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Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia

Anil Kumar Singh, Vishal Upadhyay, Arppita Sethi, Sangita Chowdhury, Shivkant Mishra, Shailendra Prasad Verma, Madan Lal Brahma Bhatt, Arun Kumar Trivedi

Biochem J (2024) 481 (10): 653–666.

https://doi.org/10.1042/BCJ20240027

Published: 10 May 2024

...Anil Kumar Singh; Vishal Upadhyay; Arppita Sethi; Sangita Chowdhury; Shivkant Mishra; Shailendra Prasad Verma; Madan Lal Brahma Bhatt; Arun Kumar Trivedi E3 ubiquitin ligase, ring finger protein 138 (RNF138) is involved in several biological processes; however, its role in myeloid differentiation...

View articletitled, Ring finger protein 138 inhibits transcription factor C/EBPα protein turnover leading to differentiation arrest in acute myeloid leukemia

Includes: Supplementary data

Articles

Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity

Ariely Barbosa Leite, Antoniel Augusto Severo Gomes, Ana Caroline de Castro Nascimento Sousa, Marcos Roberto de Mattos Fontes, Sergio Schenkman, Nilmar Silvio Moretti

Biochem J (2020) 477 (9): 1733–1744.

https://doi.org/10.1042/BCJ20200142

Published: 15 May 2020

... 2020 © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2020 aldolase differentiation glycolysis lysine acetylation Trypanosoma Environmental adaptation is regulated at different levels, from gene expression to enzymatic strategies...

View articletitled, Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity

Includes: Supplementary data

Articles

Histone demethylase KDM6B regulates human podocyte differentiation in vitro

Yanyan Guo, Zuying Xiong, Xiaoqiang Guo

Biochem J (2019) 476 (12): 1741–1751.

https://doi.org/10.1042/BCJ20180968

Published: 26 June 2019

...Yanyan Guo; Zuying Xiong; Xiaoqiang Guo Podocytes are terminally differentiated and highly specialized glomerular cells, which have an essential role as a filtration barrier against proteinuria. Histone methylation has been shown to influence cell development, but its role in podocyte...

View articletitled, Histone demethylase KDM6B regulates human podocyte differentiation in vitro

Articles

The pro-inflammatory cytokines IFNγ/TNFα increase chromogranin A-positive neuroendocrine cells in the colonic epithelium

José Antonio Hernández-Trejo, Dimelza Suárez-Pérez, Itzel Zenidel Gutiérrez-Martínez, Omar Eduardo Fernandez-Vargas, Carolina Serrano, Aurora Antonia Candelario-Martínez, Marco Antonio Meraz-Ríos, Alí Francisco Citalán-Madrid, Marcela Hernández-Ruíz, Elba Reyes-Maldonado, Ricardo Valle-Rios, Jacobo H. Feintuch-Unger, Michael Schnoor, Nicolás Villegas-Sepúlveda, Oscar Medina-Contreras, Porfirio Nava

Biochem J (2016) 473 (21): 3805–3818.

https://doi.org/10.1042/BCJ20160390

Published: 27 October 2016

.../TNFα treatment. Similarly, we observed that CgA-positive cells in the colonic mucosa of patients with colitis expressed Akt and autophagy markers. These findings suggest that Akt signaling and autophagy control differentiation of the intestinal EEC lineage during inflammation. Correspondence...

View articletitled, The pro-inflammatory cytokines IFNγ/TNFα increase chromogranin A-positive neuroendocrine cells in the colonic epithelium

Includes: Supplementary data

Articles

The role of the mtDNA set point in differentiation, development and tumorigenesis

Xin Sun, Justin C. St. John

Biochem J (2016) 473 (19): 2955–2971.

https://doi.org/10.1042/BCJ20160008

Published: 27 September 2016

..., and, as a result, the establishment of the mtDNA set point is required for sequential cell lineage commitment. The failure to establish the mtDNA set point results in incomplete differentiation or embryonic arrest. The regulation of mtDNA copy number during differentiation is closely associated with cellular gene...

View articletitled, The role of the mtDNA set point in differentiation, development and tumorigenesis

Articles

Osteopontin mediates mineralization and not osteogenic cell development in vitro

Erik Holm, Jared S. Gleberzon, Yinyin Liao, Esben S. Sørensen, Frank Beier, Graeme K. Hunter, Harvey A. Goldberg

Biochem J (2014) 464 (3): 355–364.

https://doi.org/10.1042/BJ20140702

Published: 05 December 2014

...) in osteogenic cultures resulted in increased mineralization with no change in osteogenic gene expression. Supplementation with bovine milk OPN and OPN-derived peptides resulted in reduced mineralization in osteogenic cultures. differentiation mineralization osteoblast osteopontin small integrin...

