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Keywords: cytochrome P450
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Articles
Identification of the contact region responsible for the formation of the homomeric CYP1A2•CYP1A2 complex
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2021) 478 (11): 2163–2178.
Published: 11 June 2021
...Aratrika Saha; J. Patrick Connick; James R. Reed; Charles S. Lott; Wayne L. Backes Previous studies showed that cytochrome P450 1A2 (CYP1A2) forms a homomeric complex that influences its metabolic characteristics. Specifically, CYP1A2 activity exhibits a sigmoidal response as a function of NADPH...
Includes: Supplementary data
Articles
Heteromeric complex formation between human cytochrome P450 CYP1A1 and heme oxygenase-1
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Journal:
Biochemical Journal
Biochem J (2021) 478 (2): 377–388.
Published: 27 January 2021
...J. Patrick Connick; James R. Reed; George F. Cawley; Wayne L. Backes P450 and heme oxygenase-1 (HO-1) receive their necessary electrons by interaction with the NADPH-cytochrome P450 reductase (POR). As the POR concentration is limiting when compared with P450 and HO-1, they must effectively compete...
Includes: Supplementary data
Articles
Nicola A. Scott, Laura J. Sharpe, Isabelle M. Capell-Hattam, Samuel J. Gullo, Winnie Luu, Andrew J. Brown
Journal:
Biochemical Journal
Biochem J (2020) 477 (2): 541–555.
Published: 31 January 2020
.... Correspondence: Andrew J. Brown ( [email protected] ) 3 9 2019 22 12 2019 2 1 2020 6 1 2020 cholesterol cytochrome P450 DHCR24 lanosterol 14α-demethylase MARCH6 protein turnover Dysregulation of cholesterol homeostasis leads to numerous diseases including...
Includes: Supplementary data
Articles
Toward a systems approach to cytochrome P450 ensemble: interactions of CYP2E1 with other P450 species and their impact on CYP1A2
Available to PurchaseNadezhda Y. Davydova, Bikash Dangi, Marc A. Maldonado, Nikita E. Vavilov, Victor G. Zgoda, Dmitri R. Davydov
Journal:
Biochemical Journal
Biochem J (2019) 476 (23): 3661–3685.
Published: 12 December 2019
...Nadezhda Y. Davydova; Bikash Dangi; Marc A. Maldonado; Nikita E. Vavilov; Victor G. Zgoda; Dmitri R. Davydov In this study, we investigate the ability of ethanol-inducible CYP2E1 to interact with other cytochrome P450 species and affect the metabolism of their substrates. As a model system, we used...
Includes: Supplementary data
Articles
Phosphorylation of human placental aromatase CYP19A1
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Journal:
Biochemical Journal
Biochem J (2019) 476 (21): 3313–3331.
Published: 11 November 2019
... 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 androgens cytochrome p450 enzyme activity estrogens mass spectrometry The enzyme aromatase (AROM; CYP19A1 ), an integral membrane protein of the endoplasmic reticulum, is synonymous...
Includes: Supplementary data
Articles
Specificity and mechanism of carbohydrate demethylation by cytochrome P450 monooxygenases
Open Access
Journal:
Biochemical Journal
Biochem J (2018) 475 (23): 3875–3886.
Published: 12 December 2018
... because enzymes need to overcome a high energy barrier. Our structural and computational analysis revealed how a member of the cytochrome P450 family evolved to oxidize a carbohydrate ligand. Using structural biology, we ascertained the molecular determinants of substrate specificity and revealed a highly...
Includes: Supplementary data
Articles
Structural insights into oxidation of medium-chain fatty acids and flavanone by myxobacterial cytochrome P450 CYP267B1
Available to PurchaseIlona K. Jóźwik, Martin Litzenburger, Yogan Khatri, Alexander Schifrin, Marco Girhard, Vlada Urlacher, Andy-Mark W.H. Thunnissen, Rita Bernhardt
Journal:
Biochemical Journal
Biochem J (2018) 475 (17): 2801–2817.
