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Keywords: drug screening
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Articles
Audrey Colomba, Martina Fitzek, Roger George, Gregory Weitsman, Selene Roberts, Laura Zanetti-Domingues, Michael Hirsch, Daniel J. Rolfe, Shahid Mehmood, Andrew Madin, Jeroen Claus, Svend Kjaer, Ambrosius P. Snijders, Tony Ng, Marisa Martin-Fernandez, David M. Smith, Peter J. Parker
Journal:
Biochemical Journal
Biochem J (2020) 477 (17): 3329–3347.
Published: 10 September 2020
... for their function [ 5 , 6 ]. For example, ATP-bound STRAD α adopts an ‘active’ closed conformation required for its oligomerisation with MO25 and LKB1 to promote tumour-suppressor activity of LKB1 [ 7 , 8 ]. allostery drug screening HER3 inhibitor pseudokinases Through their function as allosteric...
Includes: Multimedia, Supplementary data
Articles
Catherine E. Scull, Yinfeng Zhang, Nichole Tower, Lynn Rasmussen, Indira Padmalayam, Robert Hunter, Ling Zhai, Robert Bostwick, David A. Schneider
Journal:
Biochemical Journal
Biochem J (2019) 476 (15): 2209–2219.
Published: 09 August 2019
... is energetically costly. To balance the demand for cell growth with the extensive metabolic cost of ribosome biogenesis, cells have evolved robust regulatory networks to control ribosome biogenesis. cancer drug screening ribosome RNA polymerase I © 2019 The Author(s). Published by Portland Press...
Includes: Supplementary data