Page 1 | Search Results | Biochemical Journal

1-50 of 60

Sort by

Sort Order Select

Articles

Cardiac substrate metabolism in type 2 diabetes

Jordan S. F. Chan, Tanin Shafaati, John R. Ussher

Biochem J (2025) 482 (10): 499–518.

https://doi.org/10.1042/BCJ20240189

Published: 13 May 2025

... metabolism, and increasing evidence supports that these perturbations in substrate metabolism can directly contribute to cardiac dysfunction. Furthermore, type 2 diabetes (T2D) is a major risk factor for increased cardiovascular disease burden, while also being characterized by a very distinct metabolic...

View articletitled, Cardiac substrate metabolism in type 2 diabetes

Articles

Identification of a 10-mer peptide from the death domain of MyD88 which attenuates inflammation and insulin resistance and improves glucose metabolism

Mehmood Ali, Tripti Kumari, Arvind Gupta, Sariyah Akhtar, Rahul Dev Verma, Jimut Kanti Ghosh

Biochem J (2024) 481 (4): 191–218.

https://doi.org/10.1042/BCJ20230369

Published: 13 February 2024

...Mehmood Ali; Tripti Kumari; Arvind Gupta; Sariyah Akhtar; Rahul Dev Verma; Jimut Kanti Ghosh Insulin resistance (IR) is the key pathophysiological cause of type 2 diabetes, and inflammation has been implicated in it. The death domain (DD) of the adaptor protein, MyD88 plays a crucial role...

View articletitled, Identification of a 10-mer peptide from the death domain of MyD88 which attenuates inflammation and insulin resistance and improves glucose metabolism

Includes: Supplementary data

Articles

Non-cross-linking advanced glycation end products affect prohormone processing

Sebastian Brings, Walter Mier, Barbro Beijer, Elisabeth Kliemank, Stephan Herzig, Julia Szendroedi, Peter P. Nawroth, Thomas Fleming

Biochem J (2024) 481 (1): 33–44.

https://doi.org/10.1042/BCJ20230321

Published: 04 January 2024

...Sebastian Brings; Walter Mier; Barbro Beijer; Elisabeth Kliemank; Stephan Herzig; Julia Szendroedi; Peter P. Nawroth; Thomas Fleming Advanced glycation end products (AGEs) are non-enzymatic post-translational modifications of amino acids and are associated with diabetic complications. One proposed...

View articletitled, Non-cross-linking advanced glycation end products affect prohormone processing

Includes: Supplementary data

Articles

Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing

In Collection

Awards

Guy A. Rutter, Vaibhav Sidarala, Brett A. Kaufman, Scott A. Soleimanpour

Biochem J (2023) 480 (11): 773–789.

https://doi.org/10.1042/BCJ20230167

Published: 07 June 2023

...Guy A. Rutter; Vaibhav Sidarala; Brett A. Kaufman; Scott A. Soleimanpour Glucose-regulated insulin secretion becomes defective in all forms of diabetes. The signaling mechanisms through which the sugar acts on the ensemble of beta cells within the islet remain a vigorous area of research after more...

View articletitled, Mitochondrial metabolism and dynamics in pancreatic beta cell glucose sensing

Articles

Insulin and cancer: a tangled web

In Collection

Celebrating 100 years of insulin research

Brooks P. Leitner, Stephan Siebel, Ngozi D. Akingbesote, Xinyi Zhang, Rachel J. Perry

Biochem J (2022) 479 (5): 583–607.

https://doi.org/10.1042/BCJ20210134

Published: 04 March 2022

... BY) . Correspondence: Rachel J. Perry ( [email protected] ) cancer metabolism diabetes immunometabolism Currently, the Centers for Disease Control have identified thirteen tumor types of which overweight and obesity increase risk [ 1–27 ] ( Table 1 ). In most of these, excess weight also worsens...

View articletitled, Insulin and cancer: a tangled web

Articles

Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance

In Collection

Celebrating 100 years of insulin research

Sara M. Frangos, David J. Bishop, Graham P. Holloway

Biochem J (2021) 478 (21): 3809–3826.

https://doi.org/10.1042/BCJ20210145

Published: 09 November 2021

...Sara M. Frangos; David J. Bishop; Graham P. Holloway While the etiology of type 2 diabetes is multifaceted, the induction of insulin resistance in skeletal muscle is a key phenomenon, and impairments in insulin signaling in this tissue directly contribute to hyperglycemia. Despite the lack...

