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Keywords: endocytosis
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Articles
Importance of accessibility to the extracellular juxtamembrane stalk region of membrane protein for substrate recognition by viral ubiquitin ligase K5
Available to PurchaseMizuho Kajikawa, Mizuki Hata, Maho Ishimura, Nanae Imaizumi, Minako Kimura, Kei Miyano, Toyoyuki Ose, Daisuke Asai, Satoshi Ishido, Taisei Kanamoto
Journal:
Biochemical Journal
Biochem J (2022) 479 (20): 2261–2278.
Published: 28 October 2022
... Kajikawa ([email protected]) 19 6 2022 30 9 2022 17 10 2022 © 2022 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2022 endocytosis Kaposi's sarcoma-associated herpesvirus molecular interactions transmembrane proteins...
Includes: Supplementary data
Articles
Clathrin: the molecular shape shifter
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Journal:
Biochemical Journal
Biochem J (2021) 478 (16): 3099–3123.
Published: 26 August 2021
...Katherine M. Wood; Corinne J. Smith Clathrin is best known for its contribution to clathrin-mediated endocytosis yet it also participates to a diverse range of cellular functions. Key to this is clathrin's ability to assemble into polyhedral lattices that include curved football or basket shapes...
Articles
Crystal structure of human APPL BAR-PH heterodimer reveals a flexible dimeric BAR curve: implication in mutual regulation of endosomal targeting
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Journal:
Biochemical Journal
Biochem J (2020) 477 (24): 4769–4783.
Published: 24 December 2020
... crystallography curvature endocytosis heterodimer APPL1 APPL2 curvature endocytosis heterodimerization structure x-ray crystallography In response to extracellular stimuli, signaling transduction usually elicits endocytosis and intracellular trafficking of plasma membrane receptors, which...
Includes: Supplementary data
Articles
Journal:
Biochemical Journal
Biochem J (2020) 477 (12): 2327–2345.
Published: 26 June 2020
...Alessandra Casamento; Emmanuel Boucrot Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Clathrin-mediated endocytosis (CME) is the housekeeping pathway in resting cells but additional Clathrin-independent endocytic (CIE) routes, including Fast Endophilin...
Articles
The role of PTB domain containing adaptor proteins on PICALM-mediated APP endocytosis and localization
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Journal:
Biochemical Journal
Biochem J (2019) 476 (14): 2093–2109.
Published: 31 July 2019
... be endocytosed from the cell surface. The phosphatidylinositol binding clathrin assembly protein (PICALM) is involved in clathrin-mediated endocytosis and polymorphisms in and near the gene locus were identified as genetic risk factors for AD. PICALM overexpression enhances APP internalization and Aβ production...
Includes: Supplementary data
Articles
Insulin-induced exocytosis regulates the cell surface level of low-density lipoprotein-related protein-1 in Müller Glial cells
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Journal:
Biochemical Journal
Biochem J (2018) 475 (9): 1669–1685.
Published: 15 May 2018
... experiments were carried out with MIO-M1 cells transfected with the mLRP4-GFP-HA plasmid and polyclonal rabbit anti-HA-tag antibody (1/1000). endocytosis GTPases intracellular signaling membranes trafficking Low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) is a member...
Includes: Supplementary data
Articles
P2X7 receptor cross-talk regulates ATP-induced pannexin 1 internalization
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Journal:
Biochemical Journal
Biochem J (2017) 474 (13): 2133–2144.
Published: 13 June 2017
...-mediated, cholesterol-dependent P2X7R–Panx1 clustering and endocytosis. These findings have important implications for understanding the role of Panx1 in the nervous system and provide important new insights into Panx1–P2X7R cross-talk. Confocal imaging and analysis were performed blinded...
Includes: Supplementary data
Articles
Deubiquitylating enzymes in receptor endocytosis and trafficking
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Journal:
Biochemical Journal
Biochem J (2016) 473 (24): 4507–4525.
Published: 09 December 2016
...Aidan P. McCann; Christopher J. Scott; Sandra Van Schaeybroeck; James F. Burrows In recent times, our knowledge of the roles ubiquitin plays in multiple cellular processes has expanded exponentially, with one example being the role of ubiquitin in receptor endocytosis and trafficking. This has...
