1-41 of 41
Keywords: dimerization
Close
Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Articles
Biochem J (2020) 477 (20): 3951–3962.
Published: 23 October 2020
... and enzymes to exhibit a wide variety of biological effects. The 3FTxs have further expanded their pharmacological space through covalent or noncovalent dimerization. Synergistic-type toxins (SynTxs) isolated from the deadly mamba venoms, although nontoxic, have been known to enhance the toxicity of other...
Includes: Supplementary data
Articles
Biochem J (2020) 477 (17): 3387–3399.
Published: 17 September 2020
... to other structures in PDB. Molecular dynamics simulations and dynamic light scattering results support that the binding of sunitinib in the PK domain destabilized the dimer conformation of RNase L and allosterically inhibited its ribonuclease activity. Our study suggested that dimer destabilization could...
Includes: Supplementary data
Articles
Biochem J (2017) 474 (3): 427–443.
Published: 20 January 2017
... or variant amino acids. These variable residues are positioned near the zinc-binding (and dimerization) site and the stability determinant for the B-repeat fold. We have characterized four B-repeat constructs to assess the functional relevance of the two Aap B-repeat subtypes. Analytical ultracentrifugation...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (19): 3081–3098.
Published: 27 September 2016
... of the phosphotyrosine (Tyr888) residue in the activation loop suppressed kinase activity, while neither mutation affected guanylate cyclase activity. Size exclusion and analytical ultracentrifugation analysis of the PSKR1cd suggest that it is reversibly dimeric in solution, which was further confirmed by biflourescence...
Includes: Supplementary data
Articles
Biochem J (2016) 473 (19): 3205–3219.
Published: 27 September 2016
... in response to many cytokines and growth factors. Recently, the roles for unphosphorylated STAT3 (U-STAT3) have been described in response to cytokine stimulation, in cancers, and in the maintenance of heterochromatin stability. It has been reported that U-STAT3 dimerizes, shuttles between the cytoplasm...
Includes: Supplementary data
Articles
Biochem J (2015) 471 (1): 101–109.
Published: 21 September 2015
... in a variety of cancers. EphA3 activation is believed to follow a ‘seeding mechanism’ model, in which ligand binding to the monomeric receptor acts as a trigger for signal-productive receptor clustering. We study EphA3 lateral interactions on the surface of live cells and we demonstrate that EphA3 forms dimers...
Includes: Supplementary data
Articles
Biochem J (2015) 467 (1): 37–46.
Published: 20 March 2015
...Tilen Koklic; Rima Chattopadhyay; Rinku Majumder; Barry R. Lentz Factor Va competes factor Xa off of inactive factor Xa dimers to amplify thrombin production, both because it releases dimer inhibition and because of its cofactor activity. This suggests an unanticipated mechanism by which platelet...
Includes: Supplementary data
Articles
Biochem J (2015) 465 (1): 139–147.
Published: 12 December 2014
... strongly implicated in patients with an LRRK2 mutation. Our data confirm previous assumptions that the C-terminal subdomain of COR functions as a dimerization device. We show that the dimer formation is independent of nucleotide. The affinity for GDP/GTP is in the micromolar range, the result of which...
Includes: Supplementary data
Articles
Articles
Articles
Biochem J (2012) 446 (3): 469–475.
Published: 28 August 2012
...-ular polarization, mobilization and endocytosis. The N-terminal 250 amino acids of MIM undergo homodimerization and form a structural module with the characteristic of an I-BAR [inverse BAR (Bin/amphiphysin/Rvs)] domain. To discern the role of the dimeric configuration in the function of MIM, we...
Includes: Supplementary data
Articles
Biochem J (2012) 444 (2): e3–e5.
Published: 11 May 2012
... mechanism and the substrate specificity of MALT1. These intriguing findings convincingly demonstrate the importance of MALT1 dimerization for its catalytic activity and pave the way for novel therapeutic approaches that target this crucial regulator of lymphoma survival and proliferation. 1 To whom...
Articles
Biochem J (2011) 436 (2): e1–e2.
Published: 13 May 2011
... receptors are related GTPases, and they are predicted to engage in homodimerization and/or heterodimerization. Although such dimerization has been studied extensively, its exact function in vivo remains elusive. In this issue of the Biochemical Journal , Oreb et al. present evidence that homodimerization...
