... diacylglycerol (DAG) endocytosis glycosylphosphatidylinositol-specific phospholipase C (GPI-PLC) signalling transferrin Trypanosoma brucei Endocytosis in eukaryotes is important for uptake of some nutrients (e.g. iron, and cholesterol esters), maintenance of cell volume and for modulation of cell...

... Journal compilation © 2008 Biochemical Society 2008 ceramide chromatin diacylglycerol (DAG) nuclear membrane sphingomyelin (SM) The involvement of SM (sphingomyelin) and PC (phosphatidylcholine) in signal transduction [ 1 , 2 ], and the role of DAG (diacylglycerol) and ceramides in cell...

... diacylglycerol (DAG) guanine-nucleotide-exchange factor (GEF) membrane binding phorbol ester cDNAs encoding the C1 domains were generated by PCR from cDNAs and cloned into the pEGFP-C1 vector (Clontech) to create GFP–C1 domain fusion proteins upon expression. The sequences of the encoded C1 domain...

... [2, 4, 6-trimethyl- N -( m -3-trifluoromethylphenyl)benzenesulfonamide] were obtained from Calbiochem. © The Authors Journal compilation © 2007 Biochemical Society 2007 diacylglycerol (DAG) Golgi GTP-binding protein βγ subunits (Gβγ) phospholipase C (PLC) protein kinase D (PKD...

... variant designated as Rac1b is mainly expressed in colon and breast cancer tissues [ 8 , 9 ]. The Biochemical Society, London 2007 chimaerin diacylglycerol (DAG) phorbol ester protein kinase C (PKC) Rac GTPase-activating protein (RacGAP) Like most other small GTPases, Rac acts...

... complexity of DAG signalling due to the activation of PKC-independent path- ways, and cast doubts regarding the selectivity of phorbol esters and DAG analogues as selective PKC activators. Key words: 2-chimaerin, diacylglycerol (DAG), phorbol ester, protein kinase C (PKC), Rac-GTPase-activating protein (Rac...