Articles
The intricate regulation and complex functions of the Class III phosphoinositide 3-kinase Vps34
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Journal:
Biochemical Journal
Biochem J (2016) 473 (15): 2251–2271.
Published: 28 July 2016
[email protected] ). 29 2 2016 25 3 2016 30 3 2016 © 2016 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society 2016 autophagy Class III phosphoinositide 3-kinase endocytosis phosphoinositide 3-kinase phosphorylation/dephosphorylation Vps34...
Articles
Septin oligomerization regulates persistent expression of ErbB2/HER2 in gastric cancer cells
Available to PurchaseElizabeth A. Marcus, Elmira Tokhtaeva, Shahlo Turdikulova, Joseph Capri, Julian P. Whitelegge, David R. Scott, George Sachs, Fedor Berditchevski, Olga Vagin
Journal:
Biochemical Journal
Biochem J (2016) 473 (12): 1703–1718.
Published: 10 June 2016
..., septins protect ErbB2 from ubiquitylation, endocytosis and lysosomal degradation. The FCF-induced degradation pathway is distinct from and additive with the degradation induced by inhibiting ErbB2 chaperone Hsp90. These results identify septins as novel regulators of ErbB2 expression that contribute...
Includes: Supplementary data
Articles
Interdependence of ATP signalling and pannexin channels; the servant was really the master all along?
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Journal:
Biochemical Journal
Biochem J (2015) 472 (3): e27–e30.
Published: 27 November 2015
... [email protected] . This work was supported by operating grant support to M.F.J. from the Canadian Institutes of Health Research (CIHR) [grant number MOP-125901]. CIE clathrin-independent endocytosis CME clathrin-mediated endocytosis EEA1 early endosome antigen 1 ER...
Articles
Soybean extracts increase cell surface ZIP4 abundance and cellular zinc levels: a potential novel strategy to enhance zinc absorption by ZIP4 targeting
Available to PurchaseAyako Hashimoto, Katsuma Ohkura, Masakazu Takahashi, Kumiko Kizu, Hiroshi Narita, Shuichi Enomoto, Yusaku Miyamae, Seiji Masuda, Masaya Nagao, Kazuhiro Irie, Hajime Ohigashi, Glen K. Andrews, Taiho Kambe
Journal:
Biochemical Journal
Biochem J (2015) 472 (2): 183–193.
Published: 13 November 2015
... such soybean extracts were identified that were specifically able to decrease mZip4 endocytosis in response to zinc. These soybean extracts also effectively increased the abundance of apically localized mZip4 in transfected polarized Caco2 and Madin–Darby canine kidney cells and, moreover, two apically...
Includes: Supplementary data
Articles
Michael D.J. Parkinson, Siân C. Piper, Nicholas A. Bright, Jennifer L. Evans, Jessica M. Boname, Katherine Bowers, Paul J. Lehner, J. Paul Luzio
Journal:
Biochemical Journal
Biochem J (2015) 471 (1): 79–88.
Published: 21 September 2015
... ligase that promotes Lys 63 -linked polyubiquitination of MHC class I, providing the signal for clathrin-mediated endocytosis. Endocytosis is followed by sorting into the intralumenal vesicles (ILVs) of multivesicular bodies (MVBs) and eventual delivery to lysosomes. The sorting of MHC class I into MVBs...
Articles
ATP stimulates pannexin 1 internalization to endosomal compartments
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Journal:
Biochemical Journal
Biochem J (2015) 470 (3): 319–330.
Published: 04 September 2015
... correlation coefficient of Panx1–EGFP and antibodies for sub-cellular compartment-specific markers was determined per cell in each region of interest. The data for ≥50 cells was averaged for each biological replicate ( n =4). adenosine 5′-triphosphate (ATP) endocytosis endosomes pannexin 1...
Includes: Multimedia, Supplementary data
Articles
Inositol lipid phosphatases in membrane trafficking and human disease
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Journal:
Biochemical Journal
Biochem J (2014) 461 (2): 159–175.
Published: 26 June 2014
... endocytosis human disease inositol phosphatase membrane traffic phosphoinositide secretory pathway Phosphoinositides are a family of lipid molecules that play critical roles in the cell [ 1 , 2 ]. Derived from phosphorylation of phosphatidylinositol (PtdIns), phosphoinositides consist of two...