View articletitled, Osteopontin mediates mineralization and not osteogenic cell development in vitro

Articles

hnRNP K in PU.1-containing complexes recruited at the CD11b promoter: a distinct role in modulating granulocytic and monocytic differentiation of AML-derived cells

Ervin Nika, Federica Brugnoli, Manuela Piazzi, Elisabetta Lambertini, Silvia Grassilli, Alberto Bavelloni, Roberta Piva, Silvano Capitani, Valeria Bertagnolo

Biochem J (2014) 463 (1): 115–122.

https://doi.org/10.1042/BJ20140358

Published: 08 September 2014

...Ervin Nika; Federica Brugnoli; Manuela Piazzi; Elisabetta Lambertini; Silvia Grassilli; Alberto Bavelloni; Roberta Piva; Silvano Capitani; Valeria Bertagnolo PU.1 is essential for the differentiation of haemopoietic precursors and is strongly implicated in leukaemogenesis, yet the protein...

View articletitled, hnRNP K in PU.1-containing complexes recruited at the CD11b promoter: a distinct role in modulating granulocytic and monocytic differentiation of AML-derived cells

Articles

Autophagy is required and protects against apoptosis during myoblast differentiation

Elliott M. McMillan, Joe Quadrilatero

Biochem J (2014) 462 (2): 267–277.

https://doi.org/10.1042/BJ20140312

Published: 07 August 2014

...Elliott M. McMillan; Joe Quadrilatero Several degradative systems assist in formation of multinucleated terminally differentiated myotubes. However, the role of autophagy in this process has not been examined. GFP–LC3B (light chain 3 beta) puncta, LC3B-II protein and LysoTracker fluorescence...

View articletitled, Autophagy is required and protects against apoptosis during myoblast differentiation

Articles

TM4SF5 suppression disturbs integrin α5-related signalling and muscle development in zebrafish

Yoon-Ju Choi, Hyun Ho Kim, Jeong-gyun Kim, Hye-Jin Kim, Minkyung Kang, Mi-Sook Lee, Jihye Ryu, Haeng Eun Song, Seo Hee Nam, Doohyung Lee, Kyu-Won Kim, Jung Weon Lee

Biochem J (2014) 462 (1): 89–101.

https://doi.org/10.1042/BJ20140177

Published: 24 July 2014

... in the differentiation of C2C12 mouse myoblast cells to multinuclear muscle cells. Taken together, the results show that TM4SF5 controls muscle differentiation via co-operation with integrin α5-related signalling. 1 These authors contributed equally to this work. 2 Correspondence may be addressed...

View articletitled, TM4SF5 suppression disturbs integrin α5-related signalling and muscle development in zebrafish

Includes: Supplementary data

Articles

GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling

Jie Li, Jianping Fang, Yi Qin, Wenfeng Liao, Hailing Liu, Yifa Zhou, Kan Ding

Biochem J (2014) 459 (2): 405–415.

https://doi.org/10.1042/BJ20131360

Published: 28 March 2014

... converts GlcA (D -glucuronic acid) into IdoA (L -iduronic acid). However, the function of GLCE in neuritogenesis is largely unknown. In the present study we showed that GLCE depletion caused arrested PC12 cell growth and promoted the cell neuritogenesis and differentiation induced by NGF (nerve growth...

View articletitled, GLCE regulates PC12 cell neuritogenesis induced by nerve growth factor through activating SMAD/ID3 signalling

Includes: Supplementary data

Articles

Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1

Stewart M. Coleman, Alan R. Prescott, Judith E. Sleeman

Biochem J (2014) 458 (2): 267–280.

https://doi.org/10.1042/BJ20130870

Published: 14 February 2014

... transcription and splicing activity. Moreover, immunolocalization studies in lens sections suggest that a change in MBNL1 distribution is important during lens growth and differentiation. Although these data suggest that the loss of MBNL1 function due to accumulation in foci is an unlikely explanation for DM1...

View articletitled, Transcriptionally correlated subcellular dynamics of MBNL1 during lens development and their implication for the molecular pathology of myotonic dystrophy type 1

Includes: Multimedia, Supplementary data

Articles

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A

Mervi T. Hyvönen, Taina Koponen, Janne Weisell, Marko Pietilä, Alex R. Khomutov, Jouko Vepsäläinen, Leena Alhonen, Tuomo A. Keinänen

Biochem J (2013) 453 (3): 467–474.

https://doi.org/10.1042/BJ20130263

Published: 12 July 2013

...Mervi T. Hyvönen; Taina Koponen; Janne Weisell; Marko Pietilä; Alex R. Khomutov; Jouko Vepsäläinen; Leena Alhonen; Tuomo A. Keinänen We have shown previously that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. In the present study, we examined the mechanism...

