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Articles

Globular C1q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function

Emma Anders, Daniel Nebel, Johannes Westman, Heiko Herwald, Bengt-Olof Nilsson, Daniel Svensson

Biochem J (2018) 475 (4): 775–786.

https://doi.org/10.1042/BCJ20170857

Published: 23 February 2018

... ) 9 11 2017 16 1 2018 18 1 2018 22 1 2018 © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2018 cytokine gC1qR (gC1qBP) inflammation MCP-1 (CCL2) periodontal ligament cells (PDL cells) protein–protein interactions...

View articletitled, Globular C1q receptor (p33) binds and stabilizes pro-inflammatory MCP-1: a novel mechanism for regulation of MCP-1 production and function

Includes: Supplementary data

Articles

miR-429 regulates alveolar macrophage inflammatory cytokine production and is involved in LPS-induced acute lung injury

Ji Xiao, Jing Tang, Quan Chen, Dan Tang, Meimei Liu, Min Luo, Yan Wang, Jiazheng Wang, Zhenyu Zhao, Chaoke Tang, Deming Wang, Zhongcheng Mo

Biochem J (2015) 471 (2): 281–291.

https://doi.org/10.1042/BJ20131510

Published: 02 October 2015

... to LPS (lipopolysaccharide) stimulation and the miR-429 mimics increased the production of pro-inflammatory cytokines. However, anti- miR-429 reduced the LPS-induced production of pro-inflammatory cytokines. These results provide direct evidence that miR-429 is involved in the LPS-induced inflammatory...

View articletitled, miR-429 regulates alveolar macrophage inflammatory cytokine production and is involved in LPS-induced acute lung injury

Includes: Supplementary data

Articles

Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

Ivan H. W. Ng, Dominic C. H. Ng, David A. Jans, Marie A. Bogoyevitch

Biochem J (2012) 447 (1): 125–136.

https://doi.org/10.1042/BJ20120941

Published: 12 September 2012

... of STAT3α, gene knockout studies have revealed that both forms play critical roles. We have expressed STAT3α and STAT3β at comparable levels to facilitate a direct comparison of their functional effects, and have shown their different cytokine-stimulated kinetics of phosphorylation and nuclear translocation...

View articletitled, Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes

Includes: Supplementary data

Articles

Effects of the novel mitochondrial protein mimitin in insulin-secreting cells

Katarzyna Hanzelka, Lukasz Skalniak, Jolanta Jura, Sigurd Lenzen, Ewa Gurgul-Convey

Biochem J (2012) 445 (3): 349–359.

https://doi.org/10.1042/BJ20111920

Published: 13 July 2012

...Katarzyna Hanzelka; Lukasz Skalniak; Jolanta Jura; Sigurd Lenzen; Ewa Gurgul-Convey Mimitin, a novel mitochondrial protein, has been shown to act as a molecular chaperone for the mitochondrial complex I and to regulate ATP synthesis. During Type 1 diabetes development, pro-inflammatory cytokines...

View articletitled, Effects of the novel mitochondrial protein mimitin in insulin-secreting cells

Articles

The human NUPR1/P8 gene is transcriptionally activated by transforming growth factor β via the SMAD signalling pathway

Roxane M. Pommier, Johann Gout, David F. Vincent, Carla E. Cano, Bastien Kaniewski, Sylvie Martel, Jonathan Rodriguez, Geneviève Fourel, Ulrich Valcourt, Julien C. Marie, Juan L. Iovanna, Laurent Bartholin

Biochem J (2012) 445 (2): 285–293.

https://doi.org/10.1042/BJ20120368

Published: 27 June 2012

..., which are more or less specific to a given stress factor. 5 3 2012 1 5 2012 1 5 2012 27 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cytokine nuclear protein 1 (NUPR1) promoter SMAD stress transforming growth factor β (TGFβ) Among...

View articletitled, The human NUPR1/P8 gene is transcriptionally activated by transforming growth factor β via the SMAD signalling pathway

Includes: Supplementary data

Articles

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter

Maria A. Whitehead, Michele Bombardieri, Costantino Pitzalis, Bart Vanhaesebroeck

Biochem J (2012) 443 (3): 857–867.

https://doi.org/10.1042/BJ20112214

Published: 16 April 2012

...://creativecommons.org/licenses/by-nc/2.5/ ) which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. bioinformatics cytokine inflammation promoter PIK3CD tumour necrosis factor α (TNFα) Antibodies were as follows: anti...

