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Keywords: development
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Biochem J (2024) 481 (24): 1967–1976.
Published: 23 December 2024
... weak circadian rhythms, reflecting a species-specific developmental timing of circadian rhythms that aligns with slower developmental progress of human fetus compared with mice [ 18 ]. Recently, our lab characterized the development of circadian rhythms from human iPSCs to human intestinal...
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Biochem J (2023) 480 (3): 177–196.
Published: 07 February 2023
... affect seed development and later germination. For these reasons, investigating seed quality in response to climate changes is a step to propose new crop varieties and practices that will bring solutions for our future. Correspondence: Christophe Bailly ([email protected]...
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Biochem J (2022) 479 (5): 641–659.
Published: 04 March 2022
... expression to trigger chloroplast development. To test this hypothesis, we have interrogated how the developmental patterns of transcripts and metabolites is changed in the developmental gradient in barley leaves. We firstly investigated the intracellular distribution of WHY1 between proplastids and nuclei...
Includes: Supplementary data
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Biochem J (2019) 476 (13): 1857–1873.
Published: 02 July 2019
... stages, in the developing muscles, brain and heart. The chac1 knockdown was embryonic lethal, and the developmental defects were seen primarily in the myotome, brain and heart where chac1 was maximally expressed. The phenotypes could be rescued by the WT Chac1 but not by the catalytically inactive Chac1...
Includes: Multimedia, Supplementary data
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Biochem J (2019) 476 (6): 931–950.
Published: 22 March 2019
.... Impaired angiogenesis in Dcbld2 −/− mice and dcbld2 KD zebrafish indicates that there may be a broader developmental role of DCBLD2 that remains as yet unexplored. For example, signaling mechanisms that govern angiogenesis are similarly central to proper nervous system development [ 53 , 54...
Includes: Supplementary data
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Biochem J (2016) 473 (19): 2955–2971.
Published: 27 September 2016
... for further research, especially for developmental disorders and cancers. development differentiation DNA methylation mitochondrial DNA pluripotency tumorigenesis Correspondence: Justin St John ( [email protected] ) 22 1 2016 17 5 2016 6 6 2016 © 2016 The Author...
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Biochem J (2012) 445 (1): 1–10.
Published: 15 June 2012
...Feride Oeztuerk-Winder; Juan-Jose Ventura Regulation of stem cells is essential for development and adult tissue homoeostasis. The proper control of stem cell self-renewal and differentiation maintains organ physiology, and disruption of such a balance results in disease. There are many mechanisms...
Articles
Biochem J (2012) 444 (3): 375–382.
Published: 29 May 2012
... propensity to differentiate by directly regulating the level of activity of a component of the differentiation machinery. Far from being uniformly expressed in all neural tissues of the developing embryo, cell cycle regulators frequently show tissue- and developmental stage-dependent patterns...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 419 (3): 585–593.
Published: 14 April 2009
... developmental pathways. The availability of powerful molecular and genetic tools, the sequencing of the Nematostella genome and the accessibility of Nematostella development to laboratory manipulations make Nematostella an ideal organism for studies in evolutionary genomics [ 4 , 6 ]. The embryonic...
Includes: Supplementary data
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Biochem J (2009) 419 (2): 437–445.
Published: 27 March 2009
... was particularly notable in oenocytes. During development the dPrx5 levels co-varied with ecdysone pulses, suggesting inter-relationship between ecdystreroids and dPrx5 expression. The importance of dPrx5 for development was further underscored by the embryonic lethal phenotype of progeny derived from the dprx5...
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Biochem J (2008) 412 (3): 399–413.
Published: 28 May 2008
... regulated by the Wnt signalling pathway (see below), suggesting that there are likely to be complex feedback loops in the regulation of PRH expression during development. PRH regulates a plethora of developmental decisions and probably as a consequence of this the Prh gene is itself subject...
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Biochem J (2007) 402 (1): 153–161.
Published: 25 January 2007
... nucleotides: (i) extracellular cAMP that induces chemotaxis during aggregation and differentiation in slugs; (ii) intracellular cAMP that mediates development; and (iii) intracellular cGMP that mediates chemotaxis. It appears that each cyclic nucleotide pool is degraded by a combination of enzymes that have...
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Biochem J (2006) 397 (2): 233–246.
Published: 28 June 2006
... in the wings and in between the second and third helices, which are notably the locations of most structural variations. The importance of forkhead transcription factors in embryonic development was quickly recognized (reviewed in [ 5 , 6 ]), and our knowledge of their function in developmental...
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Biochem J (2003) 374 (2): 381–391.
Published: 01 September 2003
... proliferation, cytokinesis, developmental responses (such as the transition from a growth to differentiation phase) and, in higher eukaryotes, proper brain development. Distantly related to MAPK (mitogen-acitvated protein kinase) and Cdk (cyclin- dependent protein kinase) [1 4], the DYRK family is charac...
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Biochem J (2002) 368 (1): 263–271.
Published: 15 November 2002
... of pme-1 and pme-2 is also developmentally regulated. Together, these results show that PARP-1 and −2 are conserved in evolution and must have important functions in multicellular organisms. We propose using C. elegans as a model to understand better the functions of these enzymes. 1 To whom...
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Biochem J (2002) 365 (3): 833–840.
Published: 01 August 2002
..., in intron 7 of the gene. METEX expression is developmentally regulated, showing no correlation with DNA MTase expression. In fact, DNA MTase transcripts are present at high concen- trations in the early developmental stages, while METEX is expressed at late stages of development. Two METEX cDNA clones (Met1...
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Biochem J (2000) 350 (2): 589–597.
Published: 23 August 2000
... identified as a major protein during fetal life and is also involved in important functions such as inhibition of the insulin receptor tyrosine kinase activity, protease inhibitory activities and development-associated regulation of calcium metabolism and osteogenesis. Furthermore, fetuin-A is a key partner...
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Biochem J (2000) 345 (1): 99–106.
Published: 17 December 1999
... product accelerated ODC degradation in vitro . These results show that both zebrafish antizymes are induced by polyamines but their mRNA species are expressed differently during development. The difference in activities on ODC degradation suggests their functional divergence. 1 Present address...
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Biochem J (2000) 345 (1): 69–75.
Published: 17 December 1999
... development. At weaning time, an increase in the intestinal level of polyamines (and especially that of spermine) was observed, owing partly to the higher level of spermine found in solid food given to rats at this period in comparison with the level found in milk. To study the role of this polyamine...
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