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1-26 of 26
Keywords: development
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Articles
Development of circadian rhythms in mammalian systems
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2024) 481 (24): 1967–1976.
Published: 23 December 2024
... weak circadian rhythms, reflecting a species-specific developmental timing of circadian rhythms that aligns with slower developmental progress of human fetus compared with mice [ 18 ]. Recently, our lab characterized the development of circadian rhythms from human iPSCs to human intestinal...
Articles
Impact of climate perturbations on seeds and seed quality for global agriculture
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2023) 480 (3): 177–196.
Published: 07 February 2023
... affect seed development and later germination. For these reasons, investigating seed quality in response to climate changes is a step to propose new crop varieties and practices that will bring solutions for our future. Correspondence: Christophe Bailly ([email protected]...
Articles
WHIRLY1 functions in the nucleus to regulate barley leaf development and associated metabolite profiles
Open AccessBarbara Karpinska, Nurhayati Razak, Euan K. James, Jenny A. Morris, Susan R. Verrall, Peter E. Hedley, Robert D. Hancock, Christine H. Foyer
Journal:
Biochemical Journal
Biochem J (2022) 479 (5): 641–659.
Published: 04 March 2022
... expression to trigger chloroplast development. To test this hypothesis, we have interrogated how the developmental patterns of transcripts and metabolites is changed in the developmental gradient in barley leaves. We firstly investigated the intracellular distribution of WHY1 between proplastids and nuclei...
Includes: Supplementary data
Articles
The glutathione degrading enzyme, Chac1, is required for calcium signaling in developing zebrafish: redox as an upstream activator of calcium
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2019) 476 (13): 1857–1873.
Published: 02 July 2019
... stages, in the developing muscles, brain and heart. The chac1 knockdown was embryonic lethal, and the developmental defects were seen primarily in the myotome, brain and heart where chac1 was maximally expressed. The phenotypes could be rescued by the WT Chac1 but not by the catalytically inactive Chac1...
Includes: Multimedia, Supplementary data
Articles
The DCBLD receptor family: emerging signaling roles in development, homeostasis and disease
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2019) 476 (6): 931–950.
Published: 22 March 2019
.... Impaired angiogenesis in Dcbld2 −/− mice and dcbld2 KD zebrafish indicates that there may be a broader developmental role of DCBLD2 that remains as yet unexplored. For example, signaling mechanisms that govern angiogenesis are similarly central to proper nervous system development [ 53 , 54...
Includes: Supplementary data
Articles
The role of the mtDNA set point in differentiation, development and tumorigenesis
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2016) 473 (19): 2955–2971.
Published: 27 September 2016
... for further research, especially for developmental disorders and cancers. development differentiation DNA methylation mitochondrial DNA pluripotency tumorigenesis Correspondence: Justin St John ( [email protected] ) 22 1 2016 17 5 2016 6 6 2016 © 2016 The Author...
Articles
GlxA is a new structural member of the radical copper oxidase family and is required for glycan deposition at hyphal tips and morphogenesis of Streptomyces lividans
Available to PurchaseAmanda K. Chaplin, Marloes L.C. Petrus, Giulia Mangiameli, Michael A. Hough, Dimitri A. Svistunenko, Peter Nicholls, Dennis Claessen, Erik Vijgenboom, Jonathan A.R. Worrall
Journal:
Biochemical Journal
Biochem J (2015) 469 (3): 433–444.
Published: 23 July 2015
...Amanda K. Chaplin; Marloes L.C. Petrus; Giulia Mangiameli; Michael A. Hough; Dimitri A. Svistunenko; Peter Nicholls; Dennis Claessen; Erik Vijgenboom; Jonathan A.R. Worrall Streptomyces lividans displays a distinct dependence on copper to fully initiate morphological development. Evidence has...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2013) 449 (2): 401–413.
Published: 14 December 2012
... these developmental changes, the gland requires exquisite regulation of proliferation, differentiation and apoptosis to allow for the proper growth and development of ducts throughout puberty, differentiation of secretory alveolar cells for milk production throughout pregnancy and extensive gland remodelling...
Articles
The many faces of p38 mitogen-activated protein kinase in progenitor/stem cell differentiation
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Journal:
Biochemical Journal
Biochem J (2012) 445 (1): 1–10.
Published: 15 June 2012
...Feride Oeztuerk-Winder; Juan-Jose Ventura Regulation of stem cells is essential for development and adult tissue homoeostasis. The proper control of stem cell self-renewal and differentiation maintains organ physiology, and disruption of such a balance results in disease. There are many mechanisms...