View articletitled, Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A

Includes: Supplementary data

Articles

ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours

M. Luisa Campos, Víctor J. Sánchez-Arévalo Lobo, Annie Rodolosse, Cara J. Gottardi, Andrea Mafficini, Stefania Beghelli, Maria Scardoni, Claudio Bassi, Aldo Scarpa, Francisco X. Real

Biochem J (2013) 451 (3): 395–405.

https://doi.org/10.1042/BJ20120873

Published: 12 April 2013

...M. Luisa Campos; Víctor J. Sánchez-Arévalo Lobo; Annie Rodolosse; Cara J. Gottardi; Andrea Mafficini; Stefania Beghelli; Maria Scardoni; Claudio Bassi; Aldo Scarpa; Francisco X. Real The PTF1 (pancreas transcription factor 1) complex is a master regulator of differentiation of acinar cells...

View articletitled, ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours

Includes: Supplementary data

Articles

Dedifferentiated follicular granulosa cells derived from pig ovary can transdifferentiate into osteoblasts

Yoshinao Oki, Hiromasa Ono, Takeharu Motohashi, Nobuki Sugiura, Hiroyuki Nobusue, Koichiro Kano

Biochem J (2012) 447 (2): 239–248.

https://doi.org/10.1042/BJ20120172

Published: 26 September 2012

...Yoshinao Oki; Hiromasa Ono; Takeharu Motohashi; Nobuki Sugiura; Hiroyuki Nobusue; Koichiro Kano Transdifferentiation is the conversion of cells from one differentiated cell type into another. How functionally differentiated cells already committed to a specific cell lineage can transdifferentiate...

View articletitled, Dedifferentiated follicular granulosa cells derived from pig ovary can transdifferentiate into osteoblasts

Includes: Supplementary data

Articles

Upstream stimulatory factor 1 activates GATA5 expression through an E-box motif

Bohao Chen, Rona Hsu, Zhenping Li, Paul C. Kogut, Qingxia Du, Kelly Rouser, Blanca Camoretti-Mercado, Julian Solway

Biochem J (2012) 446 (1): 89–98.

https://doi.org/10.1042/BJ20111942

Published: 27 July 2012

[email protected] ). 31 10 2011 18 5 2012 25 5 2012 25 5 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cancer differentiation enhancer-box (E-box) GATA5 transcription factor upstream stimulatory factor 1 (USF1) GATA5 is a member of the GATA...

View articletitled, Upstream stimulatory factor 1 activates GATA5 expression through an E-box motif

Includes: Supplementary data

Articles

Co-ordination of cell cycle and differentiation in the developing nervous system

Christopher Hindley, Anna Philpott

Biochem J (2012) 444 (3): 375–382.

https://doi.org/10.1042/BJ20112040

Published: 29 May 2012

...Christopher Hindley; Anna Philpott During embryonic development, cells must divide to produce appropriate numbers, but later must exit the cell cycle to allow differentiation. How these processes of proliferation and differentiation are co-ordinated during embryonic development has been poorly...

View articletitled, Co-ordination of cell cycle and differentiation in the developing nervous system

Includes: Multimedia, Supplementary data

Articles

CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G 1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells

Ke Gong, Jia Xie, Hong Yi, Wenhua Li

Biochem J (2012) 443 (3): 735–746.

https://doi.org/10.1042/BJ20111685

Published: 16 April 2012

..., differentiation and apoptosis in human leukaemia cell lines and primary myeloid leukaemia cells. The results showed that at low concentrations (<1 μM), CS055 induced G 1 arrest. At moderate concentrations (0.5 μM–2 μM), CS055 induced differentiation, as determined by the increased expression of the myeloid...

View articletitled, CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G 1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells

Includes: Supplementary data

Articles

Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation

Xiaoling Wang, Ji Wang, Vera Huang, Robert F. Place, Long-Cheng Li

Biochem J (2012) 443 (3): 821–828.

https://doi.org/10.1042/BJ20111491

Published: 16 April 2012

...), REST (RE1-silencing transcription factor), OCT4 (octamer-binding protein 4) and REX1 (reduced expression protein 1). Treatment with RA (retinoic acid) triggers NCCIT cell differentiation, reducing NANOG and OCT4 expression and up-regulating several neural markers [i.e. ASCL1 (achaete-scute complex...

