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1-33 of 33
Keywords: cytochrome C
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Articles
Journal:
Biochemical Journal
Biochem J (2024) 481 (24): 2017–2036.
Published: 23 December 2024
...) correspond to the haem numbering resulting from the superimposition of the haems in cytochromes c 7 with those of structurally homologous tetrahaem cytochromes c 3 [ 51 ]. ( B ) Genealogical tree of the mutations performed in this work. Each mutant is placed according to its respective mutation round...
Includes: Supplementary data
Articles
Matthias Fellner, Rinky Parakra, Kirstin O. McDonald, Itamar Kass, Guy N.L. Jameson, Sigurd M. Wilbanks, Elizabeth C. Ledgerwood
Journal:
Biochemical Journal
Biochem J (2021) 478 (3): 669–684.
Published: 12 February 2021
...Matthias Fellner; Rinky Parakra; Kirstin O. McDonald; Itamar Kass; Guy N.L. Jameson; Sigurd M. Wilbanks; Elizabeth C. Ledgerwood Mutation of cytochrome c in humans causes mild autosomal dominant thrombocytopenia. The role of cytochrome c in platelet formation, and the molecular mechanism underlying...
Includes: Supplementary data
Articles
Wataru Sato, Seiji Hitaoka, Takeshi Uchida, Kyoko Shinzawa-Itoh, Kazunari Yoshizawa, Shinya Yoshikawa, Koichiro Ishimori
Journal:
Biochemical Journal
Biochem J (2020) 477 (8): 1565–1578.
Published: 29 April 2020
...Wataru Sato; Seiji Hitaoka; Takeshi Uchida; Kyoko Shinzawa-Itoh; Kazunari Yoshizawa; Shinya Yoshikawa; Koichiro Ishimori In the electron transfer (ET) reaction from cytochrome c (Cyt c ) to cytochrome c oxidase (C c O), we determined the number and sites of the hydration water released from...
Includes: Supplementary data
Articles
Ruifang Li, Chen Chen, Beibei Zhang, Hongjuan Jing, Zichao Wang, Chunling Wu, Pu Hao, Yong Kuang, Minghang Yang
Journal:
Biochemical Journal
Biochem J (2019) 476 (20): 3069–3080.
Published: 30 October 2019
...) increased. Accordingly, we assessed apoptotic processes in Candida tropicalis cells post-treatment with CGA-N9 and found cytochrome c leakage, chromatin condensation and DNA degradation. The interaction of CGA-N9 with DNA in vitro showed that CGA-N9 did not degrade DNA but bound to DNA via an electrostatic...
Articles
Ruifang Li, Ruiling Zhang, Yanhui Yang, Xueqin Wang, Yanjie Yi, Pei Fan, Zhengwei Liu, Chen Chen, Junpeng Chang
Journal:
Biochemical Journal
Biochem J (2018) 475 (7): 1385–1396.
Published: 16 April 2018
... membrane potential, in which the former plays key roles in the initiation of apoptosis and the latter is a sign of the cell apoptosis. Accordingly, we assessed the apoptosis features of Candida tropicalis cells after treatment with CGA-N12 and found the following: leakage of cytochrome c and uptake...
Articles
Adeline Gand, Laure Selme-Roussel, Sabrina Collin, Guy Branlant, Christophe Jacob, Sandrine Boschi-Muller
Journal:
Biochemical Journal
Biochem J (2015) 468 (2): 271–282.
Published: 22 May 2015
...Adeline Gand; Laure Selme-Roussel; Sabrina Collin; Guy Branlant; Christophe Jacob; Sandrine Boschi-Muller TlpAs (thioredoxin-like proteins) are bacterial thioredoxin-like periplasmic disulfide oxidoreductases generally involved in cytochrome c maturation (Ccm) process. They contain a characteristic...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2014) 458 (2): 259–265.
