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Keywords: cytochrome c
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Biochem J (2019) 476 (20): 3069–3080.
Published: 30 October 2019
...) increased. Accordingly, we assessed apoptotic processes in Candida tropicalis cells post-treatment with CGA-N9 and found cytochrome c leakage, chromatin condensation and DNA degradation. The interaction of CGA-N9 with DNA in vitro showed that CGA-N9 did not degrade DNA but bound to DNA via an electrostatic...
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Biochem J (2012) 442 (1): 191–197.
Published: 27 January 2012
..., and no efficient protein-mediated process has been identified. Recently, we observed that ferric cytochrome c can promote S -nitrosoglutathione formation from NO and glutathione by acting as an electron acceptor under anaerobic conditions. In the present study, we show that this mechanism is also robust under...
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Biochem J (2009) 420 (3): 485–492.
Published: 27 May 2009
... of these proteins, two with 12 haems (GSU1996, GSU0592) and one with 27 haems (GSU2210), suggest that they are formed with domains homologous to the trihaem cytochrome c 7 . Although all three haems have bis-His co-ordination in cytochromes c 7 , in each domain of the above polymers, the haem equivalent to haem IV...
Includes: Supplementary data
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Biochem J (2005) 392 (3): 583–587.
Published: 06 December 2005
... and cytochrome c , there was a good correlation between the second-order reduction rate constant and the redox potential, E m (Fe III /Fe II ): The rate of reduction of cytochrome c by BH 4 [(6 R )-5,6,7,8-tetrahydrobiopterin] was determined to be similar to that of the reduction of cytochrome c by diMePH 4...
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Biochem J (2005) 389 (1): 197–206.
Published: 21 June 2005
... the release of cytochrome c from mitochondria into the cytosol and exhibited cytotoxicity, but NDPE did not. RBL cells, a rat basophil leukaemia-derived line, that overexpress phospholipid hydroperoxide glutathione peroxidase in mitochondria were found to be highly resistant to the cytotoxic effect of MNPE...
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Biochem J (2004) 381 (1): 19–23.
Published: 22 June 2004
... protein stability, ATP synthase assembly, cristae morphology and cytochrome c storage within cristae. We then investigated the effects of inactivation of Pcp1p/Mgm1p on Tim11p/ATP synthase in the context of cristae morphology (Figure 2 B). We found that Δ pcp1 (Figure 2 C) and Δ mgm1 (Figure 2 D...
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Biochem J (2004) 379 (3): 805–813.
Published: 01 May 2004
... of Bax (Bcl-associated X protein) to mitochondria is linked with release of cytochrome c and subsequent activation of a caspase cascade [Shou, Li, Prabhakaran, Borowitz and Isom (2003) Toxicol. Sci. 75 , 99–107]. In the present study, the relationship of the cyanide-induced increase in cytosolic free Ca...
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Biochem J (2003) 371 (3): 1055–1064.
Published: 01 May 2003
... caspase activation and apoptosis (downstream of mitochondrial membrane depolarization) and cytochrome c release. However, caspase activity was not restored by the strong reducing agent dithiothreitol, as predicted for S-nitrosation reactions, thereby excluding active-site-thiol modification of caspases...
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Biochem J (2003) 371 (1): 115–124.
Published: 01 April 2003
...-nitrophenyl)methane sulphonamide has been shown previously to cause apoptosis in intestinal epithelial cells. In the present study, we attempted to elucidate the underlying mechanisms and we can now show that a mitochondrial pathway is employed. Inhibition of COX-2 causes release of cytochrome c , as shown...
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Biochem J (2002) 368 (3): 915–921.
Published: 15 December 2002
...Xavier ROUCOU; Sylvie MONTESSUIT; Bruno ANTONSSON; Jean-Claude MARTINOU In response to various apoptotic stimuli, Bax, a pro-apoptotic member of the Bcl-2 family, is oligomerized and permeabilizes the mitochondrial outer membrane to apoptogenic factors, including cytochrome c . Bax oligomerization...
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Biochem J (2002) 367 (2): 483–489.
Published: 15 October 2002
... the transcriptional control of a phoA promotor and with the Escherichia coli alkaline phosphatase signal sequence, was expressed in E. coli containing a plasmid expressing the genes for cytochrome c maturation proteins constitutively. Haem-containing inactive protein in inclusion bodies was renatured and reactivated...
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Biochem J (2002) 367 (1): 169–178.
Published: 01 October 2002
... the cytosol was relatively small. In the second phase, Bax was very largely removed from the cytosol and sequestered into large aggregates associated with the mitochondria. To test which of the phases involved cytochrome c release, cells were transfected with a red fluorescent protein—cytochrome c fusion...
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Biochem J (2001) 353 (2): 411–416.
Published: 08 January 2001
...-superoxide dismutase. Release of superoxide anion into the intermembrane space is a controversial topic, partly unresolved by the reaction of superoxide anion with cytochrome c , which faces the intermembrane space and is present in this compartment at a high concentration. This study was aimed at assessing...
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Biochem J (2000) 345 (3): 711–717.
Published: 25 January 2000
...Amita SINHA; Sushma YADAV; Rizwan AHMAD; Faizan AHMAD To test the validity of thermodynamic parameters from the equilibrium method, we have studied the reversible heat-induced denaturations of lysozyme, ribonuclease A, cytochrome c and myoglobin at various pH values, using absorption spectral...