View articletitled, Induction of NANOG expression by targeting promoter sequence with small activating RNA antagonizes retinoic acid-induced differentiation

Includes: Supplementary data

Articles

Erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells

Peter Burton, David R. Adams, Achamma Abraham, Robert W. Allcock, Zhong Jiang, Angela McCahill, Jane Gilmour, John McAbney, Alexandra Kaupisch, Nicole M. Kane, George S. Baillie, Andrew H. Baker, Graeme Milligan, Miles D. Houslay, Joanne C. Mountford

Biochem J (2010) 432 (3): 575–599.

https://doi.org/10.1042/BJ20100726

Published: 25 November 2010

... potential for use in pharmaceutical development and therapeutics; however, to realize this potential, there is a requirement for simple and reproducible cell culture methods that provide adequate numbers of cells of suitable quality. We have discovered a novel way of blocking the spontaneous differentiation...

View articletitled, Erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells

Includes: Supplementary data

Articles

Oct-4 controls cell-cycle progression of embryonic stem cells

Jungwoon Lee, Yeorim Go, Inyoung Kang, Yong-Mahn Han, Jungho Kim

Biochem J (2010) 426 (2): 171–181.

https://doi.org/10.1042/BJ20091439

Published: 09 February 2010

... is known about how the cell-cycle fate is regulated in ES cells. Oct-4, a master switch of pluripotency, plays an important role in maintaining the pluripotent state of ES cells and may prevent the expression of genes activated during differentiation. Using ZHBTc4 ES cells, we have investigated the effect...

View articletitled, Oct-4 controls cell-cycle progression of embryonic stem cells

Articles

p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation

Annie Rodolosse, Maria-Luisa Campos, Ilse Rooman, Mathieu Lichtenstein, Francisco X. Real

Biochem J (2009) 418 (2): 463–473.

https://doi.org/10.1042/BJ20080293

Published: 11 February 2009

... and for the activation and maintenance of the acinar differentiation programme in the exocrine pancreas. High-level expression of exocrine digestive enzymes, a hallmark of mature acinar cells, depends largely on the trimeric complex PTF1, formed by p48, RBP-L (recombination signal-binding protein 1-like) and a class...

View articletitled, p/CAF modulates the activity of the transcription factor p48/Ptf1a involved in pancreatic acinar differentiation

Includes: Supplementary data

Articles

Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation

Annika C. Schüller, Zamal Ahmed, John E. Ladbury

Biochem J (2008) 410 (1): 205–211.

https://doi.org/10.1042/BJ20070859

Published: 29 January 2008

... including the receptor, the activation of downstream signalling pathways and cell differentiation. Our results show that the effects of both of these extracellular mutations have unexpected intracellular phenotypes and cellular responses. Receptor phosphorylation was altered in both the ligand-stimulated...

View articletitled, Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation

Articles

Interactions between Hairy/Enhancer of Split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex

Bidyut Ghosh, Steven D. Leach

Biochem J (2006) 393 (3): 679–685.

https://doi.org/10.1042/BJ20051063

Published: 13 January 2006

...Bidyut Ghosh; Steven D. Leach In the developing pancreas, the onset of exocrine differentiation is driven by the activity of the PTF1 (pancreas transciption factor 1) transcriptional complex, which is comprised of the class II bHLH (basic helix–loop–helix) protein, Ptf1-p48 [also known as Ptf1a...

View articletitled, Interactions between Hairy/Enhancer of Split-related proteins and the pancreatic transcription factor Ptf1-p48 modulate function of the PTF1 transcriptional complex

Articles

The forkhead transcription factor Foxi1 directly activates the AE4 promoter

Ingo Kurth, Moritz Hentschke, Suna Hentschke, Uwe Borgmeyer, Andreas Gal, Christian A. Hübner

Biochem J (2006) 393 (1): 277–283.

https://doi.org/10.1042/BJ20051094

Published: 12 December 2005

... renal tubular acidosis due to an intercalated cell-differentiation defect. Collecting duct cells in these mice are characterized by the absence of inter-calated cell markers including AE4. To test whether Slc4a9 is a direct target gene of Foxi1, an AE4 promoter construct was generated for a cell-based...

View articletitled, The forkhead transcription factor Foxi1 directly activates the AE4 promoter

Articles

Effect of ATP on preadipocyte migration and adipocyte differentiation by activating P2Y receptors in 3T3-L1 cells

Mariko Omatsu-Kanbe, Kazuko Inoue, Yusuke Fujii, Takefumi Yamamoto, Takahiro Isono, Norihisa Fujita, Hiroshi Matsuura

Biochem J (2006) 393 (1): 171–180.

https://doi.org/10.1042/BJ20051037

Published: 12 December 2005

...) in a concentration dependent manner. In this cell line, growth arrest is required before initiation of differentiation and growth-arrested post-confluent cells can be converted into adipocytes by the presence of the adipogenic hormones dexamethasone, 3-isobutyl-1-methylxanthine and insulin. On the other hand, those...