View articletitled, Revisiting the contribution of mitochondrial biology to the pathophysiology of skeletal muscle insulin resistance

Articles

Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics

In Collection

Adipose biology

Alexander Yang, Emilio P. Mottillo

Biochem J (2020) 477 (5): 985–1008.

https://doi.org/10.1042/BCJ20190468

Published: 13 March 2020

... and that lipolysis can mediate homeostatic metabolic signals at both the cellular and whole-body level to promote inter-organ communication. Finally, adipocyte lipolysis is involved in various diseases such as cancer, type 2 diabetes and fatty liver disease, and targeting adipocyte lipolysis is of therapeutic...

View articletitled, Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics

Articles

Differential receptor selectivity of the FGF15/FGF19 orthologues determines distinct metabolic activities in db/db mice

Ann Maria K. Hansen, Sara G. Vienberg, Kirsten Lykkegaard, Xin Zhao, Guo Tingqing, Dan Han, Xujia Zhang, Henning Thøgersen, Kristian Sass-Ørum, Tina Tagmose, Kirsten Raun, Birgitte Andersen

Biochem J (2018) 475 (18): 2985–2996.

https://doi.org/10.1042/BCJ20180555

Published: 25 September 2018

... administered to diabetic mice. The present study was designed to clarify why two human proteins with distinct physiological functions both lower BG in db/db mice and if the mouse orthologue FGF15 has similar effect to FGF19 and FGF21. Recombinant human FGF19, -21 and a mouse FGF15 variant (C110S) were...

View articletitled, Differential receptor selectivity of the FGF15/FGF19 orthologues determines distinct metabolic activities in db/db mice

Includes: Supplementary data

Articles

Vitamin D deficiency and diabetes

Michael J. Berridge

Biochem J (2017) 474 (8): 1321–1332.

https://doi.org/10.1042/BCJ20170042

Published: 24 March 2017

...Michael J. Berridge Vitamin D deficiency has been linked to the onset of diabetes. This review summarizes the role of Vitamin D in maintaining the normal release of insulin by the pancreatic beta cells (β-cells). Diabetes is initiated by the onset of insulin resistance. The β-cells can overcome...

View articletitled, Vitamin D deficiency and diabetes

Articles

Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity

Yiguo Zhang, Yuancai Xiang

Biochem J (2016) 473 (8): 961–1000.

https://doi.org/10.1042/BJ20151182

Published: 08 April 2016

... of Nrf1 results in spontaneous development of non-alcoholic steatohepatitis, hepatoma, diabetes and neurodegenerative diseases in animal models. 1 To whom correspondence should be addressed (email [email protected] , or [email protected] ). © 2016 The Author(s). Published by Portland...

View articletitled, Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity

Articles

High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation

Sujith Dassanayaka, Ryan D. Readnower, Joshua K. Salabei, Bethany W. Long, Allison L. Aird, Yu-Ting Zheng, Senthilkumar Muthusamy, Heberty T. Facundo, Bradford G. Hill, Steven P. Jones

Biochem J (2015) 467 (1): 115–126.

https://doi.org/10.1042/BJ20141018

Published: 20 March 2015

...Sujith Dassanayaka; Ryan D. Readnower; Joshua K. Salabei; Bethany W. Long; Allison L. Aird; Yu-Ting Zheng; Senthilkumar Muthusamy; Heberty T. Facundo; Bradford G. Hill; Steven P. Jones Previous reports indicate that hyperglycaemia/diabetes enhances flux through accessory pathways, such as protein O...

View articletitled, High glucose induces mitochondrial dysfunction independently of protein O-GlcNAcylation

Includes: Supplementary data

Articles

Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

Guy A. Rutter, Timothy J. Pullen, David J. Hodson, Aida Martinez-Sanchez

Biochem J (2015) 466 (2): 203–218.

https://doi.org/10.1042/BJ20141384

Published: 20 February 2015

...Guy A. Rutter; Timothy J. Pullen; David J. Hodson; Aida Martinez-Sanchez Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis in man and many other animals. Defective insulin secretion underlies all forms of diabetes mellitus, a disease currently reaching...

View articletitled, Pancreatic β-cell identity, glucose sensing and the control of insulin secretion

Articles

Pdx1 and USF transcription factors co-ordinately regulate Alx3 gene expression in pancreatic β-cells

Antonio Fernández-Pérez, Mario Vallejo

Biochem J (2014) 463 (2): 287–296.

https://doi.org/10.1042/BJ20140643

Published: 22 September 2014

...Antonio Fernández-Pérez; Mario Vallejo Alterations in transcription factors expressed in insulin-producing islet β-cells generate pancreatic dysfunction leading to diabetes. The homeodomain transcription factor Alx3 ( aristaless -like homeobox 3) expressed in pancreatic islets participates...

