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Keywords: cytochrome P450
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Biochem J (2021) 478 (11): 2163–2178.
Published: 11 June 2021
...Aratrika Saha; J. Patrick Connick; James R. Reed; Charles S. Lott; Wayne L. Backes Previous studies showed that cytochrome P450 1A2 (CYP1A2) forms a homomeric complex that influences its metabolic characteristics. Specifically, CYP1A2 activity exhibits a sigmoidal response as a function of NADPH...
Includes: Supplementary data
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Biochem J (2021) 478 (2): 377–388.
Published: 27 January 2021
...J. Patrick Connick; James R. Reed; George F. Cawley; Wayne L. Backes P450 and heme oxygenase-1 (HO-1) receive their necessary electrons by interaction with the NADPH-cytochrome P450 reductase (POR). As the POR concentration is limiting when compared with P450 and HO-1, they must effectively compete...
Includes: Supplementary data
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Biochem J (2020) 477 (2): 541–555.
Published: 31 January 2020
... License 4.0 (CC BY) . Open access for this article was enabled by the participation of University of New South Wales in an all-inclusive Read & Publish pilot with Portland Press and the Biochemical Society under a transformative agreement with CAUL. cholesterol cytochrome P450 DHCR24...
Includes: Supplementary data
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Biochem J (2019) 476 (21): 3313–3331.
Published: 11 November 2019
... Hospital, University of Toronto, Toronto, ON, Canada © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 androgens cytochrome p450 enzyme activity estrogens mass spectrometry The enzyme aromatase (AROM; CYP19A1 ), an integral membrane...
Includes: Supplementary data
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Biochem J (2018) 475 (23): 3875–3886.
Published: 12 December 2018
... because enzymes need to overcome a high energy barrier. Our structural and computational analysis revealed how a member of the cytochrome P450 family evolved to oxidize a carbohydrate ligand. Using structural biology, we ascertained the molecular determinants of substrate specificity and revealed a highly...
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Biochem J (2018) 475 (13): 2167–2177.
Published: 05 July 2018
... transformation involves combined demethylation and γ-lactone ring formation, catalyzed in bacteria by the cytochrome P450 CYP112 in three individual steps, which involves large structural changes in the transition from substrate to product, with further divergence in the recently demonstrated use of two separate...
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Biochem J (2017) 474 (19): 3241–3252.
Published: 15 September 2017
...Ji Won Park; Aria Byrd; Choon-myung Lee; Edward T. Morgan Nitric oxide (NO) is known to down-regulate drug-metabolizing cytochrome P450 enzymes in an enzyme-selective manner. Ubiquitin–proteasome-dependent and -independent pathways have been reported. Here, we studied the regulation of expression...
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Biochem J (2014) 464 (2): 241–249.
Published: 14 November 2014
...Ji Won Park; James R. Reed; Lauren M. Brignac-Huber; Wayne L. Backes Cytochrome P450 (P450) function is dependent on the ability of these enzymes to successfully interact with their redox partners, NADPH-cytochrome P450 reductase (CPR) and cytochrome b 5 , in the endoplasmic reticulum (ER). Because...
Includes: Supplementary data
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Biochem J (2014) 460 (2): 247–259.
Published: 13 May 2014
.... These high value products are complex to synthesize, but are increasingly important in drug safety testing. The vast majority of drugs are metabolized by cytochromes P450 (P450s), with oxidative transformations usually being highly regio - and stereo -selective. The PPIs (proton pump inhibitors) are drugs...
Includes: Supplementary data
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Biochem J (2013) 454 (2): 209–216.
Published: 09 August 2013
...Yisheng Wu; Qiang Wang; Matthew L. Hillwig; Reuben J. Peters Natural products biosynthesis often requires the action of multiple CYPs (cytochromes P450), whose ability to introduce oxygen, increasing solubility, is critical for imparting biological activity. In previous investigations of rice...
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Biochem J (2012) 446 (3): 489–497.
Published: 28 August 2012
... that affect P450 function. To address this problem, the catalytic activities of several P450s were examined in reconstituted systems containing NADPH–POR (cytochrome P450 reductase) and a single P450. CYP2B4 (cytochrome P450 2B4)-, CYP2E1 (cytochrome P450 2E1)- and CYP1A2 (cytochrome P450 1A2)-mediated...
Includes: Supplementary data
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Biochem J (2012) 445 (3): 377–382.