View articletitled, Effect of ATP on preadipocyte migration and adipocyte differentiation by activating P2Y receptors in 3T3-L1 cells

Articles

Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gβγ-mediated activation of Ras and p38 MAPK

Jiazhen Guan, Yuan Luo, Bradley M. Denker

Biochem J (2005) 392 (2): 389–397.

https://doi.org/10.1042/BJ20042102

Published: 22 November 2005

... a role in differentiation, its function remains unknown. We established Tet-off inducible expression of Pcp2 in PC12 cells (rat pheochromocytoma cells) to determine whether Pcp2 regulates neuronal differentiation. Utilizing a polyclonal antibody, Pcp2 was localized in the cell body and throughout...

View articletitled, Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gβγ-mediated activation of Ras and p38 MAPK

Articles

Mechanistic and functional changes in Ca 2+ entry after retinoic acid-induced differentiation of neuroblastoma cells

Anna M. BROWN, Fiona C. RIDDOCH, Andrew ROBSON, Christopher P. F. REDFERN, Timothy R. CHEEK

Biochem J (2005) 388 (3): 941–948.

https://doi.org/10.1042/BJ20042127

Published: 07 June 2005

...Anna M. BROWN; Fiona C. RIDDOCH; Andrew ROBSON; Christopher P. F. REDFERN; Timothy R. CHEEK We have investigated effects of neuronal differentiation on hormone-induced Ca 2+ entry. Fura-2 fluorescence measurements of undifferentiated SH-SY5Y neuroblastoma cells, stimulated with methacholine...

View articletitled, Mechanistic and functional changes in Ca 2+ entry after retinoic acid-induced differentiation of neuroblastoma cells

Articles

PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein

Elizabeth J. FOX, Sally A. STUBBS, Jimmy KYAW TUN, Jack P. LEEK, Alexander F. MARKHAM, Stephanie C. WRIGHT

Biochem J (2004) 378 (3): 817–825.

https://doi.org/10.1042/bj20031504

Published: 15 March 2004

... at its N-terminus. 1 To whom correspondence should be addressed (e-mail [email protected] ). 1 10 2003 13 11 2003 26 11 2003 26 11 2003 The Biochemical Society, London ©2004 2004 cell cycle differentiation Mad mitochondrial-targeting signal PRELI/MSF1p...

View articletitled, PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein

Articles

Selective modulation of the SM22α promoter by the binding of BTEB3 (basal transcription element-binding protein 3) to TGGG repeats

Karen M. MARTIN, Peter D. ELLIS, James C. METCALFE, Paul R. KEMP

Biochem J (2003) 375 (2): 457–463.

https://doi.org/10.1042/bj20030870

Published: 15 October 2003

..., which contain similar sequences, implying that promoter activation by BTEB3 is selective. The expression of BTEB3 is readily detectable in VSMCs in vitro and is modulated in response to injury in vivo. Key words: differentiation, gene expression, Kru¨ppel-like factor (KLF), TGGG box, transcription...

View articletitled, Selective modulation of the SM22α promoter by the binding of BTEB3 (basal transcription element-binding protein 3) to TGGG repeats

Articles

p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene

Hiroto IZUMI, Ryo OHTA, Gunji NAGATANI, Tomoko ISE, Yoshifumi NAKAYAMA, Minoru NOMOTO, Kimitoshi KOHNO

Biochem J (2003) 373 (3): 713–722.

https://doi.org/10.1042/bj20021902

Published: 01 August 2003

... in the activation of the GalNAc-T3 promoter. These results indicate a correlation between acetylation of NRF-1 by P/CAF and the butyrate-induced expression of the GalNAc-T3 gene. Additionally, induced expression of P/CAF may be a component of the adenocarcinoma differentiation process. Biochem. J. (2003) 373, 713...

View articletitled, p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene

Articles

Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc

Louise KIME, Stephanie C. WRIGHT

Biochem J (2003) 370 (1): 291–298.

https://doi.org/10.1042/bj20021679

Published: 15 February 2003

...Louise KIME; Stephanie C. WRIGHT Myc and Mad family proteins are central regulators of cellular proliferation and differentiation. We show that various Mad family genes have distinct patterns of expression during the chemically induced differentiation of mouse erythroleukaemia (MEL) cells...

