... are able to down-regulate surface IFNAR2 [ 15 ]. Signalling feedback controls operating at immediate–early times include serine/threonine kinase(s) and ubiquitin ligase(s) targeting the IFNAR1 subunit [ 16 , 17 ], as well as SOCS (suppressor of cytokine signalling)-mediated action on receptor–Jaks/Stats...

... specification cytokine signalling development mitogen-activated protein kinase (MAPK) self-renewal Embryonic development and maintenance of adult tissue homoeostasis are physiological processes where stem cells, which are characterized by their ability to self-renew and perpetuate themselves...

... containing 15% ethylene glycol, and were frozen in a nitrogen cryostream. A20 binding inhibitor of NF-κB (ABIN) cytokine signalling deubiquitinating enzyme inhibitor of κB kinase (IKK) Lys 63 -linked ubiquitin nuclear factor κB (NF-κB) TGF (transforming growth factor)-β-activated kinase (TAK1...

.... Dysregulation of IL-6-type cytokine signalling contributes to the onset and maintenance of several diseases, such as rheumatoid arthritis, inflammatory bowel disease, osteoporosis, multiple sclerosis and various types of cancer (e.g. multiple myeloma and prostate cancer). IL-6-type cytokines exert their action...

... 1 2000 The Biochemical Society, London © 2000 2000 cytokine signalling gp130 serine phosphorylation Biochem. J. (2000) 347, 89 96 (Printed in Great Britain) 89 Interleukin-6-induced STAT3 transactivation and Ser727 phosphorylation involves Vav, Rac-1 and the kinase SEK-1/MKK-4...

... The Biochemical Society, London © 2000 2000 cytokine signalling prolactin receptor proto-oncogenes tyrosine kinases Biochem. J. (2000) 345, 17 24 (Printed in Great Britain) 17 Stimulation of c-Src by prolactin is independent of Jak2 Juan A! ngel FRESNO VARA*, Mar !a Victoria CARRETERO*, Hayde! e GERO...