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Keywords: cytokine
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Articles
Biochem J (2018) 475 (4): 775–786.
Published: 23 February 2018
... ) 9 11 2017 16 1 2018 18 1 2018 22 1 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cytokine gC1qR (gC1qBP) inflammation MCP-1 (CCL2) periodontal ligament cells (PDL cells) protein–protein interactions...
Includes: Supplementary data
Articles
Biochem J (2015) 471 (2): 281–291.
Published: 02 October 2015
... sensitive to LPS (lipopolysaccharide) stimulation and the miR-429 mimics increased the production of pro-inflammatory cytokines. However, anti- miR-429 reduced the LPS-induced production of pro-inflammatory cytokines. These results provide direct evidence that miR-429 is involved in the LPS-induced...
Includes: Supplementary data
Articles
Biochem J (2012) 447 (1): 125–136.
Published: 12 September 2012
... STAT3α, gene knockout studies have revealed that both forms play critical roles. We have expressed STAT3α and STAT3β at comparable levels to facilitate a direct comparison of their functional effects, and have shown their different cytokine-stimulated kinetics of phosphorylation and nuclear translocation...
Includes: Supplementary data
Articles
Biochem J (2012) 445 (3): 349–359.
Published: 13 July 2012
...Katarzyna Hanzelka; Lukasz Skalniak; Jolanta Jura; Sigurd Lenzen; Ewa Gurgul-Convey Mimitin, a novel mitochondrial protein, has been shown to act as a molecular chaperone for the mitochondrial complex I and to regulate ATP synthesis. During Type 1 diabetes development, pro-inflammatory cytokines...
Articles
Biochem J (2012) 445 (2): 285–293.
Published: 27 June 2012
... Journal compilation © 2012 Biochemical Society 2012 cytokine nuclear protein 1 (NUPR1) promoter SMAD stress transforming growth factor β (TGFβ) A cell constantly receives a multitude of signals informing it about its condition and that of its environment. When it receives signals...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (3): 857–867.
Published: 16 April 2012
.../2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. bioinformatics cytokine inflammation promoter PIK3CD tumour necrosis factor α (TNFα) PI3Ks (phosphoinositide 3-kinases) phosphorylate...
Includes: Supplementary data
Articles
Biochem J (2012) 443 (2): 329–338.
Published: 27 March 2012
...Howard M. Johnson; Ezra N. Noon-Song; Kaisa Kemppainen; Chulbul M. Ahmed Many cytokines, hormones and growth factors use the JAK (Janus kinase)/STAT (signal transducer and activator of transcription) pathway for cell signalling and specific gene activation. In the classical model, ligand is said to...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2012) 443 (1): 297–305.
Published: 14 March 2012
... are intrinsic cytokines secreted by UVB-exposed keratinocytes that stimulate expression of NEP by fibroblasts. 1 To whom correspondence should be addressed (email imokawag@dream.ocn.ne.jp ). 20 10 2011 12 12 2011 20 12 2011 14 3 2012 © The Authors Journal...
Articles
Biochem J (2012) 442 (3): 649–659.
Published: 24 February 2012
... properly cited. cytokine lymphocyte pre-cell antigen receptor protein kinase D (PKD) T-cell antigen receptor (TCR) thymus The TCR (T-cell antigen receptor) controls the function of peripheral T-lymphocytes during adaptive immune responses. Antigen receptors also control T-cell...
Includes: Supplementary data
Articles
Biochem J (2012) 442 (1): 127–137.
Published: 27 January 2012
...-Jun, p65–p65 and USF (upstream stimulating factor) 1–USF2 complexes are recruited to the cPLA 2 γ enhancer/promoter in response to TNFα, with overexpression and dominant-negative studies implying a strong level of co-operation and interplay between these factors. Overall, our results link cytokine...
Includes: Supplementary data
Articles
Biochem J (2011) 436 (2): 253–262.
Published: 13 May 2011
... multinucleated cells that resorb bone [ 3 , 4 , 6 ]. cytokine nuclear factor of activated T-cells (NFAT) osteoclastogenesis post-translational modification receptor activator of NF-κB (nuclear factor κB) ligand (RANKL) transcription factor To generate retroviral stock, retroviral vectors were...
