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Keywords: copper
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Biochem J (2020) 477 (19): 3729–3741.
Published: 05 October 2020
...Snežana Vojvodić; Marina Stanić; Bernd Zechmann; Tanja Dučić; Milan Žižić; Milena Dimitrijević; Jelena Danilović Luković; Milica R. Milenković; Jon K. Pittman; Ivan Spasojević Microalgae have evolved mechanisms to respond to changes in copper ion availability, which are very important for normal...
Biochem J (2020) 477 (16): 3055–3058.
Published: 26 August 2020
...Yong-Sung Park; Suzie Kang; Hyewon Seo; Cheol-Won Yun The answer to the letter ‘Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus ’ has been prepared. We explained our data and showed supplementary information to answer the questions. And we respect the results of...
Includes: Supplementary data
Biochem J (2020) 477 (16): 2967–2970.
Published: 19 August 2020
...Annie Yap; Matthias Misslinger; Hubertus Haas Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening infection mainly affecting immunocompromised patients. The essential metals copper and iron play crucial roles in virulence of this mold. Recently, the copper...
Biochem J (2019) 476 (24): 3705–3719.
Published: 17 December 2019
... NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that...
Biochem J (2018) 475 (17): 2831–2845.
Published: 11 September 2018
...Yong-Sung Park; Suzie Kang; Hyewon Seo; Cheol-Won Yun Although iron and copper are co-ordinately regulated in living cells, the homeostatic effects of each of these metals on the other remain unknown. Here, we show the function of AfMac1, a transcriptional activator of the copper and iron regulons...
Includes: Supplementary data
Biochem J (2017) 474 (14): 2365–2378.
Published: 03 July 2017
...Yong-Sung Park; Tae-Hyoung Kim; Cheol-Won Yun Although copper functions as a cofactor in many physiological processes, copper overload leads to harmful effects in living cells. Thus, copper homeostasis is tightly regulated. However, detailed copper metabolic pathways have not yet been identified in...
Biochem J (2015) 470 (1): 65–76.
Published: 06 August 2015
... drive gene expression in response to transition metal exposure and that such activation may influence transition metal toxicity. We found that transition metals copper (Cu) and iron (Fe) activate recombinant TFEB and stimulate the expression of TFEB-dependent genes in TFEB-overexpressing cells. In cells...
Biochem J (2015) 466 (2): 233–242.
Published: 20 February 2015
... promotes membrane disruption. Differences in synaptic toxicity of Aβ (1–42) and Aβ (1–40) may be enhanced by the presence of Cu 2+ . Alzheimer’s disease amyloid copper oligomers lipid-membrane liposomes The most common fatal neurodegenerative disease of humans is Alzheimer's disease...
Biochem J (2012) 443 (1): 103–109.
Published: 14 March 2012
... TSH-secreting pituitary adenomas, which present with clinically similar symptoms. In the present paper we show that serum copper levels are regulated by thyroid hormone, which stimulates the synthesis and the export of the hepatic copper-transport protein ceruloplasmin into the serum. This is...
Includes: Supplementary data
Biochem J (2011) 436 (2): 481–491.
Published: 13 May 2011
...Michael A. Cater; Ygal Haupt Clioquinol (5-chloro-7-iodo-8-quinolinol) is a copper ionophore that was used primarily during the 1950–1970s as an oral antimicrobial agent. It has been established that clioquinol displays toxicity towards malignant cells, inducing caspase-dependent apoptosis. In the...
Includes: Supplementary data
Biochem J (2010) 431 (2): 257–265.
Published: 28 September 2010
... model system to study cadmium toxicity at the molecular level because it has been used to identify the molecular mechanisms of toxicity found in higher organisms. cDNA microarray and Northern blot analyses revealed that cadmium salts inhibited the expression of genes related to copper metabolism...
Biochem J (2010) 427 (2): 289–296.
Published: 29 March 2010
... measure the binding of a range of metal ions to wild-type and mutant human and murine hepcidins. In addition, the biological effects of these point mutations were tested on Caco-2 and HEK-293T human cell lines and in mice. Our results show that hepcidin-25 can form complexes with copper, nickel and zinc...
Biochem J (2009) 422 (2): 257–264.
Published: 13 August 2009
... copper Factor V subunit In the presence of Ca 2+ and an aPL (anionic phospholipid)-containing membrane, coagulation FVa [activated FV (Factor V)] accelerates the activation of prothrombin to thrombin by the serine protease FXa (activated Factor X); this represents the critical step of clot...
Biochem J (2008) 412 (1): 141–152.
Published: 25 April 2008
...Michael A. Cater; Kelly T. McInnes; Qiao-Xin Li; Irene Volitakis; Sharon La Fontaine; Julian F. B. Mercer; Ashley I. Bush In Alzheimer's disease there is abnormal brain copper distribution, with accumulation of copper in amyloid plaques and a deficiency of copper in neighbouring cells. Excess...
Biochem J (2008) 410 (2): 237–244.
