...). In addition, we have discovered that 2DG protects cells against Shiga toxins (Stxs) and inhibits release of the cytotoxic StxA 1 moiety in the endoplasmic reticulum (ER). The data indicate that the 2DG-induced protection against Stx is independent of inhibition of glycolysis or N-glycosylation, but rather...

... concentration due to release from stores within the endoplasmic reticulum (ER) and influx from the extracellular environment. In addition to regulating cytoplasmic Ca 2+ signals, these responses also affect the concentration of Ca 2+ within the ER and mitochondria. Single fluorescent protein-based Ca 2...

...-homology domain. We demonstrate that Arl6IP1 has the ability to bind to atlastin and shape the ER tubules in a reticulon-like fashion. ADP-ribosylation factor-like 6 interacting protein 1 (Arl6IP1) endoplasmic reticulum (ER) membrane-shaping protein receptor expression-enhancing protein/deleted...

... retrotranslocation from the endoplasmic reticulum to the cytosol. endoplasmic reticulum (ER) ER-degradation enhancing α-mannosidase I-like protein 1 (EDEM1) EDEM2 retrotranslocation ricin HEK-293 cells were grown under 5% CO 2 in DMEM (Dulbecco's modified Eagle's medium) supplemented with 10...

... 13 6 2012 © The Authors Journal compilation © 2012 Biochemical Society 2012 cancer endoplasmic reticulum (ER) ER membrane lipid raft-associated 2 (ERLIN2) lipogenesis oncogenesis Increased lipid and energy metabolism is a prominent feature of cancer [ 1 ]. It has been...

... Biochemical Society 2011 endoplasmic reticulum (ER) membrane protein complex Sec61 tail-anchor proteins translocon yeast Transport across the ER (endoplasmic reticulum) is a vital first committed step in the biogenesis of secretory and integral membrane proteins. These proteins are targeted...

... 9 2010 7 3 2011 9 3 2011 9 3 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endoplasmic reticulum degradation-enhancing α-mannosidase I-like protein 1 (EDEM1) endoplasmic reticulum (ER) endosomal–lysosomal degradation P250A mutation...

... in normal cells. 1 To whom correspondence should be addressed (email [email protected] ). 19 11 2010 13 1 2011 17 1 2011 17 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 Akt autophagy Bcl-2 protein family endoplasmic reticulum (ER...

... 6 1 2011 20 1 2011 20 1 2011 © The Authors Journal compilation © 2011 Biochemical Society 2011 endoplasmic reticulum (ER) homoeostasis Saccharomyces cerevisiae transcription zinc Zrg17 Zinc serves as a catalytic or structural cofactor for a large number...

..., provided the original work is properly cited. calcium endoplasmic reticulum (ER) Golli myelin basic protein (MBP) store-operated Ca 2+ entry (SOCE) stromal interaction molecule 1 (STIM1) A previous paper by Varnai et al. [ 21 ] suggested that STIM1 and Orai1 form part of a large...

... reticulum in a specialized vesicle, the VLDL transport vesicle, in rat primary hepatocytes Biochem. J. 2008 413 333 342 22 Gusarova V. Brodsky J. L. Fisher E. A. Apolipoprotein B100 exit from the endoplasmic reticulum (ER) is COPII-dependent, and its lipidation to very low density...

... stress response, the transcription factors ATF6 (activating transcription factor 6) [ 11 ] and XBP1 induce ER chaperones, folding enzymes, including PDI (protein disulfide isomerase) (as described below) and some components of ERAD [ 5 , 12 , 13 ]. endoplasmic reticulum (ER) endoplasmic reticulum...

... should be addressed (email [email protected] ). 6 7 2009 28 8 2009 6 10 2009 6 10 2009 © The Authors Journal compilation © 2010 Biochemical Society 2010 endoplasmic reticulum (ER) hypoacetylaspartia membrane protein N -acetylaspartate (NAA) N...

... Paso Drive, El Paso, TX 79905, U.S.A. 3 To whom correspondence should be addressed (email [email protected] ). 4 9 2008 3 2 2009 5 2 2009 5 2 2009 © The Authors Journal compilation © 2009 Biochemical Society 2009 drug development endoplasmic reticulum (ER...

... compilation © 2009 Biochemical Society 2009 calcium homoeostasis calreticulin endoplasmic reticulum (ER) protein folding quality control Within the lumen of the ER are a number of Ca 2+ -buffering proteins that are responsible for binding ER luminal Ca 2+ as well as being involved...

... – 11 ], whereas other studies suggest that the Golgi is the site where the formation of mature VLDL takes place [ 12 – 14a ]. apolipoprotein B (apoB) endoplasmic reticulum (ER) triacylglycerol (TAG) very-low-density lipoprotein (VLDL) VLDL transport vesicle (VTV) © The Authors Journal...

... ]. coatamer protein II signal (COPII signal) corrector cystic fibrosis cystic fibrosis transmembrane conductance regulator (CFTR) endoplasmic reticulum (ER) protein folding Figure 4 Effects of correctors, channel blockers and potentiators on cross-linking HEK-293 cells expressing M348C(TM6...

... initially tested. The probe position generating the clearest adducts with known components of the Sec61 complex was then selected for detailed analysis (results not shown). endoplasmic reticulum (ER) cross-linking independent folding domains membrane protein assembly protein associated...

... is present in neuronal elements closely associated with the glutamatergic pathways throughout the brain [ 5 ]. Functional and anatomical evidence strongly support a role of GLYT1 in regulating NMDAR-mediated neurotransmission [ 5 – 12 ]. coatomer coat protein II (COPII) endoplasmic reticulum (ER...

... containing 0.1 mM CaCl 2 (buffer A). calcium store chaperone endoplasmic reticulum (ER) glucose-regulated protein of 94 kDa (GRP94) heat-shock protein (HSP) GRP94 (glucose-regulated protein of 94 kDa), also known as gp96 (glycoprotein 96), is an ER (endoplasmic reticulum) molecular...

... reticulum (ER) inositol trisphosphate receptor (IP 3 R) RBL-2H3 cell line yellow fluorescent protein (YFP) agonist A rise in cytosolic Ca 2+ is a key trigger for the regulation of a huge variety of cell processes [ 1 ]. One source of cytosolic Ca 2+ in many cells is the release of Ca 2+ from...

... The Biochemical Society, London 2006 eukaryotic initiation factor-2α (eIF2α) endoplasmic reticulum (ER) mitogen associated protein kinase (MAPK) calcium homoeostasis stress response immediate-early (IE) genes The total RNA used for microarray analysis was isolated using Atlas Pure Total RNA...

... be sent (email [email protected] ). 19 5 2005 20 9 2005 21 9 2005 21 9 2005 The Biochemical Society, London 2005 calcium (Ca 2+ ) cytoskeleton endoplasmic reticulum (ER) inositol 1,4,5-trisphosphate 3-kinases A and B (IP3KA and IP3KB) proteolysis subcellular...

... correspond to residues 1–211, 212–711 and 712–994 of SERCA1, and residues 1–264, 265–788 and 789–1159 of PMCA3 respectively. Only chimaeras containing the N-terminal segment of SERCA1 were located in the endoplasmic reticulum (ER), whereas chimaeras containing the N-terminal segment from PMCA3 were able...