Articles
Rupesh Paudyal, Adam Jamaluddin, James P. Warren, Siamsa M. Doyle, Stéphanie Robert, Stuart L. Warriner, Alison Baker
Journal:
Biochemical Journal
Biochem J (2014) 460 (2): 177–185.
Published: 13 May 2014
...) and are essential for the gravitropic response in plants. The present study characterizes an inhibitor of endomembrane protein trafficking, TE1 (trafficking and endocytosis inhibitor 1/TENin1) that reduces gravitropic root bending in Arabidopsis thaliana seedlings. Short-term TE1 treatment causes accumulation of PM...
Includes: Supplementary data
Articles
Beyond dsRNA: Toll-like receptor 3 signalling in RNA-induced immune responses
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Journal:
Biochemical Journal
Biochem J (2014) 458 (2): 195–201.
Published: 14 February 2014
... through clathrin- and raftlin-dependent endocytosis and delivered to endosomal TLR3. The dsRNA uptake machinery, in addition to TLR3, is critical for extracellular viral RNA-induced immune responses. A wide spectrum of TLR3 ligand structures beyond dsRNA and their delivery systems provide new insights...
Articles
βTrCP interacts with the ubiquitin-dependent endocytosis motif of the GH receptor in an unconventional manner
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Journal:
Biochemical Journal
Biochem J (2013) 453 (2): 291–301.
Published: 28 June 2013
... by the endocytosis of the receptor via βTrCP (β-transducin repeat-containing protein). In the present study, we show that βTrCP interacts directly via its WD40 domain with the UbE (ubiquitin-dependent endocytosis) motif in GHR, promoting GHR ubiquitination in vitro . NMR experiments demonstrated that the UbE motif...
Articles
The Arf GAP AGAP2 interacts with β-arrestin2 and regulates β 2 -adrenergic receptor recycling and ERK activation
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Journal:
Biochemical Journal
Biochem J (2013) 452 (3): 411–421.
Published: 31 May 2013
... 2013 AGAP2 β-arrestin2 Arf GTPase-activating protein endocytosis G-protein-coupled receptor recycling endosome β 2 ARs (β 2 -adrenergic receptors) are members of the GPCR (G-protein-coupled receptor) superfamily and couple to both G s and G i proteins [ 1 , 2 ]. Agonist binding to β 2...
Articles
Tumour cells can employ extracellular Ins(1,2,3,4,5,6) P 6 and multiple inositol-polyphosphate phosphatase 1 (MINPP1) dephosphorylation to improve their proliferation
Available to PurchaseSabine Windhorst, Hongying Lin, Christine Blechner, Werner Fanick, Laura Brandt, Maria A. Brehm, Georg W. Mayr
Journal:
Biochemical Journal
Biochem J (2013) 450 (1): 115–125.
Published: 24 January 2013
... correspondence should be addressed (email [email protected] ). 3 10 2012 15 11 2012 28 11 2012 28 11 2012 © The Authors Journal compilation © 2013 Biochemical Society 2013 endocytosis Ins(1,2,3,4,5,6) P 6 (InsP 6 ) micro nutrients myo -inositol phytase phytate...
Includes: Supplementary data
Articles
EHD2 shuttles to the nucleus and represses transcription
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Journal:
Biochemical Journal
Biochem J (2012) 444 (3): 383–394.
Published: 29 May 2012
.... There are four EHD proteins in mammalian cells, EHD1–EHD4, each with diverse roles in the recycling pathway of endocytosis. EHD2 is a plasma-membrane-associated member of the EHD family that regulates internalization. Since several endocytic proteins have been shown to undergo nucleocytoplasmic shuttling...
Includes: Supplementary data
Articles
Dab2 is a key regulator of endocytosis and post-endocytic trafficking of the cystic fibrosis transmembrane conductance regulator
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Journal:
Biochemical Journal
Biochem J (2012) 441 (2): 633–643.
Published: 21 December 2011
...Lianwu Fu; Andras Rab; Li Ping Tang; Steven M. Rowe; Zsuzsa Bebok; James F. Collawn CFTR (cystic fibrosis transmembrane conductance regulator) is expressed in the apical membrane of epithelial cells. Cell-surface CFTR levels are regulated by endocytosis and recycling. A number of adaptor proteins...
