... among different phyla. It exerts an important cytoprotective function against oxidative damage and plays a role in innate immunity, where it also contributes to prevent parenchymal tissue from the cytotoxicity of pro-inflammatory agonists released by the activation of the immune response activation...

... dysfunction and atherogenesis. We have investigated the hypothesis that PKCϵ (protein kinase Cϵ) is an important upstream regulator of cytoprotective pathways in vascular ECs (endothelial cells). Depletion of PKCϵ in human ECs reduced expression of the cytoprotective genes A1, A20 and Bcl-2. Conversely...

... A 595 /min and converted into pmoles using a standard curve constructed from 0 to 40 pmol of appropriate pyridine nucleotide. Samples were corrected for volume and finally expressed as both μM pyridine nucleotide±S.D. and the NAD+/NADH ratio±S.D. cancer cytoprotection energy metabolism NADH...

... was to clarify whether GlyR (glycine receptor) acts as a key mediator in cytoprotection of glycine. cDNA encoding human GlyRα1 (α1-subunit of glycine receptor) was transfected into HEK-293 cells. The membrane integrity of the cells with or without GlyRα1 was examined by the uptake of marker compounds...

...Pilar CIDAD; Angeles ALMEIDA; Juan P. BOLAÑOS Recently, we have reported that the inhibition of mitochondrial respiration by nitric oxide (NO) leads to an up-regulation of glycolysis and affords cytoprotection against energy failure through the stimulation of AMPK (5′-AMP-activated protein kinase...

...-dependent stimuli. Alteration of the Nrf2–Keap1 interaction enables Nrf2 to translocate to the nucleus, bind to the antioxidant-responsive element (ARE) and initiate the transcription of genes coding for detoxifying enzymes and cytoprotective proteins. This response is also triggered by a class...

... functions by binding to and promoting the metabolism of FAs, thereby reducing their intracellular concentration. In this study we investigated the putative cytoprotective role of FABPs in a Madin–Darby canine kidney (MDCK) cell model for renal damage. We studied the effects of transfection with cDNA...

... externalization, mitochondrial depolarization and cell shrinkage. To further clarify the role of K + ions in apoptosis, cytoprotection by elevated extracellular [K + ] was studied. Induction of apoptosis by diverse death-receptor and chemical stimuli in two cell lines was inhibited prior to phosphatidylserine...

... to comprehending its role in cytoprotection. In transfected lung epithelial cells, a human-growth-hormone reporter gene system was utilized to identify a potential enhancer in the MnSOD genomic fragment previously shown to contain multiple DNase-I-hypersensitive sites. Northern analysis demonstrated a 10-20-fold...