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Keywords: docking-site peptide
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Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity
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Journal:
Biochemical Journal
Biochem J (2003) 370 (3): 1077–1085.
Published: 15 March 2003
... and MKP-1. In addition, these docking-site peptides inhibited MEK2—ERK2 binding. The MAPK-docking site of MEK1 also potently stimulated ERK2-mediated phosphorylation of a target site on the same peptide. Control peptides with mutations of conserved basic and hydrophobic residues of the MAPK-docking site...