Articles
Journal:
Biochemical Journal
Biochem J (2012) 444 (3): 375–382.
Published: 29 May 2012
... propensity to differentiate by directly regulating the level of activity of a component of the differentiation machinery. Far from being uniformly expressed in all neural tissues of the developing embryo, cell cycle regulators frequently show tissue- and developmental stage-dependent patterns...
Includes: Multimedia, Supplementary data
Articles
Molecular analysis of heparan sulfate biosynthetic enzyme machinery and characterization of heparan sulfate structure in Nematostella vectensis
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2009) 419 (3): 585–593.
Published: 14 April 2009
... developmental pathways. The availability of powerful molecular and genetic tools, the sequencing of the Nematostella genome and the accessibility of Nematostella development to laboratory manipulations make Nematostella an ideal organism for studies in evolutionary genomics [ 4 , 6 ]. The embryonic...
Includes: Supplementary data
Articles
Peroxiredoxin 5 confers protection against oxidative stress and apoptosis and also promotes longevity in Drosophila
Available to PurchaseSvetlana N. Radyuk, Katarzyna Michalak, Vladimir I. Klichko, Judith Benes, Igor Rebrin, Rajindar S. Sohal, William C. Orr
Journal:
Biochemical Journal
Biochem J (2009) 419 (2): 437–445.
Published: 27 March 2009
... was particularly notable in oenocytes. During development the dPrx5 levels co-varied with ecdysone pulses, suggesting inter-relationship between ecdystreroids and dPrx5 expression. The importance of dPrx5 for development was further underscored by the embryonic lethal phenotype of progeny derived from the dprx5...
Articles
Journal:
Biochemical Journal
Biochem J (2008) 412 (3): 399–413.
Published: 28 May 2008
... regulated by the Wnt signalling pathway (see below), suggesting that there are likely to be complex feedback loops in the regulation of PRH expression during development. PRH regulates a plethora of developmental decisions and probably as a consequence of this the Prh gene is itself subject...
Articles
Seven Dictyostelium discoideum phosphodiesterases degrade three pools of cAMP and cGMP
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2007) 402 (1): 153–161.
Published: 25 January 2007
... nucleotides: (i) extracellular cAMP that induces chemotaxis during aggregation and differentiation in slugs; (ii) intracellular cAMP that mediates development; and (iii) intracellular cGMP that mediates chemotaxis. It appears that each cyclic nucleotide pool is degraded by a combination of enzymes that have...
Articles
In control of biology: of mice, men and Foxes
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2006) 397 (2): 233–246.
Published: 28 June 2006
... in the wings and in between the second and third helices, which are notably the locations of most structural variations. The importance of forkhead transcription factors in embryonic development was quickly recognized (reviewed in [ 5 , 6 ]), and our knowledge of their function in developmental...
Articles
Interactions between Hairy/Enhancer of Split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2006) 393 (3): 679–685.
Published: 13 January 2006
...Bidyut Ghosh; Steven D. Leach In the developing pancreas, the onset of exocrine differentiation is driven by the activity of the PTF1 (pancreas transciption factor 1) transcriptional complex, which is comprised of the class II bHLH (basic helix–loop–helix) protein, Ptf1-p48 [also known as Ptf1a...
Articles
dDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in Drosophila
Available to PurchasePamela A. LOCHHEAD, Gary SIBBET, Ross KINSTRIE, Tava CLEGHON, Margie RYLATT, Deborah K. MORRISON, Vaughn CLEGHON
Journal:
Biochemical Journal
Biochem J (2003) 374 (2): 381–391.
Published: 01 September 2003
... proliferation, cytokinesis, developmental responses (such as the transition from a growth to differentiation phase) and, in higher eukaryotes, proper brain development. Distantly related to MAPK (mitogen-acitvated protein kinase) and Cdk (cyclin- dependent protein kinase) [1 4], the DYRK family is charac...
Articles
The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2002) 368 (1): 263–271.
Published: 15 November 2002
... of pme-1 and pme-2 is also developmentally regulated. Together, these results show that PARP-1 and −2 are conserved in evolution and must have important functions in multicellular organisms. We propose using C. elegans as a model to understand better the functions of these enzymes. 1 To whom...
