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Keywords: cysteine
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Articles
Serine acetyltransferase from Neisseria gonorrhoeae ; structural and biochemical basis of inhibition
Journal:
Biochemical Journal
Biochem J (2022) 479 (1): 57–74.
Published: 06 January 2022
...Keely E. A. Oldham; Erica J. Prentice; Emma L. Summers; Joanna L. Hicks Serine acetyltransferase (SAT) catalyzes the first step in the two-step pathway to synthesize l -cysteine in bacteria and plants. SAT synthesizes O -acetylserine from substrates l -serine and acetyl coenzyme A and is a key...
Includes: Supplementary data
Articles
In Collection
Seeds
Davide Gerna, Thomas Roach, Erwann Arc, Wolfgang Stöggl, Margherita Limonta, Patrizia Vaccino, Ilse Kranner
Journal:
Biochemical Journal
Biochem J (2018) 475 (23): 3725–3743.
Published: 06 December 2018
....) seeds to a hot steam treatment (‘BioFlash’), which accelerated water uptake, resulting in faster germination and seedling growth, typical traits of primed seed. Before the completion of germination, metabolite profiling of seeds revealed advanced accumulation of several amino acids (especially cysteine...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (8): 1073–1083.
Published: 08 April 2016
... by Bcl-2 homology 3 domain (BH3) proteins. Some of the compounds induced Bax/Bak-dependent apoptosis in cells. Activation of Bax by the most active compound was poorly inhibited by the anti-apoptotic protein Bcl-XL and requires a cysteine residue at position 126 of Bax that is not required for activation...
Includes: Supplementary data
Articles
Louise V. Holyoake, Stuart Hunt, Guido Sanguinetti, Gregory M. Cook, Mark J. Howard, Michelle L. Rowe, Robert K. Poole, Mark Shepherd
Journal:
Biochemical Journal
Biochem J (2016) 473 (6): 693–701.
Published: 10 March 2016
...Louise V. Holyoake; Stuart Hunt; Guido Sanguinetti; Gregory M. Cook; Mark J. Howard; Michelle L. Rowe; Robert K. Poole; Mark Shepherd The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli . A cydD mutant strain was used to probe the influence of CydDC upon reduced...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2016) 473 (1): 55–66.
Published: 09 December 2015
... the function and activity mechanism of this protein, the crystal structure of SAV1875 from S. aureus was determined. The overall fold of SAV1875 is similar to that observed for the DJ-1/ThiJ/ Pf pI superfamily. The cysteine residue located in the dimeric interface (Cys 105 ) forms a catalytic triad with His...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 465 (3): 371–382.
Published: 22 January 2015
...P. Patrick Dotson, II; Alexander A. Karakashian; Mariana N. Nikolova-Karakashian Neutral sphingomyelinase-2 (nSMase-2) is the major sphingomyelinase activated in response to pro-inflammatory cytokines and during oxidative stress. It is a membrane-bound 655 amino acid protein containing 22 cysteine...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2015) 465 (1): 127–137.
Published: 12 December 2014
... disulfide bond between the two cysteine residues Cys 38 and Cys 83 , interacts with lipids to induce a change in haem co-ordination. The dimeric protein with intermolecular disulfide bonds and monomeric protein without an intramolecular disulfide bond does not exhibit these changes in haem co-ordination...
Articles
Gerardo G. Piroli, Allison M. Manuel, Michael D. Walla, Matthew J. Jepson, Jonathan W. C. Brock, Mathur P. Rajesh, Ross M. Tanis, William E. Cotham, Norma Frizzell
Journal:
Biochemical Journal
Biochem J (2014) 462 (2): 231–245.
Published: 07 August 2014
...Gerardo G. Piroli; Allison M. Manuel; Michael D. Walla; Matthew J. Jepson; Jonathan W. C. Brock; Mathur P. Rajesh; Ross M. Tanis; William E. Cotham; Norma Frizzell Protein succination is a stable post-translational modification that occurs when fumarate reacts with cysteine residues to generate 2SC...
Articles
Journal:
Biochemical Journal
Biochem J (2013) 451 (2): 145–154.
Published: 28 March 2013
...-methylthiobutyrate (KMTB) and formate. Transamination of KMTB by an as-yet unknown enzyme and co-substrate results in the formation of Met, which is converted into SAM by SAMS. © The Authors Journal compilation © 2013 Biochemical Society 2013 cysteine ethylene methionine salvage cycle polyamine...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 445 (2): 247–254.
Published: 27 June 2012
...Norma Frizzell; Sonia A. Thomas; James A. Carson; John W. Baynes 2SC [ S -(2-succino)-cysteine] is a chemical modification formed by a Michael addition reaction of fumarate with cysteine residues in proteins. Formation of 2SC, termed ‘succination’ of proteins, increases in adipocytes grown in high...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 445 (2): 275–283.
