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Keywords: endocytosis
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Biochem J (2021) 478 (16): 3099–3123.
Published: 26 August 2021
...Katherine M. Wood; Corinne J. Smith Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also participates to a diverse range of cellular functions. Key to this is clathrin's ability to assemble into polyhedral lattices that include curved football or basket shapes...
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Biochem J (2020) 477 (24): 4769–4783.
Published: 24 December 2020
... on APPL1 BAR-PH homodimer have been identified. In response to extracellular stimuli, signaling transduction usually elicits endocytosis and intracellular trafficking of plasma membrane receptors, which require adaptor proteins to properly recruit and assemble signaling components for specific...
Includes: Supplementary data
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Biochem J (2020) 477 (12): 2327–2345.
Published: 26 June 2020
...Alessandra Casamento; Emmanuel Boucrot Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Clathrin-mediated endocytosis (CME) is the housekeeping pathway in resting cells but additional Clathrin-independent endocytic (CIE) routes, including Fast Endophilin...
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Biochem J (2019) 476 (14): 2093–2109.
Published: 31 July 2019
... be endocytosed from the cell surface. The phosphatidylinositol binding clathrin assembly protein (PICALM) is involved in clathrin-mediated endocytosis and polymorphisms in and near the gene locus were identified as genetic risk factors for AD. PICALM overexpression enhances APP internalization and Aβ production...
Includes: Supplementary data
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Biochem J (2017) 474 (13): 2133–2144.
Published: 13 June 2017
...-mediated, cholesterol-dependent P2X7R–Panx1 clustering and endocytosis. These findings have important implications for understanding the role of Panx1 in the nervous system and provide important new insights into Panx1–P2X7R cross-talk. Correspondence: Leigh Anne Swayne ( lswayne@uvic.ca ) 5 4...
Includes: Supplementary data
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Biochem J (2016) 473 (24): 4507–4525.
Published: 09 December 2016
...Aidan P. McCann; Christopher J. Scott; Sandra Van Schaeybroeck; James F. Burrows In recent times, our knowledge of the roles ubiquitin plays in multiple cellular processes has expanded exponentially, with one example being the role of ubiquitin in receptor endocytosis and trafficking. This has...
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Biochem J (2016) 473 (15): 2251–2271.
Published: 28 July 2016
... 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2016 autophagy Class III phosphoinositide 3-kinase endocytosis phosphoinositide 3-kinase phosphorylation/dephosphorylation Vps34 Vps34 (vacuolar protein sorting 34) is a member...
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Biochem J (2016) 473 (12): 1703–1718.
Published: 10 June 2016
..., septins protect ErbB2 from ubiquitylation, endocytosis and lysosomal degradation. The FCF-induced degradation pathway is distinct from and additive with the degradation induced by inhibiting ErbB2 chaperone Hsp90. These results identify septins as novel regulators of ErbB2 expression that contribute...
Includes: Supplementary data
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Biochem J (2015) 472 (3): e27–e30.
Published: 27 November 2015
... of Health Research (CIHR) [grant number MOP-125901]. CIE clathrin-independent endocytosis CME clathrin-mediated endocytosis EEA1 early endosome antigen 1 ER endoplasmic reticulum NMDARs N-Methyl-D-aspartic acid receptors Panx1 pannexin 1 References 1...
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Biochem J (2015) 470 (3): 319–330.
Published: 04 September 2015
...). This novel finding raises important considerations with regards to Panx1 surface stability in diverse scenarios in which ATP can be rapidly elevated in the extracellular space. adenosine 5′-triphosphate (ATP) endocytosis endosomes pannexin 1 pannexin1 trafficking Six individual pannexin 1...
Includes: Multimedia, Supplementary data
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Biochem J (2014) 461 (2): 159–175.
Published: 26 June 2014
... endocytosis human disease inositol phosphatase membrane traffic phosphoinositide secretory pathway Phosphoinositides are a family of lipid molecules that play critical roles in the cell [ 1 , 2 ]. Derived from phosphorylation of phosphatidylinositol (PtdIns), phosphoinositides consist of two...
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Biochem J (2014) 458 (2): 195–201.
Published: 14 February 2014
... through clathrin- and raftlin-dependent endocytosis and delivered to endosomal TLR3. The dsRNA uptake machinery, in addition to TLR3, is critical for extracellular viral RNA-induced immune responses. A wide spectrum of TLR3 ligand structures beyond dsRNA and their delivery systems provide new insights...
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Biochem J (2013) 452 (3): 411–421.