Published: 13 July 2012
...Haiyan Sun; Choon-myung Lee; Shweta Tripathi; Kyung-Bo Kim; Edward T. Morgan CYP2B proteins in rat hepatocytes undergo NO-dependent proteolytic degradation, but the mechanisms and the reasons for the specificity towards only certain P450 (cytochrome P450) enzymes are yet unknown. In the present...
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Biochem J (2011) 433 (1): 85–93.
Published: 15 December 2010
...Wen Yang; Stephen G. Bell; Hui Wang; Weihong Zhou; Mark Bartlam; Luet-Lok Wong; Zihe Rao The cytochrome P450 CYP101D2 from Novosphingobium aromaticivorans DSM12444 is closely related to CYP101D1 from the same bacterium and to P450cam (CYP101A1) from Pseudomonas putida . All three are capable...
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Biochem J (2010) 429 (3): 435–449.
Published: 14 July 2010
... and succinylcholine. The subject area developed rapidly, particularly with regard to genetic factors affecting drug disposition. There is now comprehensive understanding of the molecular basis for variable drug metabolism by the cytochromes P450 and also for variable glucuronidation, acetylation and methylation...
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Biochem J (2009) 417 (1): 65–80.
Published: 12 December 2008
...–cytochrome P450 reductase and P450 domains. Selected mutations at residue 264 in the haem (P450) domain of the enzyme lead to novel amino acid sixth (distal) co-ordination ligands to the haem iron. The catalytic, spectroscopic and thermodynamic properties of the A264M, A264Q and A264C variants were...
Includes: Supplementary data
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Biochem J (2009) 417 (1): 43–58.
Published: 12 December 2008
...Robert D. Finn; Colin J. Henderson; Claire L. Scott; C. Roland Wolf The liver is responsible for key metabolic functions, including control of normal homoeostasis in response to diet and xenobiotic metabolism/detoxification. We have shown previously that inactivation of the hepatic cytochrome P450...
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Biochem J (2006) 396 (2): 235–242.
Published: 15 May 2006
... 2005 23 1 2006 20 2 2006 20 2 2006 The Biochemical Society, London 2006 antiangiogenesis anticancer agent cytochrome P450 microtubule tubulin tubulysin A Most drugs currently available for the treatment of cancer are mechanistically based on the inhibition...
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Biochem J (2006) 395 (3): 641–652.
Published: 11 April 2006
...Richard K. Hughes; Eric J. Belfield; Mylrajan Muthusamay; Anuja Khan; Arthur Rowe; Stephen E. Harding; Shirley A. Fairhurst; Stephen Bornemann; Ruth Ashton; Roger N. F. Thorneley; Rod Casey We describe the detailed biochemical characterization of CYP74C3 (cytochrome P450 subfamily 74C3...
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Biochem J (2005) 391 (3): 631–640.
Published: 25 October 2005
...Nicole Y. Marden; Michael Murray The human cytochrome P450 2J2 (CYP2J2) generates cytoprotective epoxyeicosatrienoic acids from arachidonic acid. Expression of CYP2J2 is decreased in hypoxia, and the resultant decrease in CYP2J2-derived epoxyeicosanoids may contribute to the pathogenesis of cardiac...
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Biochem J (2003) 373 (3): 669–680.
Published: 01 August 2003
...Nicole Y. MARDEN; Eva FIALA-BEER; Shi-Hua XIANG; Michael MURRAY The cytochrome P450 (CYP) 2J2 arachidonic acid epoxygenase gene was down-regulated at a pre-translational level in human hepatoma-derived HepG2 cells incubated in a hypoxic environment; under these conditions, the expression of c-Jun...
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Biochem J (2002) 362 (3): 545–551.
Published: 08 March 2002
..., London ©2002 2002 cytochrome P450 membrane topology peptide antibody prostaglandin prostaglandin I 2 synthase Abbreviations used: ER, endoplasmic reticulum; PGIS, prostaglandin I 2 synthase; TXAS, thromboxane A 2 synthase; PGHS, prostaglandin H 2 (PGH 2 ) synthase; SLO...
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Biochem J (2001) 355 (2): 509–515.
Published: 06 April 2001
.... We recently described a novel cytochrome P450 enzyme, cyp7b1, strongly expressed in the hippocampus of rodent brain, which catalyses the metabolism of DHEA, pregnenolone and 25-hydroxycholesterol to 7α-hydroxy products. In the light of this new enzyme, we have examined its possible role in 7α...