View articletitled, Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc

Articles

CCAAT/enhancer-binding proteins: structure, function and regulation

Dipak P. RAMJI, Pelagia FOKA

Biochem J (2002) 365 (3): 561–575.

https://doi.org/10.1042/bj20020508

Published: 01 August 2002

... and characterized to date (C/EBPα—C/EBPζ), with further diversity produced by the generation of different sized polypeptides, predominantly by differential use of translation initiation sites, and extensive protein—protein interactions both within the family and with other transcription factors. The function...

View articletitled, CCAAT/enhancer-binding proteins: structure, function and regulation

Articles

Identification of a developmentally regulated iron superoxide dismutase of Trypanosoma brucei

Mostafa KABIRI, Dietmar STEVERDING

Biochem J (2001) 360 (1): 173–177.

https://doi.org/10.1042/bj3600173

Published: 08 November 2001

.... Inhibitor studies with purified recombinant FeSOD expressed in Escherichia coli confirmed that the enzyme is an iron-containing SOD. The FeSOD is developmentally regulated in the parasite, expression being lowest in the cell-cycle-arrested, short stumpy bloodstream forms. Differential expression...

View articletitled, Identification of a developmentally regulated iron superoxide dismutase of Trypanosoma brucei

Articles

S-phase-specific expression of the Mad3 gene in proliferating and differentiating cells

Elizabeth J. FOX, Stephanie C. WRIGHT

Biochem J (2001) 359 (2): 361–367.

https://doi.org/10.1042/bj3590361

Published: 08 October 2001

...Elizabeth J. FOX; Stephanie C. WRIGHT The Myc/Max/Mad transcription factor network plays a central role in the control of cellular proliferation, differentiation and apoptosis. In order to elucidate the biological function of Mad3, we have analysed the precise temporal patterns of Mad3 mRNA...

View articletitled, S-phase-specific expression of the Mad3 gene in proliferating and differentiating cells

Articles

Lysophosphatidic acid promotes phorbol-ester-induced apoptosis in TF-1 cells by interfering with adhesion

Jin-Mei LAI, Ching-Yi LU, Hsin-Fang YANG-YEN, Zee-Fen CHANG

Biochem J (2001) 359 (1): 227–233.

https://doi.org/10.1042/bj3590227

Published: 24 September 2001

...Jin-Mei LAI; Ching-Yi LU; Hsin-Fang YANG-YEN; Zee-Fen CHANG When exposed to PMA, the erythroblastic cell line TF-1 and its cytokine-independent variant D2 cells can be induced to undergo differentiation and apoptosis. In this study we investigated the mechanism responsible for the differential...

View articletitled, Lysophosphatidic acid promotes phorbol-ester-induced apoptosis in TF-1 cells by interfering with adhesion

Articles

Semicarbazide-sensitive amine oxidase activation promotes adipose conversion of 3T3-L1 cells

Nathalie MERCIER, Marthe MOLDES, Khadija EL HADRI, Bruno FÈVE

Biochem J (2001) 358 (2): 335–342.

https://doi.org/10.1042/bj3580335

Published: 24 August 2001

..., a physiological substrate of SSAO, promoted adipocyte differentiation in a time- and dose-dependent manner. This effect could be related to SSAO activation, since it was antagonized in the presence of the SSAO inhibitor semicarbazide, but not in the presence of the monoamine oxidase inhibitor pargyline...

View articletitled, Semicarbazide-sensitive amine oxidase activation promotes adipose conversion of 3T3-L1 cells

Articles

Metalloprotease-disintegrin ADAM 12 interacts with α-actinin-1

Yi CAO, Qing KANG, Anna ZOLKIEWSKA

Biochem J (2001) 357 (2): 353–361.

https://doi.org/10.1042/bj3570353

Published: 09 July 2001

...Yi CAO; Qing KANG; Anna ZOLKIEWSKA ADAM 12, a member of the ADAM family of proteins (containing A D isintegrin A nd M etalloprotease domain), has been implicated in differentiation and fusion of myoblasts. While the extracellular domain of ADAM 12 contains an active metalloprotease and a region...

View articletitled, Metalloprotease-disintegrin ADAM 12 interacts with α-actinin-1

Articles

G-protein-coupled-receptor activation of the smooth muscle calponin gene

Nickolai O. DULIN, Sergei N. ORLOV, Chad M. KITCHEN, Tatyana A. VOYNO-YASENETSKAYA, Joseph M. MIANO

Biochem J (2001) 357 (2): 587–592.

https://doi.org/10.1042/bj3570587

Published: 09 July 2001

...Nickolai O. DULIN; Sergei N. ORLOV; Chad M. KITCHEN; Tatyana A. VOYNO-YASENETSKAYA; Joseph M. MIANO A hallmark of cultured smooth muscle cells (SMCs) is the rapid down-regulation of several lineage-restricted genes that define their in vivo differentiated phenotype. Identifying factors...