Published: 11 September 2018
...Ilona K. Jóźwik; Martin Litzenburger; Yogan Khatri; Alexander Schifrin; Marco Girhard; Vlada Urlacher; Andy-Mark W.H. Thunnissen; Rita Bernhardt Oxidative biocatalytic reactions performed by cytochrome P450 enzymes (P450s) are of high interest for the chemical and pharmaceutical industries...
Includes: Supplementary data
Articles
Probing the specificity of CYP112 in bacterial gibberellin biosynthesis
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Journal:
Biochemical Journal
Biochem J (2018) 475 (13): 2167–2177.
Published: 05 July 2018
... transformation involves combined demethylation and γ-lactone ring formation, catalyzed in bacteria by the cytochrome P450 CYP112 in three individual steps, which involves large structural changes in the transition from substrate to product, with further divergence in the recently demonstrated use of two separate...
Includes: Supplementary data
Articles
Structural and functional characterisation of the cytochrome P450 enzyme CYP268A2 from Mycobacterium marinum
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Journal:
Biochemical Journal
Biochem J (2018) 475 (4): 705–722.
Published: 16 February 2018
...Stella A. Child; Elise F. Naumann; John B. Bruning; Stephen G. Bell Members of the cytochrome P450 monooxygenase family CYP268 are found across a broad range of Mycobacterium species including the pathogens Mycobacterium avium , M. colombiense , M. kansasii , and M . marinum . CYP268A2, from M...
Includes: Supplementary data
Articles
Toward a systems approach to the human cytochrome P450 ensemble: interactions between CYP2D6 and CYP2E1 and their functional consequences
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Journal:
Biochemical Journal
Biochem J (2017) 474 (20): 3523–3542.
Published: 10 October 2017
...Dmitri R. Davydov; Nadezhda Y. Davydova; John T. Rodgers; Thomas H. Rushmore; Jeffrey P. Jones Functional cross-talk among human drug-metabolizing cytochrome P450 through their association is a topic of emerging importance. Here, we studied the interactions of human CYP2D6, a major metabolizer...
Articles
Nitric oxide stimulates cellular degradation of human CYP51A1, the highly conserved lanosterol 14α-demethylase
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Journal:
Biochemical Journal
Biochem J (2017) 474 (19): 3241–3252.
Published: 15 September 2017
...Ji Won Park; Aria Byrd; Choon-myung Lee; Edward T. Morgan Nitric oxide (NO) is known to down-regulate drug-metabolizing cytochrome P450 enzymes in an enzyme-selective manner. Ubiquitin–proteasome-dependent and -independent pathways have been reported. Here, we studied the regulation of expression...
Includes: Supplementary data
Articles
Electron transfer by human wild-type and A287P mutant P450 oxidoreductase assessed by transient kinetics: functional basis of P450 oxidoreductase deficiency
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Journal:
Biochemical Journal
Biochem J (2015) 468 (1): 25–31.
Published: 05 May 2015
...Yi Jin; Mo Chen; Trevor M. Penning; Walter L. Miller Cytochrome P450 oxidoreductase (POR) is a 2-flavin protein that transfers electrons from NADPH via its FAD and FMN moieties to all microsomal cytochrome P450 enzymes, including steroidogenic and drug-metabolizing P450s. Defects in the POR gene...
Articles
Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity
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Journal:
Biochemical Journal
Biochem J (2015) 467 (1): 1–15.
Published: 20 March 2015
...James B.Y.H. Behrendorff; Weiliang Huang; Elizabeth M.J. Gillam Cytochrome P450 enzymes are renowned for their ability to insert oxygen into an enormous variety of compounds with a high degree of chemo- and regio-selectivity under mild conditions. This property has been exploited in Nature...