Articles
EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity
Available to PurchaseSigi Benjamin, Hilla Weidberg, Debora Rapaport, Olga Pekar, Marina Nudelman, Daniel Segal, Koret Hirschberg, Shulamit Katzav, Marcelo Ehrlich, Mia Horowitz
Journal:
Biochemical Journal
Biochem J (2011) 439 (3): 433–445.
Published: 13 October 2011
...Sigi Benjamin; Hilla Weidberg; Debora Rapaport; Olga Pekar; Marina Nudelman; Daniel Segal; Koret Hirschberg; Shulamit Katzav; Marcelo Ehrlich; Mia Horowitz EHDs [EH (Eps15 homology)-domain-containing proteins] participate in different stages of endocytosis. EHD2 is a plasma-membrane-associated EHD...
Includes: Supplementary data
Articles
Ubiquitin-mediated internalization of connexin43 is independent of the canonical endocytic tyrosine-sorting signal
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Journal:
Biochemical Journal
Biochem J (2011) 437 (2): 255–267.
Published: 28 June 2011
... their internalization and degradation. Furthermore, this internalization induced by Ub was shown to be independent of the YXXØ motif present on Cx43. © The Authors Journal compilation © 2011 Biochemical Society 2011 connexin43 (Cx43) endocytosis epidermal growth factor receptor substrate 15 (Eps15) gap...
Includes: Multimedia, Supplementary data
Articles
Functional analysis of Dictyostelium IBARa reveals a conserved role of the I-BAR domain in endocytosis
Available to PurchaseDouwe M. Veltman, Giulio Auciello, Heather J. Spence, Laura M. Machesky, Joshua Z. Rappoport, Robert H. Insall
Journal:
Biochemical Journal
Biochem J (2011) 436 (1): 45–52.
Published: 27 April 2011
... with clathrin plaques, although its homologues IRSp53 and IRTKS (insulin receptor tyrosine kinase substrate) associate with other punctate structures. The results from the present study suggest that I-BAR-containing proteins help generate the mem-brane curvature required for endocytosis and implies...
Includes: Supplementary data
Articles
Visualization of retrovirus uptake and delivery into acidic endosomes
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Journal:
Biochemical Journal
Biochem J (2011) 434 (3): 559–569.
Published: 24 February 2011
...Kosuke Miyauchi; Mariana Marin; Gregory B. Melikyan Diverse enveloped viruses enter cells by endocytosis and fusion with intracellular compartments. Recent evidence suggests that HIV also infects permissive cell lines by fusing with endosomes in a pH-independent manner. This finding highlights...
Includes: Supplementary data
Articles
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor
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Journal:
Biochemical Journal
Biochem J (2011) 434 (2): 343–351.
Published: 11 February 2011
... 2011 endocytosis deubiquitinating enzyme (DUB) granulocyte colony-stimulating factor 3 (CSF3) receptor signal transducer and activator of transcription (STAT) 5 suppressor of cytokine signalling (SOCS) 3 Deubiquitinating enzymes remove Ub (ubiquitin) from their target substrates...
Articles
The myotubularin family of lipid phosphatases in disease and in spermatogenesis
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Journal:
Biochemical Journal
Biochem J (2011) 433 (2): 253–262.
Published: 22 December 2010
... in spermatogenic defects. Other studies have shown that MTMR2 functions in endocytosis and membrane trafficking. In the testis, MTMR2 interacts and co-localizes with c-Src/phospho-Src-(Tyr 416 ), a non-receptor protein tyrosine kinase that regulates the phosphorylation state of proteins at the apical ES...
Includes: Supplementary data
Articles
Specific amino acids in the BAR domain allow homodimerization and prevent heterodimerization of sorting nexin 33
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Journal:
Biochemical Journal
Biochem J (2011) 433 (1): 75–83.
Published: 15 December 2010
...Bastian Dislich; Manuel E. Than; Stefan F. Lichtenthaler SNX33 (sorting nexin 33) is a homologue of the endocytic prote-in SNX9 and has been implicated in actin polymerization and the endocytosis of the amyloid precursor protein. SNX33 belongs to the large family of BAR (Bin/amphiphysin/Rvs) domain...