View articletitled, Pdx1 and USF transcription factors co-ordinately regulate Alx3 gene expression in pancreatic β-cells

Includes: Supplementary data

Articles

The glycation site specificity of human serum transferrin is a determinant for transferrin's functional impairment under elevated glycaemic conditions

André M. N. Silva, Paulo R. H. Sousa, João T. S. Coimbra, Natércia F. Brás, Rui Vitorino, Pedro A. Fernandes, Maria J. Ramos, Maria Rangel, Pedro Domingues

Biochem J (2014) 461 (1): 33–42.

https://doi.org/10.1042/BJ20140133

Published: 13 June 2014

...André M. N. Silva; Paulo R. H. Sousa; João T. S. Coimbra; Natércia F. Brás; Rui Vitorino; Pedro A. Fernandes; Maria J. Ramos; Maria Rangel; Pedro Domingues The mechanisms involving iron toxicity in diabetes mellitus are not completely understood. However, the spontaneous reaction of reducing sugars...

View articletitled, The glycation site specificity of human serum transferrin is a determinant for transferrin's functional impairment under elevated glycaemic conditions

Articles

Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescence

Bogumil Zelent, Anne Raimondo, Amy Barrett, Carol W. Buettger, Pan Chen, Anna L. Gloyn, Franz M. Matschinsky

Biochem J (2014) 459 (3): 551–564.

https://doi.org/10.1042/BJ20131363

Published: 11 April 2014

... formation between these two allosterically regulated proteins. 11 10 2013 3 2 2014 26 2 2014 26 2 2014 allosteric regulation co-operativity diabetes fructose phosphate ester glucokinase glucokinase regulatory protein metabolic regulation © 2014 Author(s) 2014...

View articletitled, Analysis of the co-operative interaction between the allosterically regulated proteins GK and GKRP using tryptophan fluorescence

Includes: Supplementary data

Articles

Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes

Robert Stöhr, Massimo Federici

Biochem J (2013) 454 (1): 1–11.

https://doi.org/10.1042/BJ20130121

Published: 26 July 2013

...Robert Stöhr; Massimo Federici For some time now it has been known that diabetes and atherosclerosis are chronic inflammatory diseases that are closely associated with one another and often develop together. In both there is an increase in tissue-wide inflammation that is exhibited...

View articletitled, Insulin resistance and atherosclerosis: convergence between metabolic pathways and inflammatory nodes

Articles

Metabolic inflexibility and protein lysine acetylation in heart mitochondria of a chronic model of Type 1 diabetes

Shraddha S. Vadvalkar, C. Nathan Baily, Satoshi Matsuzaki, Melinda West, Yasvir A. Tesiram, Kenneth M. Humphries

Biochem J (2013) 449 (1): 253–261.

https://doi.org/10.1042/BJ20121038

Published: 07 December 2012

...Shraddha S. Vadvalkar; C. Nathan Baily; Satoshi Matsuzaki; Melinda West; Yasvir A. Tesiram; Kenneth M. Humphries Diabetic cardiomyopathy refers to the changes in contractility that occur to the diabetic heart that can arise in the absence of vascular disease. Mitochondrial bioenergetic deficits...

View articletitled, Metabolic inflexibility and protein lysine acetylation in heart mitochondria of a chronic model of Type 1 diabetes

Articles

CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes

Yeliz Angin, Laura K. M. Steinbusch, Peter J. Simons, Sabrina Greulich, Nicole T. H. Hoebers, Kim Douma, Marc A. M. J. van Zandvoort, Will A. Coumans, Wino Wijnen, Michaela Diamant, D. Margriet Ouwens, Jan F. C. Glatz, Joost J. F. P. Luiken

Biochem J (2012) 448 (1): 43–53.

https://doi.org/10.1042/BJ20120060

Published: 18 October 2012

... equally to this work. 2 To whom correspondence should be addressed (email [email protected] ). 9 1 2012 14 6 2012 10 7 2012 10 7 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cardiac metabolism CD36 diabetes insulin...

View articletitled, CD36 inhibition prevents lipid accumulation and contractile dysfunction in rat cardiomyocytes

Includes: Supplementary data

Articles

Effects of the novel mitochondrial protein mimitin in insulin-secreting cells

Katarzyna Hanzelka, Lukasz Skalniak, Jolanta Jura, Sigurd Lenzen, Ewa Gurgul-Convey

Biochem J (2012) 445 (3): 349–359.

https://doi.org/10.1042/BJ20111920

Published: 13 July 2012

...Katarzyna Hanzelka; Lukasz Skalniak; Jolanta Jura; Sigurd Lenzen; Ewa Gurgul-Convey Mimitin, a novel mitochondrial protein, has been shown to act as a molecular chaperone for the mitochondrial complex I and to regulate ATP synthesis. During Type 1 diabetes development, pro-inflammatory cytokines...

