... and receptor activation studies. cytokine receptor ectodomain granulocyte/macrophage colony-stimulating factor (GM-CSF) interleukin 3 (IL-3) interleukin 5 (IL-5) surface entropy reduction The cytokine interleukin-3 (IL-3) is a key factor in the regulation of haemopoietic stem and progenitor...

...Jeffrey J. Babon; Isabelle S. Lucet; James M. Murphy; Nicos A. Nicola; Leila N. Varghese The JAK (Janus kinase) family members serve essential roles as the intracellular signalling effectors of cytokine receptors. This family, comprising JAK1, JAK2, JAK3 and TYK2 (tyrosine kinase 2), was first...

...Que T. Lambert; Anuradha Pradhan; J. Devon Roll; Gary W. Reuther Cytokines and their receptors regulate haemopoiesis by controlling cellular growth, survival and differentiation. Thus it is not surprising that mutations of cytokine receptors contribute to the formation of haemopoietic disorders...

... to the cytokine class I receptor superfamily (or haemopoietin receptor family), which includes GHR [GH (growth hormone) receptor], the EPO (erythropoietin) receptor, gp130 and IL-4R (IL-4 receptor)/IL-13R (IL-13 receptor). The characteristic feature of this family is the extracellular cytokine-receptor homology...

... epithelial function and cancer; (iii) the interplay between β1 integrins and EGF (epidermal growth factor) receptor; (iv) signal integration connecting integrins and cytokine receptors for interleukins, prolactin and interferons; and (v) how integrins and syndecans co-operate in cell migration. 1...

... domains. Several members, including CIS (cytokine-inducible SH2 protein), SOCS1 and SOCS3, are induced rapidly upon cytokine receptor activation and function in a negative-feedback loop, attenuating signalling at the receptor level. We used a recently developed mammalian two-hybrid system [MAPPIT...

... apoptosis cytokine receptor phosphatase protein kinase signal transduction Abbreviations used: [ 14 C]-SAPC, stearoyl-arachidonoyl-[ 14 C]phosphatidylcholine; cPLA 2 , cytosolic phospholipase A 2 ; fura 2/AM, fura 2 acetoxymethyl ester; [ 3 H]arachidonic acid, [5,6,8,9,11,12,14,15- 3 H(N...

... receptor. This gene, termed likely interleukin or cytokine receptor-2 ( LICR2 ), is located on chromosome 1, at 25kb from the IL22R (IL-22 receptor) gene, and is constitutively expressed in most tissues. A chimaeric receptor, consisting of the extracellular domain of the IL-10 receptorα chain...

... Society, London ©2002 2002 apoptosis cytokine receptor human protein kinase/phosphatase signal transduction Abbreviations used: ATF-2, activating transcription factor 2; cPLA 2 , cytosolic phospholipase A 2 ; CrmA, cytokine response modifier A; DMEM, Dulbecco's modified Eagle's medium...

... The Biochemical Society, London © 2001 2001 cytokine receptor inhibition signalling STAT Biochem. J. (2001) 353, 223 230 (Printed in Great Britain) 223 Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3) Florence MAGRANGEAS, Olivier...

..., London © 2000 2000 cytokine receptor interleukins Jak/STAT pathway Janus kinase Biochem. J. (2000) 349, 261 266 (Printed in Great Britain) 261 A single amino acid substitution (Trp666 ! Ala) in the interbox1/2 region of the interleukin-6 signal transducer gp130 abrogates binding of JAK1...