Published: 14 February 2014
...Tracy M. Josephs; Ian M. Morison; Catherine L. Day; Sigurd M. Wilbanks; Elizabeth C. Ledgerwood The peroxidase activity of cytochrome c may play a key role in the release of cytochrome c from the mitochondrial intermembrane space in the intrinsic apoptosis pathway. Induction of the peroxidase...
Includes: Supplementary data
Articles
Badri S. Rajagopal, Ann N. Edzuma, Michael A. Hough, Katie L. I. M. Blundell, Valerian E. Kagan, Alexandr A. Kapralov, Lewis A. Fraser, Julea N. Butt, Gary G. Silkstone, Michael T. Wilson, Dimitri A. Svistunenko, Jonathan A. R. Worrall
Journal:
Biochemical Journal
Biochem J (2013) 456 (3): 441–452.
Published: 22 November 2013
... of the G41S mutant of human cytochrome c can be explained by a higher than wild-type peroxidase activity triggered by phospholipid binding. A key complex in mitochondrial apoptosis involves cytochrome c and the phospholipid cardiolipin. In this complex cytochrome c has its native axial Met 80 ligand...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 442 (1): 191–197.
Published: 27 January 2012
..., and no efficient protein-mediated process has been identified. Recently, we observed that ferric cytochrome c can promote S -nitrosoglutathione formation from NO and glutathione by acting as an electron acceptor under anaerobic conditions. In the present study, we show that this mechanism is also robust under...
Articles
Journal:
Biochemical Journal
Biochem J (2011) 436 (2): 493–505.
Published: 13 May 2011
...Philippe Pasdois; Joanne E. Parker; Elinor J. Griffiths; Andrew P. Halestrap Oxidized cytochrome c is a powerful superoxide scavenger within the mitochondrial IMS (intermembrane space), but the importance of this role in situ has not been well explored. In the present study, we investigated...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2010) 427 (1): 105–112.
Published: 15 March 2010
... 344 rats. OXPHOS (oxidative phosphorylation) of intact mitochondria and cytochrome c oxidase activity in permeabilized mitochondria were determined with polarographic assays. The activities of the ETC (electron transport chain) complexes and the cytochrome content in solubilized mitochondria were...
Includes: Supplementary data
Articles
Leonor Morgado, Ana P. Fernandes, Yuri Y. Londer, P. Raj Pokkuluri, Marianne Schiffer, Carlos A. Salgueiro
Journal:
Biochemical Journal
Biochem J (2009) 420 (3): 485–492.
Published: 27 May 2009
... of these proteins, two with 12 haems (GSU1996, GSU0592) and one with 27 haems (GSU2210), suggest that they are formed with domains homologous to the trihaem cytochrome c 7 . Although all three haems have bis-His co-ordination in cytochromes c 7 , in each domain of the above polymers, the haem equivalent to haem IV...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2007) 407 (2): 179–187.
Published: 25 September 2007
...Erta Kalanxhi; Carmichael J. A. Wallace Cyt c (cytochrome c ) has been traditionally envisioned as rapidly diffusing in two dimensions at the surface of the mitochondrial inner membrane when not engaged in redox reactions with physiological partners. However, the discovery of the extended lipid...
Articles
Journal:
Biochemical Journal
Biochem J (2007) 405 (1): 115–122.
Published: 13 June 2007
...Emily E. Franklin; John D. Robertson Sequential activation of caspases is critical for the execution of apoptosis. Recent evidence suggests caspase 2 is a significant upstream caspase capable of initiating mitochondrial events, such as the release of cytochrome c . In particular, in vitro studies...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 392 (3): 583–587.
Published: 06 December 2005
... and cytochrome c , there was a good correlation between the second-order reduction rate constant and the redox potential, E m (Fe III /Fe II ): The rate of reduction of cytochrome c by BH 4 [(6 R )-5,6,7,8-tetrahydrobiopterin] was determined to be similar to that of the reduction of cytochrome c by diMePH 4...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 392 (2): 399–406.
