...Lorenza A. D’Alessandro; Ursula Klingmüller; Marcel Schilling In health and disease, liver cells are continuously exposed to cytokines and growth factors. While individual signal transduction pathways induced by these factors were studied in great detail, the cellular responses induced by repeated...

... was critical for cytokine expression induced by Syk-coupled CLRs — dectin-1 and macrophage-inducible C-type lectin. Immunoblotting analyses revealed that 3BP2 was required for the dectin-1-induced activation of NF-κB p65. The impaired expression of cytokines and activation of NF-κB in 3BP2-mutant cells were...

... transfection lowered Smyd1 protein stability. Incubation of EA.hy926 cells with the pro-inflammatory cytokine TNF-α resulted in a constant increase in Smyd1 mRNA and protein over 24 h, while incubation with IFN-γ induced a transient increase in Smyd1 expression, which peaked at 6 h and decreased to control...

...Jeffrey J. Babon; Dina Stockwell; Ladina DiRago; Jian-Guo Zhang; Artem Laktyushin; Jose Villadangos; Alan Ching; Satoshi Ishido; Douglas J. Hilton; Warren S. Alexander; Nicos A. Nicola Interleukin 6 (IL6) is a cytokine that regulates a number of important immune and inflammatory pathways. We used...

... for phagocytosis. Finally, Gpat4 −/− BMDM expressed and released more pro-inflammatory cytokines and chemokines after macrophage activation, suggesting a role for GPAT4 in suppressing inflammatory responses. Together, these results provide evidence that glycerolipid synthesis directed by GPAT4 is important...

... oxidants and increased expression of cytokines. Moreover, astrocytes incubated with the different species induced hippocampal neuronal death in co-culture, and cytotoxicity was particularly enhanced by exposure to fibrillar α-syn. Further exploration of the mechanisms behind astrocyte activation...

... with lipopolysaccharide (LPS) or tumour necrosis factor-α (TNF-α) exhibited reduced expression of the pro-inflammatory cytokines Cxcl10, Ccl5 and Cxcl1, whereas the anti-inflammatory molecules IL1r2 and IL-10 were induced. Consistent with this result, DT pre-treatment inhibited nuclear factor κB (NF-κB) nuclear...

... microenvironment is not entirely understood owing to the complex cross-talk between pro-inflammatory and tumorigenic mediators such as cytokines, chemokines, oncogenes, enzymes, transcription factors and immune cells. These molecular mediators are critical linchpins between inflammation and cancer...

... is protection of the lower respiratory tract from the destructive effects of neutrophil elastase during an inflammatory response. Circulating levels of AAT rise 2–3-fold during inflammation and the liver produces most of this increase. The cytokines oncostatin M (OSM) and interleukin-6 have been shown...

... inhibited by enzymic degradation of plasma arginine by ADI-SS PEG 20000 . Interestingly, pretreatment with ADI-SS PEG 20000 did not inhibit the anti-tumour activity of TNFα in vitro or in vivo . This treatment may allow greater amounts of TNFα, as well as other cytokines, to be administered while abrogating...

... of the interleukin-6-type cytokines. Whereas the membrane-distal half of the gp130 extracellular part confers ligand binding and has been subject to intense investigation, the structural and functional features of its membrane-proximal half are poorly understood. On the basis of predictions of tertiary structure...

...Aneta KASZA; Krzysztof ROGOWSKI; Witold KILARSKI; Radoslaw SOBOTA; Tytus BERNAS; Jurek DOBRUCKI; James TRAVIS; Aleksander KOJ; Marcin BUGNO; Tomasz KORDULA The effects of the production of two closely related cytokines, oncostatin M (OSM) and leukaemia inhibitory factor (LIF), by astrocytoma cells...

... of the HAS isoenzymes were expressed in human articular chondrocytes, synovial fibroblasts and osteosarcoma cells, whether their expression could be modulated by growth factors (insulin-like growth factor-1, basic fibroblast growth factor and transforming growth factor (TGF-β1) and cytokines [interleukin 1β1...

..., it was shown that nitric oxide released from cytokine-stimulated adipocytes attenuated the lipolytic effect of isoproterenol by inactivating the catecholamine. In contrast with very recent findings, which suggest that nitric oxide impairs the β-adrenergic action of isoproterenol through intracellular...

... of the rat and human enhancer elements involves the ability to promote cytokine-inducible transcription in the absence of a classical promoter. 1 To whom correspondence should be sent (e-mail hnick@;ufbi.ufl.edu). 23 8 1999 4 1 2000 27 1 2000 The Biochemical Society, London ©...

... (e-mail [email protected]). 1 2 1999 19 5 1999 9 6 1999 The Biochemical Society, London © 1999 1999 N-acetylcysteine cytokines glutathione hepatotoxins liver injury Biochem. J. (1999) 342, 21 25 (Printed in Great Britain) 21 S-Adenosylmethionine attenuates...

... with decorin with an apparent K d of 100 nM in a solid-phase assay. Dermatopontin inhibited the formation of the decorin–TGF-β1 complex. Decorin also competed with dermatopontin for the binding of this cytokine. The dermatopontin–decorin complex bound 3-fold more TGF-β1 than did each component individually...