Includes: Supplementary data
Articles
Biochem J (2011) 435 (2): 381–390.
Published: 29 March 2011
...Christopher J. Clarke; Emily A. Cloessner; Patrick L. Roddy; Yusuf A. Hannun Activation of N-SMase (neutral sphingomyelinase) is an established part of the response of cytokines such as TNF (tumour necrosis factor)-α. However, it remains unclear which of the currently cloned N-SMase isoforms...
Includes: Supplementary data
Articles
Biochem J (2010) 432 (1): 153–163.
Published: 25 October 2010
..., however, required for efficient antigen receptor-induced cytokine production in T-lymphocytes and for optimal T-cell-dependent antibody responses in vivo . Our results reveal a key in vivo role for PKD2 in regulating the function of mature peripheral lymphocytes during adaptive immune responses. They also...
Articles
Biochem J (2010) 429 (1): 1–12.
Published: 14 June 2010
...Christopher C. Rider; Barbara Mulloy The BMPs (bone morphogenetic proteins) and the GDFs (growth and differentiation factors) together form a single family of cystine-knot cytokines, sharing the characteristic fold of the TGFβ (transforming growth factor-β) superfamily. Besides the ability to...
Includes: Supplementary data
Articles
Biochem J (2009) 423 (3): 315–321.
Published: 12 October 2009
... Society 2009 cancer cytokine inflammation isothiocyanate (ITC) macrophage migration inhibitory factor (MIF) tautomerase Dietary ITCs (isothiocyanates), such as PEITC (phenethyl ITC) and sulforaphane, are prevalent in cruciferous vegetables. Cancer prevention by ITCs is widely attributed...
Includes: Supplementary data
Articles
Biochem J (2009) 421 (3): 473–482.
Published: 15 July 2009
... Society 2009 cell membrane cytokine glycyrrhizin inflammation signalling Toll-like receptor (TLR) The innate immune system responds to invading microbes by detecting highly conserved structures of pathogens through interaction with TLRs (Toll-like receptors). In humans, ten TLRs (TLR1...
Includes: Supplementary data
Articles
Biochem J (2008) 415 (2): 289–296.
Published: 25 September 2008
... regulated at the DNA binding and transcriptional levels after cytokine stimulation. We now show that co-activators have a differential impact on the transactivation of HNF-4α-sensitive genes via HNF-4α-binding sites in ApoB , TTR or α 1 - AT promoters. PGC-1α strongly enhances the transactivation of ApoB...
Articles
Biochem J (2008) 412 (3): e17–e19.
Published: 28 May 2008
... evidence has emerged that HIF-1α is also responsive to many stimuli under normoxic conditions, including thrombin, growth factors, vasoactive peptides, insulin, lipopolysaccharide and cytokines such as TNF-α (tumour necrosis factor-α), and in many cases reactive oxygen species are involved. One important...
Articles
Biochem J (2008) 412 (1): 65–72.
Published: 25 April 2008
... factor for T-cells and is a potent inducer of the chemokine MCP-1 (monocyte chemoattractant protein-1). Recent studies have focused on the negative regulation of IL-6 signal transduction through the IL-6-induced feedback inhibitors SOCS (suppressor of cytokine signalling) 1 and SOCS3 or the protein...
Includes: Supplementary data
Articles
Biochem J (2008) 411 (2): 227–231.
Published: 27 March 2008
...Nicholas P. Mullin; Adam Yates; Arthur J. Rowe; Bianca Nijmeijer; Douglas Colby; Paul N. Barlow; Malcolm D. Walkinshaw; Ian Chambers The defining activity of the homeodomain protein Nanog is the ability to confer cytokine-independent self-renewal upon ES (embryonic stem) cells in which it is...
Includes: Supplementary data
Articles
Biochem J (2006) 398 (3): 577–583.