Articles
Biochem J (2010) 429 (3): 553–563.
Published: 14 July 2010
... function in mitochondrial protein import. Based on analytical ultracentrifugation, cross-linking, size-exclusion chromatography and multi-angle light scattering, we found that the soluble cytosolic fragment of human Tom70 exists in equilibrium between monomer and dimer. A point mutation introduced...
Includes: Supplementary data
Articles
Articles
Articles
Articles
Articles
Articles
Biochem J (2006) 396 (2): 201–214.
Published: 15 May 2006
... for expression in one particular tissue or cell type. Three-dimensional structures of several S100 family members have shown that the proteins assume a dimeric structure consisting of two EF-hand motifs per monomer. Calcium binding to these S100 proteins, with the exception of S100A10, results in an approx. 40...
Articles
Articles
Articles
Articles
Articles
Articles
Biochem J (2003) 373 (3): 747–757.
Published: 01 August 2003
... these come under the ZHX family. The minimal functional domains of ZHX2 were then characterized. The dimerization domain with both ZHX1 and ZHX2 is the region containing HD1, the domain that interacts with NF-YA is the HD1 to HD2 region, the repressor domain is the HD1 to a proline-rich region. Lastly, using...
Articles
Articles
Biochem J (2002) 368 (3): 799–808.
Published: 15 December 2002
... are the predominant MM-CKs, whereas the M3M3-CK achieves its homodimeric state at lower temperature. We postulated testable homology models to investigate the chemical properties of these dimeric interfaces. M1M1-CK was used as a reference to compare the structural differences with the M3M3-CK dimer. The calculated...
Articles
Articles
Biochem J (2002) 362 (2): 317–327.
Published: 22 February 2002
... reported transfection studies which suggest the formation of lateral heterodimers and homo- dimers, our results also provide direct quantitative information on the strength of these interactions which are essential for understanding the adhesion mechanism. Key words: Ca#+ binding, cell adhesion...
Articles
Biochem J (2001) 360 (3): 645–649.
Published: 10 December 2001
... that both cysteine residues were involved in disulphide interactions. Substitution of either cysteine residue resulted in a reduction or loss of oligomers, although dimers of the secretory form of EGFP remained. Mutation of these residues did not adversely affect the fluorescence of EGFP. EGFP oligomers...
Articles
Articles
Articles
Articles
Articles
Biochem J (2001) 353 (3): 611–620.
Published: 25 January 2001
... the sc ARE, but, although the AR fragment dimerizes on the element, the GR fragment does not. Comparing the affinities of the DNA-binding domains for mutant forms of the sc ARE revealed that dimeric GR binding is actively excluded by the left hexamer and more precisely by the presence of a G residue...
Articles
Biochem J (2000) 350 (1): 53–60.
Published: 09 August 2000
...Mark T. YOUNG; Roland BECKMANN; Ashley M. TOYE; Michael J. A. TANNER We have examined the mechanism by which glycophorin A (GPA) facilitates the movement of the human red-cell anion exchanger (band 3, AE1) to the cell surface. GPA itself forms stable dimers in membranes and detergent solution. Four...
Articles
Articles
Biochem J (1999) 341 (3): 555–561.
Published: 26 July 1999
...-terminal cysteine residues essential for dimerization, but cellular and/or structural constraints appear to influence homo- and heterodimerization patterns. Dimerization patterns of the (V+C) - isoform were studied under native conditions within canine articular cartilage and experimentally in COS-7, NIH...
Articles
Biochem J (1999) 341 (3): 523–528.
Published: 26 July 1999
... receptor, although less efficiently than in heterodimers of wild-type receptors. The kinase-active receptor was only minimally phosphorylated. Thus the phosphorylation within the receptor dimer occurred in trans between the components. Analyses of the abilities of heterodimeric receptor complexes of one...
Articles
Biochem J (1999) 338 (1): 131–138.
Published: 08 February 1999
... m for ATP 9-fold. WT activity displayed a hyperbolic dependence on enzyme concentration, consistent with a requirement for dimerization or aggregation for activity. This activity was also enhanced by anti-Flag antibodies. In contrast, the dependence of DY814 activity on enzyme concentration...