View articletitled, Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter

Includes: Supplementary data

Articles

Steroid-like signalling by interferons: making sense of specific gene activation by cytokines

Howard M. Johnson, Ezra N. Noon-Song, Kaisa Kemppainen, Chulbul M. Ahmed

Biochem J (2012) 443 (2): 329–338.

https://doi.org/10.1042/BJ20112187

Published: 27 March 2012

...Howard M. Johnson; Ezra N. Noon-Song; Kaisa Kemppainen; Chulbul M. Ahmed Many cytokines, hormones and growth factors use the JAK (Janus kinase)/STAT (signal transducer and activator of transcription) pathway for cell signalling and specific gene activation. In the classical model, ligand is said...

View articletitled, Steroid-like signalling by interferons: making sense of specific gene activation by cytokines

Includes: Multimedia, Supplementary data

Articles

Epithelial–mesenchymal interaction during UVB-induced up-regulation of neutral endopeptidase

Hiroaki Nakajima, Yoshiyuki Ezaki, Tomoyashu Nagai, Ryosuke Yoshioka, Genji Imokawa

Biochem J (2012) 443 (1): 297–305.

https://doi.org/10.1042/BJ20111876

Published: 14 March 2012

... are intrinsic cytokines secreted by UVB-exposed keratinocytes that stimulate expression of NEP by fibroblasts. cytokine elastase fibroblast neutral endopeptidase (NEP) skin wrinkling UV light 1 To whom correspondence should be addressed (email [email protected] ). 20 10 2011...

View articletitled, Epithelial–mesenchymal interaction during UVB-induced up-regulation of neutral endopeptidase

Articles

Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

Maria N. Navarro, Linda V. Sinclair, Carmen Feijoo-Carnero, Rosemary Clarke, Sharon A. Matthews, Doreen A. Cantrell

Biochem J (2012) 442 (3): 649–659.

https://doi.org/10.1042/BJ20111700

Published: 24 February 2012

... is properly cited. cytokine lymphocyte pre-cell antigen receptor protein kinase D (PKD) T-cell antigen receptor (TCR) thymus Accordingly, to explore in detail the role of PKD2 in thymocyte development we backcrossed mice expressing defined α/β TCRs to either PKD2 null mice or mice deficient...

View articletitled, Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells

Includes: Supplementary data

Articles

Induction of group IVC phospholipase A 2 in allergic asthma: transcriptional regulation by TNFα in bronchoepithelial cells

Justin S. Bickford, Kimberly J. Newsom, John-David Herlihy, Christian Mueller, Benjamin Keeler, Xiaolei Qiu, Jewell N. Walters, Nan Su, Shannon M. Wallet, Terence R. Flotte, Harry S. Nick

Biochem J (2012) 442 (1): 127–137.

https://doi.org/10.1042/BJ20111269

Published: 27 January 2012

...-Jun, p65–p65 and USF (upstream stimulating factor) 1–USF2 complexes are recruited to the cPLA 2 γ enhancer/promoter in response to TNFα, with overexpression and dominant-negative studies implying a strong level of co-operation and interplay between these factors. Overall, our results link cytokine...

View articletitled, Induction of group IVC phospholipase A 2 in allergic asthma: transcriptional regulation by TNFα in bronchoepithelial cells

Includes: Supplementary data

Articles

RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation

Jung Ha Kim, Kabsun Kim, Bang Ung Youn, Hye Mi Jin, Ji-Young Kim, Jang Bae Moon, Aeran Ko, Sang-Beom Seo, Kwang-Youl Lee, Nacksung Kim

Biochem J (2011) 436 (2): 253–262.

https://doi.org/10.1042/BJ20110062

Published: 13 May 2011

... sequence (5′-TATGCAGTCGTCGAGGAATTG-3′). cytokine nuclear factor of activated T-cells (NFAT) osteoclastogenesis post-translational modification receptor activator of NF-κB (nuclear factor κB) ligand (RANKL) transcription factor Next, we tested whether HAT proteins, such as p300 and PCAF...

View articletitled, RANKL induces NFATc1 acetylation and stability via histone acetyltransferases during osteoclast differentiation

Includes: Supplementary data

Articles

Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells

Christopher J. Clarke, Emily A. Cloessner, Patrick L. Roddy, Yusuf A. Hannun

Biochem J (2011) 435 (2): 381–390.

https://doi.org/10.1042/BJ20101752

Published: 29 March 2011

...Christopher J. Clarke; Emily A. Cloessner; Patrick L. Roddy; Yusuf A. Hannun Activation of N-SMase (neutral sphingomyelinase) is an established part of the response of cytokines such as TNF (tumour necrosis factor)-α. However, it remains unclear which of the currently cloned N-SMase isoforms...

View articletitled, Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells

Includes: Supplementary data

Articles

Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

Sharon A. Matthews, Maria N. Navarro, Linda V. Sinclair, Elizabeth Emslie, Carmen Feijoo-Carnero, Doreen A. Cantrell

Biochem J (2010) 432 (1): 153–163.

https://doi.org/10.1042/BJ20101188

Published: 25 October 2010

..., required for efficient antigen receptor-induced cytokine production in T-lymphocytes and for optimal T-cell-dependent antibody responses in vivo . Our results reveal a key in vivo role for PKD2 in regulating the function of mature peripheral lymphocytes during adaptive immune responses. They also confirm...

