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Keywords: development
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Articles
Biochem J (2019) 476 (13): 1857–1873.
Published: 02 July 2019
... stages, in the developing muscles, brain and heart. The chac1 knockdown was embryonic lethal, and the developmental defects were seen primarily in the myotome, brain and heart where chac1 was maximally expressed. The phenotypes could be rescued by the WT Chac1 but not by the catalytically inactive Chac1...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2019) 476 (6): 931–950.
Published: 22 March 2019
.... Impaired angiogenesis in Dcbld2 −/− mice and dcbld2 KD zebrafish indicates that there may be a broader developmental role of DCBLD2 that remains as yet unexplored. For example, signaling mechanisms that govern angiogenesis are similarly central to proper nervous system development [ 53 , 54...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (19): 2955–2971.
Published: 27 September 2016
... for further research, especially for developmental disorders and cancers. Correspondence: Justin St John ( justin.stjohn@hudson.org.au ) 22 1 2016 17 5 2016 6 6 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 development...
Articles
Biochem J (2015) 469 (3): 433–444.
Published: 23 July 2015
...Amanda K. Chaplin; Marloes L.C. Petrus; Giulia Mangiameli; Michael A. Hough; Dimitri A. Svistunenko; Peter Nicholls; Dennis Claessen; Erik Vijgenboom; Jonathan A.R. Worrall Streptomyces lividans displays a distinct dependence on copper to fully initiate morphological development. Evidence has...
Includes: Supplementary data
Articles
Biochem J (2013) 449 (2): 401–413.
Published: 14 December 2012
..., the mammary gland undergoes extensive gland remodelling to revert back to a virgin gland state in a process known as involution [ 4 ]. Throughout these developmental changes, the gland requires exquisite regulation of proliferation, differentiation and apoptosis to allow for the proper growth and development...
Articles
Biochem J (2012) 445 (1): 1–10.
Published: 15 June 2012
...Feride Oeztuerk-Winder; Juan-Jose Ventura Regulation of stem cells is essential for development and adult tissue homoeostasis. The proper control of stem cell self-renewal and differentiation maintains organ physiology, and disruption of such a balance results in disease. There are many mechanisms...
Articles
Biochem J (2012) 444 (3): 375–382.
Published: 29 May 2012
... with differentiation during neurogenesis Development 2011 138 4267 4277 14 Vernon A. E. Philpott A. The developmental expression of cell cycle regulators in Xenopus laevis Gene Expression Patterns 2003 3 179 192 15 Ma C. Papermaster D. Cepko C. L. A unique pattern...
Includes: Multimedia, Supplementary data
Articles
Biochem J (2009) 419 (3): 585–593.
Published: 14 April 2009
... regulate HS–growth factor interactions in various developmental processes [ 3 ]. The requirements for sulfated HS chains for the development of metazoans is undisputable, as seen in Drosophila melanogaster , Caenorhabditis elegans , Mus musculus and other model organisms [ 3 ], but the evolutionary...
Includes: Supplementary data
Articles
Biochem J (2009) 419 (2): 437–445.
Published: 27 March 2009
... was particularly notable in oenocytes. During development the dPrx5 levels co-varied with ecdysone pulses, suggesting inter-relationship between ecdystreroids and dPrx5 expression. The importance of dPrx5 for development was further underscored by the embryonic lethal phenotype of progeny derived from the dprx5...
Articles
Biochem J (2008) 412 (3): 399–413.
Published: 28 May 2008
...Abdenour Soufi; Padma-Sheela Jayaraman The PRH (proline-rich homeodomain) [also known as Hex (haematopoietically expressed homeobox)] protein is a critical regulator of vertebrate development. PRH is able to regulate cell proliferation and differentiation and is required for the formation...
Articles
Biochem J (2007) 402 (1): 153–161.
Published: 25 January 2007
... nucleotides: (i) extracellular cAMP that induces chemotaxis during aggregation and differentiation in slugs; (ii) intracellular cAMP that mediates development; and (iii) intracellular cGMP that mediates chemotaxis. It appears that each cyclic nucleotide pool is degraded by a combination of enzymes that have...
Articles
Biochem J (2006) 397 (2): 233–246.
