...Marten Villmow; Monika Baumann; Miroslav Malesevic; Rolf Sachs; Gerd Hause; Marcus Fändrich; Jochen Balbach; Cordelia Schiene-Fischer Cyclophilins interact directly with the Alzheimer's disease peptide Aβ (amyloid β-peptide) and are therefore involved in the early stages of Alzheimer's disease. Aβ...

... mutant showed elevated PLA 2 activity and lacked the GTP-dependent stimulation by elicitor, but regained this capability after pre-incubation with G α . The inhibition by G α and the GTP-dependent stimulation of PLA 2 were diminished by inhibitors of peptidylprolyl cis – trans isomerases. A cyclophilin...

...Miriam Laxa; Janine König; Karl-Josef Dietz; Andrea Kandlbinder Cyps (cyclophilins) are ubiquitous proteins of the immunophilin superfamily with proposed functions in protein folding, protein degradation, stress response and signal transduction. Conserved cysteine residues further suggest a role...

...=caspase-6>caspase-3. To identify the possible locus of cyclosporin A action, we used an antisense oligodeoxynucleotide to suppress the level of cyclophilin-A to < 5% of its control value. Cyclophilin-A suppression largely reproduced the inhibitory effects of cyclosporin A. These results provide...

... correspondence should be addressed (e-mail jungbaue@;hp01.boku.ac.at). 21 7 1999 5 10 1999 15 11 1999 The Biochemical Society, London © 2000 2000 co-operativity cyclophilin heat-shock proteins real-time biological interaction assay surface plasmon resonance Biochem. J. (2000...

...Martin CROMPTON This article reviews the involvement of the mitochondrial permeability transition pore in necrotic and apoptotic cell death. The pore is formed from a complex of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase and cyclophilin-D (CyP-D) at contact sites...