View articletitled, Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells

Articles

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

Christopher C. Rider, Barbara Mulloy

Biochem J (2010) 429 (1): 1–12.

https://doi.org/10.1042/BJ20100305

Published: 14 June 2010

...Christopher C. Rider; Barbara Mulloy The BMPs (bone morphogenetic proteins) and the GDFs (growth and differentiation factors) together form a single family of cystine-knot cytokines, sharing the characteristic fold of the TGFβ (transforming growth factor-β) superfamily. Besides the ability...

View articletitled, Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

Includes: Supplementary data

Articles

Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)

Janet V. Cross, Joshua M. Rady, Frank W. Foss, Jr, Charles E. Lyons, Timothy L. Macdonald, Dennis J. Templeton

Biochem J (2009) 423 (3): 315–321.

https://doi.org/10.1042/BJ20091170

Published: 12 October 2009

...: Department of Chemistry and Biochemistry, University of Texas at Arlington, Arlington, TX 76019, U.S.A. 30 7 2009 20 8 2009 1 9 2009 1 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 cancer cytokine inflammation isothiocyanate (ITC) macrophage...

View articletitled, Nutrient isothiocyanates covalently modify and inhibit the inflammatory cytokine macrophage migration inhibitory factor (MIF)

Includes: Supplementary data

Articles

Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signalling

Bärbel Schröfelbauer, Johanna Raffetseder, Maria Hauner, Andrea Wolkerstorfer, Wolfgang Ernst, Oliver H. J. Szolar

Biochem J (2009) 421 (3): 473–482.

https://doi.org/10.1042/BJ20082416

Published: 15 July 2009

... Biochemical Society 2009 cell membrane cytokine glycyrrhizin inflammation signalling Toll-like receptor (TLR) RAW 264.7 cells were incubated for 60 min with 40 nM FITC-labelled CpG-ODN (InvivoGen) with or without glycyrrhizin, washed twice in PBS, fixed with 4% (w/v) paraformaldehyde for 10...

View articletitled, Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signalling

Includes: Supplementary data

Articles

Modulation of hepatocyte nuclear factor-4α function by the peroxisome-proliferator-activated receptor-γ co-activator-1α in the acute-phase response

Zhongyan Wang, Peter A. Burke

Biochem J (2008) 415 (2): 289–296.

https://doi.org/10.1042/BJ20080355

Published: 25 September 2008

... regulated at the DNA binding and transcriptional levels after cytokine stimulation. We now show that co-activators have a differential impact on the transactivation of HNF-4α-sensitive genes via HNF-4α-binding sites in ApoB , TTR or α 1 - AT promoters. PGC-1α strongly enhances the transactivation of ApoB...

View articletitled, Modulation of hepatocyte nuclear factor-4α function by the peroxisome-proliferator-activated receptor-γ co-activator-1α in the acute-phase response

Articles

The cross-talk between NF-κB and HIF-1: further evidence for a significant liaison

Agnes Görlach, Steve Bonello

Biochem J (2008) 412 (3): e17–e19.

https://doi.org/10.1042/BJ20080920

Published: 28 May 2008

... evidence has emerged that HIF-1α is also responsive to many stimuli under normoxic conditions, including thrombin, growth factors, vasoactive peptides, insulin, lipopolysaccharide and cytokines such as TNF-α (tumour necrosis factor-α), and in many cases reactive oxygen species are involved. One important...

View articletitled, The cross-talk between NF-κB and HIF-1: further evidence for a significant liaison

Articles

Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation

Radoslaw M. Sobota, Pia J. Müller, Peter C. Heinrich, Fred Schaper

Biochem J (2008) 412 (1): 65–72.

https://doi.org/10.1042/BJ20071572

Published: 25 April 2008

... factor for T-cells and is a potent inducer of the chemokine MCP-1 (monocyte chemoattractant protein-1). Recent studies have focused on the negative regulation of IL-6 signal transduction through the IL-6-induced feedback inhibitors SOCS (suppressor of cytokine signalling) 1 and SOCS3 or the protein...

View articletitled, Prostaglandin E1 inhibits IL-6-induced MCP-1 expression by interfering specifically in IL-6-dependent ERK1/2, but not STAT3, activation

Includes: Supplementary data

Articles

The pluripotency rheostat Nanog functions as a dimer

Nicholas P. Mullin, Adam Yates, Arthur J. Rowe, Bianca Nijmeijer, Douglas Colby, Paul N. Barlow, Malcolm D. Walkinshaw, Ian Chambers

Biochem J (2008) 411 (2): 227–231.

https://doi.org/10.1042/BJ20080134

Published: 27 March 2008

...Nicholas P. Mullin; Adam Yates; Arthur J. Rowe; Bianca Nijmeijer; Douglas Colby; Paul N. Barlow; Malcolm D. Walkinshaw; Ian Chambers The defining activity of the homeodomain protein Nanog is the ability to confer cytokine-independent self-renewal upon ES (embryonic stem) cells in which...