Published: 31 May 2013
... ). 21 6 2012 7 3 2013 26 3 2013 26 3 2013 © The Authors Journal compilation © 2013 Biochemical Society 2013 AGAP2 β-arrestin2 Arf GTPase-activating protein endocytosis G-protein-coupled receptor recycling endosome β 2 ARs (β 2 -adrenergic receptors) are members...
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Biochem J (2012) 444 (3): 383–394.
Published: 29 May 2012
.... There are four EHD proteins in mammalian cells, EHD1–EHD4, each with diverse roles in the recycling pathway of endocytosis. EHD2 is a plasma-membrane-associated member of the EHD family that regulates internalization. Since several endocytic proteins have been shown to undergo nucleocytoplasmic shuttling...
Includes: Supplementary data
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Biochem J (2011) 439 (3): 433–445.
Published: 13 October 2011
...Sigi Benjamin; Hilla Weidberg; Debora Rapaport; Olga Pekar; Marina Nudelman; Daniel Segal; Koret Hirschberg; Shulamit Katzav; Marcelo Ehrlich; Mia Horowitz EHDs [EH (Eps15 homology)-domain-containing proteins] participate in different stages of endocytosis. EHD2 is a plasma-membrane-associated EHD...
Includes: Supplementary data
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Biochem J (2011) 437 (2): 255–267.
Published: 28 June 2011
..., brain, kidney and bone marrow [ 3 , 4 ]. 1 To whom correspondence should be addressed (email hgirao@ibili.uc.pt ). 16 12 2010 21 4 2011 9 5 2011 9 5 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 connexin43 (Cx43) endocytosis...
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Biochem J (2011) 436 (1): 45–52.
Published: 27 April 2011
... with clathrin plaques, although its homologues IRSp53 and IRTKS (insulin receptor tyrosine kinase substrate) associate with other punctate structures. The results from the present study suggest that I-BAR-containing proteins help generate the mem-brane curvature required for endocytosis and implies...
Includes: Supplementary data
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Biochem J (2011) 434 (3): 559–569.
Published: 24 February 2011
...Kosuke Miyauchi; Mariana Marin; Gregory B. Melikyan Diverse enveloped viruses enter cells by endocytosis and fusion with intracellular compartments. Recent evidence suggests that HIV also infects permissive cell lines by fusing with endosomes in a pH-independent manner. This finding highlights...
Includes: Supplementary data
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Biochem J (2011) 434 (2): 343–351.
Published: 11 February 2011
... 2011 endocytosis deubiquitinating enzyme (DUB) granulocyte colony-stimulating factor 3 (CSF3) receptor signal transducer and activator of transcription (STAT) 5 suppressor of cytokine signalling (SOCS) 3 HEK-293T (human embryonic kidney cells expressing the large T-antigen of simian virus...
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Biochem J (2011) 433 (2): 253–262.
Published: 22 December 2010
... in spermatogenic defects. Other studies have shown that MTMR2 functions in endocytosis and membrane trafficking. In the testis, MTMR2 interacts and co-localizes with c-Src/phospho-Src-(Tyr 416 ), a non-receptor protein tyrosine kinase that regulates the phosphorylation state of proteins at the apical ES...
Includes: Supplementary data
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Biochem J (2011) 433 (1): 75–83.
Published: 15 December 2010
...Bastian Dislich; Manuel E. Than; Stefan F. Lichtenthaler SNX33 (sorting nexin 33) is a homologue of the endocytic prote-in SNX9 and has been implicated in actin polymerization and the endocytosis of the amyloid precursor protein. SNX33 belongs to the large family of BAR (Bin/amphiphysin/Rvs) domain...
Includes: Supplementary data
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Biochem J (2010) 430 (2): 305–313.
Published: 13 August 2010
...Marie-Christine Gasingirwa; Jacqueline Thirion; Jeannine Mertens-Strijthagen; Simone Wattiaux-De Coninck; Bruno Flamion; Robert Wattiaux; Michel Jadot It has been suggested that intracellular Hyal-1 (hyaluronidase-1), which is considered a lysosomal enzyme, originates via endocytosis of the serum...
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Biochem J (2010) 429 (1): 185–193.
Published: 14 June 2010
...Maya Shvartsman; Eitan Fibach; Z. Ioav Cabantchik In the present study we analysed the mechanism of intracellular routing of iron acquired by erythroid cells via receptor-mediated endocytosis of Tf-Fe [Tf (transferrin)-iron]. Using real-time fluorimetry and flow cytometry, in conjunction...
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Biochem J (2010) 428 (1): 33–45.