Published: 28 June 2006
... in developmental biology and cellular functions such as metabolism, cell division and cell survival. The importance of forkhead transcription factors is underlined by the developmental defects observed in mutant model organisms, and multiple human disorders and cancers which can be attributed to mutations within...
Articles
Biochem J (2006) 393 (3): 679–685.
Published: 13 January 2006
...Bidyut Ghosh; Steven D. Leach In the developing pancreas, the onset of exocrine differentiation is driven by the activity of the PTF1 (pancreas transciption factor 1) transcriptional complex, which is comprised of the class II bHLH (basic helix–loop–helix) protein, Ptf1-p48 [also known as Ptf1a...
Articles
Biochem J (2003) 374 (2): 381–391.
Published: 01 September 2003
... in such fundamental processes as the regulation of cell proliferation, cytokinesis, developmental responses (such as the transition from a growth to differentiation phase) and, in higher eukaryotes, proper brain development. Distantly related to MAPK (mitogen-acitvated protein kinase) and Cdk (cyclin- dependent...
Articles
Biochem J (2002) 368 (1): 263–271.
Published: 15 November 2002
... of pme-1 and pme-2 is also developmentally regulated. Together, these results show that PARP-1 and −2 are conserved in evolution and must have important functions in multicellular organisms. We propose using C. elegans as a model to understand better the functions of these enzymes. 1 To whom...
Articles
Biochem J (2002) 365 (3): 833–840.
Published: 01 August 2002
..., in intron 7 of the gene. METEX expression is developmentally regulated, showing no correlation with DNA MTase expression. In fact, DNA MTase transcripts are present at high concen- trations in the early developmental stages, while METEX is expressed at late stages of development. Two METEX cDNA clones (Met1...
Articles
Biochem J (2002) 361 (2): 231–241.
Published: 08 January 2002
... is expressed uniformly in all zones of the bovine rib growth plate (Figure 2, right-hand panel). Earlier reports [24], which indicate Fgfr1 message levels only in the hypertrophic zones of developing mouse embryos, could be due to developmental differences between the two species. However, relative levels...
Articles
Biochem J (2001) 360 (1): 39–47.
Published: 08 November 2001
...Takeshi YABU; Shuji KISHI; Toshiro OKAZAKI; Michiaki YAMASHITA Caspase-3 was cloned from zebrafish embryos and its properties were characterized to identify the biological implications of caspase in embryogenesis and apoptosis in zebrafish, which is a model organism in vertebrate developmental...
Articles
Biochem J (2000) 350 (2): 589–597.
Published: 23 August 2000
... identified as a major protein during fetal life and is also involved in important functions such as inhibition of the insulin receptor tyrosine kinase activity, protease inhibitory activities and development-associated regulation of calcium metabolism and osteogenesis. Furthermore, fetuin-A is a key partner...
Articles
Biochem J (2000) 349 (3): 689–692.
Published: 25 July 2000
... will appear in DDBJ, EMBL, GenBank ® and GSDB Nucleotide Sequence Databases under the accession number AF223401. 24 2 2000 30 5 2000 1 6 2000 The Biochemical Society, London © 2000 2000 development differential display in situ hybridization trophoblast Biochem. J. (2000...
Articles
Biochem J (2000) 345 (1): 99–106.
Published: 17 December 1999
... product accelerated ODC degradation in vitro . These results show that both zebrafish antizymes are induced by polyamines but their mRNA species are expressed differently during development. The difference in activities on ODC degradation suggests their functional divergence. 1 Present address...
Articles
Biochem J (2000) 345 (1): 69–75.
Published: 17 December 1999
... development. At weaning time, an increase in the intestinal level of polyamines (and especially that of spermine) was observed, owing partly to the higher level of spermine found in solid food given to rats at this period in comparison with the level found in milk. To study the role of this polyamine...
Articles
Biochem J (1999) 339 (2): 443–451.
Published: 08 April 1999
...Christopher SEMSARIAN; Pramod SUTRAVE; David R. RICHMOND; Robert M. GRAHAM Insulin-like growth factor-I (IGF-I) is an important autocrine/paracrine mediator of skeletal-muscle growth and development. To develop a definitive cultured cell model of skeletal-muscle hypertrophy, C2C12 cells were stably...