Published: 22 November 2005
...Daisuke Suto; Kazuaki Sato; Yoshihiro Ohba; Tetsuhiko Yoshimura; Junichi Fujii Stimuli for apoptotic signalling typically induce release of cyt c (cytochrome c ) from mitochondria. Cyt c then initiates the formation of the apoptosome, comprising Apaf-1 (apoptotic protease-activating factor 1...
Includes: Supplementary data
Articles
Kaoru OTSU, Kazuaki SATO, Yoshitaka IKEDA, Hirotaka IMAI, Yasuhito NAKAGAWA, Yoshihiro OHBA, Junichi FUJII
Journal:
Biochemical Journal
Biochem J (2005) 389 (1): 197–206.
Published: 21 June 2005
... the release of cytochrome c from mitochondria into the cytosol and exhibited cytotoxicity, but NDPE did not. RBL cells, a rat basophil leukaemia-derived line, that overexpress phospholipid hydroperoxide glutathione peroxidase in mitochondria were found to be highly resistant to the cytotoxic effect of MNPE...
Articles
Journal:
Biochemical Journal
Biochem J (2005) 386 (1): 73–83.
Published: 08 February 2005
...Ran ZALK; Adrian ISRAELSON; Erez S. GARTY; Heftsi AZOULAY-ZOHAR; Varda SHOSHAN-BARMATZ The VDAC (voltage-dependent anion channel) plays a central role in apoptosis, participating in the release of apoptogenic factors including cytochrome c . The mechanisms by which VDAC forms a protein-conducting...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 381 (1): 19–23.
Published: 22 June 2004
... protein stability, ATP synthase assembly, cristae morphology and cytochrome c storage within cristae. 1 To whom correspondence should be addressed (e-mail [email protected] ). 5 5 2004 6 4 2004 30 4 2004 5 5 2004 The Biochemical Society, London 2004 ATP synthase...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 379 (3): 805–813.
Published: 01 May 2004
... of Bax (Bcl-associated X protein) to mitochondria is linked with release of cytochrome c and subsequent activation of a caspase cascade [Shou, Li, Prabhakaran, Borowitz and Isom (2003) Toxicol. Sci. 75 , 99–107]. In the present study, the relationship of the cyanide-induced increase in cytosolic free Ca...
Articles
Gerd HEIMLICH, Alastair D. McKINNON, Katussevani BERNARDO, Dieter BRDICZKA, John C. REED, Renate KAIN, Martin KRÖNKE, Juliane M. JÜRGENSMEIER
Journal:
Biochemical Journal
Biochem J (2004) 378 (1): 247–255.
Published: 15 February 2004
... and translocates to mitochondrial membranes, where it inserts and mediates the release of cytochrome c from the intermembrane space into the cytosol. However, the domains of Bax that are essential for the induction of cytochrome c release are still elusive. Therefore various Bax deletion mutants were generated...
Articles
Journal:
Biochemical Journal
Biochem J (2004) 378 (1): 213–217.
Published: 15 February 2004
...Vladimir GOGVADZE; John D. ROBERTSON; Mari ENOKSSON; Boris ZHIVOTOVSKY; Sten ORRENIUS The mechanisms regulating mitochondrial outer-membrane permeabilization and the release of cytochrome c during apoptosis remain controversial. In the present study, we show in an in vitro model system...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 375 (1): 215–220.
Published: 01 October 2003
...Jerzy KRUK; Małgorzata JEMIOŁA-RZEMIŃSKA; Kazimierz STRZAŁKA We have found that, at low light intensity (5–10 μmol photons·m −2 ·s −1 ), photoreduction of cyt (cytochrome) c by isolated thylakoids was not inhibited by dinitrophenylether of iodonitrothymol, an inhibitor of the cyt b 6 – f complex...
Articles
Katia M. DESBIENS, Réna G. DESCHESNES, Mireille M. LABRIE, Yan DESFOSSÉS, Herman LAMBERT, Jacques LANDRY, Kerstin BELLMANN
Journal:
Biochemical Journal
Biochem J (2003) 372 (2): 631–641.