View articletitled, The pluripotency rheostat Nanog functions as a dimer

Includes: Supplementary data

Articles

Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling

Meng Lin, Stefan Rose-John, Joachim Grötzinger, Udo Conrad, Jürgen Scheller

Biochem J (2006) 398 (3): 577–583.

https://doi.org/10.1042/BJ20060544

Published: 29 August 2006

... as an ELP (elastin-like peptide)-fusion protein (mini-gp130–ELP). Mini-gp130–ELP consists of the first three domains of gp130 (Ig-like domain and cytokine binding module) fused to 100 repeats of ELP. Expression of mini-gp130–ELP did not affect the growth rate or morphology of the transgenic plants...

View articletitled, Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling

Includes: Supplementary data

Articles

Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis

Heping Cao, Leesa J. Deterding, John D. Venable, Elizabeth A. Kennington, John R. Yates, III, Kenneth B. Tomer, Perry J. Blackshear

Biochem J (2006) 394 (1): 285–297.

https://doi.org/10.1042/BJ20051316

Published: 27 January 2006

... phosphorylation sites in the anti-inflammatory protein TTP in mammalian cells and should provide the molecular basis for further studies on the function and regulation of TTP in controlling pro-inflammatory cytokines. EMSAs (electrophoretic mobility-shift assays) were performed to evaluate the ARE-binding...

View articletitled, Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis

Includes: Supplementary data

Articles

Intracellular signalling pathways activated by leptin

Gema Frühbeck

Biochem J (2006) 393 (1): 7–20.

https://doi.org/10.1042/BJ20051578

Published: 12 December 2005

...Gema Frühbeck Leptin is a versatile 16 kDa peptide hormone, with a tertiary structure resembling that of members of the long-chain helical cytokine family. It is mainly produced by adipocytes in proportion to fat size stores, and was originally thought to act only as a satiety factor. However...

View articletitled, Intracellular signalling pathways activated by leptin

Articles

A role for tumour necrosis factor α in human small bowel iron transport

Naveen Sharma, Abas H. Laftah, Matthew J. Brookes, Brian Cooper, Tariq Iqbal, Chris Tselepis

Biochem J (2005) 390 (2): 437–446.

https://doi.org/10.1042/BJ20050256

Published: 23 August 2005

...Naveen Sharma; Abas H. Laftah; Matthew J. Brookes; Brian Cooper; Tariq Iqbal; Chris Tselepis Cytokines are integral to the development of anaemia of chronic inflammation. Cytokines modulate hepcidin expression and iron sequestration by the reticuloendothelial system but their direct effects...

View articletitled, A role for tumour necrosis factor α in human small bowel iron transport

Articles

Activation of RelA homodimers by tumour necrosis factor α: a possible transcriptional activator in human vascular endothelial cells

Nobuyuki Marui, Russell M. Medford, Mushtaq Ahmad

Biochem J (2005) 390 (1): 317–324.

https://doi.org/10.1042/BJ20041659

Published: 09 August 2005

...Nobuyuki Marui; Russell M. Medford; Mushtaq Ahmad In vascular endothelial cells, cytokines induce genes that are expressed in inflammatory lesions partly through the activation of transcription factor NF-κB (nuclear factor-κB). Among the members of the NF-κB/rel protein family, homodimers...

View articletitled, Activation of RelA homodimers by tumour necrosis factor α: a possible transcriptional activator in human vascular endothelial cells

Articles

Sp3 is involved in the regulation of SOCS3 gene expression

Christian EHLTING, Dieter HÄUSSINGER, Johannes G. BODE

Biochem J (2005) 387 (3): 737–745.

https://doi.org/10.1042/BJ20041101

Published: 26 April 2005

...Christian EHLTING; Dieter HÄUSSINGER; Johannes G. BODE Cytokine-induced expression of SOCS (suppressor of cytokine signalling) molecules is important for the negative regulatory control of STAT (signal transduction and activators of transcription)-dependent cytokine signalling, e.g. for the signal...

