal cancer cell line HCT-116 +/+ resulted...
Includes: Supplementary data
Articles
Lauren M. Hare, Toby J. Phesse, Paul M. Waring, Karen G. Montgomery, Kathryn M. Kinross, Kevin Mills, Vincent Roh, Joan K. Heath, Robert G. Ramsay, Matthias Ernst, Wayne A. Phillips
Journal:
Biochemical Journal
Biochem J (2014) 458 (2): 251–258.
Published: 14 February 2014
... in approximately 20% of sporadic CRCs (colorectal cancers), but the role of these mutations in the pathogenesis of CRC remains unclear. In the present study we used a novel mouse model to investigate the role of the Pik3ca H1047R mutation, the most common PIK3CA mutation in CRC, during the development...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2009) 422 (3): 493–501.
Published: 27 August 2009
... and both proteins co-localize in SW480 colorectal cancer cells. The interaction with CBP also enhances both DNA-tethered and TCF/LEF1 (lymphoid enhancing factor 1)-dependent transcriptional activity of Pygopus. Furthermore, immunoprecipitated Pygopus protein complexes displayed CBP-dependent histone...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2004) 379 (1): 209–216.
Published: 01 April 2004
... cancers. Two missense mutations in the C-terminal domain of Smad4, D351H (Asp 351 →His) and D537Y (Asp 537 →Tyr), have been described recently in the human colorectal cancer cell lines CACO-2 and SW948 respectively [Woodford-Richens, Rowan, Gorman, Halford, Bicknell, Wasan, Roylance, Bodmer and Tomlinson...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 374 (2): 481–488.
Published: 01 September 2003
...Alun HUGHES; Nicholas I. SMITH; Heather M. WALLACE Naproxen, sulindac and salicylate, three NSAIDs (non-steroidal anti-inflammatory drugs), were cytotoxic to human colorectal cancer cells in culture. Toxicity was accompanied by significant depletion of intracellular polyamine content. Inhibition...