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Keywords: conformational change
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Biochem J (2015) 472 (3): 339–352.
Published: 27 November 2015
... suggests that phosphoregulation plays a key role in the assembly and disassembly of adherens junctions. conformational change recombinant protein expression small-angle X-ray scattering (SAXS) Intercellular junctions, including adherens junctions, tight junctions and gap junctions, enable...
Articles
Biochem J (2015) 468 (3): 475–484.
Published: 15 June 2015
.... Lastly, we explore the conformational changes that occur in class I KARIs upon binding of cofactor and metal ions. The class I KARI structures indicate that the active sites close upon binding NAD(P)H, similar to what is observed in the class II KARIs of rice and spinach and different from the opening...
Includes: Supplementary data
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Biochem J (2011) 439 (2): 215–225.
Published: 28 September 2011
... insights into the catalytic mechanism of hGSTk and other GSTks. Substrate binding induces a conformational change of the active site from an ‘open’ conformation in the apo-form to a ‘closed’ conformation in the GTX-bound complex, facilitating formations of the G site (GSH-binding site) and the H site...
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Biochem J (2010) 429 (2): 379–389.
Published: 28 June 2010
... change dermatan sulfate heparin non-essential activation substrate inhibition Allostery is the coupling of conformational changes between two separated sites. Initially described in oligomeric systems [ 1 – 3 ], allostery is known today as a widely used mechanism in the regulation...
Includes: Supplementary data
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Biochem J (2009) 417 (2): 477–483.
Published: 23 December 2008
.... This minidomain bound to Zn 2+ with a stoichiometry of ≈0.7 and an apparent dissociation constant of <500 nM. Fluorescence quenching and 8-anilinonaphthalene-1-sulfonic acid fluorescence methods revealed that Zn 2+ binding resulted in conformational changes characterized by shielding of hydrophobic regions...
Includes: Supplementary data
Articles
Biochem J (2007) 401 (1): 353–363.
Published: 11 December 2006
... and in neuroendocrine cells. K d was determined to be 1.2×10 −7 M in the presence of Ca 2+ and 1.5×10 −6 M in the absence of Ca 2+ . The comparatively low Ca 2+ affinity for secretagogin and the fact that it undergoes Ca 2+ -induced conformational changes and interacts with SNAP-25 raise the possibility...
Includes: Supplementary data
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Articles
Biochem J (2005) 392 (3): 443–448.
Published: 06 December 2005
... occupancy at both substrate-binding sites (Hcy plus betaine, or Hcy plus DMG). Betaine or DMG alone do not bind to the enzyme, indicating that the conformational change associated with Hcy binding creates the betaine-binding site. CBHcy [ S -(δ-carboxybutyl)- D , L -homocysteine] is a bisubstrate analogue...
Articles
Biochem J (2005) 391 (2): 203–213.
Published: 10 October 2005
... activation of gene expression is extremely rapid and change in temperature affects the DNA-binding properties of H-NS. The reduction in gene repression brought about by the increase in temperature is concomitant with a conformational change in the protein, resulting in the decrease in size of high-order...
Includes: Supplementary data
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Articles
Biochem J (2004) 380 (2): 401–407.
Published: 01 June 2004
..., the precise conformational changes that take place in head region of integrins (the site of ligand binding) during activation are not well understood. The portion of the integrin β subunit involved in ligand recognition contains a von Willebrand factor type A domain, which comprises a central β-sheet...
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Biochem J (2003) 372 (1): e1–e2.
Published: 15 May 2003
...Robert INSALL This commentary describes the study by Calleja and co-workers, who have used fluorescence resonance energy transfer between two fluorescent proteins fused to one protein kinase (protein kinase B/Akt) to reveal conformational changes in a functional protein. The findings of their study...
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Biochem J (2003) 369 (1): 39–44.
Published: 01 January 2003
... To whom correspondence should be addressed (e-mail: cambillau@afmb.cnrs-mrs.fr and darbon@afmb.cnrs-mrs.fr ). 2 8 2002 9 9 2002 9 9 2002 The Biochemical Society, London ©2003 2003 conformational change membrane NMR pheromone-binding protein Abbreviations used...
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Biochem J (2000) 349 (3): 835–841.
Published: 25 July 2000
...-sulphonic acid as a probe showed that low pH may induce the conformational change of TCS that leads to the hydrophobic-site exposure, and the CD result showed that this conformational change did not alter its secondary structure. Such conformational change leads to an intermediate state, called the ‘molten...
Articles
Biochem J (1999) 341 (3): 545–554.
Published: 26 July 1999
... the regulatory mechanism of the reversible phosphorylation reaction toward certain enzymes is being assessed. 1 e-mail zxwang@sun5.ibp.ac.cn 8 3 1999 21 4 1999 14 5 1999 The Biochemical Society, London © 1999 1999 enzyme kinetics conformational change co-operativity...