View articletitled, Sp3 is involved in the regulation of SOCS3 gene expression

Articles

Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-κB activation and interleukin-8 secretion in human bronchial epithelial cells

Yutong ZHAO, Peter V. USATYUK, Rhett CUMMINGS, Bahman SAATIAN, Donghong HE, Tonya WATKINS, Andrew MORRIS, Ernst Wm. SPANNHAKE, David N. BRINDLEY, Viswanathan NATARAJAN

Biochem J (2005) 385 (2): 493–502.

https://doi.org/10.1042/BJ20041160

Published: 07 January 2005

... (Amersham). bioactive phospholipid cytokine inflammation interleukin-8 secretion lipid phosphate phosphatase-1 (LPP-1) lysophosphatidic acid (LPA) The bioactive phospholipids LPA (lysophosphatidic acid) and S1P (sphingosine 1-phosphate) are present in biological fluids and tissues [ 1...

View articletitled, Lipid phosphate phosphatase-1 regulates lysophosphatidic acid-induced calcium release, NF-κB activation and interleukin-8 secretion in human bronchial epithelial cells

Articles

Tumour necrosis factor α (TNF)–TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling

Gabriele SASS, Noula D. SHEMBADE, Gisa TIEGS

Biochem J (2005) 385 (2): 537–544.

https://doi.org/10.1042/BJ20040279

Published: 07 January 2005

... proteins and possible mediators of TNF tolerance. In vitro experiments revealed that overexpression of SOCS1 (silencer of cytokine signalling 1), a member of the SOCS family of proteins, as well as of HO-1 (haem oxygenase-1), but not of SOCS2 or SOCS3, protected isolated primary mouse hepatocytes from TNF...

View articletitled, Tumour necrosis factor α (TNF)–TNF receptor 1-inducible cytoprotective proteins in the mouse liver: relevance of suppressors of cytokine signalling

Includes: Supplementary data

Articles

Sp1 and Smad transcription factors co-operate to mediate TGF-β-dependent activation of amyloid-β precursor protein gene transcription

Fabian DOCAGNE, Cecilia GABRIEL, Nathalie LEBEURRIER, Sylvain LESNÉ, Yannick HOMMET, Laurent PLAWINSKI, Eric T. MacKENZIE, Denis VIVIEN

Biochem J (2004) 383 (2): 393–399.

https://doi.org/10.1042/BJ20040682

Published: 08 October 2004

...) according to the manufacturer's instructions. Alzheimer's disease cytokine luciferase promoter Smad transforming growth factor-β AD (Alzheimer's disease) is a neurodegenerative disease associated with progressive memory loss and leading to dementia. Two histological characteristics...

View articletitled, Sp1 and Smad transcription factors co-operate to mediate TGF-β-dependent activation of amyloid-β precursor protein gene transcription

Articles

The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity

Michael WELSH, Charlotte WELSH, Maria EKMAN, Johan DIXELIUS, Robert HÄGERKVIST, Cecilia ANNERÉN, Björn ÅKERBLOM, Siavosh MAHBOOBI, Subhashini CHANDRASEKHARAN, Edison T. LIU

Biochem J (2004) 382 (1): 261–268.

https://doi.org/10.1042/BJ20040285

Published: 10 August 2004

...Michael WELSH; Charlotte WELSH; Maria EKMAN; Johan DIXELIUS; Robert HÄGERKVIST; Cecilia ANNERÉN; Björn ÅKERBLOM; Siavosh MAHBOOBI; Subhashini CHANDRASEKHARAN; Edison T. LIU Hallmarks of the inflammatory process in Type I diabetes are macrophage activation, local release of β-cell-toxic cytokines...

View articletitled, The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity

Articles

Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide

Philip BUFLER, Fabia GAMBONI-ROBERTSON, Tania AZAM, Soo-Hyun KIM, Charles A. DINARELLO

Biochem J (2004) 381 (2): 503–510.

https://doi.org/10.1042/BJ20040217

Published: 06 July 2004

... 26 3 2004 26 3 2004 The Biochemical Society, London 2004 cytokine gene regulation interleukin 1 lipopolysaccharide monocyte macrophage The IL-1 (interleukin 1) family is an expanding family of cytokines sharing a similar all β-barrel structure consisting of 12 β...

View articletitled, Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide

Articles

The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

Hua LING, Anneliese D. RECKLIES

Biochem J (2004) 380 (3): 651–659.

https://doi.org/10.1042/bj20040099

Published: 15 June 2004

... with inflammatory and degenerative arthritis. In order to assess the role of HC-gp39 in matrix degradation induced by inflammatory cytokines, we have examined its effect on the responses of connective tissue cells to TNF-α (tumour necrosis factor-α) and IL-1 (interleukin-1) with respect to activation of signalling...