Published: 01 June 2003
... with deregulated expression of c-Myc resulted in nuclear fragmentation that was accompanied in all cells by the activation of Bax and the translocation of cytochrome c from the mitochondria to the cytoplasm. None of these features of apoptosis was induced in control Rat-1 cells. p38 was also activated by cisplatin...
Articles
Hagen SCHROETER, Clinton S. BOYD, Ruhi AHMED, Jeremy P. E. SPENCER, Roger F. DUNCAN, Catherine RICE-EVANS, Enrique CADENAS
Journal:
Biochemical Journal
Biochem J (2003) 372 (2): 359–369.
Published: 01 June 2003
...Hagen SCHROETER; Clinton S. BOYD; Ruhi AHMED; Jeremy P. E. SPENCER; Roger F. DUNCAN; Catherine RICE-EVANS; Enrique CADENAS The molecular mechanisms underlying the initiation and control of the release of cytochrome c during mitochondrion-dependent apoptosis are thought to involve...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 371 (3): 1055–1064.
Published: 01 May 2003
... caspase activation and apoptosis (downstream of mitochondrial membrane depolarization) and cytochrome c release. However, caspase activity was not restored by the strong reducing agent dithiothreitol, as predicted for S-nitrosation reactions, thereby excluding active-site-thiol modification of caspases...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 371 (1): 115–124.
Published: 01 April 2003
...-nitrophenyl)methane sulphonamide has been shown previously to cause apoptosis in intestinal epithelial cells. In the present study, we attempted to elucidate the underlying mechanisms and we can now show that a mitochondrial pathway is employed. Inhibition of COX-2 causes release of cytochrome c , as shown...
Articles
Journal:
Biochemical Journal
Biochem J (2003) 370 (1): 283–290.
Published: 15 February 2003
...—10 μ M) strongly induced cyclosporin A-sensitive mitochondrial swelling. Selenium also promoted both calcium release from the matrix of isolated mitochondria and uncoupled respiration. The MPT-inducing effect of selenium provoked the release of cytochrome c , a pro-apoptotic factor...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 368 (3): 915–921.
Published: 15 December 2002
...Xavier ROUCOU; Sylvie MONTESSUIT; Bruno ANTONSSON; Jean-Claude MARTINOU In response to various apoptotic stimuli, Bax, a pro-apoptotic member of the Bcl-2 family, is oligomerized and permeabilizes the mitochondrial outer membrane to apoptogenic factors, including cytochrome c . Bax oligomerization...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 367 (2): 483–489.
Published: 15 October 2002
... the transcriptional control of a phoA promotor and with the Escherichia coli alkaline phosphatase signal sequence, was expressed in E. coli containing a plasmid expressing the genes for cytochrome c maturation proteins constitutively. Haem-containing inactive protein in inclusion bodies was renatured and reactivated...
Articles
Journal:
Biochemical Journal
Biochem J (2002) 367 (1): 169–178.
Published: 01 October 2002
... the cytosol was relatively small. In the second phase, Bax was very largely removed from the cytosol and sequestered into large aggregates associated with the mitochondria. To test which of the phases involved cytochrome c release, cells were transfected with a red fluorescent protein—cytochrome c fusion...
Articles
Journal:
Biochemical Journal
Biochem J (2001) 353 (2): 411–416.
Published: 08 January 2001
...-superoxide dismutase. Release of superoxide anion into the intermembrane space is a controversial topic, partly unresolved by the reaction of superoxide anion with cytochrome c , which faces the intermembrane space and is present in this compartment at a high concentration. This study was aimed at assessing...
Articles
Journal:
Biochemical Journal
Biochem J (2000) 345 (3): 711–717.
Published: 25 January 2000
...Amita SINHA; Sushma YADAV; Rizwan AHMAD; Faizan AHMAD To test the validity of thermodynamic parameters from the equilibrium method, we have studied the reversible heat-induced denaturations of lysozyme, ribonuclease A, cytochrome c and myoglobin at various pH values, using absorption spectral...