Published: 29 August 2006
... ELP (elastin-like peptide)-fusion protein (mini-gp130–ELP). Mini-gp130–ELP consists of the first three domains of gp130 (Ig-like domain and cytokine binding module) fused to 100 repeats of ELP. Expression of mini-gp130–ELP did not affect the growth rate or morphology of the transgenic plants, and...
Includes: Supplementary data
Articles
Biochem J (2006) 394 (1): 285–297.
Published: 27 January 2006
... phosphorylation sites in the anti-inflammatory protein TTP in mammalian cells and should provide the molecular basis for further studies on the function and regulation of TTP in controlling pro-inflammatory cytokines. 1 To whom correspondence should be addressed (email caoh@ba.ars.usda.gov ). 11 8...
Includes: Supplementary data
Articles
Biochem J (2006) 393 (1): 7–20.
Published: 12 December 2005
...Gema Frühbeck Leptin is a versatile 16 kDa peptide hormone, with a tertiary structure resembling that of members of the long-chain helical cytokine family. It is mainly produced by adipocytes in proportion to fat size stores, and was originally thought to act only as a satiety factor. However, the...
Articles
Biochem J (2005) 390 (2): 437–446.
Published: 23 August 2005
...Naveen Sharma; Abas H. Laftah; Matthew J. Brookes; Brian Cooper; Tariq Iqbal; Chris Tselepis Cytokines are integral to the development of anaemia of chronic inflammation. Cytokines modulate hepcidin expression and iron sequestration by the reticuloendothelial system but their direct effects on...
Articles
Biochem J (2005) 390 (1): 317–324.
Published: 09 August 2005
...Nobuyuki Marui; Russell M. Medford; Mushtaq Ahmad In vascular endothelial cells, cytokines induce genes that are expressed in inflammatory lesions partly through the activation of transcription factor NF-κB (nuclear factor-κB). Among the members of the NF-κB/rel protein family, homodimers of the...
Articles
Biochem J (2005) 387 (3): 737–745.
Published: 26 April 2005
...Christian EHLTING; Dieter HÄUSSINGER; Johannes G. BODE Cytokine-induced expression of SOCS (suppressor of cytokine signalling) molecules is important for the negative regulatory control of STAT (signal transduction and activators of transcription)-dependent cytokine signalling, e.g. for the signal...
Articles
Biochem J (2005) 385 (2): 537–544.
Published: 07 January 2005
... proteins and possible mediators of TNF tolerance. In vitro experiments revealed that overexpression of SOCS1 (silencer of cytokine signalling 1), a member of the SOCS family of proteins, as well as of HO-1 (haem oxygenase-1), but not of SOCS2 or SOCS3, protected isolated primary mouse hepatocytes from TNF...
Includes: Supplementary data
Articles
Biochem J (2005) 385 (2): 493–502.
Published: 07 January 2005
... cytokine inflammation interleukin-8 secretion lipid phosphate phosphatase-1 (LPP-1) lysophosphatidic acid (LPA) The bioactive phospholipids LPA (lysophosphatidic acid) and S1P (sphingosine 1-phosphate) are present in biological fluids and tissues [ 1 – 3 ]. LPA induces a variety of signalling...
Articles
Biochem J (2004) 383 (2): 393–399.
Published: 08 October 2004
... 2004 9 7 2004 The Biochemical Society, London 2004 Alzheimer's disease cytokine luciferase promoter Smad transforming growth factor-β AD (Alzheimer's disease) is a neurodegenerative disease associated with progressive memory loss and leading to dementia. Two histological...
Articles
Biochem J (2004) 382 (1): 261–268.
Published: 10 August 2004
...Michael WELSH; Charlotte WELSH; Maria EKMAN; Johan DIXELIUS; Robert HÄGERKVIST; Cecilia ANNERÉN; Björn ÅKERBLOM; Siavosh MAHBOOBI; Subhashini CHANDRASEKHARAN; Edison T. LIU Hallmarks of the inflammatory process in Type I diabetes are macrophage activation, local release of β-cell-toxic cytokines...
Articles
Biochem J (2004) 381 (2): 503–510.
