... in receptor sensitization and activation. Conversely, TRPV1 desensitization occurs via a calcium-dependent mechanism and leads to receptor de-phosphorylation. Importantly, we recently demonstrated that TRPV1 association with β-arrestin-2 is critical to receptor desensitization via its ability to scaffold...

... 2+ mobilization, PKC (protein kinase C) signalling and α-granule secretion, as well as to a complete lack of dense granule secretion. Interestingly, subthreshold PAR4 activation rapidly abrogated PAR1 signalling desensitization by differentially reconstituting these affected signalling events...

...George S. Baillie; David R. Adams; Narinder Bhari; Thomas M. Houslay; Suryakiran Vadrevu; Dong Meng; Xiang Li; Allan Dunlop; Graeme Milligan; Graeme B. Bolger; Enno Klussmann; Miles D. Houslay β 2 -ARs (β 2 -adrenoceptors) become desensitized rapidly upon recruitment of cytosolic β-arrestin. PDE4D5...

... of their activation. The Biochemical Society, London 2006 calcium desensitization memory nicotinic acid–adenine dinucleotide phosphate (NAADP) sea urchin egg time sensing 1 To whom correspondence should be addressed (email [email protected] ). 30 1 2006 15 3 2006 21 3 2006...

... was purchased from Jackson Immunoresearch Laboratories, Inc. Oligonucleotides were synthesized by Genosys Biotechnologies. All other reagents were A. R. or molecular biology grade, and were used without further purification. desensitization farnesyl protein transferase inhibitor isoprenylation...

...Frank NEUSCHÄFER-RUBE; Ricardo HERMOSILLA; Mathias REHWALD; Lars RÖNNSTRAND; Ralf SCHÜLEIN; Christer WERNSTEDT; Gerhard Paul PÜSCHEL hEP4-R (human prostaglandin E 2 receptor, subtype EP4) is a G s -linked heterotrimeric GPCR (G-protein-coupled receptor). It undergoes agonist-induced desensitization...

... adapter protein β-arrestin desensitization endocytosis G-protein-coupled receptor (GPCR) seven-membrane-spanning receptor (7MSR) Abbreviations used: AP, adapter protein; β 2 AR, β 2 -adrenergic receptor; βARK, β-adrenergic receptor kinase; ARF, ADP-ribosylation factor; ARNO, ARF nucleotide...

... desensitization fertilization The Biochemical Society, London ©2003 2003 8 5 2003 17 7 2003 13 8 2003 13 8 2003 1 To whom correspondence should be addressed (e-mail [email protected] ). Biochem. J. (2003) 375, 805 812 (Printed in Great Britain) 805 Modulation of NAADP...

...Claire V. HARPER; Jackson C. KIRKMAN-BROWN; Christopher L. R. BARRATT; Stephen J. PUBLICOVER Progesterone induces a biphasic Ca 2+ influx and consequent acrosome reaction in human spermatozoa. We have used two procedures to vary the stimulus (dosage and prior receptor desensitization...

... with adrenoceptor desensitization. 1 To whom correspondence should be addressed (e-mail [email protected] ). 17 12 1999 17 5 2000 22 6 2000 The Biochemical Society, London © 2000 2000 Biochem. J. (2000) 350, 413 419 (Printed in Great Britain) 413 Cross-talk between receptors...

... deletion also displayed decreased functional desensitization compared with the full-length receptor. desensitization internalization receptors Biochem. J. (2000) 346, 711 718 (Printed in Great Britain) 711 Kinetic analysis of the internalization and recycling of [3H]TRH and C-terminal truncations...

...-terminus. 1 To whom correspondence should be addressed ( [email protected] ). 23 4 1999 13 7 1999 25 8 1999 The Biochemical Society, London © 1999 1999 desensitization G-protein-coupled receptor kinases receptor regulation site-directed mutagenesis...

... to rapid degradation. desensitization down-regulation GIRK1/CIR G-protein palmitoylation Biochem. J. (1999) 342, 387 395 (Printed in Great Britain) 387 Palmitoylation of the recombinant human A1 adenosine receptor : enhanced proteolysis of palmitoylation-deficient mutant receptors Zhenhai GAO...

... be addressed (e-mail [email protected] ). 17 8 1998 25 11 1998 18 12 1998 The Biochemical Society, London © 1999 1999 desensitization FLAG hexahistidine purinergic signalling Biochem. J. (1999) 338, 729 736 (Printed in Great Britain) 729 Purification of A1 adenosine...