View articletitled, Effects of the novel mitochondrial protein mimitin in insulin-secreting cells

Articles

The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress

Ling Yan, Shuangli Guo, Marie Brault, Jamie Harmon, R. Paul Robertson, Rizwan Hamid, Roland Stein, Elizabeth Yang

Biochem J (2012) 444 (2): 239–247.

https://doi.org/10.1042/BJ20111606

Published: 11 May 2012

... the serine/threonine PP2A (protein phosphatase 2A) holoenzyme containing the B55α regulatory subunit, with nuclear import of FOXO1 in pancreatic islet β-cells under oxidative stress, a condition associated with cellular dysfunction in Type 2 diabetes. The mechanism of FOXO1 dephosphorylation and nuclear...

View articletitled, The B55α-containing PP2A holoenzyme dephosphorylates FOXO1 in islet β-cells under oxidative stress

Articles

Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1 , Ngn3 and MafA

Ersin Akinci, Anannya Banga, Lucas V. Greder, James R. Dutton, Jonathan M. W. Slack

Biochem J (2012) 442 (3): 539–550.

https://doi.org/10.1042/BJ20111678

Published: 24 February 2012

... diabetes in streptozotocin-treated NOD-SCID (non-obese diabetic severe combined immunodeficiency) mice. However the transformation is not complete. The cells lack expression of several genes important for beta cell function and they do not show glucose-sensitive insulin secretion. We conclude...

View articletitled, Reprogramming of pancreatic exocrine cells towards a beta (β) cell character using Pdx1 , Ngn3 and MafA

Includes: Supplementary data

Articles

IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade

Graeme I. Lancaster, Beata Skiba, Christine Yang, Hayley T. Nicholls, Katherine G. Langley, M. H. Stanley Chan, Clinton R. Bruce, Gordon W. Rewcastle, Peter R. Shepherd, Michael Karin, Mark A. Febbraio

Biochem J (2012) 442 (3): 723–732.

https://doi.org/10.1042/BJ20112037

Published: 24 February 2012

...-forming units)/cell in DMEM for 2 h. Medium was subsequently supplemented with 10% (v/v) FBS. Subsequent experiments were conducted 24–48 h after infection, following overnight serum starvation. © The Authors Journal compilation © 2012 Biochemical Society 2012 adipocyte diabetes inhibitor...

View articletitled, IκB kinase β (IKKβ) does not mediate feedback inhibition of the insulin signalling cascade

Includes: Supplementary data

Articles

The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer

Lynley D. Pound, Yan Hang, Suparna A. Sarkar, Yingda Wang, Laurel A. Milam, James K. Oeser, Richard L. Printz, Catherine E. Lee, Roland Stein, John C. Hutton, Richard M. O'Brien

Biochem J (2011) 433 (1): 95–105.

https://doi.org/10.1042/BJ20101488

Published: 15 December 2010

... association studies have shown that a polymorphic variant in SLC30A8 is associated with altered susceptibility to Type 2 diabetes and we recently reported that glucose-stimulated insulin secretion is decreased in islets isolated from Slc30a8 -knockout mice. The present study examines the molecular basis...

View articletitled, The pancreatic islet β-cell-enriched transcription factor Pdx-1 regulates Slc30a8 gene transcription through an intronic enhancer

Includes: Supplementary data

Articles

Prevention of diabetic nephropathy in Ins2 +/−AkitaJ mice by the mitochondria-targeted therapy MitoQ

Balu K. Chacko, Colin Reily, Anup Srivastava, Michelle S. Johnson, Yaozu Ye, Elena Ulasova, Anupam Agarwal, Kurt R. Zinn, Michael P. Murphy, Balaraman Kalyanaraman, Victor Darley-Usmar

Biochem J (2010) 432 (1): 9–19.

https://doi.org/10.1042/BJ20100308

Published: 25 October 2010

... resulting from chronic exposure to high glucose in long-term diabetic patients. We hypothesized that a mitochondria-targeted antioxidant would prevent kidney damage in the Ins2 +/−AkitaJ mouse model (Akita mice) of Type 1 diabetes. To test this we orally administered a mitochondria-targeted ubiquinone...

View articletitled, Prevention of diabetic nephropathy in Ins2 +/−AkitaJ mice by the mitochondria-targeted therapy MitoQ

Articles

Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes

Kathleen G. Mountjoy

Biochem J (2010) 428 (3): 305–324.

https://doi.org/10.1042/BJ20091957

Published: 27 May 2010

... cause human obesity, or protect against it, the melanocortin system is by far the most significant. The present review is a discussion of the current understanding of the roles and mechanism of action of POMC, melanocortin receptors and AgRP (agouti-related peptide) in obesity and Type 2 diabetes...

