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Keywords: differentiation
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Biochem J (2020) 477 (9): 1733–1744.
Published: 15 May 2020
... in the catalytic site structure and substrate binding. Altogether, our data demonstrated for the first time that protein acetylation might be another mechanism for regulating glycolytic enzymes in T. brucei . aldolase differentiation glycolysis lysine acetylation Trypanosoma Environmental...
Includes: Supplementary data
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Biochem J (2019) 476 (12): 1741–1751.
Published: 26 June 2019
...Yanyan Guo; Zuying Xiong; Xiaoqiang Guo Podocytes are terminally differentiated and highly specialized glomerular cells, which have an essential role as a filtration barrier against proteinuria. Histone methylation has been shown to influence cell development, but its role in podocyte...
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Biochem J (2016) 473 (19): 2955–2971.
Published: 27 September 2016
..., and, as a result, the establishment of the mtDNA set point is required for sequential cell lineage commitment. The failure to establish the mtDNA set point results in incomplete differentiation or embryonic arrest. The regulation of mtDNA copy number during differentiation is closely associated with cellular gene...
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Biochem J (2014) 464 (3): 355–364.
Published: 05 December 2014
... differentiation and the promotion or inhibition of mineral growth and/or nucleation. One protein implicated in the inhibition of mineral formation is osteopontin (OPN). 1 To whom correspondence should be addressed (email hagoldbe@uwo.ca ). 3 6 2014 29 8 2014 13 10 2014 13 10 2014...
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Biochem J (2014) 462 (2): 267–277.
Published: 07 August 2014
...Elliott M. McMillan; Joe Quadrilatero Several degradative systems assist in formation of multinucleated terminally differentiated myotubes. However, the role of autophagy in this process has not been examined. GFP–LC3B (light chain 3 beta) puncta, LC3B-II protein and LysoTracker fluorescence...
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Biochem J (2014) 462 (1): 89–101.
Published: 24 July 2014
... in the differentiation of C2C12 mouse myoblast cells to multinuclear muscle cells. Taken together, the results show that TM4SF5 controls muscle differentiation via co-operation with integrin α5-related signalling. 1 These authors contributed equally to this work. 2 Correspondence may be addressed...
Includes: Supplementary data
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Biochem J (2014) 459 (2): 405–415.
Published: 28 March 2014
... converts GlcA (D -glucuronic acid) into IdoA (L -iduronic acid). However, the function of GLCE in neuritogenesis is largely unknown. In the present study we showed that GLCE depletion caused arrested PC12 cell growth and promoted the cell neuritogenesis and differentiation induced by NGF (nerve growth...
Includes: Supplementary data
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Biochem J (2013) 453 (3): 467–474.
Published: 12 July 2013
...Mervi T. Hyvönen; Taina Koponen; Janne Weisell; Marko Pietilä; Alex R. Khomutov; Jouko Vepsäläinen; Leena Alhonen; Tuomo A. Keinänen We have shown previously that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. In the present study, we examined the mechanism...
Includes: Supplementary data
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Biochem J (2012) 447 (2): 239–248.
Published: 26 September 2012
...Yoshinao Oki; Hiromasa Ono; Takeharu Motohashi; Nobuki Sugiura; Hiroyuki Nobusue; Koichiro Kano Transdifferentiation is the conversion of cells from one differentiated cell type into another. How functionally differentiated cells already committed to a specific cell lineage can transdifferentiate...
Includes: Supplementary data
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Biochem J (2012) 446 (1): 89–98.
Published: 27 July 2012
... the first evidence that USF1 activates GATA5 gene expression through the E-box motif and suggests a potential mechanism (disruption of the E-box) by which GATA5 promoter methylation reduces GATA5 expression in cancer. cancer differentiation enhancer-box (E-box) GATA5 transcription factor upstream...
Includes: Supplementary data
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Biochem J (2012) 444 (3): 375–382.
