... is adapted to specifically detect the protease activity of β-genera coronavirus 3CLpro enzymes. The data show specific detection of purified recombinant 3CLpro from SARS-CoV-2 and OC43 human coronaviruses, providing a clear red to blue colour change, which can be easily interpreted by eye and which can...

..., cats have been infected naturally, and bats are potential reservoirs of SARS-CoV-2. Cows serve as a reservoir for bovine coronavirus (BCoV) a respiratory infection of cattle that is a betacoronavirus [ 11 , 12 ] distantly related to SARS-CoV-2 [ 7 ]. Of considerable note, two BCoV-related coronaviruses...

... Commons Attribution License 4.0 (CC BY) . antiviral coronavirus COVID-19 Coronaviruses encode multiple enzymes important for viral replication [ 1 ], and any of these could be attractive drug targets. We identified inhibitors of seven enzymes, described in the accompanying papers. Table 1...

...Ronald T. Hay The coronavirus pandemic has had a huge impact on public health with over 165 million people infected, 3.4 million deaths and a hugely deleterious effect on most economies. While vaccination effectively protects against the disease it is likely that viruses will evolve that can...

... coronaviruses . Antimicrob. Agents Chemother. 58 , 4894 – 4898 10.1128/AAC.02994-14 40 Yu , M.S. , Lee , J. , Lee , J.M. , Kim , Y. , Chin , Y.W. , Jee , J.G. et al. (2012) Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus...

... etiologic agent is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a single-stranded positive-sense RNA virus. Coronaviruses rely on the enzymatic activity of the replication–transcription complex (RTC) to multiply inside host cells. The RTC core catalytic component is the RNA-dependent...

... and the Biochemical Society under a transformative agreement with JISC. coronavirus COVID-19 endonuclease nsp15 SARS-CoV-2 (severe-acute-respiratory-syndrome coronavirus-2) is the coronavirus that causes the human coronavirus disease (COVID-19) [ 1 , 2 ]. SARS-CoV-1 and MERS-CoV caused severe...

... antiviral agents would be extremely useful to complement the vaccination program. The causative agent of COVID-19 is a novel coronavirus, SARS-CoV-2, which encodes at least nine enzymatic activities that all have drug targeting potential. The papain-like protease (PLpro) contained in the nsp3 protein...

... by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) . coronavirus covid-19 methyltransferase mRNA cap The SARS-CoV-2 virus is a novel respiratory pathogen that is able to infect both animals and humans...

... all coronaviruses, with SARS-CoV-1 and 2 sharing roughly 96% sequence identity with the greatest degree of sequence conservation around the active site [ 14 ]. Nsp5 cleaves polyproteins after a glutamine residue, which is the case for the vast majority of coronavirus main proteases but is rare...

... on behalf of the Biochemical Society 2021 Correspondence: George M. Burslem ([email protected]) chemical biology coronavirus drug discovery and design SARS-CoV-2 The ongoing global pandemic of coronavirus disease 2019 (COVID-19) is caused by a recently emerged...

... References 1 WHO . Novel Coronavirus (2019-nCoV) situation report-77 . https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200406-sitrep-77-covid-19.pdf?sfvrsn=21d1e632_2 (Accessed on 7 April 2020) 2 Wu , F. , Zhao , S. , Yu , B. , Chen , Y.M. , Wang , W...

...Boris Krichel; Sven Falke; Rolf Hilgenfeld; Lars Redecke; Charlotte Uetrecht Severe acute respiratory syndrome coronavirus is the causative agent of a respiratory disease with a high case fatality rate. During the formation of the coronaviral replication/transcription complex, essential steps...