... in the active and allosteric sites of 3CLpro that could be targeted with competitive and noncompetitive inhibitors as new therapeutics against COVID-19. Correspondence: Wael M. Rabeh ([email protected]) 30 1 2023 27 5 2023 30 5 2023 © 2023 The Author(s). Published by Portland...

...Cameron Lee Shetler; Juliana C. Ferreira; Thyago H. S. Cardoso; Edson M.A. Silva; Nitin K. Saksena; Wael M. Rabeh Coronaviruses have been responsible for multiple challenging global pandemics, including coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome...

...Stefanie M. Bader; James P. Cooney; Marc Pellegrini; Marcel Doerflinger Two years after the emergence of SARS-CoV-2, our understanding of COVID-19 disease pathogenesis is still incomplete. Despite unprecedented global collaborative scientific efforts and rapid vaccine development, an uneven vaccine...

...John F.X. Diffley In response to the COVID-19 pandemic, we began a project in March 2020 to identify small molecule inhibitors of SARS-CoV-2 enzymes from a library of chemical compounds containing many established pharmaceuticals. Our hope was that inhibitors we found might slow the replication...

... The coronavirus disease 2019 (COVID-19) pandemic, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global public health challenge. While the efficacy of vaccines against emerging and future virus variants remains unclear, there is a need for therapeutics. Repurposing existing...

...Agustina P. Bertolin; Florian Weissmann; Jingkun Zeng; Viktor Posse; Jennifer C. Milligan; Berta Canal; Rachel Ulferts; Mary Wu; Lucy S. Drury; Michael Howell; Rupert Beale; John F.X. Diffley The coronavirus disease 2019 (COVID-19) global pandemic has turned into the largest public health...

...Berta Canal; Ryo Fujisawa; Allison W. McClure; Tom D. Deegan; Mary Wu; Rachel Ulferts; Florian Weissmann; Lucy S. Drury; Agustina P. Bertolin; Jingkun Zeng; Rupert Beale; Michael Howell; Karim Labib; John F.X. Diffley SARS-CoV-2 is responsible for COVID-19, a human disease that has caused over 2...

.... Diffley The COVID-19 pandemic has emerged as the biggest life-threatening disease of this century. Whilst vaccination should provide a long-term solution, this is pitted against the constant threat of mutations in the virus rendering the current vaccines less effective. Consequently, small molecule...

...; Karim Labib; John F.X. Diffley The COVID-19 pandemic has presented itself as one of the most critical public health challenges of the century, with SARS-CoV-2 being the third member of the Coronaviridae family to cause a fatal disease in humans. There is currently only one antiviral compound, remdesivir...

... Beale; Karim Labib; Nicola O'Reilly; John F.X. Diffley The coronavirus 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spread around the world with unprecedented health and socio-economic effects for the global population. While different vaccines...