Published: 27 June 2012
...Hannah Birke; Florian H. Haas; Luit J. De Kok; Janneke Balk; Markus Wirtz; Rüdiger Hell In higher plants, biosynthesis of cysteine is catalysed by OAS-TL [ O -acetylserine(thiol)lyase], which replaces the activated acetyl group of O -acetylserine with sulfide. The enzyme is present in cytosol...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2009) 424 (3): 491–500.
Published: 10 December 2009
... oxidizing extracellular environments, as maintained by the cysteine/cystine (Cys/CySS) redox couple, induce mitochondria-derived ROS (reactive oxygen species) generation and cause the activation of Nrf2 (nuclear factor-erythroid 2-related factor 2), inducing an antioxidant response. NIH 3T3 cells were...
Articles
Journal:
Biochemical Journal
Biochem J (2009) 422 (1): 171–180.
Published: 29 July 2009
...Aimee L. Eggler; Evan Small; Mark Hannink; Andrew D. Mesecar Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor that activates transcription of a battery of cytoprotective genes by binding to the ARE (antioxidant response element). Nrf2 is repressed by the cysteine-rich...
Articles
Arun Kumar, Lijo John, Md. Mahmood Alam, Ankit Gupta, Gayatri Sharma, Beena Pillai, Shantanu Sengupta
Journal:
Biochemical Journal
Biochem J (2006) 396 (1): 61–69.
Published: 26 April 2006
...Arun Kumar; Lijo John; Md. Mahmood Alam; Ankit Gupta; Gayatri Sharma; Beena Pillai; Shantanu Sengupta Intracellular thiols like cysteine, homocysteine and glutathione play a critical role in the regulation of important cellular processes. Alteration of intracellular thiol concentration results...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2006) 394 (1): 267–273.
Published: 27 January 2006
...John E. Dominy, Jr; Lawrence L. Hirschberger; Relicardo M. Coloso; Martha H. Stipanuk Mammalian metabolism of ingested cysteine is conducted principally within the liver. The liver tightly regulates its intracellular cysteine pool to keep levels high enough to meet the many catabolic and anabolic...
Articles
Journal:
Biochemical Journal
Biochem J (2006) 393 (1): 181–190.
Published: 12 December 2005
...Jeong-In Lee; Joann Kang; Martha H. Stipanuk GCL (glutamate–cysteine ligase) is a heterodimer of a GCLC (GCL catalytic subunit) that possesses all of the enzymatic activity and a GCLM (GCL modifier subunit) that alters the K i of GCLC for GSH. We hypothesized that the expression of GCLM...
Articles
Siddhartha S. Ghosh, Yang Lu, Sung W. Lee, Xia Wang, Chandan Guha, Jayanta Roy-Chowdhury, Namita Roy-Chowdhury
Journal:
Biochemical Journal
Biochem J (2005) 392 (3): 685–692.
Published: 06 December 2005
...) mutation, predicting a C177Y substitution, and patient B had a nt 466 T→C mutation on one allele and a nt 1070 A→G mutation on the other, predicting a C156R and a Q357R substitution respectively. All 11 cysteine residues of mature human UGT1A1 are highly conserved in other human UGT isoforms and in rat...
Articles
Sandra MÜLLER, Manuela SCHÖTTLER, Sylvia SCHÖN, Christian PRANTE, Thomas BRINKMANN, Joachim KUHN, Christian GÖTTING, Knut KLEESIEK
Journal:
Biochemical Journal
Biochem J (2005) 386 (2): 227–236.
Published: 22 February 2005
... homodimers through disulphide bridges. In addition, the role of the cysteine residues was investigated by site-directed mutagenesis combined with chemical modifications of XT-I by N -phenylmaleimide. Replacement of Cys 471 or Cys 574 with alanine led to a complete loss of catalytic activity, indicating...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 382 (2): 631–639.
Published: 24 August 2004
...Joon-Won LEE; Jee-Eun KIM; Eun-Jung PARK; Jin-Hyun KIM; Chang-Hun LEE; Seung-Rock LEE; Jongbum KWON The platelet-derived growth factor receptor-β (PDGFR-β) has a number of conserved cysteine residues on its cytoplasmic domain. We have examined whether the cysteine residues play a role...
Articles
Isao ISHII, Noriyuki AKAHOSHI, Xiao-Nian YU, Yuriko KOBAYASHI, Kazuhiko NAMEKATA, Gen KOMAKI, Hideo KIMURA
Journal:
Biochemical Journal
Biochem J (2004) 381 (1): 113–123.
