... conformational changes enzyme–substrate interactions phosphorylation small-molecule inhibitor ULK kinase Membrane abscission is the ultimate step in several physiologically important processes such as exosome budding and cytokinesis [ 1 ]. Any connection between two membrane substructures is cut...

... or [email protected] ). 13 4 2016 25 4 2016 19 5 2016 19 5 2016 © 2016 The Author(s). published by Portland Press Limited on behalf of the Biochemical Society 2016 coagulation Factor IX conformational changes crystal structure enzyme kinetics substrate-binding site...

... transiently associate to form a tetramer that acts as an allosteric switch for higher rate of GMP formation. Biochemical and biophysical studies reveal that sequential conformational changes and interdomain communications regulate tetramer formation via dimer. Our studies also show that overexpression...

... biochemical data are inconsistent with a known high-resolution crystal structure of the catalytic intermediate of the protein, and biophysical data indicate that the protein undergoes conformational changes that affect enzyme activity. In order to further elucidate the solution structure of this important...

... light on the role of this accessory domain present in a certain subset of ABC-ATPase in the fine-tuning of three-dimensional structure and biological function. ABC (ATP-binding-cassette)-ATPase conformational changes dimer Förster resonance energy transfer (FRET) osmoprotection 1...

... Aarhus C, Denmark. 2 To whom correspondence should be addressed (e-mail [email protected] ). 4 9 2000 28 3 2001 19 4 2001 The Biochemical Society, London ©2001 2001 conformational changes high-affinity binding protein stability site-directed mutagenesis...