View articletitled, Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes

Articles

Wnt signalling and the control of cellular metabolism

Jaswinder K. Sethi, Antonio Vidal-Puig

Biochem J (2010) 427 (1): 1–17.

https://doi.org/10.1042/BJ20091866

Published: 15 March 2010

... diabetes metabolic syndrome metabolism obesity Wnt signalling The name Wnt is derived from a combination of two homologous genes; W g (the Drosophila wingless gene) and I nt [the murine homologue MMTV (mouse mammary tumour virus) integration site 1 gene]. Wnts represent a large morphogenic...

View articletitled, Wnt signalling and the control of cellular metabolism

Includes: Multimedia, Supplementary data

Articles

Regulation and function of selenoproteins in human disease

Frederick P. Bellinger, Arjun V. Raman, Mariclair A. Reeves, Marla J. Berry

Biochem J (2009) 422 (1): 11–22.

https://doi.org/10.1042/BJ20090219

Published: 29 July 2009

... ], and myxedematous endemic cretinism, a form of mental retardation occurring in regions of Africa [ 35 ], both involve concurrent selenium and iodine deficiency [ 36 ]. © The Authors Journal compilation © 2009 Biochemical Society 2009 cancer diabetes Keshan disease multiminicore disease...

View articletitled, Regulation and function of selenoproteins in human disease

Includes: Multimedia, Supplementary data

Articles

Identification of a pancreatic stellate cell population with properties of progenitor cells: new role for stellate cells in the pancreas

Eugenia Mato, Maria Lucas, Jordi Petriz, Ramon Gomis, Anna Novials

Biochem J (2009) 421 (2): 181–191.

https://doi.org/10.1042/BJ20081466

Published: 26 June 2009

... that express the ABCG2 + transporter and have the capacity to transdifferentiate into insulin-producing cells. Although the potential therapeutic application remains to be tested, PaSCs could represent a future option for insulin replacement in diabetes research. 2 To whom correspondence should be sent...

View articletitled, Identification of a pancreatic stellate cell population with properties of progenitor cells: new role for stellate cells in the pancreas

Includes: Supplementary data

Articles

The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease

Lisa M. Ooms, Kristy A. Horan, Parvin Rahman, Gillian Seaton, Rajendra Gurung, Dharini S. Kethesparan, Christina A. Mitchell

Biochem J (2009) 419 (1): 29–49.

https://doi.org/10.1042/BJ20081673

Published: 13 March 2009

... of cellular functions by regulating the levels of specific phosphoinositides. Emerging studies have implicated their loss or gain of function in human disease. cancer diabetes inflammation Lowe's syndrome 5-phosphatase phosphoinositide Figure 1 Diverse roles of phosphoinositides Activation...

View articletitled, The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease

Includes: Multimedia, Supplementary data

Articles

Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization

Franklin Liu, Qing Dallas-Yang, Gino Castriota, Paul Fischer, Francesca Santini, Marc Ferrer, Jing Li, Taro E. Akiyama, Joel P. Berger, Bei B. Zhang, Guoqiang Jiang

Biochem J (2009) 418 (2): 413–420.

https://doi.org/10.1042/BJ20082051

Published: 11 February 2009

... in diabetic human and animal subjects. The goal of the present study is to develop a cell-based assay for identifying negative regulators of GLUT4 translocation as potential targets for the treatment of Type 2 diabetes. Traditional GLUT4 translocation assays performed in differentiated myocytes or adipocytes...

View articletitled, Development of a novel GLUT4 translocation assay for identifying potential novel therapeutic targets for insulin sensitization

Articles

Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-γ agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions

G. William Wong, Sarah A. Krawczyk, Claire Kitidis-Mitrokostas, Tracy Revett, Ruth Gimeno, Harvey F. Lodish

Biochem J (2008) 416 (2): 161–177.

https://doi.org/10.1042/BJ20081240

Published: 12 November 2008

... of obesity and diabetes, both in animal models and in humans [ 4 , 6 ]. Molecular mechanisms that underlie reduced adiponectin expression despite increased adiposity remain largely unknown, although TNFα secreted by adipocytes and the infiltrated macrophages are a likely cause for adiponectin down-regulation...

View articletitled, Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-γ agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions

Includes: Supplementary data

Articles

Glucose regulation of insulin gene expression in pancreatic β-cells

Sreenath S. Andrali, Megan L. Sampley, Nathan L. Vanderford, Sabire Özcan

Biochem J (2008) 415 (1): 1–10.

https://doi.org/10.1042/BJ20081029

Published: 12 September 2008

... is also observed in a patient carrying a homozygous single nucleotide deletion in the PDX1 gene [ 48 ]. β-Cell-specific disruption of the PDX1 gene results in diabetes with aging and suggests that Pdx-1 is essential for maintenance of β-cell identity [ 49 ]. These findings indicate that Pdx-1...