Published: 06 July 2004
... should be addressed (e-mail Philip.Bufler@med.uni-muenchen.de ). 9 2 2004 25 3 2004 26 3 2004 26 3 2004 The Biochemical Society, London 2004 cytokine gene regulation interleukin 1 lipopolysaccharide monocyte macrophage The IL-1 (interleukin 1) family is an...
Articles
Biochem J (2004) 380 (3): 651–659.
Published: 15 June 2004
... inflammatory and degenerative arthritis. In order to assess the role of HC-gp39 in matrix degradation induced by inflammatory cytokines, we have examined its effect on the responses of connective tissue cells to TNF-α (tumour necrosis factor-α) and IL-1 (interleukin-1) with respect to activation of signalling...
Articles
Biochem J (2004) 380 (2): 425–433.
Published: 01 June 2004
... murine T-cells. In the present study, we found that antigen-induced airway eosinophilia, a typical response dependent on Th2 (T-helper cell type 2) cytokines, as well as mRNA expression of Th2 cytokines, including IL-4, are suppressed in Neu-1-deficient mice, thereby demonstrating the in vivo role of...
Articles
Biochem J (2004) 377 (3): 763–768.
Published: 01 February 2004
... Biochemical Society, London ©2004 2004 cytokine gene regulation sepsis transcription transcription factor Abbreviations used: DEX, dexamethasone; EMSA, electrophoretic mobility-shift assay; GST, glutathione S-transferase; HNF1, hepatic nuclear factor 1; IL, interleukin; IL6DEX-NP, IL-6-plus...
Articles
Biochem J (2003) 376 (3): 545–552.
Published: 15 December 2003
... cytokine immune cell signalling inflammation macrophage protein kinase C (PKC) T-cell receptor (TCR) Abbreviations used: AP-1, activator protein-1; APC, antigen-presenting cell; BCR, B-cell receptor; Btk, Bruton's tyrosine kinase; CARD, caspase recruitment domain; CARMA1, CARD/membrane...
Articles
Biochem J (2003) 375 (1): 23–32.
Published: 01 October 2003
...Dimitri HARMEGNIES; Xiao-Ming WANG; Paul VANDENBUSSCHE; Arnaud LEON; Patricia VUSIO; Joachim GRÖTZINGER; Yannick JACQUES; Erik GOORMAGHTIGH; Bart DEVREESE; Jean CONTENT Human interleukin-11 (hIL-11) is a multi-potential cytokine that is involved in numerous biological activities, such as...
Articles
Biochem J (2003) 372 (2): 495–502.
Published: 01 June 2003
...W. Douglas FAIRLIE; David De SOUZA; Nicos A. NICOLA; Manuel BACA Cytokines of the interleukin-6 family utilize the shared cytokine receptor gp130 in the formation of active signalling complexes. Tyrosine-757 (Y757) on this receptor is critical for negative regulation of gp130-mediated signalling...
Articles
Biochem J (2003) 371 (2): 395–403.
Published: 15 April 2003
..., London ©2003 2003 cytokine Fn14 signal transduction tumour necrosis factor (TNF) tumour-necrosis-factor-like weak inducer of apoptosis (TWEAK) Abbreviations used: aa, amino acid(s); AcNPV, Autographa californica nuclear polyhedrosis virus; AP-1, activator protein-1; CRE, cAMP...
Articles
Biochem J (2003) 371 (2): 603–608.
Published: 15 April 2003
...Atsushi SATO; Saburo SONE Type I interferons (IFNs) are cytokines that are used clinically as antiviral and antitumour agents. The interaction of IFNs with their heterodimeric type I IFN receptor comprised of IFNAR1 and IFNAR2 is a first step to inducing biological actions. Here, we describe the...
Articles
Biochem J (2003) 370 (2): 591–599.
Published: 01 March 2003
... authors have contributed equally to this work. 2 To whom correspondence should be addressed (e-mail cameier@bluewin.ch ). 12 8 2002 7 11 2002 8 11 2002 8 11 2002 The Biochemical Society, London ©2003 2003 cytokine long leptin receptor isoform (OB-Rb) monocyte...
Articles
Biochem J (2003) 369 (2): 331–339.
