... 11 9 2022 15 9 2022 16 9 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 bacterial activity docking Schiff base urease The Urease belongs to amidohydrolase family that is widely distributed in nature...

.... Therefore, we tested whether basic amino acids with side chains shorter than lysine can interact with the ASCT2 binding site. Molecular docking of L-1,3-diaminopropionic acid (L-DAP) and L-DAB suggested that these compounds bind to ASCT2. Consistent with this prediction, L-DAP and L-DAB, but not ornithine...

... in reconstituted exocytic reactions mediated by neuronal and non-neuronal SNAREs. We show that Munc18a plays a direct role in promoting proteoliposome clustering, underlying vesicle docking during exocytosis. In the three different fusion reactions examined, Munc18a-dependent clustering requires an intact N...

... ( [email protected] , [email protected] ) 31 8 2016 4 10 2016 14 10 2016 14 10 2016 © 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society 2016 docking meso -diaminopimelic acid molecular recognition NOD1 peptidoglycan...

... achieve this goal by utilizing docking grooves in the kinase domain or heterologous protein adaptors to reduce ‘off pathway’ targeting. We now provide evidence that the nuclear protein kinase CLK1 (cell division cycle2-like kinase 1) important for splicing regulation departs from these classic paradigms...

... families of protein kinases. The SRPKs (SR-specific protein kinases) efficiently phosphorylate the arginine/serine dipeptides in the RS domain using a conserved docking groove in the kinase domain. In contrast, CLKs (Cdc2-like kinases) lack a docking groove and phosphorylate both arginine/serine and serine...

... in the highlighted sequence motifs. We show quinol-derivative-binding poses obtained through docking simulations. comparative modelling docking haem–copper oxidase quinol oxidase sequence–structure alignment A wide variety of haem–copper oxidases involved in the reduction of dioxygen to water have...

... and of inflammatory and neuropathic pain. We have described recently that docking-groove-dependent interactions are important for p38 MAPK-mediated signal transduction. Thus virtual screening was performed to identify putative docking-groove-targeted p38 MAPK inhibitors. Several compounds of the benzo-oxadiazol...

.... Here, we investigated the interaction sites of the two molecules, using docking, synthetic peptides, ELISAs and conformational interaction site mapping. Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val 2718 -Arg-Lys-Arg-Leu 2722 , Tyr 2738 -Tyr 2739 , Tyr...

... or indirectly involved in binding and select one of their equi-energetic conformations for best fitting in the complex. The complete reversal of an iduronic acid conformation preferred in the free state is also demonstrated for the first time. Preliminary docking studies provided information...

... (DDT) docking knockdown resistance (kdr) molecular modelling pyrethroids sodium channel The selective conductance of sodium ions across the plasma membrane by the voltage-gated sodium channel underlies the propagation of action potentials in neuronal cells of both vertebrates...

...Crestina L. BEITES; Kristen A. CAMPBELL; William S. TRIMBLE SNARE (soluble N -ethylmaleimide-sensitive fusion protein attachment protein receptor) proteins are supposed to mediate the docking and/or fusion of the vesicle with the plasma membrane. However, it is not clearly understood how...

... by complementary electrostatics. Given the diffuse nature of its acidic patch, parsley PCu is an atypical example of a plant PCu. The interaction of this PCu with turnip cyt f was investigated by stopped-flow kinetics, NMR spectroscopy and protein-docking simulations. We show that, despite the altered acidic patch...

... studies that illuminate the mechanisms used by three families of Ser/Thr protein kinases to achieve substrate specificity. These kinases rely on direct docking interactions with substrates, using sites distinct from the phospho-acceptor sequences. Docking interactions also contribute to the specificity...