Includes: Supplementary data
Articles
Endocytosis of hyaluronidase-1 by the liver
Available to PurchaseMarie-Christine Gasingirwa, Jacqueline Thirion, Jeannine Mertens-Strijthagen, Simone Wattiaux-De Coninck, Bruno Flamion, Robert Wattiaux, Michel Jadot
Journal:
Biochemical Journal
Biochem J (2010) 430 (2): 305–313.
Published: 13 August 2010
...Marie-Christine Gasingirwa; Jacqueline Thirion; Jeannine Mertens-Strijthagen; Simone Wattiaux-De Coninck; Bruno Flamion; Robert Wattiaux; Michel Jadot It has been suggested that intracellular Hyal-1 (hyaluronidase-1), which is considered a lysosomal enzyme, originates via endocytosis of the serum...
Articles
Transferrin-iron routing to the cytosol and mitochondria as studied by live and real-time fluorescence
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Journal:
Biochemical Journal
Biochem J (2010) 429 (1): 185–193.
Published: 14 June 2010
...Maya Shvartsman; Eitan Fibach; Z. Ioav Cabantchik In the present study we analysed the mechanism of intracellular routing of iron acquired by erythroid cells via receptor-mediated endocytosis of Tf-Fe [Tf (transferrin)-iron]. Using real-time fluorimetry and flow cytometry, in conjunction...
Articles
Adaptor protein 2 regulates receptor-mediated endocytosis and cyst formation in Giardia lamblia
Available to PurchaseMaria R. Rivero, Cecilia V. Vranych, Mariano Bisbal, Belkys A. Maletto, Andrea S. Ropolo, Maria C. Touz
Journal:
Biochemical Journal
Biochem J (2010) 428 (1): 33–45.
Published: 28 April 2010
..., suggesting its involvement in endocytosis. Uptake experiments using standard molecules for the study of endocytosis revealed that gAP2 specifically participated in the endocytosis of LDL (low-density lipoprotein). Targeted down-regulation of the gene encoding gμ2 in growing and encysting trophozoites...
Includes: Supplementary data
Articles
Analysis of the dual function of the ESCRT-III protein Snf7 in endocytic trafficking and in gene expression
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Journal:
Biochemical Journal
Biochem J (2009) 424 (1): 89–97.
Published: 23 October 2009
... © The Authors Journal compilation © 2009 Biochemical Society 2009 endocytosis endosomal sorting complex required for transport (ESCRT) multivesicular body Rim101 pathway Snf7/chromatin modifying protein 4 (CHMP4) vacuolar protein sorting During endocytosis, cell surface proteins...
Articles
Dynasore inhibits removal of wild-type and ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) from the plasma membrane
Available to PurchaseAndrew Young, Martina Gentzsch, Cynthia Y. Abban, Ying Jia, Patricio I. Meneses, Robert J. Bridges, Neil A. Bradbury
Journal:
Biochemical Journal
Biochem J (2009) 421 (3): 377–385.
Published: 15 July 2009
...Andrew Young; Martina Gentzsch; Cynthia Y. Abban; Ying Jia; Patricio I. Meneses; Robert J. Bridges; Neil A. Bradbury Dynasore, a small molecule inhibitor of dynamin, was used to probe the role of dynamin in the endocytosis of wild-type and mutant CFTR (cystic fibrosis transmembrane conductance...
Articles
Low concentration thresholds of plasma membranes for rapid energy-independent translocation of a cell-penetrating peptide
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Journal:
Biochemical Journal
Biochem J (2009) 420 (2): 179–191.
Published: 13 May 2009
... peptide (CPP) cholesterol endocytosis fluorescence microscopy methyl-β-cyclodextrin (MβCD) octa-arginine Cholesterol is a major constituent of the mammalian plasma membrane, accounting for between 30 and 40 mol% of the total lipid content [ 24 ]. The conformational structure of cholesterol...
Includes: Multimedia, Supplementary data
Articles
Identification of a conserved F-box protein 6 interactor essential for endocytosis and cytokinesis in fission yeast
Available to PurchaseIsabelle Jourdain, Nathalie Spielewoy, James Thompson, Susheela Dhut, John R. Yates, III, Takashi Toda
Journal:
Biochemical Journal
Biochem J (2009) 420 (2): 169–180.