Published: 15 January 2003
... 10 2002 1 10 2002 The Biochemical Society, London ©2003 2003 cytokine inflammation transcription factor Abbreviations used: AcP, IL-1R accessory protein; BCA, bicinchoninic acid; EMSA, electrophoretic mobility shift assay; (E)GFP, (enhanced) green fluorescent protein; IL...
Articles
Biochem J (2002) 361 (1): 105–111.
Published: 17 December 2001
...Claude HAAN; Peter C. HEINRICH; Iris BEHRMANN We analysed the interaction of gp130, the common signal-transducing receptor chain of interleukin (IL)-6 type cytokines, with Jak1, the Janus family kinase which is crucial for signal transduction of this group of cytokines. With a truncated chimaeric...
Articles
Biochem J (2001) 360 (2): 285–294.
Published: 26 November 2001
...Eliana M. COCCIA; Emilia STELLACCI; Mauro VALTIERI; Barbara MASELLA; Tiziana FECCIA; Giovanna MARZIALI; John HISCOTT; Ugo TESTA; Cesare PESCHLE; Angela BATTISTINI Numerous transcription factors allow haematopoietic cells to respond to lineage- and stage-specific cytokines and to act as their...
Articles
Biochem J (2001) 357 (2): 373–383.
Published: 09 July 2001
... structure co-ordinates of T. spiralis MIF are in the PDB (file 1HFO). 12 1 2001 12 3 2001 26 4 2001 The Biochemical Society, London ©2001 2001 cytokine dopachrome tautomerase Trichuris Abbreviations used: AMSH, a signal-transducing adaptor protein involved in...
Articles
Biochem J (2001) 356 (2): 473–480.
Published: 24 May 2001
...Kathryn M. SCHUBERT; Vincent DURONIO Alterations in the expression of various Bcl-2 family members may act as one means by which a cell's survival may be regulated. The mechanism by which cytokines regulate expression of Bcl-2 family members was examined in the haemopoietic cell line TF-1. Cytokine...
Articles
Biochem J (2001) 355 (1): 29–38.
Published: 26 February 2001
... reduces fever, acute inflammation caused by local mediators such as cytokines, delayed hypersensitivity, and chronic and local inflammation [2]. The mechanism by which a-MSH exhibits immunomodulatory activities is not fully understood, but it is believed that a-MSH and related peptides have the potential...
Articles
Biochem J (2001) 354 (2): 233–242.
Published: 22 February 2001
... the first report of a designed peptide having a well-defined biological function as a novel cytokine, which may be an effective anti-angiogenic agent for therapeutic use against various pathological disorders, such as neoplasia, rheumatoid arthritis, diabetic retinopathy and restenosis. apoptosis...
Articles
Biochem J (2001) 354 (2): 439–446.
Published: 22 February 2001
...Chuen-Mao YANG; Chin-Sung CHIEN; Chuan-Chwan WANG; Yan-Mei HSU; Chi-Tso CHIU; Chih-Chung LIN; Shue-Fen LUO; Li-Der HSIAO Elevated levels of several cytokines including interleukin-1β (IL-1β) have been detected in airway fluid of asthmatic patients. Inhalation of IL-1β induced a bronchial hyper...
Articles
Biochem J (2000) 350 (1): 291–298.
Published: 09 August 2000
...David J. GRAINGER; Emma K. FROW The cytokine transforming growth factor β1 (TGF-β1) is secreted in a latent form that has no known biological activity. The conversion of latent TGF-β1 into its biologically active 25kDa form is thought to be an important step in the regulation of TGF-β activity...
Articles
Biochem J (2000) 345 (3): 741–747.
Published: 25 January 2000
...Daniel SLIVA; Minyi GU; Yuan Xiao ZHU; Jun CHEN; Schickwann TSAI; Xiaoping DU; Yu-Chung YANG Interleukin 9 (IL-9) exerts its pleiotropic effects through the IL-9 receptor (IL-9R) complex, which consists of the IL-9R α-chain, which determines the cytokine specificity, and the IL-2 receptor γ-chain...