Articles
Cytochrome P450 system proteins reside in different regions of the endoplasmic reticulum
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Journal:
Biochemical Journal
Biochem J (2014) 464 (2): 241–249.
Published: 14 November 2014
...Ji Won Park; James R. Reed; Lauren M. Brignac-Huber; Wayne L. Backes Cytochrome P450 (P450) function is dependent on the ability of these enzymes to successfully interact with their redox partners, NADPH-cytochrome P450 reductase (CPR) and cytochrome b 5 , in the endoplasmic reticulum (ER). Because...
Includes: Supplementary data
Articles
CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation
Available to PurchaseJulia Keller, Alexandra Ellieva, Dengke K. Ma, Jingjuan Ju, Erik Nehk, Anne Konkel, John R. Falck, Wolf-Hagen Schunck, Ralph Menzel
Journal:
Biochemical Journal
Biochem J (2014) 464 (1): 61–71.
Published: 23 October 2014
... used to model key aspects of ischaemia/reperfusion injury. A genetic suppressor screen demonstrated a direct causal role of CYP (cytochrome P450)-13A12 in this response and suggested that CYP-eicosanoids, which in mammals influence the contractility of cardiomyocytes and vascular smooth muscle cells...
Articles
Human P450-like oxidation of diverse proton pump inhibitor drugs by ‘gatekeeper’ mutants of flavocytochrome P450 BM3
Available to PurchaseChristopher F. Butler, Caroline Peet, Kirsty J. McLean, Michael T. Baynham, Richard T. Blankley, Karl Fisher, Stephen E. J. Rigby, David Leys, Michael W. Voice, Andrew W. Munro
Journal:
Biochemical Journal
Biochem J (2014) 460 (2): 247–259.
Published: 13 May 2014
.... These high value products are complex to synthesize, but are increasingly important in drug safety testing. The vast majority of drugs are metabolized by cytochromes P450 (P450s), with oxidative transformations usually being highly regio - and stereo -selective. The PPIs (proton pump inhibitors) are drugs...
Includes: Supplementary data
Articles
Picking sides: distinct roles for CYP76M6 and CYP76M8 in rice oryzalexin biosynthesis
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Journal:
Biochemical Journal
Biochem J (2013) 454 (2): 209–216.
Published: 09 August 2013
...Yisheng Wu; Qiang Wang; Matthew L. Hillwig; Reuben J. Peters Natural products biosynthesis often requires the action of multiple CYPs (cytochromes P450), whose ability to introduce oxygen, increasing solubility, is critical for imparting biological activity. In previous investigations of rice...
Articles
Effect of homomeric P450–P450 complexes on P450 function
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Journal:
Biochemical Journal
Biochem J (2012) 446 (3): 489–497.
Published: 28 August 2012
... that affect P450 function. To address this problem, the catalytic activities of several P450s were examined in reconstituted systems containing NADPH–POR (cytochrome P450 reductase) and a single P450. CYP2B4 (cytochrome P450 2B4)-, CYP2E1 (cytochrome P450 2E1)- and CYP1A2 (cytochrome P450 1A2)-mediated...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2012) 445 (3): 377–382.
Published: 13 July 2012
...Haiyan Sun; Choon-myung Lee; Shweta Tripathi; Kyung-Bo Kim; Edward T. Morgan CYP2B proteins in rat hepatocytes undergo NO-dependent proteolytic degradation, but the mechanisms and the reasons for the specificity towards only certain P450 (cytochrome P450) enzymes are yet unknown. In the present...
Includes: Supplementary data
Articles
Eicosanoid formation by a cytochrome P450 isoform expressed in the pharynx of Caenorhabditis elegans
Available to PurchaseMandy Kosel, Waltraud Wild, Alexandra Bell, Michael Rothe, Carsten Lindschau, Christian E. W. Steinberg, Wolf-Hagen Schunck, Ralph Menzel
Journal:
Biochemical Journal
Biochem J (2011) 435 (3): 689–700.