Published: 29 May 2012
...Christopher Hindley; Anna Philpott During embryonic development, cells must divide to produce appropriate numbers, but later must exit the cell cycle to allow differentiation. How these processes of proliferation and differentiation are co-ordinated during embryonic development has been poorly...
Includes: Multimedia, Supplementary data
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Biochem J (2010) 426 (2): 171–181.
Published: 09 February 2010
... is known about how the cell-cycle fate is regulated in ES cells. Oct-4, a master switch of pluripotency, plays an important role in maintaining the pluripotent state of ES cells and may prevent the expression of genes activated during differentiation. Using ZHBTc4 ES cells, we have investigated the effect...
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Biochem J (2009) 418 (2): 463–473.
Published: 11 February 2009
... and for the activation and maintenance of the acinar differentiation programme in the exocrine pancreas. High-level expression of exocrine digestive enzymes, a hallmark of mature acinar cells, depends largely on the trimeric complex PTF1, formed by p48, RBP-L (recombination signal-binding protein 1-like) and a class...
Includes: Supplementary data
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Biochem J (2006) 393 (1): 277–283.
Published: 12 December 2005
... renal tubular acidosis due to an intercalated cell-differentiation defect. Collecting duct cells in these mice are characterized by the absence of inter-calated cell markers including AE4. To test whether Slc4a9 is a direct target gene of Foxi1, an AE4 promoter construct was generated for a cell-based...
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Biochem J (2003) 375 (2): 457–463.
Published: 15 October 2003
..., which contain similar sequences, implying that promoter activation by BTEB3 is selective. The expression of BTEB3 is readily detectable in VSMCs in vitro and is modulated in response to injury in vivo. Key words: differentiation, gene expression, Kru¨ppel-like factor (KLF), TGGG box, transcription...
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Biochem J (2003) 370 (1): 291–298.
Published: 15 February 2003
...Louise KIME; Stephanie C. WRIGHT Myc and Mad family proteins are central regulators of cellular proliferation and differentiation. We show that various Mad family genes have distinct patterns of expression during the chemically induced differentiation of mouse erythroleukaemia (MEL) cells...
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Biochem J (2002) 365 (3): 561–575.
Published: 01 August 2002
... and characterized to date (C/EBPα—C/EBPζ), with further diversity produced by the generation of different sized polypeptides, predominantly by differential use of translation initiation sites, and extensive protein—protein interactions both within the family and with other transcription factors. The function...
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Biochem J (2001) 360 (1): 173–177.
Published: 08 November 2001
.... Inhibitor studies with purified recombinant FeSOD expressed in Escherichia coli confirmed that the enzyme is an iron-containing SOD. The FeSOD is developmentally regulated in the parasite, expression being lowest in the cell-cycle-arrested, short stumpy bloodstream forms. Differential expression...
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Biochem J (2001) 359 (2): 361–367.
Published: 08 October 2001
...Elizabeth J. FOX; Stephanie C. WRIGHT The Myc/Max/Mad transcription factor network plays a central role in the control of cellular proliferation, differentiation and apoptosis. In order to elucidate the biological function of Mad3, we have analysed the precise temporal patterns of Mad3 mRNA...
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Biochem J (2001) 359 (1): 227–233.
Published: 24 September 2001
...Jin-Mei LAI; Ching-Yi LU; Hsin-Fang YANG-YEN; Zee-Fen CHANG When exposed to PMA, the erythroblastic cell line TF-1 and its cytokine-independent variant D2 cells can be induced to undergo differentiation and apoptosis. In this study we investigated the mechanism responsible for the differential...
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Biochem J (2001) 358 (2): 335–342.
Published: 24 August 2001
..., a physiological substrate of SSAO, promoted adipocyte differentiation in a time- and dose-dependent manner. This effect could be related to SSAO activation, since it was antagonized in the presence of the SSAO inhibitor semicarbazide, but not in the presence of the monoamine oxidase inhibitor pargyline...