Published: 12 February 2008
...Paul Davies; David R. Brown There has been an enormous body of literature published in the last 10 years concerning copper and PrP (prion protein). Despite this, there is still no generally accepted role for copper in the function of PrP or any real consensus as to how and to what affinity copper...
Biochem J (2007) 407 (3): 435–450.
Published: 12 October 2007
... including 8HQ and phenanthroline derivatives and the sulfur compound PDTC (pyrrolidine dithiocarbamate) elevated cellular metal levels (copper and zinc), and resulted in substantial loss of secreted Aβ. Generally, the ability to inhibit Aβ levels correlated with a higher lipid solubility of the ligands and...
Biochem J (2007) 402 (2): 241–250.
Published: 12 February 2007
...Belinda Hardman; Agnes Michalczyk; Mark Greenough; James Camakaris; Julian F. B. Mercer; M. Leigh Ackland Copper deficiency during pregnancy results in early embryonic death and foetal structural abnormalities including skeletal, pulmonary and cardiovascular defects. During pregnancy, copper is...
Biochem J (2007) 402 (1): 135–141.
Published: 25 January 2007
...Dola Das; Nisha Tapryal; Shyamal K. Goswami; Paul L. Fox; Chinmay K. Mukhopadhyay Cp (ceruloplasmin), a copper containing plasma protein, mainly synthesized in the liver, is known to be functional between the interface of iron and copper metabolism. We have reported previously that Cp is regulated...
Biochem J (2006) 398 (1): 63–71.
Published: 27 July 2006
...Prim de Bie; Bart van de Sluis; Ezra Burstein; Karen J. Duran; Ruud Berger; Colin S. Duckett; Cisca Wijmenga; Leo W. J. Klomp COMMD [copper metabolism gene MURR1 (mouse U2af1-rs1 region 1) domain] proteins constitute a recently identified family of NF-κB (nuclear factor κB)-inhibiting proteins...
Biochem J (2005) 390 (3): 777–786.
Published: 05 September 2005
... nucleotide sequence data reported will appear in DDBJ, EMBL, GenBank® and GSDB Nucleotide Sequence Databases under the accession number AY529486. 6 4 2005 19 5 2005 20 5 2005 20 5 2005 The Biochemical Society, London 2005 copper influx MDCK cell pufferfish SLC39A3...
Biochem J (2005) 388 (1): 371–378.
Published: 10 May 2005
...-linked glycosylation sites and binds copper under physiological conditions. In contrast with PrP C , PrP Sc is insoluble in non-ionic detergents and does not bind to Cu 2+ ions. Hence, we utilized copper binding to separate and characterize both PrP isoforms. Infected and uninfected murine brain and...
Biochem J (2005) 387 (1): 247–255.
Published: 22 March 2005
... the N-terminal domain binds five Cu 2+ ions. In the present study, we have investigated copper-catalysed oxidation of a recombinant mouse prion protein, PrP 23–231 . The copper-loaded PrP 23–231 was found to be carbonylated by incubation with dopamine. Besides the formation of carbonyls, a cross...
Biochem J (2004) 383 (2): 303–309.
Published: 08 October 2004
...Adam SOUTHON; Richard BURKE; Melanie NORGATE; Philip BATTERHAM; James CAMAKARIS Copper homoeostasis was investigated in the Drosophila melanogaster S2 cell line to develop an insect model for the study of copper regulation. Real-time PCR studies have demonstrated expression in S2 cells of putative...
Biochem J (2004) 381 (3): 803–811.
Published: 27 July 2004
...Dominique RASOLOSON; Lirong SHI; Curtis R. CHONG; Bjorn F. KAFSACK; David J. SULLIVAN, Jr Copper, like iron, is a transition metal that can generate oxygen radicals by the Fenton reaction. The Plasmodium parasite invades an erythrocyte host cell containing 20 μM copper, of which 70% is contained in...
Biochem J (2004) 380 (3): 805–813.
Published: 15 June 2004
...Michael A. CATER; John FORBES; Sharon La FONTAINE; Diane COX; Julian F. B. MERCER The Wilson protein (ATP7B) is a copper-transporting CPx-type ATPase defective in the copper toxicity disorder Wilson disease. In hepatocytes, ATP7B delivers copper to apo-ceruloplasmin and mediates the excretion of...
Biochem J (2004) 380 (1): 273–282.
Published: 15 May 2004
...Edmond WONG; Alana M. THACKRAY; Raymond BUJDOSO Prion diseases are characterized by conformational change in the copper-binding protein PrP (prion protein). Polymorphisms in ovine PrP at amino acid residues 136, 154 and 171 are associated with variation in susceptibility to scrapie. PrP VRQ [PrP...
Biochem J (2004) 378 (3): 1031–1037.
Published: 15 March 2004
...Luke PASE; Ilia VOSKOBOINIK; Mark GREENOUGH; James CAMAKARIS MNK (Menkes copper-translocating P-type ATPase, or the Menkes protein; ATP7A) plays a key role in regulating copper homoeostasis in humans. MNK has been shown to have a dual role in the cell: it delivers copper to cuproenzymes in the...