View articletitled, G-protein-coupled-receptor activation of the smooth muscle calponin gene

Articles

Up-regulation of steroid sulphatase activity in HL60 promyelocytic cells by retinoids and 1α,25-dihydroxyvitamin D3

Philip J. HUGHES, Lucy E. TWIST, Jennifer DURHAM, M. Ansar CHOUDHRY, Mark DRAYSON, Roshantha CHANDRARATNA, Robert H. MICHELL, Christopher J. KIRK, Geoffrey BROWN

Biochem J (2001) 355 (2): 361–371.

https://doi.org/10.1042/bj3550361

Published: 06 April 2001

... marker of myeloid differentiation that is expressed before the differentiating cells stop proliferating. Use of agonists and antagonists against retinoid receptor-α and retinoid receptor-X revealed that both classes of retinoid receptor can drive steroid sulphatase up-regulation. Steroid sulphatase...

View articletitled, Up-regulation of steroid sulphatase activity in HL60 promyelocytic cells by retinoids and 1α,25-dihydroxyvitamin D3

Articles

Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition

Feng-Xia LIANG, Ina RIEDEL, Fang-Ming DENG, Ge ZHOU, Cong XU, Xue-Ru WU, Xiang-Peng KONG, Roland MOLL, Tung-Tien SUN

Biochem J (2001) 355 (1): 13–18.

https://doi.org/10.1042/bj3550013

Published: 26 February 2001

... of Dermatology (e-mail [email protected] ). 2 10 2000 3 1 2001 23 1 2001 The Biochemical Society, London © 2001 2001 bladder epithelium differentiation tetraspanin urothelium Biochem. J. (2001) 355, 13 18 (Printed in Great Britain) 13 Organization of uroplakin subunits...

View articletitled, Organization of uroplakin subunits: transmembrane topology, pair formation and plaque composition

Articles

Resistance of bone marrow-derived macrophages to apoptosis is associated with the expression of X-linked inhibitor of apoptosis protein in primary cultures of bone marrow cells

Hong LIN, Catheryne CHEN, Ben D.-M. CHEN

Biochem J (2001) 353 (2): 299–306.

https://doi.org/10.1042/bj3530299

Published: 08 January 2001

... cells were induced to undergo proliferation and differentiation into mature macrophages in vitro with cell morphology similar to that of tissue macrophages by day 7Ő10. Immunoblot analyses showed that bone marrow precursors express appreciable levels of caspase-3 and caspase-9 but no or very low levels...

View articletitled, Resistance of bone marrow-derived macrophages to apoptosis is associated with the expression of X-linked inhibitor of apoptosis protein in primary cultures of bone marrow cells

Articles

Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate

Wen GUO, Ji-Kyung CHOI, James L. KIRKLAND, Barbara E. CORKEY, James A. HAMILTON

Biochem J (2000) 349 (2): 463–471.

https://doi.org/10.1042/bj3490463

Published: 10 July 2000

... as well as their effects on preadipocyte differentiation. We found that less octanoate than oleate was stored and that more octanoate than oleate was oxidized. Octanoate was esterified to a greater extent at the sn -1,3 position of glyceryl carbons than at the sn -2 position, whereas the opposite was true...

View articletitled, Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate

Articles

Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells

Isabelle VAN SEUNINGEN, Michaël PERRAIS, Pascal PIGNY, Nicole PORCHET, Jean-Pierre AUBERT

Biochem J (2000) 348 (3): 675–686.

https://doi.org/10.1042/bj3480675

Published: 07 June 2000

...Isabelle VAN SEUNINGEN; Michaël PERRAIS; Pascal PIGNY; Nicole PORCHET; Jean-Pierre AUBERT Control of gene expression in intestinal cells is poorly understood. Molecular mechanisms that regulate transcription of cellular genes are the foundation for understanding developmental and differentiation...

View articletitled, Sequence of the 5′-flanking region and promoter activity of the human mucin gene MUC5B in different phenotypes of colon cancer cells

Articles

Activation of tyrosine kinases by α1A-adrenergic and growth factor receptors in transfected PC12 cells

Hongying ZHONG, Kenneth P. MINNEMAN

Biochem J (1999) 344 (3): 889–894.

https://doi.org/10.1042/bj3440889

Published: 08 December 1999

..., but not in response to EGF or NGF. PP2 also completely blocked NE-induced PC12 cell differentiation, but had no measurable effect on NGF-induced differentiation. These studies show that activation of mitogen-activated protein kinase pathways by G-protein-coupled receptors and tyrosine kinase receptors proceed through...