Published: 13 May 2009
... are defective in endocytosis. Furthermore, towards the end of cytokinesis, constriction of the actomyosin ring and dissociation of type II myosin and septum materials are substantially delayed in the absence of functional Sip1. These results indicate that the conserved Sip1 protein comprises a novel non-SCF F...
Includes: Multimedia, Supplementary data
Articles
Channel-interacting PDZ protein, ‘CIPP’, interacts with proteins involved in cytoskeletal dynamics
Available to PurchaseEmanuele Alpi, Elena Landi, Manuela Barilari, Michela Serresi, Piero Salvadori, Angela Bachi, Luciana Dente
Journal:
Biochemical Journal
Biochem J (2009) 419 (2): 289–300.
Published: 27 March 2009
... . Neuronal phenotype was induced by 72 h of incubation with 100 ng/ml NGF (nerve growth factor) (Alomone Labs). © The Authors Journal compilation © 2009 Biochemical Society 2009 actin/tubulin remodelling channel-interacting PDZ protein (CIPP) Cypin endocytosis insulin receptor tyrosine kinase...
Includes: Supplementary data
Articles
Dab2 regulates clathrin assembly and cell spreading
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Journal:
Biochemical Journal
Biochem J (2009) 418 (3): 701–715.
Published: 25 February 2009
... phosphoprotein and a monomeric adaptor for clathrin-mediated endocytosis. In the present study, we employed GFP (green fluorescent protein) fusion constructs of different isoforms and mutants of rat Dab2 and characterized their effect on the size, distribution and dynamics of clathrin assemblies. Enhanced levels...
Includes: Multimedia, Supplementary data
Articles
Glycosylphosphatidylinositol-specific phospholipase C regulates transferrin endocytosis in the African trypanosome
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Journal:
Biochemical Journal
Biochem J (2009) 417 (3): 685–694.
Published: 16 January 2009
... the virulence of a pleomorphic strain of the parasite, for reasons that are not clear. In the present paper, we report that GPI-PLC stimulates endocytosis of transferrin by 300–500%. Surprisingly, GPI-PLC is not detected at endosomes, suggesting that the enzyme does not interact directly with the endosomal...
Articles
Janus kinases promote cell-surface expression and provoke autonomous signalling from routing-defective G-CSF receptors
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Journal:
Biochemical Journal
Biochem J (2009) 417 (3): 737–746.
Published: 16 January 2009
...). In addition to their role in phosphorylation of receptor tyrosine residues and downstream signalling substrates, JAKs have recently been implicated in controlling expression of cytokine receptors, predominantly by masking critical motifs involved in endocytosis and lysosomal targeting. In the present study...
Articles
Sorting out PtdIns(4,5) P 2 and clathrin-coated vesicles in plants
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Journal:
Biochemical Journal
Biochem J (2008) 415 (3): e1–e3.
Published: 15 October 2008
... in plants. A study in this issue of the Biochemical Journal by König et al. reports for the first time in this kingdom the association of PtdIns(4,5) P 2 with an endomembrane fraction enriched for clathrin. This work is discussed in the context of current evidence for constitutive and evoked endocytosis...
Articles
CD95 ligation and intracellular membrane flow
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Journal:
Biochemical Journal
Biochem J (2008) 413 (3): e11–e12.
Published: 15 July 2008
.... report another aspect on endocytosis in response to CD95 ligation in type II cells, namely a caspase-independent endocytosis with vesicle translocation to the mitochondrial compartment, suggestive of an interplay between both organelles in the sense of an ‘organelle scrambling’. Thus early effects...
Articles
Endosomal compartment contributes to the propagation of CD95/Fas-mediated signals in type II cells
Available to PurchasePaola Matarrese, Valeria Manganelli, Tina Garofalo, Antonella Tinari, Lucrezia Gambardella, Kenneth Ndebele, Roya Khosravi-Far, Maurizio Sorice, Mauro Degli Esposti, Walter Malorni
Journal:
Biochemical Journal
Biochem J (2008) 413 (3): 467–478.
Published: 15 July 2008
... encompasses a series of subcellular changes that are mandatory for, or even bolster, the apoptotic cascade. In the present study, we analysed the role of endocytosis in the propagation of cell death signalling after CD95/Fas engagement in type II cells (CEM cells). We show that this receptor–ligand...