Biochem J (2004) 378 (2): 617–624.
Published: 01 March 2004
...Lucía TAPIA; Mauricio GONZÁLEZ-AGÜERO; Mónica F. CISTERNAS; Miriam SUAZO; Verónica CAMBIAZO; Ricardo UAUY; Mauricio GONZÁLEZ MTs (metallothioneins) increase the resistance of cells to exposure to high Cu (copper) levels. Characterization of the MT–Cu complex suggests that MT has an important role...
Biochem J (2004) 377 (1): 95–105.
Published: 01 January 2004
... addressed (e-mail Haltia@cc.helsinki.fi or Liisa.Laakkonen@helsinki.fi ). 20 5 2003 5 9 2003 26 9 2003 26 9 2003 The Biochemical Society, London ©2004 2004 copper metal ion transport nucleotide-binding domain P 1 -type ATPase Wilson disease Abbreviations...
Biochem J (2003) 371 (2): 597–601.
Published: 15 April 2003
...Kvetoslava BURDA; Jerzy KRUK; Georg H. SCHMID; Kazimierz STRZALKA We have found that elevated copper concentrations, apart from the inhibition of oxygen evolution, changed the initial states distribution of the oxygen-evolving complex. Already at low concentrations, copper ions oxidized the low...
Biochem J (2002) 365 (3): 809–816.
Published: 01 August 2002
...Colin G. SAYSELL; Winston S. TAMBYRAJAH; Jeremy M. MURRAY; Carrie M. WILMOT; Simon E.V. PHILLIPS; Michael J. McPHERSON; Peter F. KNOWLES Copper amine oxidases are homodimeric enzymes containing one Cu 2+ ion and one 2,4,5-trihydroxyphenylalanine quinone (TPQ) per monomer. Previous studies with the...
Biochem J (2002) 364 (3): 807–815.
Published: 15 June 2002
...Tim RASMUSSEN; Ben C. BERKS; Julea N. BUTT; Andrew J. THOMSON Nitrous oxide reductase catalyses the reduction of nitrous oxide to dinitrogen at a unique tetranuclear copper site, called Cu Z , which has a central inorganic sulphide ligand. Limited incubation with oxygen during the preparation of...
Biochem J (2002) 362 (2): 253–258.
Published: 22 February 2002
...Alana M. THACKRAY; Robert KNIGHT; Stephen J. HASWELL; Raymond BUJDOSO; David R. BROWN The prion protein (PrP) has been shown to bind copper. In the present study we have investigated whether prion disease in a mouse scrapie model resulted in modification of metal concentrations. We found changes in...
Biochem J (2001) 354 (2): 397–406.
Published: 22 February 2001
... protecting against electrophiles. We report that MT protection against Cu-induced cytotoxicity can be reversed and pro-oxidant and pro-apoptotic effects can be induced in HL-60 cells exposed to NO. We demonstrate that in ZnCl 2 -pretreated HL-60 cells loaded with copper nitrilotriacetate (Cu-NTA), exposure...
Biochem J (2000) 352 (2): 511–518.
Published: 24 November 2000
.... Direct interaction of PrP106–126 with the prion protein was found to make cells more susceptible to copper toxicity, inhibited copper uptake into cells and inhibited the superoxide dismutase-like activity of the prion protein. Direct inhibition of prion protein function by PrP Sc may be necessary for...
Biochem J (1999) 344 (1): 1–5.
Published: 08 November 1999
... recombinant chicken PrP C confirming the evolutionary conserved phenotype suggested by sequence similarity. Acquisition of copper by PrP C during protein folding endowed SOD activity on the protein but the addition of copper following refolding did not. PrP C dependent SOD activity was abolished by deletion...
Biochem J (1999) 341 (3): 655–663.
Published: 26 July 1999
...Paola GIARDINA; Gianna PALMIERI; Andrea SCALONI; Bianca FONTANELLA; Vincenza FARACO; Giovanna CENNAMO; Giovanni SANNIA A new laccase isoenzyme (POXA1b, where POX is phenol oxidase), produced by Pleurotus ostreatus in cultures supplemented with copper sulphate, has been purified and fully...
Biochem J (1999) 338 (3): 659–665.
Published: 08 March 1999
... PDTC exposure to increases in the expression of the GCS catalytic and regulatory subunit genes demonstrated that induction by PDTC could be partially blocked by treatment with the thiol agent N -acetylcysteine and by the copper chelator bathocuproine disulphonic acid. These findings suggested that the...
Biochem J (1999) 338 (2): 553–560.
Published: 22 February 1999
...Ceri A. MORRIS; Beate NICOLAUS; Viola SAMPSON; John L. HARWOOD; Peter KILLE A cDNA library was constructed from macroalgae adapted to prolonged elevated environmental copper levels. To investigate the possible existence of a metallothionein (MT) gene, the library was screened with degenerate probes...