... cell viability and cellular ATP concentration in a dose-dependent manner after 72 and 120 h incubation, an effect that was not observed after 24 h incubation or in non-NNNT-expressing cells at any time point. Taken together, these results suggest that NNMT may be a detoxification pathway for BCs...

... detoxification DGA1 LRO1 triacylglycerol Sphingolipids are essential structural components of cell membranes that also have messenger functions regulating the proliferation, survival and death of cells. The yeast sphingolipids consist of LCBs (long-chain bases), LCB-1-phosphates, ceramides, IPCs...

... understood. In particular, the expression and functions of XMEs (xenobiotic-metabolizing enzymes) that could contribute to chemical detoxification in L. pneumophila have been poorly documented at the molecular and functional levels. In the present paper we report the identification and biochemical...

.... cyanobacterium detoxification glutathione transferase (GST) isothiocyanate microbial enzyme The enzyme family of GSTs (glutathione transferases) (EC 2.5.1.18) hosts multifunctional proteins with representatives in all oxygen-utilizing organisms representing all kingdoms. Mammalian GSTs are the best...

... and AB158415. 14 9 2004 6 12 2004 20 12 2004 20 12 2004 The Biochemical Society, London 2005 detoxification glutathione conjugation hepatopancreas Pagrus major red sea bream xenobiotics GSH is a tripeptide that acts during phase II metabolism to conju-gate...

... chemotherapy, may be thwarted by such self-preservation. 1 To whom correspondence should be addressed (e-mail [email protected] ). 10 6 2003 14 7 2003 23 7 2003 23 7 2003 The Biochemical Society, London ©2003 2003 detoxification glutathione transferase (GST) self...

... highly specialized for this function, indicates that metabolism of products of lipid peroxidation is a highly conserved biochemical pathway with probable detoxification as well as regulatory functions. Biochem. J. (2003) 370, 661 669 (Printed in Great Britain) 661 Cloning, expression and biochemical...

... that hGSTM4- 4 might be the human counterpart of mouse GSTM7-7. Reverse transcription-PCR analysis using mGSTM7-specific primers revealed that mGSTM7 is widely expressed in tissues of female A}J mice, including liver, forestomach, lung, kidney, colon and spleen. Key words: detoxification, glutathione...

... GSH-dependent enzymes, which causes a reduction in intrinsic detoxification capacity in the KO animal. These data also indicate that attenuated induction of GSH-dependent enzymes in Nrf2 −/− mice probably accounts for their failure to adapt to chronic exposure to chemical and oxidative stress. 2...

...Hiromi IKEDA; Mohamed S. SERRIA; Ikuko KAKIZAKI; Ichiro HATAYAMA; Kimihiko SATOH; Shigeki TSUCHIDA; Masami MURAMATSU; Shinzo NISHI; Masaharu SAKAI The Pi-class glutathione S-transferases (GSTs) play pivotal roles in the detoxification of xenobiotics, carcinogenesis and drug resistance...

...David SHEEHAN; Gerardene MEADE; Vivienne M. FOLEY; Catriona A. DOWD The glutathione transferases (GSTs; also known as glutathione S-transferases) are major phase II detoxification enzymes found mainly in the cytosol. In addition to their role in catalysing the conjugation of electrophilic...

... physiological roles for class Sigma GST between species. The evolution of divergent functions for the hPGDS and rPGDS is discussed in the context of the orthologous enzyme from chicken. Key words: detoxification, gene expression, prostaglandin syn- thesis. maintenance of body temperature, prevention of platelet...

... 14 6 2000 The Biochemical Society, London © 2000 2000 ATP-dependent transport detoxification glutathione oxidative stress Biochem. J. (2000) 350, 555 561 (Printed in Great Britain) 555 Multidrug resistance protein MRP1 protects against the toxicity of the major lipid peroxidation...

... 8 3 1999 The Biochemical Society, London © 1999 1999 airborne chemicals detoxification glucuronidation olfactory enzymes Biochem. J. (1999) 340, 837 843 (Printed in Great Britain) 837 Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase Gabriele...

..., London © 1999 1999 gene organization glutathione S-transferases detoxification Biochem. J. (1999) 337, 141 151 (Printed in Great Britain) 141 Gene structure, expression and chromosomal localization of murine Theta class glutathione transferase mGSTT1-1 Angela T. WHITTINGTON*, Vanicha VICHAI...