Published: 28 April 2010
..., suggesting its involvement in endocytosis. Uptake experiments using standard molecules for the study of endocytosis revealed that gAP2 specifically participated in the endocytosis of LDL (low-density lipoprotein). Targeted down-regulation of the gene encoding gμ2 in growing and encysting trophozoites...
Includes: Supplementary data
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Biochem J (2009) 424 (1): 89–97.
Published: 23 October 2009
... ). 24 6 2009 25 8 2009 2 9 2009 2 9 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 endocytosis endosomal sorting complex required for transport (ESCRT) multivesicular body Rim101 pathway Snf7/chromatin modifying protein 4 (CHMP4) vacuolar protein...
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Biochem J (2009) 420 (2): 179–191.
Published: 13 May 2009
... could be exploited for delivering bioactive entities. cell-penetrating peptide (CPP) cholesterol endocytosis fluorescence microscopy methyl-β-cyclodextrin (MβCD) octa-arginine © The Authors Journal compilation © 2009 Biochemical Society 2009 CPPs (cell-penetrating peptides...
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Biochem J (2009) 420 (2): 169–180.
Published: 13 May 2009
... are defective in endocytosis. Furthermore, towards the end of cytokinesis, constriction of the actomyosin ring and dissociation of type II myosin and septum materials are substantially delayed in the absence of functional Sip1. These results indicate that the conserved Sip1 protein comprises a novel non-SCF F...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 419 (2): 289–300.
Published: 27 March 2009
...@biologia.unipi.it ). 8 7 2008 3 11 2008 13 1 2009 13 1 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 actin/tubulin remodelling channel-interacting PDZ protein (CIPP) Cypin endocytosis insulin receptor tyrosine kinase substrate protein p53 (IRSp53...
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Biochem J (2009) 418 (3): 701–715.
Published: 25 February 2009
... phosphoprotein and a monomeric adaptor for clathrin-mediated endocytosis. In the present study, we employed GFP (green fluorescent protein) fusion constructs of different isoforms and mutants of rat Dab2 and characterized their effect on the size, distribution and dynamics of clathrin assemblies. Enhanced levels...
Includes: Multimedia, Supplementary data
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Biochem J (2009) 417 (3): 737–746.
Published: 16 January 2009
...). In addition to their role in phosphorylation of receptor tyrosine residues and downstream signalling substrates, JAKs have recently been implicated in controlling expression of cytokine receptors, predominantly by masking critical motifs involved in endocytosis and lysosomal targeting. In the present study...
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Biochem J (2008) 415 (3): e1–e3.
Published: 15 October 2008
... in plants. A study in this issue of the Biochemical Journal by König et al. reports for the first time in this kingdom the association of PtdIns(4,5) P 2 with an endomembrane fraction enriched for clathrin. This work is discussed in the context of current evidence for constitutive and evoked endocytosis...
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Biochem J (2008) 413 (3): 467–478.
Published: 15 July 2008
... encompasses a series of subcellular changes that are mandatory for, or even bolster, the apoptotic cascade. In the present study, we analysed the role of endocytosis in the propagation of cell death signalling after CD95/Fas engagement in type II cells (CEM cells). We show that this receptor–ligand...
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Biochem J (2008) 413 (3): e11–e12.
Published: 15 July 2008
.... report another aspect on endocytosis in response to CD95 ligation in type II cells, namely a caspase-independent endocytosis with vesicle translocation to the mitochondrial compartment, suggestive of an interplay between both organelles in the sense of an ‘organelle scrambling’. Thus early effects...
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Biochem J (2008) 413 (2): 251–259.
Published: 26 June 2008
... plasma membrane. 1 To whom correspondence should be addressed (e-mail vogel@imbg.ku.dk ). 31 10 2007 7 4 2008 10 4 2008 10 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 endocytosis hepatocyte growth factor activator inhibitor-1 (HAI-1...
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Biochem J (2008) 412 (3): 415–423.
Published: 28 May 2008
...Joshua Z. Rappoport Investigations into the mechanisms which regulate entry of integral membrane proteins, and associated ligands, into the cell through vesicular carriers (endocytosis) have greatly benefited from the application of live-cell imaging. Several excellent recent reviews have detailed...
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Biochem J (2007) 405 (1): 147–155.
Published: 13 June 2007
... for their internalization by clathrin-mediated endocytosis and subsequent trafficking, our results support a model whereby ubiquitin and clathrin adaptor binding sites act in concert to remove ENaC from the cell surface. 1 Present address: Department of Physiology II, Institute of Physiology, University...