View articletitled, The chitinase 3-like protein human cartilage glycoprotein 39 inhibits cellular responses to the inflammatory cytokines interleukin-1 and tumour necrosis factor-alpha

Articles

Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor

Peng WANG, Ji ZHANG, Hong BIAN, Ping WU, Reshma KUVELKAR, Ted T. KUNG, Yvette CRAWLEY, Robert W. EGAN, M. Motasim BILLAH

Biochem J (2004) 380 (2): 425–433.

https://doi.org/10.1042/bj20031896

Published: 01 June 2004

... in murine T-cells. In the present study, we found that antigen-induced airway eosinophilia, a typical response dependent on Th2 (T-helper cell type 2) cytokines, as well as mRNA expression of Th2 cytokines, including IL-4, are suppressed in Neu-1-deficient mice, thereby demonstrating the in vivo role...

View articletitled, Induction of lysosomal and plasma membrane-bound sialidases in human T-cells via T-cell receptor

Articles

Decreased expression levels of rat liver glutathione S-transferase A2 and albumin during the acute phase response are mediated by HNF1 (hepatic nuclear factor 1) and IL6DEX-NP

Richard WHALEN, Susan H. VOSS, Thomas D. BOYER

Biochem J (2004) 377 (3): 763–768.

https://doi.org/10.1042/bj20031256

Published: 01 February 2004

... to increased IL6DEX-NP binding. IL6DEX-NP appears to be an important negative regulator of gene expression in vitro and in vivo . cytokine gene regulation sepsis transcription transcription factor Abbreviations used: DEX, dexamethasone; EMSA, electrophoretic mobility-shift assay; GST...

View articletitled, Decreased expression levels of rat liver glutathione S-transferase A2 and albumin during the acute phase response are mediated by HNF1 (hepatic nuclear factor 1) and IL6DEX-NP

Articles

Emerging and diverse roles of protein kinase C in immune cell signalling

Seng-Lai TAN, Peter J. PARKER

Biochem J (2003) 376 (3): 545–552.

https://doi.org/10.1042/bj20031406

Published: 15 December 2003

... their actions could point to new avenues for development of treatments for immune disorders. 1 To whom correspondence should be addressed (e-mail [email protected] ). 16 9 2003 20 10 2003 22 10 2003 22 10 2003 The Biochemical Society, London ©2003 2003 cytokine immune...

View articletitled, Emerging and diverse roles of protein kinase C in immune cell signalling

Articles

Characterization of a potent human interleukin-11 agonist

Dimitri HARMEGNIES, Xiao-Ming WANG, Paul VANDENBUSSCHE, Arnaud LEON, Patricia VUSIO, Joachim GRÖTZINGER, Yannick JACQUES, Erik GOORMAGHTIGH, Bart DEVREESE, Jean CONTENT

Biochem J (2003) 375 (1): 23–32.

https://doi.org/10.1042/bj20030459

Published: 01 October 2003

...Dimitri HARMEGNIES; Xiao-Ming WANG; Paul VANDENBUSSCHE; Arnaud LEON; Patricia VUSIO; Joachim GRÖTZINGER; Yannick JACQUES; Erik GOORMAGHTIGH; Bart DEVREESE; Jean CONTENT Human interleukin-11 (hIL-11) is a multi-potential cytokine that is involved in numerous biological activities...

View articletitled, Characterization of a potent human interleukin-11 agonist

Articles

Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2

W. Douglas FAIRLIE, David De SOUZA, Nicos A. NICOLA, Manuel BACA

Biochem J (2003) 372 (2): 495–502.

https://doi.org/10.1042/bj20030104

Published: 01 June 2003

...W. Douglas FAIRLIE; David De SOUZA; Nicos A. NICOLA; Manuel BACA Cytokines of the interleukin-6 family utilize the shared cytokine receptor gp130 in the formation of active signalling complexes. Tyrosine-757 (Y757) on this receptor is critical for negative regulation of gp130-mediated signalling...

View articletitled, Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2

Articles

A peptide mimetic of human interferon (IFN)-beta

Atsushi SATO, Saburo SONE

Biochem J (2003) 371 (2): 603–608.

https://doi.org/10.1042/bj20020993

Published: 15 April 2003

...Atsushi SATO; Saburo SONE Type I interferons (IFNs) are cytokines that are used clinically as antiviral and antitumour agents. The interaction of IFNs with their heterodimeric type I IFN receptor comprised of IFNAR1 and IFNAR2 is a first step to inducing biological actions. Here, we describe...

View articletitled, A peptide mimetic of human interferon (IFN)-beta

Articles

The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation

Sharron A.N. BROWN, Christine M. RICHARDS, Heather N. HANSCOM, Sheau-Line Y. FENG, Jeffrey A. WINKLES

Biochem J (2003) 371 (2): 395–403.

https://doi.org/10.1042/bj20021730

Published: 15 April 2003

..., London ©2003 2003 cytokine Fn14 signal transduction tumour necrosis factor (TNF) tumour-necrosis-factor-like weak inducer of apoptosis (TWEAK) Abbreviations used: aa, amino acid(s); AcNPV, Autographa californica nuclear polyhedrosis virus; AP-1, activator protein-1; CRE, cAMP...