Published: 13 April 2011
...Mandy Kosel; Waltraud Wild; Alexandra Bell; Michael Rothe; Carsten Lindschau; Christian E. W. Steinberg; Wolf-Hagen Schunck; Ralph Menzel Caenorhabditis elegans harbours several CYP (cytochrome P450) genes that are homologous with mammalian CYP isoforms important to the production...
Includes: Supplementary data
Articles
The structure of CYP101D2 unveils a potential path for substrate entry into the active site
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Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 85–93.
Published: 15 December 2010
...Wen Yang; Stephen G. Bell; Hui Wang; Weihong Zhou; Mark Bartlam; Luet-Lok Wong; Zihe Rao The cytochrome P450 CYP101D2 from Novosphingobium aromaticivorans DSM12444 is closely related to CYP101D1 from the same bacterium and to P450cam (CYP101A1) from Pseudomonas putida . All three are capable...
Includes: Supplementary data
Articles
Kinetics of electron transfer between NADPH-cytochrome P450 reductase and cytochrome P450 3A4
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Journal:
Biochemical Journal
Biochem J (2010) 432 (3): 485–494.
Published: 25 November 2010
...Yassar Farooq; Gordon C. K. Roberts We have incorporated CYP3A4 (cytochrome P450 3A4) and CPR (NADPH-cytochrome P450 reductase) into liposomes with a high lipid/protein ratio by an improved method. In the purified proteoliposomes, CYP3A4 binds testosterone with K d (app)=36±6 μM and Hill...
Includes: Supplementary data
Articles
Characterization of the xenobiotic response of Caenorhabditis elegans to the anthelmintic drug albendazole and the identification of novel drug glucoside metabolites
Available to PurchaseSteven T. Laing, Al Ivens, Roz Laing, Sai Ravikumar, Victoria Butler, Debra J. Woods, John S. Gilleard
Journal:
Biochemical Journal
Biochem J (2010) 432 (3): 505–516.
Published: 25 November 2010
... cytochrome P450s and UGTs (UDP-glucuronosyl transferases). The most highly induced genes are predominantly expressed in the worm intestine, supporting their role in drug metabolism. HPLC-MS/MS revealed the production of two novel glucoside metabolites in C. elegans identifying a major difference...
Includes: Supplementary data
Articles
Characterization of the kaurene oxidase CYP701A3, a multifunctional cytochrome P450 from gibberellin biosynthesis
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Journal:
Biochemical Journal
Biochem J (2010) 431 (3): 337–347.
Published: 11 October 2010
...Dana Morrone; Xiaoming Chen; Robert M. Coates; Reuben J. Peters KO (kaurene oxidase) is a multifunctional cytochrome P450 catalysing three sequential oxidations in gibberellin phytohormone biosynthesis. These serve to transform the C4α methyl of the ent -kaurene olefin intermediate...
Includes: Supplementary data
Articles
Pharmacogenetics and human genetic polymorphisms
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Journal:
Biochemical Journal
Biochem J (2010) 429 (3): 435–449.
Published: 14 July 2010
... and succinylcholine. The subject area developed rapidly, particularly with regard to genetic factors affecting drug disposition. There is now comprehensive understanding of the molecular basis for variable drug metabolism by the cytochromes P450 and also for variable glucuronidation, acetylation and methylation...
Articles
Glutamate–haem ester bond formation is disfavoured in flavocytochrome P450 BM3: characterization of glutamate substitution mutants at the haem site of P450 BM3
Available to PurchaseHazel M. Girvan, Colin W. Levy, Paul Williams, Karl Fisher, Myles R. Cheesman, Stephen E. J. Rigby, David Leys, Andrew W. Munro
Journal:
Biochemical Journal
Biochem J (2010) 427 (3): 455–466.
