... by the participation of the University of Liverpool in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. CHK1 inhibitor drug resistance lymphoma nuclear factor kappaB p21-activated kinases protein kinase B...

... 4.0 (CC BY) . Open access for this article was enabled by the participation of University of Liverpool in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC. drug resistance G-proteins signaling...

...Ritika Kabra; Prajakta Ingale; Shailza Singh The emergence of drug resistance is a major concern for combating against Cutaneous Leishmaniasis, a neglected tropical disease affecting 98 countries including India. Miltefosine is the only oral drug available for the disease and Miltefosine...

... the developed resistance. cancer drug resistance microtubules tubulin isotypes tubulin PTMs The structure of the microtubule and the sequences of α- and β-tubulin genes have been remarkably conserved in all the different cell types and organisms throughout evolution [ 18 ]. Cryo-EM analysis...

... 20 12 2018 20 12 2018 © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2019 acetylation drug resistance histone acetyltransferase kanamycin NMR spectroscopy ternary complex Adaptation to the changing environment...

...) transport Wilson disease protein (ATP7B) cisplatin drug resistance metal transport 1 These authors contributed equally to this work. Copper-transport proteins have emerged as the major factors affecting biological activity of cisplatin [ 6 – 8 ]. Cisplatin entry into the cell...

... evolution. Perhaps MPA production rescued IMPDH-B from deleterious genetic drift. drug resistance gene duplication IMP dehydrogenase (IMPDH) mycophenolic acid neofunctionalization Penicillium Filamentous fungi produce a vast arsenal of toxic natural products that require the presence...

...Anastasia de Luca; Noemi Moroni; Annalucia Serafino; Alessandra Primavera; Anna Pastore; Jens Z. Pedersen; Raffaele Petruzzelli; Maria Grazia Farrace; Pasquale Pierimarchi; Gabriella Moroni; Giorgio Federici; Paola Sinibaldi Vallebona; Mario Lo Bello Acquired drug resistance was found...

.... 1 To whom correspondence should be addressed (email [email protected] ). 3 7 2008 13 1 2009 27 1 2009 27 1 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 ATPase chemotherapy cisplatin drug resistance Wilson disease...

... relief from stress-induced translational repression and to the acquisition of drug resistance. 1 Present address: UCB-Celltech (NCE Biology), Slough SL1 3WE, U.K. 2 Present address: Vice-Chancellor's Office, Durham University, The University Offices, Old Elvet, Durham DH1 3HP, U.K...

... cell line, CABA-PTX. The acquisition of the PTX-resistant phenotype is accompanied by unique alterations in the complex sphingolipid pattern found on lipid extraction. In the drug-resistant cell line, the levels of sphingomyelin and neutral glycosphingolipids were unchanged compared with the drug...

... of the incoming nucleotide. 1 To whom correspondence should be addressed (email [email protected] ). 22 6 2004 21 10 2004 17 11 2004 17 11 2004 The Biochemical Society, London 2005 ddNTPs drug resistance fidelity HIV polymerase reverse transcriptase HIV-1...

...Natisha MAGAN; Agnieszka P. SZREMSKA; Richard J. ISAACS; Kathryn M. STOWELL topo IIα (topoisomerase IIα) is a major target of several commonly used anticancer drugs and is subject to down-regulation at the transcriptional level in some drug-resistant cell lines and tumours in response...

...Svenja MEIERJOHANN; Rolf D. WALTER; Sylke MÜLLER Malaria is one of the most devastating tropical diseases despite the availability of numerous drugs acting against the protozoan parasite Plasmodium in its human host. However, the development of drug resistance renders most of the existing drugs...

.... These sublines lost 92—97% of parental [ 3 H]methotrexate influx rates. Genomic PCR single-strand conformational polymorphism analysis and sequencing revealed that most of these drug-resistant sublines harboured RFC mutations that surprisingly clustered in two confined regions in exons 2 and 3. The majority...

... VBL100. As a general rule, drug resistance normally results in resistance to apoptosis induction. By contrast, a paradoxical activity is exerted in this cell model by the cytokine tumour necrosis factor-α (TNF-α), which is capable of inducing apoptosis in P-170-expressing variants better than in wild...

... words: base-excision repair, cancer chemotherapy, drug resistance, O -methylguanine, post-translational modification. [2,4]. With bifunctional alkylating agents such as 1,3-bis(2- chloroethyl)-1-nitrosourea, the removal of chloroethyl adducts from guanine prevents the production of cytotoxic DNA inter...

...Nasser FOTOUHI-ARDAKANI; Gerald BATIST The rat glutathione S-transferase-A3-subunit ( GSTA3 ) gene is a member of the class Alpha GSTs, which we have previously reported to be overexpressed in anti-cancer-drug-resistant cells. In this study, we report the isolation and characterization...

... the weak antimalarial activities of these compounds. Key words: chlorpromazine, drug resistance, malaria, Plas- modium falciparum. A second toxic insult derives from the fact that when oxy- haemoglobin is released into the food vacuole of the parasite at pH 5.2, it is rapidly converted to methaemoglobin [7...