View articletitled, The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation

Articles

Leptin activates the promoter of the interleukin-1 receptor antagonist through p42/44 mitogen-activated protein kinase and a composite nuclear factor kappaB/PU.1 binding site

Magali G. DREYER, Cristiana E. JUGE-AUBRY, Cem GABAY, Ursula LANG, Françoise ROHNER-JEANRENAUD, Jean-Michel DAYER, Christoph A. MEIER

Biochem J (2003) 370 (2): 591–599.

https://doi.org/10.1042/bj20021270

Published: 01 March 2003

... in transient transfection experiments, the protein INTRODUCTION Leptin is an adipocyte-derived cytokine-like peptide hormone regulating appetite and energy homoeostasis at the hypothalamic level [1]. However, leptin has also been shown to exhibit direct effects on other tissues [2 6]. While we and others have...

View articletitled, Leptin activates the promoter of the interleukin-1 receptor antagonist through p42/44 mitogen-activated protein kinase and a composite nuclear factor kappaB/PU.1 binding site

Articles

Regulation of nuclear translocation of nuclear factor-kappaB relA: evidence for complex dynamics at the single-cell level

Kenneth SCHOOLEY, Ping ZHU, Steven K. DOWER, Eva E. QWARNSTRÖM

Biochem J (2003) 369 (2): 331–339.

https://doi.org/10.1042/bj20020253

Published: 15 January 2003

... in the response to IL-1. The single-cell assay revealed the presence of responder and non- responder subpopulations, with an enhanced proportion of INTRODUCTION The nuclear factor-jB (NF-jB) pathway, which is central in regulation of the inflammatory response [1], is activated by cytokines such as interleukin-1...

View articletitled, Regulation of nuclear translocation of nuclear factor-kappaB relA: evidence for complex dynamics at the single-cell level

Articles

Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation

Claude HAAN, Peter C. HEINRICH, Iris BEHRMANN

Biochem J (2002) 361 (1): 105–111.

https://doi.org/10.1042/bj3610105

Published: 17 December 2001

...Claude HAAN; Peter C. HEINRICH; Iris BEHRMANN We analysed the interaction of gp130, the common signal-transducing receptor chain of interleukin (IL)-6 type cytokines, with Jak1, the Janus family kinase which is crucial for signal transduction of this group of cytokines. With a truncated chimaeric...

View articletitled, Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation

Articles

Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation

Eliana M. COCCIA, Emilia STELLACCI, Mauro VALTIERI, Barbara MASELLA, Tiziana FECCIA, Giovanna MARZIALI, John HISCOTT, Ugo TESTA, Cesare PESCHLE, Angela BATTISTINI

Biochem J (2001) 360 (2): 285–294.

https://doi.org/10.1042/bj3600285

Published: 26 November 2001

...Eliana M. COCCIA; Emilia STELLACCI; Mauro VALTIERI; Barbara MASELLA; Tiziana FECCIA; Giovanna MARZIALI; John HISCOTT; Ugo TESTA; Cesare PESCHLE; Angela BATTISTINI Numerous transcription factors allow haematopoietic cells to respond to lineage- and stage-specific cytokines and to act...

View articletitled, Ectopic expression of interferon regulatory factor-1 potentiates granulocytic differentiation

Articles

Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis

Timothy H. P. TAN, Steve A. V. EDGERTON, Rashmi KUMARI, Mark S. B. McALISTER, S. Mark ROWE, Sylvia NAGL, Laurence H. PEARL, Murray E. SELKIRK, Albert E. BIANCO, Nicholas F. TOTTY, Chris ENGWERDA, Carolyn A. GRAY, David J. MEYER

Biochem J (2001) 357 (2): 373–383.

https://doi.org/10.1042/bj3570373

Published: 09 July 2001

...). In conclusion TsMIF has structural, catalytic and cell-migration-inhibitory properties which indicate that it is partially orthologous to mammalian MIF. Key words: cytokine, dopachrome, tautomerase, Trichuris. A homologue of macrophage migration-inhibitory factor (MIF) was the first molecule isolated from T...

View articletitled, Macrophage migration inhibitory factor of the parasitic nematode Trichinella spiralis

Articles

Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis

Kathryn M. SCHUBERT, Vincent DURONIO

Biochem J (2001) 356 (2): 473–480.

https://doi.org/10.1042/bj3560473

Published: 24 May 2001

...Kathryn M. SCHUBERT; Vincent DURONIO Alterations in the expression of various Bcl-2 family members may act as one means by which a cell's survival may be regulated. The mechanism by which cytokines regulate expression of Bcl-2 family members was examined in the haemopoietic cell line TF-1. Cytokine...