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Biochem J (2001) 357 (2): 353–361.
Published: 09 July 2001
...Yi CAO; Qing KANG; Anna ZOLKIEWSKA ADAM 12, a member of the ADAM family of proteins (containing A D isintegrin A nd M etalloprotease domain), has been implicated in differentiation and fusion of myoblasts. While the extracellular domain of ADAM 12 contains an active metalloprotease and a region...
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Biochem J (2001) 357 (2): 587–592.
Published: 09 July 2001
...Nickolai O. DULIN; Sergei N. ORLOV; Chad M. KITCHEN; Tatyana A. VOYNO-YASENETSKAYA; Joseph M. MIANO A hallmark of cultured smooth muscle cells (SMCs) is the rapid down-regulation of several lineage-restricted genes that define their in vivo differentiated phenotype. Identifying factors...
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Biochem J (2001) 355 (1): 13–18.
Published: 26 February 2001
... of Dermatology (e-mail sunt01@med.nyu.edu ). 2 10 2000 3 1 2001 23 1 2001 The Biochemical Society, London © 2001 2001 bladder epithelium differentiation tetraspanin urothelium Biochem. J. (2001) 355, 13 18 (Printed in Great Britain) 13 Organization of uroplakin subunits...
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Biochem J (2000) 349 (2): 463–471.
Published: 10 July 2000
... as well as their effects on preadipocyte differentiation. We found that less octanoate than oleate was stored and that more octanoate than oleate was oxidized. Octanoate was esterified to a greater extent at the sn -1,3 position of glyceryl carbons than at the sn -2 position, whereas the opposite was true...
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Biochem J (1999) 344 (3): 889–894.
Published: 08 December 1999
..., but not in response to EGF or NGF. PP2 also completely blocked NE-induced PC12 cell differentiation, but had no measurable effect on NGF-induced differentiation. These studies show that activation of mitogen-activated protein kinase pathways by G-protein-coupled receptors and tyrosine kinase receptors proceed through...
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Biochem J (1999) 343 (1): 265–271.
Published: 24 September 1999
...Manabu NAKAGAWA; Akiko A. OOHATA; Hiromasa TOJO; Shigeru FUJII Under starvation conditions, amoebae of Dictyostelium discoideum aggregate to form multicellular masses; the aggregates are then initiated to differentiate. We have reported previously that a signal substance exists in conditioned...
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Biochem J (1999) 339 (3): 759–766.
Published: 26 April 1999
...Claudia GUTACKER; Gerd KLOCK; Patrick DIEL; Claudia KOCH-BRANDT Clusterin (apolipoprotein J) is an extracellular glycoprotein that might exert functions in development, cell death and lipid transport. Clusterin gene expression is elevated at sites of tissue remodelling, such as differentiation...
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Biochem J (1999) 339 (1): 111–117.
Published: 25 March 1999
... only slightly increased in liver of rats refed with a high-carbohydrate diet or after partial hepatectomy. Whereas the expression of Hex mRNA was detected in hepatocytes isolated from adult rat liver and also in highly differentiated hepatoma cells, no Hex mRNA was detected in poorly differentiated...
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Biochem J (1999) 338 (2): 351–357.
Published: 22 February 1999
... only marginally induced mucin gene expression. The RARα antagonist strongly inhibited mucin gene induction and mucous cell differentiation caused by RA and by the RARα- and RARγ-selective retinoids. In contrast, the RARγ antagonist only weakly inhibited RARα-selective-retinoid-induced mucin gene...
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Biochem J (1999) 338 (2): 561–568.
Published: 22 February 1999
... the initiation of differentiation, and GPT expression was down-regulated during cellular differentiation. GPT activity decreased about 2.8-fold to a constant level in differentiated P19 cells. The results indicate that the RA-induced enzyme activity was mainly determined by increased transcription of the GPT...