View articletitled, Glucose regulation of insulin gene expression in pancreatic β-cells

Includes: Multimedia, Supplementary data

Articles

Diacylglycerol kinases: at the hub of cell signalling

Isabel Mérida, Antonia Ávila-Flores, Ernesto Merino

Biochem J (2008) 409 (1): 1–18.

https://doi.org/10.1042/BJ20071040

Published: 11 December 2007

... emerges as a key player in the regulation of cell responses, offering new possibilities of therapeutic intervention in human pathologies, including cancer, heart disease, diabetes, brain afflictions and immune dysfunctions. 1 To whom correspondence should be addressed (email [email protected]...

View articletitled, Diacylglycerol kinases: at the hub of cell signalling

Includes: Multimedia, Supplementary data

Articles

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

Christopher Lipina, Xu Huang, David Finlay, Edward J McManus, Dario R. Alessi, Calum Sutherland

Biochem J (2005) 392 (3): 633–639.

https://doi.org/10.1042/BJ20051046

Published: 06 December 2005

...Christopher Lipina; Xu Huang; David Finlay; Edward J McManus; Dario R. Alessi; Calum Sutherland GSK3 (glycogen synthase kinase-3) regulation is proposed to play a key role in the hormonal control of many cellular processes. Inhibition of GSK3 in animal models of diabetes leads to normalization...

View articletitled, Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3

Articles

Bacterial enzymes that can deglycate glucose- and fructose-modified lysine

Vincent M. Monnier

Biochem J (2005) 392 (2): e1.

https://doi.org/10.1042/BJ20051625

Published: 22 November 2005

... by fructose. 1 email [email protected] 5 10 2005 10 10 2005 The Biochemical Society, London 2005 advanced glycation end-product (AGE) diabetes fructoselysine glucoselysine glycation Maillard reaction Glycation is the process by which reducing sugars react non...

View articletitled, Bacterial enzymes that can deglycate glucose- and fructose-modified lysine

Articles

A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration

Antonio J. Ruiz-Alcaraz, Hui-Kang Liu, Daniel J. Cuthbertson, Edward J. Mcmanus, Simeen Akhtar, Christopher Lipina, Andrew D. Morris, John R. Petrie, Hari S. Hundal, Calum Sutherland

Biochem J (2005) 392 (2): 345–352.

https://doi.org/10.1042/BJ20051194

Published: 22 November 2005

... diabetes mellitus). Impaired intracellular insulin signalling is implicated as a key underlying mechanism. Attention has focused on early signalling events such as defective tyrosine phosphorylation of IRS1 (insulin receptor substrate-1), a major target for the insulin receptor tyrosine kinase...

View articletitled, A novel regulation of IRS1 (insulin receptor substrate-1) expression following short term insulin administration

Articles

Tumour necrosis factor α decreases glucose-6-phosphatase gene expression by activation of nuclear factor κB

Rolf GREMPLER, Anne KIENITZ, Torsten WERNER, Marion MEYER, Andreas BARTHEL, Fabienne AILETT, Calum SUTHERLAND, Reinhard WALTHER, Dieter SCHMOLL

Biochem J (2004) 382 (2): 471–479.

https://doi.org/10.1042/BJ20040160

Published: 24 August 2004

... or an unrelated sequence. diabetes gluconeogenesis glucose-6-phosphatase insulin liver sepsis G6Pase (glucose-6-phosphatase) catalyses the final step of the metabolic pathways that are central to hepatic glucose production, i.e. gluconeogenesis and glycogen breakdown [ 1 ]. Thus G6Pase has...

View articletitled, Tumour necrosis factor α decreases glucose-6-phosphatase gene expression by activation of nuclear factor κB

Articles

Differences in regulatory properties between human and rat glucokinase regulatory protein

Katy J. BROCKLEHURST, Rick A. DAVIES, Loranne AGIUS

Biochem J (2004) 378 (2): 693–697.

https://doi.org/10.1042/bj20031414

Published: 01 March 2004

... The Biochemical Society, London ©2004 2004 diabetes glucokinase regulatory protein hexokinase IV human glucokinase liver Abbreviations used: GKRP, glucokinase regulatory protein; fructose 1- P , fructose 1-phosphate; fructose 6- P , fructose 6-phosphate; sorbitol 6- P , sorbitol 6-phosphate...