View articletitled, Activation of tyrosine kinases by α1A-adrenergic and growth factor receptors in transfected PC12 cells

Articles

A prespore-cell-inducing factor in Dictyostelium discoideum: its purification and characterization

Manabu NAKAGAWA, Akiko A. OOHATA, Hiromasa TOJO, Shigeru FUJII

Biochem J (1999) 343 (1): 265–271.

https://doi.org/10.1042/bj3430265

Published: 24 September 1999

...Manabu NAKAGAWA; Akiko A. OOHATA; Hiromasa TOJO; Shigeru FUJII Under starvation conditions, amoebae of Dictyostelium discoideum aggregate to form multicellular masses; the aggregates are then initiated to differentiate. We have reported previously that a signal substance exists in conditioned...

View articletitled, A prespore-cell-inducing factor in Dictyostelium discoideum: its purification and characterization

Articles

Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells

Claudia GUTACKER, Gerd KLOCK, Patrick DIEL, Claudia KOCH-BRANDT

Biochem J (1999) 339 (3): 759–766.

https://doi.org/10.1042/bj3390759

Published: 26 April 1999

...Claudia GUTACKER; Gerd KLOCK; Patrick DIEL; Claudia KOCH-BRANDT Clusterin (apolipoprotein J) is an extracellular glycoprotein that might exert functions in development, cell death and lipid transport. Clusterin gene expression is elevated at sites of tissue remodelling, such as differentiation...

View articletitled, Nerve growth factor and epidermal growth factor stimulate clusterin gene expression in PC12 cells

Articles

cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein

Takashi TANAKA, Tetsuya INAZU, Kazuya YAMADA, Zaw MYINT, Vincent W. KENG, Yoshiko INOUE, Naoyuki TANIGUCHI, Tamio NOGUCHI

Biochem J (1999) 339 (1): 111–117.

https://doi.org/10.1042/bj3390111

Published: 25 March 1999

... only slightly increased in liver of rats refed with a high-carbohydrate diet or after partial hepatectomy. Whereas the expression of Hex mRNA was detected in hepatocytes isolated from adult rat liver and also in highly differentiated hepatoma cells, no Hex mRNA was detected in poorly differentiated...

View articletitled, cDNA cloning and expression of rat homeobox gene, Hex, and functional characterization of the protein

Articles

Tumour necrosis factor-α regulates expression of the CCAAT-enhancer-binding proteins (C/EBPs) α and β and determines the occupation of the C/EBP site in the promoter of the insulin-responsive glucose-transporter gene in 3T3-L1 adipocytes

Renu JAIN, Shailaja POLICE, Kelle PHELPS, Phillip H. PEKALA

Biochem J (1999) 338 (3): 737–743.

https://doi.org/10.1042/bj3380737

Published: 08 March 1999

.... The data suggest that in fully differentiated adipocytes the C/EBP site is a ligand for predominantly α/α homodimers; however, after exposure to TNF, a shift in occupancy of the site occurs and the ligands become α/β heterodimers and β/β homodimers. Partner selection in dimer formation appears...

View articletitled, Tumour necrosis factor-α regulates expression of the CCAAT-enhancer-binding proteins (C/EBPs) α and β and determines the occupation of the C/EBP site in the promoter of the insulin-responsive glucose-transporter gene in 3T3-L1 adipocytes

Articles

Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells

Ja Seok KOO, Anton M. JETTEN, Paula BELLONI, Joo-Heon YOON, Yong-Dae KIM, Paul NETTESHEIM

Biochem J (1999) 338 (2): 351–357.

https://doi.org/10.1042/bj3380351

Published: 22 February 1999

... only marginally induced mucin gene expression. The RARα antagonist strongly inhibited mucin gene induction and mucous cell differentiation caused by RA and by the RARα- and RARγ-selective retinoids. In contrast, the RARγ antagonist only weakly inhibited RARα-selective-retinoid-induced mucin gene...

View articletitled, Role of retinoid receptors in the regulation of mucin gene expression by retinoic acid in human tracheobronchial epithelial cells

Articles

Regulation of UDP-N-acetylglucosamine:dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase by retinoic acid in P19 cells

Joachim D. MEISSNER, Andreas NAUMANN, Walter H. MUELLER, Renate J. SCHEIBE

Biochem J (1999) 338 (2): 561–568.

https://doi.org/10.1042/bj3380561

Published: 22 February 1999

... the initiation of differentiation, and GPT expression was down-regulated during cellular differentiation. GPT activity decreased about 2.8-fold to a constant level in differentiated P19 cells. The results indicate that the RA-induced enzyme activity was mainly determined by increased transcription of the GPT...

View articletitled, Regulation of UDP-N-acetylglucosamine:dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase by retinoic acid in P19 cells

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