Published: 14 April 2010
...Hazel M. Girvan; Colin W. Levy; Paul Williams; Karl Fisher; Myles R. Cheesman; Stephen E. J. Rigby; David Leys; Andrew W. Munro Bacillus megaterium flavocytochrome P450 BM3 (CYP102A1) is a biotechnologically important cytochrome P450/P450 reductase fusion enzyme. Mutants I401E, F261E and L86E were...
Includes: Supplementary data
Articles
Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway
Open Access
Journal:
Biochemical Journal
Biochem J (2009) 417 (1): 43–58.
Published: 12 December 2008
...Robert D. Finn; Colin J. Henderson; Claire L. Scott; C. Roland Wolf The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification. We have shown previously that inactivation of the hepatic cytochrome P450...
Includes: Supplementary data
Articles
Novel haem co-ordination variants of flavocytochrome P450 BM3
Available to PurchaseHazel M. Girvan, Helen S. Toogood, Rachael E. Littleford, Harriet E. Seward, W. Ewen Smith, Idorenyin S. Ekanem, David Leys, Myles R. Cheesman, Andrew W. Munro
Journal:
Biochemical Journal
Biochem J (2009) 417 (1): 65–80.
Published: 12 December 2008
...–cytochrome P450 reductase and P450 domains. Selected mutations at residue 264 in the haem (P450) domain of the enzyme lead to novel amino acid sixth (distal) co-ordination ligands to the haem iron. The catalytic, spectroscopic and thermodynamic properties of the A264M, A264Q and A264C variants were...
Includes: Supplementary data
Articles
Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation
Available to PurchaseDominik N. Muller, Cosima Schmidt, Eduardo Barbosa-Sicard, Maren Wellner, Volkmar Gross, Hantz Hercule, Marija Markovic, Horst Honeck, Friedrich C. Luft, Wolf-Hagen Schunck
Journal:
Biochemical Journal
Biochem J (2007) 403 (1): 109–118.
Published: 13 March 2007
... function. To identify the CYP (cytochrome P450) isoforms catalysing this reaction in the mouse kidney, we analysed the substrate specificity of Cyp4a10, 4a12a, 4a12b and 4a14 and determined sex- and strain-specific expressions. All recombinant enzymes showed high lauric acid hydroxylase activities...
Articles
Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product
Available to PurchaseGurmeet Kaur, Melinda Hollingshead, Susan Holbeck, Vesna Schauer-Vukašinović, Richard F. Camalier, Alexander Dömling, Seema Agarwal
Journal:
Biochemical Journal
Biochem J (2006) 396 (2): 235–242.
Published: 15 May 2006
... 2005 23 1 2006 20 2 2006 20 2 2006 The Biochemical Society, London 2006 antiangiogenesis anticancer agent cytochrome P450 microtubule tubulin tubulysin A The test compound (500 μl of two times the final concentration) was mixed with 500 μl of cells (2×10 5 cells...
Includes: Supplementary data
Articles
Richard K. Hughes, Eric J. Belfield, Mylrajan Muthusamay, Anuja Khan, Arthur Rowe, Stephen E. Harding, Shirley A. Fairhurst, Stephen Bornemann, Ruth Ashton, Roger N. F. Thorneley, Rod Casey
Journal:
Biochemical Journal
Biochem J (2006) 395 (3): 641–652.
Published: 11 April 2006
...Richard K. Hughes; Eric J. Belfield; Mylrajan Muthusamay; Anuja Khan; Arthur Rowe; Stephen E. Harding; Shirley A. Fairhurst; Stephen Bornemann; Ruth Ashton; Roger N. F. Thorneley; Rod Casey We describe the detailed biochemical characterization of CYP74C3 (cytochrome P450 subfamily 74C3...
Includes: Supplementary data
Articles
Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy
Available to PurchaseAike Stortelder, Peter H. J. Keizers, Chris Oostenbrink, Chris De Graaf, Petra De Kruijf, Nico P. E. Vermeulen, Cees Gooijer, Jan N. M. Commandeur, Gert Van Der Zwan
Journal:
Biochemical Journal
Biochem J (2006) 393 (3): 635–643.