Articles
An open reading frame in intron seven of the sea urchin DNA-methyltransferase gene codes for a functional AP1 endonuclease
Available to PurchaseAnna Valentina CIOFFI, Diana FERRARA, Maria Vittoria CUBELLIS, Francesco ANIELLO, Marcella CORRADO, Francesca LIGUORI, Alessandro AMOROSO, Laura FUCCI, Margherita BRANNO
Journal:
Biochemical Journal
Biochem J (2002) 365 (3): 833–840.
Published: 01 August 2002
..., in intron 7 of the gene. METEX expression is developmentally regulated, showing no correlation with DNA MTase expression. In fact, DNA MTase transcripts are present at high concen- trations in the early developmental stages, while METEX is expressed at late stages of development. Two METEX cDNA clones (Met1...
Articles
The fibroblast growth factor receptor, FGFR3, forms gradients of intact and degraded protein across the growth plate of developing bovine ribs
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2002) 361 (2): 231–241.
Published: 08 January 2002
... only in the hypertrophic zones of developing mouse embryos, could be due to developmental differences between the two species. However, relative levels of FGFR1 and FGFR3 in the growth plate could not be compared. At the level of expressed sequence tags, Fgfr3 predominates in fetal cartilage (P. J...
Articles
Characterization of zebrafish caspase-3 and induction of apoptosis through ceramide generation in fish fathead minnow tailbud cells and zebrafish embryo
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2001) 360 (1): 39–47.
Published: 08 November 2001
...Takeshi YABU; Shuji KISHI; Toshiro OKAZAKI; Michiaki YAMASHITA Caspase-3 was cloned from zebrafish embryos and its properties were characterized to identify the biological implications of caspase in embryogenesis and apoptosis in zebrafish, which is a model organism in vertebrate developmental...
Articles
Fetuin-B, a second member of the fetuin family in mammals
Available to PurchaseEmmanuel OLIVIER, Emmanuelle SOURY, Philippe RUMINY, Annie HUSSON, Françoise PARMENTIER, Maryvonne DAVEAU, Jean-Philippe SALIER
Journal:
Biochemical Journal
Biochem J (2000) 350 (2): 589–597.
Published: 23 August 2000
... identified as a major protein during fetal life and is also involved in important functions such as inhibition of the insulin receptor tyrosine kinase activity, protease inhibitory activities and development-associated regulation of calcium metabolism and osteogenesis. Furthermore, fetuin-A is a key partner...
Articles
Cathepsin-6, a novel cysteine proteinase showing homology with and co-localized expression with cathepsin J/P in the labyrinthine layer of mouse placenta
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 349 (3): 689–692.
Published: 25 July 2000
... will appear in DDBJ, EMBL, GenBank ® and GSDB Nucleotide Sequence Databases under the accession number AF223401. 24 2 2000 30 5 2000 1 6 2000 The Biochemical Society, London © 2000 2000 development differential display in situ hybridization trophoblast Biochem. J. (2000...
Articles
Two zebrafish (Danio rerio) antizymes with different expression and activities
Available to PurchaseTakatoshi SAITO, Tomasz HASCILOWICZ, Ichiro OHKIDO, Yutaka KIKUCHI, Hitoshi OKAMOTO, Shin-ichi HAYASHI, Yasuko MURAKAMI, Senya MATSUFUJI
Journal:
Biochemical Journal
Biochem J (2000) 345 (1): 99–106.
Published: 17 December 1999
... product accelerated ODC degradation in vitro . These results show that both zebrafish antizymes are induced by polyamines but their mRNA species are expressed differently during development. The difference in activities on ODC degradation suggests their functional divergence. 1 Present address...
Articles
Influence of spermine on intestinal maturation of the glycoprotein glycosylation process in neonatal rats
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2000) 345 (1): 69–75.
Published: 17 December 1999
... development. At weaning time, an increase in the intestinal level of polyamines (and especially that of spermine) was observed, owing partly to the higher level of spermine found in solid food given to rats at this period in comparison with the level found in milk. To study the role of this polyamine...
Articles
Insulin-like growth factor (IGF-I) induces myotube hypertrophy associated with an increase in anaerobic glycolysis in a clonal skeletal-muscle cell model
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 339 (2): 443–451.
Published: 08 April 1999
...Christopher SEMSARIAN; Pramod SUTRAVE; David R. RICHMOND; Robert M. GRAHAM Insulin-like growth factor-I (IGF-I) is an important autocrine/paracrine mediator of skeletal-muscle growth and development. To develop a definitive cultured cell model of skeletal-muscle hypertrophy, C2C12 cells were stably...