Articles
Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary
Available to PurchaseSine Godiksen, Joanna Selzer-Plon, Esben D. K. Pedersen, Kathrine Abell, Hanne B. Rasmussen, Roman Szabo, Thomas H. Bugge, Lotte K. Vogel
Journal:
Biochemical Journal
Biochem J (2008) 413 (2): 251–259.
Published: 26 June 2008
... plasma membrane. 1 To whom correspondence should be addressed (e-mail [email protected] ). 31 10 2007 7 4 2008 10 4 2008 10 4 2008 © The Authors Journal compilation © 2008 Biochemical Society 2008 endocytosis hepatocyte growth factor activator inhibitor-1 (HAI-1...
Articles
Focusing on clathrin-mediated endocytosis
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Journal:
Biochemical Journal
Biochem J (2008) 412 (3): 415–423.
Published: 28 May 2008
...Joshua Z. Rappoport Investigations into the mechanisms which regulate entry of integral membrane proteins, and associated ligands, into the cell through vesicular carriers (endocytosis) have greatly benefited from the application of live-cell imaging. Several excellent recent reviews have detailed...
Articles
Lactoferrin receptor mediates apo- but not holo-lactoferrin internalization via clathrin-mediated endocytosis in trophoblasts
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Journal:
Biochemical Journal
Biochem J (2008) 411 (2): 271–278.
Published: 27 March 2008
... to a LfR of ∼105 kDa. Apo-Lf treatment significantly increased LfR abundance at the plasma membrane and internalization probably occurs via clathrin-mediated endocytosis through early and recycling endosomes, as LfR was co-localized with EEA1 (early endosome antigen 1) and TfR (transferrin receptor) using...
Articles
Enhanced cell-surface stability of rescued ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones
Available to PurchaseKaroly Varga, Rebecca F. Goldstein, Asta Jurkuvenaite, Lan Chen, Sadis Matalon, Eric J. Sorscher, Zsuzsa Bebok, James F. Collawn
Journal:
Biochemical Journal
Biochem J (2008) 410 (3): 555–564.
Published: 27 February 2008
... show that rΔF508 CFTR endocytosis is 6-fold more rapid (∼30% per 2.5 min) than WT (wild-type, ∼5% per 2.5 min) CFTR at 37 °C in polarized airway epithelial cells (CFBE41o − ). We also investigated rΔF508 CFTR endocytosis under two further conditions: in culture at the permissive temperature (27 °C...
Articles
Regulation of clathrin-dependent endocytosis by diacylglycerol kinase δ: importance of kinase activity and binding to AP2α
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Journal:
Biochemical Journal
Biochem J (2008) 409 (2): 471–479.
Published: 21 December 2007
... the molecular mechanism of DGKδ-mediated regulation of clathrin-dependent endocytosis that controls the internalization, recycling and degradation of receptors. Involvement of DGKδ in the regulation of clathrin-dependent endocytosis was previously proposed following genome-wide RNAi (RNA interference) screening...
Articles
Hetero-oligomerization of the P2Y 11 receptor with the P2Y 1 receptor controls the internalization and ligand selectivity of the P2Y 11 receptor
Available to PurchaseDenise Ecke, Theodor Hanck, Mohan E. Tulapurkar, Rainer Schäfer, Matthias Kassack, Rolf Stricker, Georg Reiser
Journal:
Biochemical Journal
Biochem J (2008) 409 (1): 107–116.
Published: 11 December 2007
... internalization of the P2Y 11 receptor. This is remarkable because the P2Y 11 receptor by itself is not able to undergo endocytosis. Co-internalization of these receptors was also seen in 1321N1 astrocytoma cells co-expressing both P2Y 11 and P2Y 1 receptors, upon stimulation with ATP or the P2Y 1 receptor...
Includes: Supplementary data
Articles
Epithelial sodium channel (ENaC) is multi-ubiquitinated at the cell surface
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Journal:
Biochemical Journal
Biochem J (2007) 405 (1): 147–155.
Published: 13 June 2007
... for their internalization by clathrin-mediated endocytosis and subsequent trafficking, our results support a model whereby ubiquitin and clathrin adaptor binding sites act in concert to remove ENaC from the cell surface. 1 Present address: Department of Physiology II, Institute of Physiology, University...
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