Published: 13 January 2006
...Aike Stortelder; Peter H. J. Keizers; Chris Oostenbrink; Chris De Graaf; Petra De Kruijf; Nico P. E. Vermeulen; Cees Gooijer; Jan N. M. Commandeur; Gert Van Der Zwan Enzyme structure and dynamics may play a main role in substrate binding and the subsequent steps in the CYP (cytochrome P450...
Includes: Supplementary data
Articles
Characterization of a c-Jun-responsive module in the 5′-flank of the human CYP2J2 gene that regulates transactivation
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Journal:
Biochemical Journal
Biochem J (2005) 391 (3): 631–640.
Published: 25 October 2005
...Nicole Y. Marden; Michael Murray The human cytochrome P450 2J2 (CYP2J2) generates cytoprotective epoxyeicosatrienoic acids from arachidonic acid. Expression of CYP2J2 is decreased in hypoxia, and the resultant decrease in CYP2J2-derived epoxyeicosanoids may contribute to the pathogenesis of cardiac...
Articles
Cytochrome P450/NADPH-dependent biosynthesis of 5,6- trans -epoxyeicosatrienoic acid from 5,6- trans -arachidonic acid
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Journal:
Biochemical Journal
Biochem J (2005) 390 (3): 719–727.
Published: 05 September 2005
... with the three cis bonds for oxidative metabolism mediated by CYP (cytochrome P450) epoxygenase and hydroxylase. This was evidenced by the detection of 5,6- trans -EET (where EET stands for epoxyeicosatrienoic acid), 5,6- erythro -dihydroxyeicosatrienoic acid and an isomer of 5-HETE. A standard of 5,6- trans...
Articles
Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice
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Journal:
Biochemical Journal
Biochem J (2005) 388 (3): 857–867.
Published: 07 June 2005
...Xiu Jun WANG; Mark CHAMBERLAIN; Olga VASSIEVA; Colin J. HENDERSON; C. Roland WOLF Cytochrome P450 reductase is the unique electron donor for microsomal cytochrome P450s; these enzymes play a major role in the metabolism of endogenous and xenobiotic compounds. In mice with a liver-specific deletion...
Includes: Supplementary data
Articles
Regulation of Cyp2a5 transcription in mouse primary hepatocytes: roles of hepatocyte nuclear factor 4 and nuclear factor I
Available to PurchaseJohanna ULVILA, Satu ARPIAINEN, Olavi PELKONEN, Kaoru AIDA, Tatsuya SUEYOSHI, Masahiko NEGISHI, Jukka HAKKOLA
Journal:
Biochemical Journal
Biochem J (2004) 381 (3): 887–894.
Published: 27 July 2004
... in DDBJ, EMBL, GenBank® and GSDB Nucleotide Sequence Databases under the accession number AY321510. 10 3 2004 28 4 2004 29 4 2004 29 4 2004 The Biochemical Society, London 2004 cytochrome P450 hepatocyte nuclear factor 4 (HNF-4) liver nuclear factor I (NF-I...
Articles
Phe120 contributes to the regiospecificity of cytochrome P450 2D6: mutation leads to the formation of a novel dextromethorphan metabolite
Available to PurchaseJack U. FLANAGAN, Jean-Didier MARÉCHAL, Richard WARD, Carol A. KEMP, Lesley A. McLAUGHLIN, Michael J. SUTCLIFFE, Gordon C. K. ROBERTS, Mark J. I. PAINE, C. Roland WOLF
Journal:
Biochemical Journal
Biochem J (2004) 380 (2): 353–360.