View articletitled, Differences in regulatory properties between human and rat glucokinase regulatory protein

Articles

Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation

Emma T. A. S. JAIKARAN, Melanie R. NILSSON, Anne CLARK

Biochem J (2004) 377 (3): 709–716.

https://doi.org/10.1042/bj20030852

Published: 01 February 2004

...Emma T. A. S. JAIKARAN; Melanie R. NILSSON; Anne CLARK Islet amyloid polypeptide (IAPP), or ‘amylin’, is co-stored with insulin in secretory granules of pancreatic islet β-cells. In Type 2 diabetes, IAPP converts into a β-sheet conformation and oligomerizes to form amyloid fibrils and islet...

View articletitled, Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation

Articles

Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing

Gabriela da SILVA XAVIER, Qingwen QIAN, Peter J. CULLEN, Guy A. RUTTER

Biochem J (2004) 377 (1): 149–158.

https://doi.org/10.1042/bj20031260

Published: 01 January 2004

... 10 2003 17 10 2003 17 10 2003 The Biochemical Society, London ©2004 2004 diabetes glucose insulin islet β-cell small interfering RNA (siRNA) Abbreviations used: ACC, acetyl-CoA carboxylase; ARNO, ADP-ribosylation factor nucleotide opener; CMV, cytomegalovirus; C T...

View articletitled, Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing

Articles

Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry

Paul J. THORNALLEY, Sinan BATTAH, Naila AHMED, Nikolaos KARACHALIAS, Stamatina AGALOU, Roya BABAEI-JADIDI, Anne DAWNAY

Biochem J (2003) 375 (3): 581–592.

https://doi.org/10.1042/bj20030763

Published: 01 November 2003

.... Advanced glycation endproduct residues were increased in blood plasma and at sites of vascular complications development in experimental diabetes; renal glomeruli, retina and peripheral nerve. In clinical uraemia, the concentrations of plasma protein advanced glycation endproduct residues increased 1–7...

View articletitled, Quantitative screening of advanced glycation endproducts in cellular and extracellular proteins by tandem mass spectrometry

Articles

A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell antigen 512 (IA-2) and phogrin (IA-2beta)

Paul G. DRAKE, Günther H. PETERS, Henrik Sune ANDERSEN, Wiljan HENDRIKS, Niels Peter H. MØLLER

Biochem J (2003) 373 (2): 393–401.

https://doi.org/10.1042/bj20021851

Published: 15 July 2003

..., diabetes, enzyme kinetics, molecular modelling, phosphatase inhibitor. INTRODUCTION IA-2 (islet-cell antigen 512) and IA-2 (phogrin) are integral membrane glycoproteins that are predominantly expressed in dense-core secretory granules of a variety of neuroendocrine tissues, including pituitary cells...

View articletitled, A novel strategy for the development of selective active-site inhibitors of the protein tyrosine phosphatase-like proteins islet-cell antigen 512 (IA-2) and phogrin (IA-2beta)

Articles

Upstream stimulatory factor (USF) and neurogenic differentiation/beta-cell E box transactivator 2 (NeuroD/BETA2) contribute to islet-specific glucose-6-phosphatase catalytic-subunit-related protein (IGRP) gene expression

Cyrus C. MARTIN, Christina A. SVITEK, James K. OESER, Eva HENDERSON, Roland STEIN, Richard M. O'BRIEN

Biochem J (2003) 371 (3): 675–686.

https://doi.org/10.1042/bj20021585

Published: 01 May 2003

... to explain how the ubiquitously expressed USF could contribute to islet-specific IGRP gene expression. Key words: diabetes, pancreas, promoter, transcription. INTRODUCTION The transcriptional mechanisms that direct the specific or enriched expression of genes such as insulin and glucagon to the islets...

View articletitled, Upstream stimulatory factor (USF) and neurogenic differentiation/beta-cell E box transactivator 2 (NeuroD/BETA2) contribute to islet-specific glucose-6-phosphatase catalytic-subunit-related protein (IGRP) gene expression

Articles

Neurogenin3 triggers beta-cell differentiation of retinoic acid-derived endoderm cells

Amedeo VETERE, Eleonora MARSICH, Matteo DI PIAZZA, Raffaella KONCAN, Fulvio MICALI, Sergio PAOLETTI

Biochem J (2003) 371 (3): 831–841.

https://doi.org/10.1042/bj20021524

Published: 01 May 2003

... bodies that produce insulin in response to glucose stimulation. This is the first report of a differentiation event induced by the ectopic expression of a transcription factor in embryonic pluri- potent stem cells. Key words: diabetes, insulin, pancreatic differentiation, tran- scription factor...

