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Keywords: disaggregate
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Articles
Jinqing Li, Zichao Yang, Han Liu, Mengjie Qiu, Tingting Zhang, Wenjuan Li, Zhaofeng Li, Tao Qi, Yurong Qiu, Lin Li, Xuefeng Zhou, Shuwen Liu, Suiyi Tan
Journal:
Biochemical Journal
Biochem J (2019) 476 (6): 1021–1035.
Published: 29 March 2019
... that ADS-J1 effectively remodeled SEVI, SEM1 86–107 fibrils and endogenous seminal fibrils. Unlike epigallocatechin gallate (EGCG), a universal amyloid fibril breaker, ADS-J1 disaggregated SEVI fibrils into monomeric peptides, which was independent of oxidation reaction. MD simulations revealed that ADS-J1...