Published: 01 June 2004
...Jack U. FLANAGAN; Jean-Didier MARÉCHAL; Richard WARD; Carol A. KEMP; Lesley A. McLAUGHLIN; Michael J. SUTCLIFFE; Gordon C. K. ROBERTS; Mark J. I. PAINE; C. Roland WOLF Although the residues that determine the preference of CYP2D6 (cytochrome P450 2D6) for compounds containing a basic nitrogen...
Articles
Role of activator protein-1 in the down-regulation of the human CYP2J2 gene in hypoxia
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Journal:
Biochemical Journal
Biochem J (2003) 373 (3): 669–680.
Published: 01 August 2003
...Nicole Y. MARDEN; Eva FIALA-BEER; Shi-Hua XIANG; Michael MURRAY The cytochrome P450 (CYP) 2J2 arachidonic acid epoxygenase gene was down-regulated at a pre-translational level in human hepatoma-derived HepG2 cells incubated in a hypoxic environment; under these conditions, the expression of c-Jun...
Articles
Generation of hepatocytes expressing functional cytochromes P450 from a pancreatic progenitor cell line in vitro
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Journal:
Biochemical Journal
Biochem J (2003) 370 (3): 763–769.
Published: 15 March 2003
... also expresses liver-specific or liver-enriched functional cytochrome P450 proteins when stimulated to trans-differentiate into hepatocytes by glucocorticoid. These data suggest that this cell line has an unusual ability to trans-differentiate into functional hepatocytes and that it could be possible...
Articles
Solution structure and topology of the N-terminal membrane anchor domain of a microsomal cytochrome P450: prostaglandin I2 synthase
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Journal:
Biochemical Journal
Biochem J (2002) 368 (3): 721–728.
Published: 15 December 2002
...Ke-He RUAN; Shui-Ping SO; Weida ZHENG; Jiaxin WU; Dawei LI; Jennifer KUNG The three-dimensional structure of a synthetic peptide corresponding to the N-terminal membrane anchor domain (residues 1—25) of prostaglandin I 2 synthase (also known as cytochrome P450 8A1), an eicosanoid-synthesizing...
Articles
Sterol 14α-demethylase activity in Streptomyces coelicolor A3(2) is associated with an unusual member of the CYP51 gene family
Available to PurchaseDavid C. LAMB, Kay FOWLER, Tobias KIESER, Nigel MANNING, Larissa M. PODUST, Michael R. WATERMAN, Diane E. KELLY, Steven L. KELLY
Journal:
Biochemical Journal
Biochem J (2002) 364 (2): 555–562.
Published: 01 June 2002
...David C. LAMB; Kay FOWLER; Tobias KIESER; Nigel MANNING; Larissa M. PODUST; Michael R. WATERMAN; Diane E. KELLY; Steven L. KELLY The annotation of the genome sequence of Streptomyces coelicolor A3(2) revealed a cytochrome P450 (CYP) resembling various sterol 14α-demethylases (CYP51). The putative...
Articles
Substrate access channel topology in membrane-bound prostacyclin synthase
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Journal:
Biochemical Journal
Biochem J (2002) 362 (3): 545–551.
Published: 08 March 2002
..., London ©2002 2002 cytochrome P450 membrane topology peptide antibody prostaglandin prostaglandin I 2 synthase Abbreviations used: ER, endoplasmic reticulum; PGIS, prostaglandin I 2 synthase; TXAS, thromboxane A 2 synthase; PGHS, prostaglandin H 2 (PGH 2 ) synthase; SLO...
Articles
cyp7b1 catalyses the 7α-hydroxylation of dehydroepiandrosterone and25-hydroxycholesterol in rat prostate
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Journal:
Biochemical Journal
Biochem J (2001) 355 (2): 509–515.
Published: 06 April 2001
.... We recently described a novel cytochrome P450 enzyme, cyp7b1, strongly expressed in the hippocampus of rodent brain, which catalyses the metabolism of DHEA, pregnenolone and 25-hydroxycholesterol to 7α-hydroxy products. In the light of this new enzyme, we have examined its possible role in 7α...
