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1-7 of 7
Keywords: doxorubicin
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Articles
Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy
Available to Purchase
Journal:
Biochemical Journal
Biochem J (2016) 473 (21): 3769–3789.
Published: 27 October 2016
...Jordan J. Bartlett; Purvi C. Trivedi; Pollen Yeung; Petra C. Kienesberger; Thomas Pulinilkunnil Doxorubicin (DOX) is an effective anti-cancer agent. However, DOX treatment increases patient susceptibility to dilated cardiomyopathy. DOX predisposes cardiomyocytes to insult by suppressing...
Includes: Supplementary data
Articles
Doxorubicin inhibits E. coli division by interacting at a novel site in FtsZ
Available to PurchasePragnya Panda, Ashoka Chary Taviti, Suresh Satpati, Mitali Madhusmita Kar, Anshuman Dixit, Tushar Kant Beuria
Journal:
Biochemical Journal
Biochem J (2015) 471 (3): 335–346.
Published: 16 October 2015
... computational, biochemical and microbial approach. From this screen, we identified doxorubicin, an anthracycline molecule that inhibits Escherichia coli division and forms filamentous cells. A fluorescence-binding assay shows that doxorubicin interacts strongly with FtsZ. A detailed biochemical analysis...
Includes: Supplementary data
Articles
Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity
Available to PurchaseManuela Polimeni, Claudia Voena, Joanna Kopecka, Chiara Riganti, Gianpiero Pescarmona, Amalia Bosia, Dario Ghigo
Journal:
Biochemical Journal
Biochem J (2011) 439 (1): 141–149.
Published: 14 September 2011
...) are still open questions. In the present paper we illustrate that a doxorubicin-resistant human colon cancer cell line (HT29-DX), exhibiting decreased doxorubicin accumulation, increased intracellular GSH content, and increased MRP1 and MRP2 expression in comparison with doxorubicin-sensitive HT29 cells...
Includes: Supplementary data
Articles
Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4α (HNF4α) gene
Available to PurchaseYutaka Maeda, Wendy W. Hwang-Verslues, Gang Wei, Takuya Fukazawa, Mary L. Durbin, Laurie B. Owen, Xuan Liu, Frances M. Sladek
Journal:
Biochemical Journal
Biochem J (2006) 400 (2): 303–313.
Published: 14 November 2006
... promoter. Overexpression of wild-type p53 down-regulated endogenous levels of both HNF4α protein and mRNA in Hep3B cells. This decrease was also observed when HepG2 cells were exposed to UV irradiation or doxorubicin, both of which increased endogenous p53 protein levels. Ectopically expressed p53...
Articles
Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium
Available to PurchaseShasi V. Kalivendi, Eugene A. Konorev, Sonya Cunningham, Sravan K. Vanamala, Eugene H. Kaji, Joy Joseph, B. Kalyanaraman
Journal:
Biochemical Journal
Biochem J (2005) 389 (2): 527–539.
Published: 05 July 2005
...Shasi V. Kalivendi; Eugene A. Konorev; Sonya Cunningham; Sravan K. Vanamala; Eugene H. Kaji; Joy Joseph; B. Kalyanaraman Doxorubicin (DOX), a widely used antitumour drug, causes dose-dependent cardiotoxicity. Cardiac mitochondria represent a critical target organelle of toxicity during DOX...
Articles
PARP inhibition sensitizes p53-deficient breast cancer cells to doxorubicin-induced apoptosis
Available to PurchaseJosé Antonio MUÑOZ-GÁMEZ, David MARTÍN-OLIVA, Rocío AGUILAR-QUESADA, Ana CAÑUELO, M. Isabel NUÑEZ, M. Teresa VALENZUELA, J. M. RUIZ de ALMODÓVAR, Gilbert de MURCIA, F. Javier OLIVER
Journal:
Biochemical Journal
Biochem J (2005) 386 (1): 119–125.
Published: 08 February 2005
...José Antonio MUÑOZ-GÁMEZ; David MARTÍN-OLIVA; Rocío AGUILAR-QUESADA; Ana CAÑUELO; M. Isabel NUÑEZ; M. Teresa VALENZUELA; J. M. RUIZ de ALMODÓVAR; Gilbert de MURCIA; F. Javier OLIVER p53 deficiency confers resistance to doxo (doxorubicin), a clinically active and widely used antitumour anthracycline...
Articles
Overexpression of the regulatory subunit of γ-glutamylcysteine synthetase in HeLa cells increases γ-glutamylcysteine synthetase activity and confers drug resistance
Available to Purchase
Journal:
Biochemical Journal
Biochem J (1999) 337 (3): 559–566.
Published: 25 January 1999
... [light subunit (GCS l ) of M r 31000]. In the present study, we have demonstrated for the first time a potential role for GCS l in resistance towards doxorubicin and cadmium chloride. Addition of recombinant GCS l to HeLa cell extracts in vitro was found to result in an increase in GCS activity...