View articletitled, Neurogenin3 triggers beta-cell differentiation of retinoic acid-derived endoderm cells

Articles

Hepatocyte nuclear factor-4alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells

Jared N. BOUSTEAD, Beth T. STADELMAIER, Angela M. EEDS, Peter O. WIEBE, Christina A. SVITEK, James K. OESER, Richard M. O'BRIEN

Biochem J (2003) 369 (1): 17–22.

https://doi.org/10.1042/bj20021382

Published: 01 January 2003

... to glycogen storage disease type 1a [3], whereas overexpression of G6Pase is thought to contribute to the increased hepatic glucose production characteristic of both type I and type II diabetes [4]. Peroxisome proliferator-activated receptor c co-activator (PGC)-1a was originally identified through its...

View articletitled, Hepatocyte nuclear factor-4alpha mediates the stimulatory effect of peroxisome proliferator-activated receptor gamma co-activator-1alpha (PGC-1alpha) on glucose-6-phosphatase catalytic subunit gene transcription in H4IIE cells

Articles

Foxa3 (HNF-3γ) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression

Yuanfang LIU, Wei SHEN, Patricia L. BRUBAKER, Klaus H. KAESTNER, Daniel J. DRUCKER

Biochem J (2002) 366 (2): 633–641.

https://doi.org/10.1042/bj20020095

Published: 01 September 2002

... The Biochemical Society, London ©2002 2002 diabetes enteroendocrine intestine islet pancreas Abbreviations used: EMSA, electrophoretic mobility-shift assay; Foxa, Forkhead box a; GLI, glucagon-like immunoreactivity; GLP, glucagon-like peptide; HNF, hepatocyte nuclear factor; RT-PCR, reverse...

View articletitled, Foxa3 (HNF-3γ) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression

Articles

Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxide

Satish PATEL, Jeroen VAN DER KAAY, Calum SUTHERLAND

Biochem J (2002) 365 (2): 537–545.

https://doi.org/10.1042/bj20020266

Published: 15 July 2002

... underlie or contribute to the development of insulin-resistant states, such as Type II diabetes mellitus. The identification of agents that can mimic key actions of insulin, thereby overriding insulin resistance, may aid the development of treatments for such disorders. Phosphoenolpyruvate carboxykinase...

View articletitled, Insulin regulation of hepatic insulin-like growth factor-binding protein-1 (IGFBP-1) gene expression and mammalian target of rapamycin (mTOR) signalling is impaired by the presence of hydrogen peroxide

Articles

Decorin suppresses transforming growth factor-β-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240

Nadia ABDEL-WAHAB, Stephen J. WICKS, Roger M. MASON, Andrew CHANTRY

Biochem J (2002) 362 (3): 643–649.

https://doi.org/10.1042/bj3620643

Published: 08 March 2002

...Nadia ABDEL-WAHAB; Stephen J. WICKS; Roger M. MASON; Andrew CHANTRY Transforming growth factor-β (TGFβ) is a key mediator of extracellular matrix (ECM) accumulation in sclerotic kidney diseases such as diabetic nephropathy. One of the main target cells for TGFβ in the kidney are glomerular...

View articletitled, Decorin suppresses transforming growth factor-β-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240

Articles

Induction of Bach1 and ARA70 gene expression at an early stage of adipocyte differentiation of mouse 3T3-L1 cells

Makoto NISHIZUKA, Tomoko TSUCHIYA, Tsutomu NISHIHARA, Masayoshi IMAGAWA

Biochem J (2002) 361 (3): 629–633.

https://doi.org/10.1042/bj3610629

Published: 25 January 2002

... The Biochemical Society, London ©2002 2002 diabetes obesity signalling factor subtraction method transcription factor Abbreviations used: C/EBP, CCAAT/enhancer-binding protein; Dex, dexamethasone; DMEM, Dulbecco's modified Eagle's medium; FBS, fetal bovine serum; IBMX, 3-isobutyl-1...

View articletitled, Induction of Bach1 and ARA70 gene expression at an early stage of adipocyte differentiation of mouse 3T3-L1 cells

Articles

myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and d-chiro-inositol

Ryan J. ARNER, K. Sandeep PRABHU, Jerry T. THOMPSON, George R. HILDENBRANDT, Andrew D. LIKEN, C. Channa REDDY

Biochem J (2001) 360 (2): 313–320.

https://doi.org/10.1042/bj3600313

Published: 26 November 2001

.... Preincubation with 1mM Fe 2+ and 2mM cysteine was essential for the enzyme's activity. d -c hiro -Inositol, a myo -inositol isomer, is a substrate for the recombinant MIOX with an estimated K m of 33.5mM. Both myo -inositol and d - chiro -inositol have been implicated in the pathogenesis of diabetes. Thus...

View articletitled, myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and d-chiro-inositol

Update search

Email alerts

CONNECT

EXPLORE

This Feature Is Available To Subscribers Only