View articletitled, Distinct roles for extracellular-signal-regulated protein kinase (ERK) mitogen-activated protein kinases and phosphatidylinositol 3-kinase in the regulation of Mcl-1 synthesis

Articles

α-Melanocyte-related tripeptide, Lys-d-Pro-Val, ameliorates endotoxin-induced nuclear factor κB translocation and activation: evidence for involvement of an interleukin-1β193–195 receptor antagonism in the alveolar epithelium

John J. E. HADDAD, Ryszard LAUTERBACH, Nayef E. SAADÉ, Bared SAFIEH-GARABEDIAN, Stephen C. LAND

Biochem J (2001) 355 (1): 29–38.

https://doi.org/10.1042/bj3550029

Published: 26 February 2001

..., acute inflammation caused by local mediators such as cytokines, delayed hypersensitivity, and chronic and local inflammation [2]. The mechanism by which a-MSH exhibits immunomodulatory activities is not fully understood, but it is believed that a-MSH and related peptides have the potential to down...

View articletitled, α-Melanocyte-related tripeptide, Lys-d-Pro-Val, ameliorates endotoxin-induced nuclear factor κB translocation and activation: evidence for involvement of an interleukin-1β193–195 receptor antagonism in the alveolar epithelium

Articles

Anginex, a designed peptide that inhibits angiogenesis

Arjan W. GRIFFIOEN, Daisy W. J. VAN DER SCHAFT, Annemarie F. BARENDSZ-JANSON, Andrew COX, Harry A. J. STRUIJKER BOUDIER, Harry F. P. HILLEN, Kevin H. MAYO

Biochem J (2001) 354 (2): 233–242.

https://doi.org/10.1042/bj3540233

Published: 22 February 2001

.... This is the first report of a designed peptide having a well-defined biological function as a novel cytokine, which may be an effective anti-angiogenic agent for therapeutic use against various pathological disorders, such as neoplasia, rheumatoid arthritis, diabetic retinopathy and restenosis. 1 To whom...

View articletitled, Anginex, a designed peptide that inhibits angiogenesis

Articles

Interleukin-1β enhances bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization in canine tracheal smooth-muscle cells: involvement of the Ras/Raf/mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway

Chuen-Mao YANG, Chin-Sung CHIEN, Chuan-Chwan WANG, Yan-Mei HSU, Chi-Tso CHIU, Chih-Chung LIN, Shue-Fen LUO, Li-Der HSIAO

Biochem J (2001) 354 (2): 439–446.

https://doi.org/10.1042/bj3540439

Published: 22 February 2001

...Chuen-Mao YANG; Chin-Sung CHIEN; Chuan-Chwan WANG; Yan-Mei HSU; Chi-Tso CHIU; Chih-Chung LIN; Shue-Fen LUO; Li-Der HSIAO Elevated levels of several cytokines including interleukin-1β (IL-1β) have been detected in airway fluid of asthmatic patients. Inhalation of IL-1β induced a bronchial hyper...

View articletitled, Interleukin-1β enhances bradykinin-induced phosphoinositide hydrolysis and Ca2+ mobilization in canine tracheal smooth-muscle cells: involvement of the Ras/Raf/mitogen-activated protein kinase (MAPK) kinase (MEK)/MAPK pathway

Articles

Thrombospondin 1 does not activate transforming growth factor β1 in a chemically defined system or in smooth-muscle-cell cultures

David J. GRAINGER, Emma K. FROW

Biochem J (2000) 350 (1): 291–298.

https://doi.org/10.1042/bj3500291

Published: 09 August 2000

...David J. GRAINGER; Emma K. FROW The cytokine transforming growth factor β1 (TGF-β1) is secreted in a latent form that has no known biological activity. The conversion of latent TGF-β1 into its biologically active 25kDa form is thought to be an important step in the regulation of TGF-β activity...

View articletitled, Thrombospondin 1 does not activate transforming growth factor β1 in a chemically defined system or in smooth-muscle-cell cultures

Articles

14-3-3ζ interacts with the α-chain of human interleukin 9 receptor

Daniel SLIVA, Minyi GU, Yuan Xiao ZHU, Jun CHEN, Schickwann TSAI, Xiaoping DU, Yu-Chung YANG

Biochem J (2000) 345 (3): 741–747.

https://doi.org/10.1042/bj3450741

Published: 25 January 2000

...Daniel SLIVA; Minyi GU; Yuan Xiao ZHU; Jun CHEN; Schickwann TSAI; Xiaoping DU; Yu-Chung YANG Interleukin 9 (IL-9) exerts its pleiotropic effects through the IL-9 receptor (IL-9R) complex, which consists of the IL-9R α-chain, which determines the cytokine specificity, and the IL-2 receptor γ-chain...

View articletitled, 14-3-3ζ interacts with the α-chain of human interleukin 9 receptor

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