Published: 22 June 2004
...Isao ISHII; Noriyuki AKAHOSHI; Xiao-Nian YU; Yuriko KOBAYASHI; Kazuhiko NAMEKATA; Gen KOMAKI; Hideo KIMURA Cystathionine γ-lyase (CSE) is the last key enzyme in the trans-sulphuration pathway for biosynthesis of cysteine from methionine. Cysteine could be provided through diet; however, CSE has...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 379 (3): 673–679.
Published: 01 May 2004
...-mail [email protected] ). 3 9 2003 5 1 2004 16 1 2004 16 1 2004 The Biochemical Society, London ©2004 2004 cysteine G-protein GTPase GTP hydrolysis site-directed mutagenesis Abbreviations used: GST, glutathione S-transferase; CHO, Chinese hamster ovary; GTP[S...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 378 (3): 1015–1021.
Published: 15 March 2004
... C843A could be biotinylated at the cell surface, indicating that a cysteine residue at position 843 is not required for cell-surface expression of the protein. The turnover rate of AE1 C843A was not significantly different from AE1. While other proteins could be palmitoylated, labelling of transiently...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 377 (2): 407–417.
Published: 15 January 2004
... cross-linking via intermolecular disulphide bonds, (2) use of a cysteine-reactive covalent cross-linking agent, (3) use of an amino-reactive covalent cross-linking agent, and (4) covalent cross-linking via direct intermolecular disulphide bridging between unpalmitoylated membrane-proximal cysteine...
Articles
Serine acetyltransferase of Escherichia coli: substrate specificity and feedback control by cysteine
Journal:
Biochemical Journal
Biochem J (2003) 375 (3): 745–752.
Published: 01 November 2003
...V. John HINDSON Although SAT (serine acetyltransferase) of Escherichia coli , which catalyses the first step in cysteine synthesis, proceeds via a random-order ternary complex reaction mechanism [Hindson and Shaw (2003) Biochemistry 42 , 3113–3119], it has been suggested that the nearly identical...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 365 (3): 649–657.
Published: 01 August 2002
... of the interfacial binding by oxidation. Furthermore, replacing the two cysteines (Cys 31 and Cys 184 ) in the Trp 61 deletion mutant caused additional resistance of the enzyme to oxidizing agents, showing that both domains of the enzyme contribute independently to its oxidative susceptibility. Since the hydrolysis...
Articles
Clive S. BUTLER, Shirley A. FAIRHURST, Stuart J. FERGUSON, Andrew J. THOMSON, Ben C. BERKS, David J. RICHARDSON, David J. LOWE
Journal:
Biochemical Journal
Biochem J (2002) 363 (3): 817–823.
Published: 24 April 2002
... of this feature, determined from ENDOR spectra collected at a range of field positions, indicated a Mo proton distance of approx. 3.2 AI , consistent with this being one of the b-methylene protons of a Mo Cys ligand. Key words: cysteine, EPR, molybdoenzymes, molybdopterin guanine dinucleotide (MGD), protons...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 350 (3): 685–692.
Published: 08 September 2000
... are not well known. However, given the central role of the liver in amino acid metabolism, we developed a rat primary hepatocyte model in which homocysteine (and cysteine) production and export were examined. The dependence of homocysteine export from incubated hepatocytes on methionine concentration fitted...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 349 (2): 567–578.
Published: 10 July 2000
...-glutathionylation of the transcription factors c-Jun and p50 by free GSNO in vitro . Both c-Jun and p50 were found to bind to immobilized GSNO through the formation of a mixed disulphide, involving a conserved cysteine residue located in the DNA-binding domains of these transcription factors. Furthermore, we show...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 348 (3): 539–549.
Published: 07 June 2000
... and pyridoxal 5ʹ-phosphate (PLP) and displays an optical absorption band extending to 700 nm, suggesting the presence of an iron-sulphide cluster. After reductive incubation with L -cysteine anaerobically, the protein catalyses the transformation of L -lysine into β-lysine in the presence of S...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 347 (1): 291–295.
Published: 27 March 2000
...Anna-Liisa LEVONEN; Risto LAPATTO; Mika SAKSELA; Kari O. RAIVIO Cystathionine γ-lyase (CGL) is the last enzyme of the trans-sulphuration pathway, which converts methionine into cysteine. To study the possible differences in enzymic activity of the two human cystathionine γ-lyase isoforms...
Articles
Journal:
Biochemical Journal
Biochem J (1999) 342 (3): 481–496.
Published: 05 September 1999
... (e-mail [email protected]). The Biochemical Society, London © 1999 1999 cysteine gene regulation pathophysiology reactive oxygen species (ROS) transcription factor Biochem. J. (1999) 342, 481 496 (Printed in Great Britain) 481 REVIEW ARTICLE Repression of gene...